{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:41:25Z","timestamp":1792500085515,"version":"4.5.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jconrel.2020.04.023","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T10:42:11Z","timestamp":1586860931000},"page":"12-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Ultrasound in tumor immunotherapy: Current status and future developments"],"prefix":"10.1016","volume":"323","author":[{"given":"Yi-Ju","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Pi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsiang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-1227","authenticated-orcid":false,"given":"Hao-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-6327","authenticated-orcid":false,"given":"Chih-Kuang","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.04.023_bb0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0010","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0015","series-title":"The Cell: A Molecular Approach","article-title":"The development and causes of cancer","author":"Cooper","year":"2000"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0020","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.1002\/jcp.27425","article-title":"Tumor microenvironment: interactions and therapy","volume":"234","author":"Najafi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0025","first-page":"1408","article-title":"The unique physiology of solid tumors: opportunities (and problems) for cancer therapy","volume":"58","author":"Brown","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature12624","article-title":"Tumour heterogeneity and cancer cell plasticity","volume":"501","author":"Meacham","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cells8091083","article-title":"Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges","volume":"8","author":"Noman","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Weinberg, hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccell.2017.02.008","article-title":"Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies","volume":"31","author":"Anderson","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.trecan.2018.02.005","article-title":"Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside","volume":"4","author":"Stylianopoulos","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0055","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0060","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13046-019-1266-0","article-title":"Advances in cancer immunotherapy 2019 - latest trends","volume":"38","author":"Kruger","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0065","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrc1586","article-title":"Immunosuppressive networks in the tumour environment and their therapeutic relevance","volume":"5","author":"Zou","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0070","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri.2016.80","article-title":"Regulatory circuits of T cell function in cancer","volume":"16","author":"Speiser","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0075","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1101\/gad.314617.118","article-title":"Roles of the immune system in cancer: from tumor initiation to metastatic progression","volume":"32","author":"Gonzalez","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imm.12023","article-title":"Anti-tumour strategies aiming to target tumour-associated macrophages","volume":"138","author":"Tang","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/cr.2016.151","article-title":"Regulatory T cells in cancer immunotherapy","volume":"27","author":"Tanaka","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jneuroim.2006.03.006","article-title":"T-cell apoptosis in human glioblastoma multiforme: implications for immunotherapy","volume":"175","author":"Walker","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.cco.0000245321.34658.f4","article-title":"Recent advances in immunotherapy for human glioma","volume":"18","author":"Carpentier","year":"2006","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002842","article-title":"T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia","volume":"3","author":"Kalos","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0110","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1001\/jama.2018.9511","article-title":"Vaccines as an integral component of cancer immunotherapy","volume":"320","author":"Schlom","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0115","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/d41573-019-00167-9","article-title":"Immuno-oncology drug development goes global","volume":"18","author":"Xin Yu","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0120","series-title":"Neoplasm","article-title":"An overview of cancer treatment modalities","author":"Zaigham Abbas","year":"2018"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0125","article-title":"Radiotherapy and immune response: the systemic effects of a local treatment","volume":"73","author":"Carvalho","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0130","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic therapy and anti-tumour immunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"2016","key":"10.1016\/j.jconrel.2020.04.023_bb0135","first-page":"1964","article-title":"Low-intensity focused ultrasound induces reversal of tumor-induced T cell tolerance and prevents immune escape","volume":"196","author":"Bandyopadhyay","year":"1950","journal-title":"J. Immunol. (Baltimore, Md.)"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/pros.10314","article-title":"Response to sublethal heat treatment of prostatic tumor cells and of prostatic tumor infiltrating T-cells","volume":"58","author":"Kramer","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0145","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1097-0045(19981101)37:3<174::AID-PROS6>3.0.CO;2-4","article-title":"Regulation of heat shock protein 27 expression of prostatic cells in response to heat treatment","volume":"37","author":"Madersbacher","year":"1998","journal-title":"Prostate"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0150","first-page":"59","article-title":"Immunomodulation in choroidal melanoma: reversal of inverted CD4\/CD8 ratios following treatment with ultrasonic hyperthermia","volume":"5","author":"Rosberger","year":"1994","journal-title":"Biotechnol. Ther."