{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:57:28Z","timestamp":1777859848073,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","award":["NGF-2018-05-023"],"award-info":[{"award-number":["NGF-2018-05-023"]}],"id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001474","name":"Singapore-MIT Alliance for Research and Technology Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013136","name":"Office of Sex Offender Sentencing, Monitoring, Apprehending, Registering, and Tracking","doi-asserted-by":"publisher","award":["ING149090-BIO"],"award-info":[{"award-number":["ING149090-BIO"]}],"id":[{"id":"10.13039\/100013136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jconrel.2019.12.031","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T22:23:30Z","timestamp":1576707810000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Adventitial injection delivery of nano-encapsulated sirolimus (Nanolimus) to injury-induced porcine femoral vessels to reduce luminal restenosis"],"prefix":"10.1016","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-9287","authenticated-orcid":false,"given":"Hui Ying","family":"Ang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon Minru","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Yin","family":"Chaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie Liang","family":"Phua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaryl Chen Koon","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip En Hou","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subbu","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze Tec","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2019.12.031_bb0005","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","article-title":"Peripheral artery disease: epidemiology and global perspectives","volume":"14","author":"Fowkes","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0010","first-page":"910","article-title":"Performance goals and endpoint assessments for clinical trials of femoropopliteal bare nitinol stents in patients with symptomatic peripheral arterial disease","volume":"69","author":"Rocha-Singh","year":"2007","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0015","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1161\/CIRCULATIONAHA.107.688341","article-title":"Sustained benefit at 2 years of primary femoropopliteal stenting compared with balloon angioplasty with optional stenting","volume":"115","author":"Schillinger","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/CIRCULATIONAHA.107.689141","article-title":"Nitinol stent implantation versus percutaneous transluminal angioplasty in superficial femoral artery lesions up to 10 cm in length: the femoral artery stenting trial (FAST)","volume":"116","author":"Krankenberg","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0025","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1056\/NEJMoa051303","article-title":"Balloon angioplasty versus implantation of nitinol stents in the superficial femoral artery","volume":"354","author":"Schillinger","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.amjcard.2006.01.091","article-title":"Effect of exercise on frequency of stent fracture in the superficial femoral artery","volume":"98","author":"Iida","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0035","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1148\/radiol.2322031345","article-title":"Primary patency of femoropopliteal arteries treated with nitinol versus stainless steel self-expanding stents: propensity score-adjusted analysis","volume":"232","author":"Sabeti","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/152660280200900111","article-title":"Balloon angioplasty and stent implantation induce a vascular inflammatory reaction","volume":"9","author":"Schillinger","year":"2002","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0045","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1583\/05-1704.1","article-title":"Drug-eluting and bare nitinol stents for the treatment of atherosclerotic lesions in the superficial femoral artery: long-term results from the SIROCCO trial","volume":"13","author":"Duda","year":"2006","journal-title":"J. Endovasc. Ther."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/01.RVI.0000151260.74519.CA","article-title":"Sirolimus-eluting versus bare nitinol stent for obstructive superficial femoral artery disease: the SIROCCO II trial","volume":"16","author":"Duda","year":"2005","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0055","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/01.CIR.0000029746.10018.36","article-title":"Sirolimus-eluting stents for the treatment of obstructive superficial femoral artery disease: six-month results","volume":"106","author":"Duda","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0060","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jvs.2008.06.006","article-title":"Stenting vs above knee polytetrafluoroethylene bypass for TransAtlantic inter-society consensus-II C and D superficial femoral artery disease","volume":"48","author":"Dosluoglu","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0065","first-page":"81","article-title":"Inter-society consensus for the management of peripheral arterial disease","volume":"26","author":"Norgren","year":"2007","journal-title":"Int. Angiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0070","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMoa0706356","article-title":"Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg","volume":"358","author":"Tepe","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0075","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.011245","article-title":"Risk of death following application of paclitaxel-coated balloons and stents in the Femoropopliteal artery of the leg: a systematic review and meta-analysis of randomized controlled trials","volume":"7","author":"Katsanos","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0080","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jconrel.2019.08.019","article-title":"Taking paclitaxel coated balloons to a higher level: predicting