{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:12:17Z","timestamp":1790673137674,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201509370020"],"award-info":[{"award-number":["201509370020"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201506170058"],"award-info":[{"award-number":["201506170058"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jconrel.2020.05.004","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T12:33:48Z","timestamp":1588682028000},"page":"134-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["A tunable and injectable local drug delivery system for personalized periodontal application"],"prefix":"10.1016","volume":"324","author":[{"given":"Bing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.J.","family":"Kouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewald M.","family":"Bronkhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Frank","family":"Walboomers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-7643","authenticated-orcid":false,"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jconrel.2020.05.004_bb0005","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S1474-4422(16)30073-4","article-title":"Global burden of stroke and risk factors in 188 countries, during 1990\u20132013: a systematic analysis for the global burden of disease study 2013","volume":"15","author":"Feigin","year":"2016","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1600-051x.2000.027001030.x","article-title":"The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results","volume":"27","author":"Cugini","year":"2000","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00784-018-2420-3","article-title":"Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis","volume":"23","author":"Cosgarea","year":"2019","journal-title":"Clin. Oral Investig."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.7243\/2053-5775-6-2","article-title":"Chronic wound management of periodontal disease","volume":"6","author":"Keller","year":"2018","journal-title":"Oral Biol. Dentistry"},{"issue":"7_suppl","key":"10.1016\/j.jconrel.2020.05.004_bb0025","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1177\/0022034512449171","article-title":"Personalized medicine: will dentistry ride the wave or watch from the beach?","volume":"91","author":"Kornman","year":"2012","journal-title":"J. Dent. Res."},{"issue":"7 Suppl","key":"10.1016\/j.jconrel.2020.05.004_bb0030","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1177\/0022034513487209","article-title":"Expanding the foundation for personalized medicine: implications and challenges for dentistry","volume":"92","author":"Garcia","year":"2013","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2020.05.004_bb0035","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0022034518810213","article-title":"A novel Thermoresponsive gel as a potential delivery system for Lipoxin","volume":"98","author":"Wang","year":"2019","journal-title":"J. Dent. Res."},{"issue":"7434","key":"10.1016\/j.jconrel.2020.05.004_bb0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature11839","article-title":"Responsive biomimetic networks from polyisocyanopeptide hydrogels","volume":"493","author":"Kouwer","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jconrel.2020.05.004_bb0045","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1039\/C9BM00661C","article-title":"Monitoring (111)In-labelled polyisocyanopeptide (PIC) hydrogel wound dressings in full-thickness wounds","volume":"7","author":"Veld","year":"2019","journal-title":"Biomater Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2020.05.004_bb0050","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2020.05.004_bb0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2018.07.044","article-title":"Imaging the porous structure in the core of degrading PLGA microparticles: the effect of molecular weight","volume":"286","author":"Mylonaki","year":"2018","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.colsurfb.2004.03.018","article-title":"Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin","volume":"36","author":"Makino","year":"2004","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2020.05.004_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2019.04.023","article-title":"Encapsulation and release of doxycycline from electrospray-generated PLGA microspheres: effect of polymer end groups","volume":"564","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2020.05.004_bb0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00396-007-1793-7","article-title":"Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system","volume":"286","author":"Bako","year":"2008","journal-title":"Colloid Polym. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2020.05.004_bb0075","first-page":"138","article-title":"Development and optimization of eugenol loaded nanostructured lipid carriers for periodontal delivery","volume":"3","author":"Pokharkar","year":"2011","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2020.05.004_bb0080","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1902\/jop.2000.71.4.521","article-title":"Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis","volume":"71","author":"Caton","year":"2000","journal-title":"J. Periodontol."},{"issue":"5","key":"10.1016\/j.jconrel.2020.05.004_bb0085","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1902\/jop.1999.70.5.490","article-title":"Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis","volume":"70","author":"Garrett","year":"1999","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2020.05.004_bb0090","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1096\/fj.05-4724fje","article-title":"RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis","volume":"20","author":"Hasturk","year":"2006","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/0022034514557331","article-title":"Proresolving nanomedicines activate bone regeneration in periodontitis","volume":"94","author":"Van Dyke","year":"2015","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2020.05.004_bb0100","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1089\/ten.teb.2019.0184","article-title":"Topical host-modulating therapy for periodontal regeneration: a systematic review and meta-analysis","volume":"25","author":"Wang","year":"2019","journal-title":"Tissue Eng. B-Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2020.05.004_bb0110","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1208\/s12249-011-9625-y","article-title":"Injectability evaluation: an open