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0155","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.ultrasmedbio.2004.08.003","article-title":"Activated anti-tumor immunity in cancer patients after high intensity focused ultrasound ablation","volume":"30","author":"Wu","year":"2004","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0160","doi-asserted-by":"crossref","first-page":"37626","DOI":"10.18632\/oncotarget.5285","article-title":"High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model","volume":"6","author":"Yuan","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0165","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.ultrasmedbio.2012.03.009","article-title":"High-intensity focused ultrasound tumor ablation activates autologous tumor-specific cytotoxic T lymphocytes","volume":"38","author":"Xia","year":"2012","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ultrasmedbio.2009.12.004","article-title":"Dendritic cells loaded with ultrasound-ablated tumour induce in vivo specific antitumour immune responses","volume":"36","author":"Deng","year":"2010","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0175","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.3748\/wjg.v16.i28.3584","article-title":"Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound","volume":"16","author":"Zhang","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0180","first-page":"252","article-title":"New technologies and techniques for prostate cancer focal therapy","volume":"70","author":"Linares-Espinos","year":"2018","journal-title":"Minerva Urol. Nefrol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0185","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1088\/0031-9155\/57\/23\/8061","article-title":"Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound","volume":"57","author":"Simon","year":"2012","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0190","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1121\/1.3626152","article-title":"Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling","volume":"130","author":"Khokhlova","year":"2011","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0195","doi-asserted-by":"crossref","first-page":"20170641","DOI":"10.1259\/bjr.20170641","article-title":"Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer","volume":"91","author":"Mauri","year":"2018","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0200","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.ultrasmedbio.2015.02.006","article-title":"Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects","volume":"41","author":"Hoogenboom","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0205","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ultrasmedbio.2018.09.006","article-title":"Boiling histotripsy ablation of renal cell carcinoma in the Eker rat promotes a systemic inflammatory response","volume":"45","author":"Schade","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0210","article-title":"Boiling histotripsy-induced partial mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers","volume":"9","author":"Pahk","year":"2019","journal-title":"Sci. Rep.-UK"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0215","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1479-5876-5-34","article-title":"Investigation of HIFU-induced anti-tumor immunity in a murine tumor model","volume":"5","author":"Hu","year":"2007","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0220","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1243\/09544119JEIM622","article-title":"Cavitation and contrast: the use of bubbles in ultrasound imaging and therapy, proceedings of the institution of mechanical engineers","volume":"224","author":"Stride","year":"2010","journal-title":"Part H, J. Eng. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0225","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.addr.2008.03.011","article-title":"Response of contrast agents to ultrasound","volume":"60","author":"Sboros","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0230","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jconrel.2005.06.015","article-title":"The role of cavitation in acoustically activated drug delivery","volume":"107","author":"Husseini","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrd1662","article-title":"Healing sound: the use of ultrasound in drug delivery and other therapeutic applications","volume":"4","author":"Mitragotri","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0240","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1038\/s41467-019-12426-9","article-title":"First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound","volume":"10","author":"Abrahao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0245","article-title":"Long-term safety of repeated blood-brain barrier opening via focused ultrasound with microbubbles in non-human primates performing a cognitive task","volume":"10","author":"Downs","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0250","doi-asserted-by":"crossref","first-page":"275","DOI":"10.7863\/ultra.34.2.275","article-title":"Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma","volume":"34","author":"Hunt","year":"2015","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1479-5876-10-221","article-title":"Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response","volume":"10","author":"Liu","year":"2012","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0260","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11517-009-0507-3","article-title":"Safety and bio-effects of ultrasound contrast agents","volume":"47","author":"ter Haar","year":"2009","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ultrasmedbio.2011.11.007","article-title":"Disruption of tumor neovasculature by microbubble enhanced ultrasound: a potential new physical therapy of anti-angiogenesis","volume":"38","author":"Liu","year":"2012","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0270","doi-asserted-by":"crossref","first-page":"11752","DOI":"10.1158\/0008-5472.CAN-05-1658","article-title":"Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma","volume":"65","author":"Jassar","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0275","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/bjc.2013.93","article-title":"Using macrophage activation to augment immunotherapy of established tumours","volume":"108","author":"Fridlender","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0280","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1038\/s41598-017-06242-8","article-title":"Low-frequency ultrasound-induced VEGF suppression and synergy with dendritic cell-mediated anti-tumor immunity in murine prostate cancer cells in vitro","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0285","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ultrasmedbio.2018.10.002","article-title":"Enhancing checkpoint inhibitor therapy with ultrasound stimulated microbubbles","volume":"45","author":"Bulner","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0290","first-page":"4478","article-title":"Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy","volume":"50","author":"Boucher","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0295","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrc1893","article-title":"Drug penetration in solid tumours","volume":"6","author":"Minchinton","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0300","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s40425-018-0376-0","article-title":"Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers","volume":"6","author":"Mushtaq","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0305","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ultrasmedbio.2018.10.033","article-title":"Microbubbles, nanodroplets and gas-stabilizing solid particles for ultrasound-mediated extravasation of unencapsulated drugs: an exposure parameter optimization study","volume":"45","author":"Mannaris","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0310","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.addr.2008.03.007","article-title":"Ultrasound mediated delivery of drugs and genes to solid tumors","volume":"60","author":"Frenkel","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0315","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0194599812436648","article-title":"Microbubble therapy enhances anti-tumor properties of cisplatin and cetuximab in vitro and in vivo","volume":"146","author":"Heath","year":"2012","journal-title":"Otolaryngol.