coating dissolution kinetics, tissue retention and dosing dynamics","volume":"310","author":"Tzafriri","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0085","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jconrel.2018.06.014","article-title":"Controlled-release nanotherapeutics: state of translation","volume":"284","author":"Tan","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0095","first-page":"123","article-title":"Nanomedicine for glaucoma: liposomes provide sustained release of latanoprost in the eye","volume":"7","author":"Natarajan","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0100","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2012.02.023","article-title":"A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study","volume":"427","author":"Skalsky","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0105","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/CIRCINTERVENTIONS.113.000195","article-title":"Adventitial nab-rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial inflammation","volume":"6","author":"Gasper","year":"2013","journal-title":"Circ. Cardiovasc. Interv"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0110","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jvir.2010.05.030","article-title":"Efficiency of drug delivery to the coronary arteries in swine is dependent on the route of administration: assessment of luminal, intimal, and adventitial coronary artery and venous delivery methods","volume":"21","author":"Karanian","year":"2010","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0115","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jvs.2013.10.051","article-title":"Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization","volume":"59","author":"Owens","year":"2014","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10717540490265243","article-title":"The effect of different lipid components on the in vitro stability and release kinetics of liposome formulations","volume":"11","author":"Anderson","year":"2004","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0125","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.biochi.2013.07.006","article-title":"Calcein release behavior from liposomal bilayer; influence of physicochemical \/mechanical\/structural properties of lipids","volume":"95","author":"Maherani","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0168-3659(98)00052-2","article-title":"Drug targeting using low density lipoprotein (LDL): physicochemical factors affecting drug loading into LDL particles","volume":"55","author":"Kader","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-5173(00)00617-7","article-title":"Solubilization of rapamycin","volume":"213","author":"Simamora","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0140","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1158\/1078-0432.CCR-12-3110","article-title":"Weekly nab-rapamycin in patients with advanced nonhematologic malignancies: final results of a phase I trial","volume":"19","author":"Gonzalez-Angulo","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0168-3659(02)00137-2","article-title":"Characterization of the initial burst release of a model peptide from poly(D,L-lactide-co-glycolide) microspheres","volume":"82","author":"Wang","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1388-1981(00)00174-8","article-title":"Liposomes as sustained release system for human interferon-gamma: biopharmaceutical aspects","volume":"1530","author":"Van Slooten","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/nn4046024","article-title":"Sustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucoma","volume":"8","author":"Natarajan","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0160","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/mp400765n","article-title":"Dynamic, nonsink method for the simultaneous determination of drug permeability and binding coefficients in liposomes","volume":"11","author":"Fugit","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0165","first-page":"49","article-title":"Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy","volume":"7","author":"Chang","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0170","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0175","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1172\/JCI119038","article-title":"Rapamycin inhibits vascular smooth muscle cell migration","volume":"98","author":"Poon","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0180","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bmb\/ldt009","article-title":"Coronary stents: historical development, current status and future directions","volume":"106","author":"Iqbal","year":"2013","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0185","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.RES.76.3.412","article-title":"Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells","volume":"76","author":"Marx","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0190","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jvir.2010.05.030","article-title":"Efficiency of drug delivery to the coronary arteries in swine is dependent on the route of administration: assessment of luminal, intimal, and adventitial coronary artery and venous delivery methods","volume":"21","author":"Karanian","year":"2010","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0195","first-page":"222","article-title":"Novel percutaneous adventitial drug delivery system for regional vascular treatment","volume":"63","author":"Ikeno","year":"2004","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0200","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jcin.2017.12.015","article-title":"Adventitial drug delivery of dexamethasone to improve primary patency in the treatment of superficial femoral and popliteal artery disease: 12-month results from the DANCE clinical trial","volume":"11","author":"Razavi","year":"2018","journal-title":"JACC. Cardiovasc. Interv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0205","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/1381612824666171227221305","article-title":"Drug-coated