{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:33:55Z","timestamp":1774877635663,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jconrel.2020.02.004","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:35:26Z","timestamp":1580729726000},"page":"421-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice"],"prefix":"10.1016","volume":"320","author":[{"given":"Yinan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghua","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-2404","authenticated-orcid":false,"given":"Jan C.M.","family":"van Hest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-4741","authenticated-orcid":false,"given":"Zhiyuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.02.004_bb0005","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(14)60493-1","article-title":"Multiple myeloma","volume":"385","author":"R\u00f6llig","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrclinonc.2012.15","article-title":"Latest advances and current challenges in the treatment of multiple myeloma","volume":"9","author":"Mahindra","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0015","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood-2014-09-568915","article-title":"Frontline therapy of multiple myeloma","volume":"125","author":"Moreau","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0020","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1073\/pnas.1401337111","article-title":"Engineered nanomedicine for myeloma and bone microenvironment targeting","volume":"111","author":"Swami","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0025","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1080\/10717544.2016.1214989","article-title":"DOPA-based paclitaxel-loaded liposomes with modifications of transferrin and alendronate for bone and myeloma targeting","volume":"23","author":"Chang","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0030","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2017.11.045","article-title":"Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma","volume":"270","author":"de la Puente","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0035","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1002\/adma.201603463","article-title":"Engineered nanoplatelets for enhanced treatment of multiple myeloma and thrombus","volume":"28","author":"Hu","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/nnm.12.216","article-title":"Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma","volume":"9","author":"Yang","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd2399","article-title":"Protein therapeutics: a summary and pharmacological classification","volume":"7","author":"Leader","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0050","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/anie.201311245","article-title":"Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy","volume":"53","author":"Wang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0055","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1073\/pnas.1515526113","article-title":"Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration","volume":"113","author":"Sellers","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0060","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1021\/acs.nanolett.6b04955","article-title":"Rational design of a polymer with robust efficacy for intracellular protein and peptide delivery","volume":"17","author":"Chang","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0065","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJMoa1505654","article-title":"Elotuzumab therapy for relapsed or refractory multiple myeloma","volume":"373","author":"Lonial","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0070","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMoa1805762","article-title":"Elotuzumab plus pomalidomide and dexamethasone for multiple myeloma","volume":"379","author":"Dimopoulos","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0075","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa1506348","article-title":"Targeting CD38 with daratumumab monotherapy in multiple myeloma","volume":"373","author":"Lokhorst","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0080","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0140-6736(15)01120-4","article-title":"Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial","volume":"387","author":"Lonial","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0085","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/s41375-019-0435-7","article-title":"Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy","volume":"33","author":"Gandhi","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nantod.2012.12.003","article-title":"Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex","volume":"8","author":"Zhao","year":"2013","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.addr.2015.10.021","article-title":"Co-delivery of chemotherapeutics and proteins for synergistic therapy","volume":"98","author":"He","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0100","article-title":"The fluorination effect of fluoroamphiphiles in cytosolic protein delivery","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0105","doi-asserted-by":"crossref","first-page":"1701086","DOI":"10.1002\/adma.201701086","article-title":"One-pot synthesis of multiple protein-encapsulated DNA flowers and their application in intracellular protein delivery","volume":"29","author":"Kim","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0110","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/ange.201711651","article-title":"Intracellular delivery of native proteins facilitated by cell-penetrating poly(disulfide)s","volume":"130","author":"Qian","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0115","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1021\/acs.nanolett.7b04976","article-title":"Hierarchical nanoassemblies-assisted combinational delivery of cytotoxic protein and antibiotic for cancer treatment","volume":"18","author":"Liu","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0120","article-title":"Polymeric micelles loading proteins through concurrent ion complexation and pH-cleavable covalent bonding for in vivo delivery","author":"Tao","year":"2019","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0125","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1002\/adfm.201502742","article-title":"Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo\u2013protein combination therapy","volume":"25","author":"Wu","year":"2015","journal-title":"Adv. Func. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201800316","article-title":"Protein toxin chaperoned by LRP-1-targeted virus-mimicking vesicles induces high-efficiency glioblastoma therapy in vivo","volume":"30","author":"Jiang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0135","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1021\/acsnano.8b05265","article-title":"Apolipoprotein E peptide-directed chimeric polymersomes mediate an ultrahigh-efficiency targeted protein therapy for glioblastoma","volume":"12","author":"Jiang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0140","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2018.10.013","article-title":"Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo","volume":"290","author":"Yang","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0145","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/ar200241v","article-title":"Before and after endosomal escape: roles of stimuli-converting siRNA\/polymer interactions in determining gene silencing efficiency","volume":"45","author":"Kwon","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2019.04.003","article-title":"Multifunctional hyaluronate\u2013nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications","volume":"303","author":"Kim","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0155","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.7150\/thno.18340","article-title":"Redox responsive hyaluronic acid nanogels for treating RHAMM (CD168) over-expressive cancer, both primary and metastatic tumors","volume":"7","author":"Yang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0160","doi-asserted-by":"crossref","first-page":"1803498","DOI":"10.1002\/adfm.201803498","article-title":"Interfering with lactate-fueled respiration for enhanced photodynamic tumor therapy by a porphyrinic MOF nanoplatform","volume":"28","author":"Chen","year":"2018","journal-title":"Adv. Func. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0165","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/acsnano.6b06658","article-title":"Overcoming the heat endurance of tumor cells by interfering the anaerobic glycolysis metabolism for improved photothermal therapy","volume":"11","author":"Chen","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jconrel.2015.01.030","article-title":"Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy","volume":"202","author":"Martens","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0175","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1021\/acsnano.7b08051","article-title":"Nanoplatform assembled from a CD44-targeted prodrug and smart liposomes for dual targeting of tumor microenvironment and cancer cells","volume":"12","author":"Lv","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201706710","article-title":"Effective and selective anti-cancer protein delivery via all-functions-in-one nanocarriers coupled with visible light-responsive, reversible protein engineering","volume":"28","author":"He","year":"2018","journal-title":"Adv. Func. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0185","doi-asserted-by":"crossref","first-page":"1700821","DOI":"10.1002\/advs.201700821","article-title":"Self-stabilized hyaluronate nanogel for intracellular codelivery of doxorubicin and cisplatin to osteosarcoma","volume":"5","author":"Zhang","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0190","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1182\/blood-2013-04-493361","article-title":"CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma","volume":"122","author":"Casucci","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0195","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/leu.2013.174","article-title":"Evidence of a role for CD44 and cell adhesion in mediating resistance to lenalidomide in multiple myeloma: therapeutic implications","volume":"28","author":"Bjorklund","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0200","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.biomac.5b00193","article-title":"Anisamide-decorated pH-sensitive degradable chimaeric polymersomes mediate potent and targeted protein delivery to lung cancer cells","volume":"16","author":"Lu","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2016.08.022","article-title":"Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: a superior alternative to Doxil and Caelyx?","volume":"239","author":"Zou","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0210","article-title":"Ligand-installed nanocarriers toward precision therapy","author":"Mi","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0215","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jconrel.2017.10.036","article-title":"Targeted cancer therapy through antibody fragments-decorated nanomedicines","volume":"268","author":"Alibakhshi","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0220","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1021\/ja005824v","article-title":"Thermodynamic stabilization mechanism of block copolymer vesicles","volume":"123","author":"Luo","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0225","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/1521-3773(20020315)41:6<1001::AID-ANIE1001>3.0.CO;2-Q","article-title":"One-step preparation of block copolymer vesicles with preferentially segregated acidic and basic corona chains","volume":"41","author":"Luo","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0230","doi-asserted-by":"crossref","first-page":"9219","DOI":"10.1021\/la501674a","article-title":"Asymmetric vesicle constructed by AB\/CB diblock copolymer mixture and its behavior: a Monte Carlo study","volume":"30","author":"Cui","year":"2014","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0235","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrc2189","article-title":"Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets","volume":"7","author":"Hideshima","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2020.02.004_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02758-9","article-title":"Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer","volume":"9","author":"Kotagiri","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0245","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1080\/10717544.2017.1384864","article-title":"Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles","volume":"24","author":"Zhong","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0250","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nri1083","article-title":"Cell death and immunity: the ABCs of granule-mediated cytotoxicity: new weapons in the arsenal","volume":"3","author":"Lieberman","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0255","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nri1983","article-title":"Perforin-mediated target-cell death and immune homeostasis","volume":"6","author":"Voskoboinik","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2020.02.004_bb0260","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrc.2016.44","article-title":"Bone metastasis: the importance of the neighbourhood","volume":"16","author":"Croucher","year":"2016","journal-title":"Nat. Rev. Cancer"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592030081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592030081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:49:58Z","timestamp":1759160998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592030081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":52,"alternative-id":["S016836592030081X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.02.004","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}