-Head Neck surg."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0320","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm0901-987","article-title":"Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy","volume":"7","author":"Jain","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0325","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1259\/bjr\/38457938","article-title":"Reducing intratumour acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumour cells and metastatic potential","volume":"84","author":"Masunaga","year":"2011","journal-title":"Brit. J. Radiol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0330","doi-asserted-by":"crossref","first-page":"18632","DOI":"10.1073\/pnas.1318415110","article-title":"Combining two strategies to improve perfusion and drug delivery in solid tumors","volume":"110","author":"Stylianopoulos","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0335","doi-asserted-by":"crossref","first-page":"R1161","DOI":"10.1016\/j.cub.2016.09.043","article-title":"Exploring novel methods for modulating tumor blood vessels in cancer treatment","volume":"26","author":"Wong","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0340","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1158\/0008-5472.CAN-04-0074","article-title":"Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors","volume":"64","author":"Tong","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0345","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nnano.2012.45","article-title":"Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner","volume":"7","author":"Chauhan","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0350","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cell.2009.01.020","article-title":"Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization","volume":"136","author":"Mazzone","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0355","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1158\/0008-5472.CAN-10-0153","article-title":"Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer","volume":"70","author":"Shrimali","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0360","doi-asserted-by":"crossref","first-page":"17561","DOI":"10.1073\/pnas.1215397109","article-title":"Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy","volume":"109","author":"Huang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0365","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biomaterials.2017.09.021","article-title":"Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy","volume":"148","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0370","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41419-017-0061-0","article-title":"Defining the role of the tumor vasculature in antitumor immunity and immunotherapy","volume":"9","author":"Schaaf","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0375","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1200\/EDBK_237987","article-title":"Reprogramming the tumor microenvironment to improve immunotherapy: emerging strategies and combination therapies","volume":"39","author":"Datta","year":"2019","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0380","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF02303818","article-title":"Cytokine-mediated gene therapy for cancer","volume":"1","author":"Miller","year":"1994","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0385","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1517\/14712598.4.10.1609","article-title":"Cytokine gene therapy for malignant glioma","volume":"4","author":"Okada","year":"2004","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0390","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1089\/hum.2011.076","article-title":"Sonoporation delivery of interleukin-27 gene therapy efficiently reduces prostate tumor cell growth in vivo","volume":"22","author":"Zolochevska","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0395","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.cgt.7700850","article-title":"Gene therapy for hepatocellular carcinoma using sonoporation enhanced by contrast agents","volume":"12","author":"Sakakima","year":"2005","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0400","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jconrel.2009.10.027","article-title":"Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure","volume":"142","author":"Suzuki","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0405","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/aje\/155.2.185-a","article-title":"Basic immunology: functions and disorders of the immune system","volume":"155","author":"Dorak","year":"2002","journal-title":"Am. J. Epidemiol."},{"issue":"2011","key":"10.1016\/j.jconrel.2020.04.023_bb0410","first-page":"1325","article-title":"Recent developments in cancer vaccines","volume":"186","author":"Palucka","year":"1950","journal-title":"J. Immunol. (Baltimore, Md.)"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0415","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jconrel.2008.10.015","article-title":"A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy","volume":"133","author":"Suzuki","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0420","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jconrel.2011.12.003","article-title":"Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis","volume":"160","author":"Oda","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0425","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1517\/14712598.2012.689279","article-title":"Genetic cancer vaccines: current status and perspectives","volume":"12","author":"Aurisicchio","year":"2012","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0430","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1016\/j.biomaterials.2010.06.058","article-title":"Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy","volume":"31","author":"Un","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0435","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/mp100369n","article-title":"Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier","volume":"8","author":"Un","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0440","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1016\/j.biomaterials.2011.08.024","article-title":"mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells","volume":"32","author":"De Temmerman","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0445","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jconrel.2014.08.011","article-title":"The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy","volume":"194","author":"Dewitte","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0450","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.1147949","article-title":"Life with oxygen","volume":"318","author":"Semenza","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0455","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/iwj.12873","article-title":"Topical oxygen therapy & micro\/nanobubbles: a new modality for tissue oxygen delivery","volume":"15","author":"Sayadi","year":"2018","journal-title":"Int. Wound J."