balloons: technologies and clinical applications","volume":"24","author":"Ang","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0210","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2016.08.018","article-title":"Materials technology in drug eluting balloons: current and future perspectives","volume":"239","author":"Xiong","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083992","article-title":"In vitro determination of drug transfer from drug-coated balloons","volume":"8","author":"Seidlitz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0220","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCINTERVENTIONS.108.830018","article-title":"Inhibition of apoptosis through localized delivery of rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery","volume":"1","author":"Reddy","year":"2008","journal-title":"Circulation Cardiovasc. Interv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0225","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbapap.2006.04.018","article-title":"Intramural delivery of Sirolimus prevents vascular remodeling following balloon injury","volume":"1774","author":"Buerke","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0230","first-page":"2197","article-title":"Preclinical evaluation of injectable sirolimus formulated with polymeric nanoparticle for cancer therapy","volume":"7","author":"Woo","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0235","first-page":"886","article-title":"Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells","volume":"59","author":"Hosoi","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0240","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0735-1097(97)00123-X","article-title":"Drug clearance and arterial uptake after local perivascular delivery to the rat carotid artery","volume":"29","author":"Lovich","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0245","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2016.05.002","article-title":"Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery","volume":"233","author":"Chaudhary","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0250","doi-asserted-by":"crossref","first-page":"e0138539","DOI":"10.1371\/journal.pone.0138539","article-title":"Coronary injury score correlates with proliferating cells and alpha-smooth muscle actin expression in stented porcine coronary arteries","volume":"10","author":"Swier","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0255","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0735-1097(92)90476-4","article-title":"Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model","volume":"19","author":"Schwartz","year":"1992","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0260","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0735-1097(97)00450-6","article-title":"In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia","volume":"31","author":"Kornowski","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0265","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.carpath.2004.06.001","article-title":"The natural history of collagen and alpha-actin expression after coronary angioplasty","volume":"13","author":"Schmidt","year":"2004","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0270","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1158\/0008-5472.CAN-08-2146","article-title":"Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta","volume":"69","author":"Rahimi","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0275","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1073\/pnas.0400918101","article-title":"Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel","volume":"101","author":"Levin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0280","series-title":"Contribution of Adventitial Fibroblasts to Neointima Formation and Vascular Remodeling","first-page":"1111","volume":"89","author":"Sartore","year":"2001"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0285","first-page":"e31","article-title":"Adventitia and perivascular","volume":"35","author":"Majesky","year":"2015","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0290","article-title":"Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis","volume":"9","author":"Shi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0295","first-page":"740","article-title":"In vivo delivery and long-term tissue retention of nano-encapsulated sirolimus using a novel porous balloon angioplasty system","volume":"12","author":"Juan","year":"2016","journal-title":"Euro Interv."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21691401.2017.1408123","article-title":"Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies","volume":"46","author":"Haeri","year":"2018","journal-title":"Artif. Cells Nanomedicine Biotechnol."},{"key":"10.1016\/j.jconrel.2019.12.031_bb0305","series-title":"Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application","first-page":"851","volume":"25","author":"Luderer","year":"2011"},{"key":"10.1016\/j.jconrel.2019.12.031_bb0310","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jcin.2017.12.015","article-title":"Adventitial drug delivery of dexamethasone to improve primary patency in the treatment of superficial femoral and popliteal artery disease: 12-month results from the DANCE clinical trial","volume":"11","author":"Razavi","year":"2018","journal-title":"J. Am. Coll. Cardiol. Intv."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365919307503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365919307503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:47Z","timestamp":1777509527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365919307503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":62,"alternative-id":["S0168365919307503"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2019.12.031","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adventitial injection delivery of nano-encapsulated sirolimus (Nanolimus) to injury-induced porcine femoral vessels to reduce luminal restenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2019.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}