{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:37:51Z","timestamp":1786991871741,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011360","name":"State Key Laboratory of Natural Medicines","doi-asserted-by":"publisher","award":["SKLNMZZCX201811"],"award-info":[{"award-number":["SKLNMZZCX201811"]}],"id":[{"id":"10.13039\/501100011360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3100877"],"award-info":[{"award-number":["3100877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473153"],"award-info":[{"award-number":["81473153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503006"],"award-info":[{"award-number":["81503006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773664"],"award-info":[{"award-number":["81773664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2015CB755504"],"award-info":[{"award-number":["2015CB755504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","award":["CPU2018GF10"],"award-info":[{"award-number":["CPU2018GF10"]}],"id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003512","name":"State Administration of Foreign Experts Affairs","doi-asserted-by":"publisher","award":["111-2-07"],"award-info":[{"award-number":["111-2-07"]}],"id":[{"id":"10.13039\/501100003512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003512","name":"State Administration of Foreign Experts Affairs","doi-asserted-by":"publisher","award":["B17047"],"award-info":[{"award-number":["B17047"]}],"id":[{"id":"10.13039\/501100003512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150698"],"award-info":[{"award-number":["BK20150698"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170747"],"award-info":[{"award-number":["BK20170747"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jconrel.2019.10.043","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T12:21:48Z","timestamp":1572265308000},"page":"236-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["An apoptotic body-biomimic liposome in situ upregulates anti-inflammatory macrophages for stabilization of atherosclerotic plaques"],"prefix":"10.1016","volume":"316","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiLi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QianQian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LingJing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-5438","authenticated-orcid":false,"given":"Can","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2019.10.043_bib0005","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0020","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOL.0000000000000440","article-title":"Mechanisms of erosion of atherosclerotic plaques","volume":"28","author":"Quillard","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0025","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jacc.2017.07.750","article-title":"Unraveling vascular inflammation: from immunology to imaging","volume":"70","author":"Teague","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0030","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/ATVBAHA.117.309045","article-title":"Linking hemorrhage, angiogenesis, macrophages, and iron metabolism in atherosclerotic vascular diseases","volume":"37","author":"Guo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0035","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/ATVBAHA.116.308461","article-title":"Role of KCa3.1 channels in macrophage polarization and its relevance in atherosclerotic plaque instability","volume":"37","author":"Xu","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCRESAHA.114.302355","article-title":"Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies","volume":"114","author":"Silvestre-Roig","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0045","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2017.09.008","article-title":"Monocyte-macrophages and t cells in atherosclerosis","volume":"47","author":"Tabas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0050","doi-asserted-by":"crossref","first-page":"17520","DOI":"10.1021\/la1029728","article-title":"Thiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages","volume":"26","author":"Choi","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0055","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.002568","article-title":"Near infrared imaging and photothermal ablation of vascular inflammation using single-walled carbon nanotubes","volume":"1","author":"Kosuge","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0060","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1002\/smll.201000596","article-title":"A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis","volume":"6","author":"Mccarthy","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0065","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrneph.2017.51","article-title":"The immunology of atherosclerosis","volume":"13","author":"Gistera","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0070","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41590-018-0113-3","article-title":"Regulation of macrophage immunometabolism in atherosclerosis","volume":"19","author":"Koelwyn","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0075","doi-asserted-by":"crossref","first-page":"31130","DOI":"10.1038\/srep31130","article-title":"Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-\/-) mice","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0080","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jacc.2005.03.041","article-title":"Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study","volume":"45","author":"Pfutzner","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0085","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/01.CIR.0000165072.01672.21","article-title":"Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study","volume":"111","author":"Langenfeld","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0090","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.jacc.2006.12.048","article-title":"The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study","volume":"49","author":"Erdmann","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0095","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jconrel.2013.06.012","article-title":"Rosiglitazone-loaded nanospheres for modulating macrophage-specific inflammation in obesity","volume":"170","author":"Di Mascolo","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0100","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1161\/CIRCULATIONAHA.111.056309","article-title":"Mice with cardiac overexpression of peroxisome proliferator-activated receptor gamma have impaired repolarization and spontaneous fatal ventricular arrhythmias","volume":"124","author":"Morrow","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0105","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0110","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201702793","article-title":"Recent advances in managing atherosclerosis via nanomedicine","volume":"14","author":"Chan","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1021\/acsnano.7b07720","article-title":"Nanoparticle functionalization with platelet membrane enables multifactored biological targeting and detection of atherosclerosis","volume":"12","author":"Wei","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2018.05.041","article-title":"Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: a dual cell therapy to regress plaques","volume":"283","author":"Zhao","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0125","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1038\/ncomms4065","article-title":"A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation","volume":"5","author":"Duivenvoorden","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0130","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.ATV.0000148548.47755.22","article-title":"Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice","volume":"25","author":"Liu","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0140","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/ATVBAHA.111.227140","article-title":"Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis","volume":"31","author":"Yamada","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0145","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI90520","article-title":"MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis","volume":"127","author":"Cai","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1172\/JCI0211638","article-title":"Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation","volume":"109","author":"Huynh","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0155","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.4049\/jimmunol.1003865","article-title":"Cutting edge: humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing","volume":"186","author":"Norling","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0160","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jconrel.2015.09.027","article-title":"Hybrid nanoparticles improve targeting to inflammatory macrophages through phagocytic signals","volume":"217","author":"Bagalkot","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0165","doi-asserted-by":"crossref","first-page":"11752","DOI":"10.1038\/srep11752","article-title":"SPECT\/CT imaging of high-risk atherosclerotic plaques using integrin-binding RGD dimer peptides","volume":"5","author":"Yoo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0170","first-page":"5080","article-title":"Bone marrow-derived macrophages (BMM): isolation and applications","volume":"2008","author":"Weischenfeldt","year":"2008","journal-title":"CSH Protoc."