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0460","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.2147\/IJN.S140462","article-title":"Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment","volume":"13","author":"Graham","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0465","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fonc.2013.00211","article-title":"Vascular permeability and drug delivery in cancers","volume":"3","author":"Azzi","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0470","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/427695a","article-title":"Pathology: cancer cells compress intratumour vessels","volume":"427","author":"Padera","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0475","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fimmu.2012.00021","article-title":"Hypoxia promotes tumor growth in linking angiogenesis to immune escape","volume":"3","author":"Chouaib","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0480","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11523-012-0233-x","article-title":"Hyperbaric oxygen therapy and cancer-a review","volume":"7","author":"Moen","year":"2012","journal-title":"Target. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0485","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcmd.2007.06.025","article-title":"Rebuilding immunity in cancer patients","volume":"40","author":"Vuk-Pavlovic","year":"2008","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0490","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/jcp.25859","article-title":"Modulating tumor hypoxia by nanomedicine for effective cancer therapy","volume":"233","author":"Jahanban-Esfahlan","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0495","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijrobp.2018.01.042","article-title":"Sensitization of hypoxic tumors to radiation therapy using ultrasound-sensitive oxygen microbubbles","volume":"101","author":"Eisenbrey","year":"2018","journal-title":"Int. J. Radiat. Oncol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195667","article-title":"Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model - a preliminary study","volume":"13","author":"Fix","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0505","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ultrasmedbio.2017.08.1883","article-title":"Lipid microbubbles as ultrasound-stimulated oxygen carriers for controllable oxygen release for tumor reoxygenation","volume":"44","author":"Yang","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0510","first-page":"1","article-title":"Engineering oxygen nanobubbles for the effective reversal of hypoxia","author":"Khan","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0515","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.7150\/thno.37750","article-title":"Normalization of tumor vasculature by oxygen microbubbles with ultrasound","volume":"9","author":"Ho","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0520","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1084\/jem.20100670","article-title":"Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2\/anti-CD40 immunotherapy","volume":"207","author":"Weiss","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0525","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0530","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2017.00065","article-title":"The hydrogen sulfide releasing molecule acetyl deacylasadisulfide inhibits metastatic melanoma","volume":"8","author":"De Cicco","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0535","doi-asserted-by":"crossref","first-page":"23919","DOI":"10.18632\/oncotarget.8081","article-title":"Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth","volume":"7","author":"Nemeth","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0540","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.2174\/0929867324666170516123206","article-title":"Glioblastoma multiforme, diagnosis and treatment; recent literature review","volume":"24","author":"Batash","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0545","doi-asserted-by":"crossref","first-page":"e729","DOI":"10.1259\/bjr\/83796755","article-title":"A clinical review of treatment outcomes in glioblastoma multiforme--the validation in a non-trial population of the results of a randomised phase III clinical trial: has a more radical approach improved survival?","volume":"85","author":"Rock","year":"2012","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0550","doi-asserted-by":"crossref","first-page":"732413","DOI":"10.1155\/2011\/732413","article-title":"Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment","volume":"2011","author":"Jackson","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0555","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1073\/pnas.79.14.4420","article-title":"Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier","volume":"79","author":"Neuwelt","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0560","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0360-3016(98)90036-0","article-title":"The fallacy of the localized supratentorial malignant glioma","volume":"15","author":"Halperin","year":"1988","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0565","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1517\/14728214.2012.679929","article-title":"Recent developments on immunotherapy for brain cancer","volume":"17","author":"Wainwright","year":"2012","journal-title":"Exp. Opin. Emerg. Drugs"},{"issue":"2002","key":"10.1016\/j.jconrel.2020.04.023_bb0570","first-page":"4772","article-title":"A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape","volume":"168","author":"Wiendl","year":"1950","journal-title":"J. Immunol. (Baltimore, Md.)"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0575","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroimage.2004.06.046","article-title":"Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications","volume":"24","author":"Hynynen","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2014.06.023","article-title":"Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood-brain barrier opening and brain drug delivery","volume":"192","author":"Chai","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0585","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/jcbfm.2009.251","article-title":"In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with focused ultrasound: a magnetic resonance imaging study","volume":"30","author":"Liu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0590","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12967-015-0451-y","article-title":"Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study","volume":"13","author":"Chen","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0595","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1148\/radiol.10090699","article-title":"Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment","volume":"255","author":"Liu","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0600","article-title":"Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0605","article-title":"Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study","volume":"8","author":"Wei","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0610","doi-asserted-by":"crossref","first-page":"11719","DOI":"10.1073\/pnas.0604318103","article-title":"Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption","volume":"103","author":"Kinoshita","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0615","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jconrel.2012.09.007","article-title":"Ultrasound-mediated blood-brain\/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model","volume":"163","author":"Park","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0620","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1148\/radiol.2016152444","article-title":"Focused ultrasound enhances central nervous system delivery of bevacizumab for malignant glioma treatment","volume":"281","author":"Liu","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0625","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(01)00455-X","article-title":"Regulation of T cell immunity by dendritic cells","volume":"106","author":"Lanzavecchia","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0630","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4110\/in.2016.16.1.1","article-title":"Regulation of Th2 cell immunity by dendritic cells","volume":"16","author":"Na","year":"2016","journal-title":"Immune Netw."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101764","article-title":"Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model","volume":"9","author":"Belcaid","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0640","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijrobp.2012.12.025","article-title":"Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas","volume":"86","author":"Zeng","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142767","article-title":"Low dose focused ultrasound induces enhanced tumor accumulation of natural killer cells","volume":"10","author":"Sta Maria","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0650","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1158\/0008-5472.CAN-12-2609","article-title":"Focused ultrasound delivers targeted immune cells to metastatic brain tumors","volume":"73","author":"Alkins","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0655","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90521","article-title":"Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols","volume":"2","author":"Silvestrini","year":"2017","journal-title":"JCI Insight."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0660","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes: key regulators of Neuroinflammation","volume":"37","author":"Colombo","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0665","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocn.2009.05.006","article-title":"The role of microglia in central nervous system immunity and glioma immunology","volume":"17","author":"Yang","year":"2010","journal-title":"J. Clin. Neurosc."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0670","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.brs.2014.11.017","article-title":"Enhancement of neurotrophic factors in astrocyte for neuroprotective effects in brain disorders using low-intensity pulsed ultrasound stimulation","volume":"8","author":"Yang","year":"2015","journal-title":"Brain Stimulat."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0675","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1038\/s41598-018-23929-8","article-title":"Preventive effect of low intensity pulsed ultrasound against experimental cerebral ischemia\/reperfusion injury via apoptosis reduction and brain-derived neurotrophic factor induction","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0680","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1038\/srep09671","article-title":"Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer\u2019s disease rat model","volume":"5","author":"Lin","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0685","article-title":"Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound","volume":"8","author":"Hsu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0690","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.expneurol.2013.05.008","article-title":"Amyloid-beta plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound","volume":"248","author":"Jordao","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0695","doi-asserted-by":"crossref","first-page":"278ra233","DOI":"10.1126\/scitranslmed.aaa2512","article-title":"Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model","volume":"7","author":"Leinenga","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0700","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1073\/pnas.1614777114","article-title":"Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation","volume":"114","author":"Kovacs","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0705","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.7150\/thno.21630","article-title":"Acute inflammatory response following increased blood-brain barrier permeability induced by focused ultrasound is dependent on microbubble dose","volume":"7","author":"McMahon","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0710","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2016.10.007","article-title":"A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer","volume":"243","author":"Dimcevski","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.04.023_bb0715","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6086","article-title":"Clinical trial of blood-brain barrier disruption by pulsed ultrasound","volume":"8","author":"Carpentier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0720","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04529-6","article-title":"Blood-brain barrier opening in alzheimer's disease using mr-guided focused ultrasound","volume":"9","author":"Lipsman","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0725","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/17425247.2018.1547279","article-title":"Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation","volume":"15","author":"Snipstad","year":"2018","journal-title":"Expert. Opin. Drug. Deliv."},{"key":"10.1016\/j.jconrel.2020.04.023_bb0730","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fphar.2019.00086","article-title":"Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920302364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920302364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:46:23Z","timestamp":1759160783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920302364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":146,"alternative-id":["S0168365920302364"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.04.023","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrasound in tumor immunotherapy: Current status and future developments","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}