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0175","first-page":"12","article-title":"Activation of murine macrophages","volume":"14","author":"Mosser","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0180","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1016\/j.biomaterials.2014.04.031","article-title":"Targeting efficiency of RGD-modified nanocarriers with different ligand intervals in response to integrin alphavbeta3 clustering","volume":"35","author":"Guo","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0185","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jconrel.2014.10.012","article-title":"RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer","volume":"196","author":"Wang","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0190","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/IJN.S124252","article-title":"Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy","volume":"12","author":"Zhang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0195","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrd3578","article-title":"Perspectives and opportunities for nanomedicine in the management of atherosclerosis","volume":"10","author":"Lobatto","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0200","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jacc.2008.12.056","article-title":"Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage","volume":"53","author":"Sluimer","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0205","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0939-6411(02)00087-5","article-title":"Atomic force microscopy imaging of novel type of polymeric colloidal nanostructures","volume":"54","author":"Montasser","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0210","doi-asserted-by":"crossref","first-page":"11600","DOI":"10.1021\/la049302v","article-title":"Vesicle adsorption and lipid bilayer formation on glass studied by atomic force microscopy","volume":"20","author":"Schonherr","year":"2004","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0215","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.cdd.4400817","article-title":"Phosphatidylserine, a death knell","volume":"8","author":"Schlegel","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s004410000203","article-title":"Detection of apoptosis in tissue sections","volume":"301","author":"Stadelmann","year":"2000","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0225","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nano.2012.05.015","article-title":"Effect of ligand density, receptor density, and nanoparticle size on cell targeting","volume":"9","author":"Elias","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0230","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1021\/acs.nanolett.5b01362","article-title":"Targeted PRINT hydrogels: the role of nanoparticle size and ligand density on cell association, biodistribution, and tumor accumulation","volume":"15","author":"Reuter","year":"2015","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0235","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jconrel.2015.04.035","article-title":"The effect of ligand density on in vivo tumor targeting of nanographene oxide","volume":"209","author":"Lee","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0240","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1021\/nn7002025","article-title":"Multiple lipid compartments slow vesicle contents release in lipases and serum","volume":"1","author":"Boyer","year":"2007","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3109\/08982104.2013.770017","article-title":"Transfer of a lipophilic drug (temoporfin) between small unilamellar liposomes and human plasma proteins: influence of membrane composition on vesicle integrity and release characteristics","volume":"23","author":"Decker","year":"2013","journal-title":"J. Liposome Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jconrel.2019.10.043_bib0250","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1007\/s00259-011-2028-1","article-title":"Radiolabelled RGD peptides for imaging and therapy","volume":"39","author":"Gaertner","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0255","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0603-713","article-title":"Imaging of angiogenesis: from microscope to clinic","volume":"9","author":"Mcdonald","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0260","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1021\/ar800243b","article-title":"Ligands for mapping alphavbeta3-integrin expression in vivo","volume":"42","author":"Schottelius","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0265","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/IJN.S124252","article-title":"Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy","volume":"12","author":"Zhang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0270","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1073\/pnas.1322725111","article-title":"Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0275","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/nn506750r","article-title":"Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging","volume":"9","author":"Lobatto","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0280","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1161\/CIRCULATIONAHA.106.646380","article-title":"Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis","volume":"114","author":"Nahrendorf","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0285","doi-asserted-by":"crossref","first-page":"22910","DOI":"10.1038\/srep22910","article-title":"E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0290","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/ATVBAHA.115.307057","article-title":"Pioglitazone-incorporated nanoparticles prevent plaque destabilization and rupture by regulating Monocyte\/Macrophage differentiation in ApoE-\/- mice","volume":"36","author":"Nakashiro","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0295","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2005.10.001","article-title":"Macrophage polarization comes of age","volume":"23","author":"Mantovani","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0300","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12933-017-0623-6","article-title":"Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17\/Treg balance in AMPK-dependent mechanisms","volume":"16","author":"Tian","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0305","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.atherosclerosis.2019.04.229","article-title":"Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARgamma","volume":"286","author":"Murakami-Nishida","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0310","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2353\/ajpath.2009.080611","article-title":"Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone","volume":"174","author":"Nakaya","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2019.10.043_bib0315","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.atherosclerosis.2006.06.025","article-title":"Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice","volume":"192","author":"Game","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jconrel.2019.10.043_bib0320","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nm1278","article-title":"Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption","volume":"11","author":"Guan","year":"2005","journal-title":"Nat. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365919306078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365919306078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:31:40Z","timestamp":1773178300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365919306078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":64,"alternative-id":["S0168365919306078"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2019.10.043","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An apoptotic body-biomimic liposome in situ upregulates anti-inflammatory macrophages for stabilization of atherosclerotic plaques","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2019.10.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}