issue","volume":"12","author":"Cilurzo","year":"2011","journal-title":"AAPS PharmSciTech"},{"issue":"22","key":"10.1016\/j.jconrel.2020.05.004_bb0115","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2217\/nnm-2017-0172","article-title":"Biological evaluation of silver nanoparticles incorporated into chitosan-based membranes","volume":"12","author":"Shao","year":"2017","journal-title":"Nanomedicine-Uk"},{"issue":"28","key":"10.1016\/j.jconrel.2020.05.004_bb0120","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1016\/j.biomaterials.2012.06.018","article-title":"Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation","volume":"33","author":"Ji","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.05.004_bb0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcis.2013.11.037","article-title":"Electrospray synthesis of monodisperse polymer particles in a broad (60nm\u20132\u03bcm) diameter range: guiding principles and formulation recipes","volume":"417","author":"Almer\u00eda","year":"2014","journal-title":"J. Colloid Interface Sci."},{"issue":"9","key":"10.1016\/j.jconrel.2020.05.004_bb0130","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1021\/acsnano.8b04022","article-title":"Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease","volume":"12","author":"Bao","year":"2018","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1902\/jop.2002.73.1.13","article-title":"Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis","volume":"73","author":"Friesen","year":"2002","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2020.05.004_bb0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1902\/jop.1997.68.4.353","article-title":"The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis","volume":"68","author":"Vandekerckhove","year":"1997","journal-title":"J. Periodontol."},{"issue":"8","key":"10.1016\/j.jconrel.2020.05.004_bb0145","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s10856-010-4098-1","article-title":"A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation","volume":"21","author":"Ji","year":"2010","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jcis.2009.05.012","article-title":"High solids loading ceramic colloidal dispersions in UV curable media via comb-polyelectrolyte surfactants","volume":"337","author":"De Hazan","year":"2009","journal-title":"J. Colloid Interface Sci."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2020.05.004_bb0155","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ijpharm.2012.05.029","article-title":"Improved physical stability and injectability of non-aqueous in situ PLGA microparticle forming emulsions","volume":"434","author":"Voigt","year":"2012","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2710.2000.00261.x","article-title":"Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases","volume":"25","author":"Vyas","year":"2000","journal-title":"J. Clin. Pharm. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2020.05.004_bb0170","article-title":"Xyloglucan based in situ gel of lidocaine HCl for the treatment of periodontosis","volume":"2016","author":"Pandit","year":"2016","journal-title":"J. Pharm."},{"issue":"41","key":"10.1016\/j.jconrel.2020.05.004_bb0175","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1002\/adfm.201502241","article-title":"Tuning hydrogel mechanics using the hofmeister effect","volume":"25","author":"Jaspers","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2020.05.004_bb0180","doi-asserted-by":"crossref","first-page":"15478","DOI":"10.1038\/ncomms15478","article-title":"Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells","volume":"8","author":"Jaspers","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.05.004_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2017.03.031","article-title":"Mechanisms of in vivo release of triamcinolone acetonide from PLGA microspheres","volume":"256","author":"Doty","year":"2017","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.jconrel.2020.05.004_bb0190","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.biomaterials.2007.12.004","article-title":"Sequential release of bioactive IGF-I and TGF-\u03b21 from PLGA microsphere-based scaffolds","volume":"29","author":"Jaklenec","year":"2008","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jconrel.2020.05.004_bb0195","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2004.75.10.1387","article-title":"Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 gamma2 chain levels in chronic periodontitis","volume":"75","author":"Emingil","year":"2004","journal-title":"J. Periodontol."},{"issue":"5","key":"10.1016\/j.jconrel.2020.05.004_bb0200","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1902\/jop.2000.71.5.768","article-title":"The effects of sustained release doxycycline on the anaerobic Flora and Antibiotic-resistant patterns in subgingival plaque and saliva","volume":"71","author":"Walker","year":"2000","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2020.05.004_bb0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1399-302X.1992.tb00520.x","article-title":"Antibiotic resistance of the subgingival microbiota following local tetracycline therapy","volume":"7","author":"Goodson","year":"1992","journal-title":"Oral Microbiol. Immunol."},{"issue":"5","key":"10.1016\/j.jconrel.2020.05.004_bb0210","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1902\/jop.2008.070515","article-title":"Locally delivered doxycycline during supportive periodontal therapy: A 3-year study","volume":"79","author":"Bogren","year":"2008","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0215","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1902\/jop.2005.76.1.66","article-title":"Non-surgical periodontal therapy with adjunctive topical doxycycline: a double-masked, randomized, controlled multicenter study. II. Microbiological results","volume":"76","author":"Ratka-Kruger","year":"2005","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.05.004_bb0220","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/00365549109023379","article-title":"Occurrence of doxycycline resistant bacteria in the oral cavity after local administration of doxycycline in patients with periodontal disease","volume":"23","author":"Larsen","year":"1991","journal-title":"Scand. J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jconrel.2020.05.004_bb0225","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-051X.1995.tb00164.x","article-title":"Bacterial resistance following subgingival and systemic administration of minocycline","volume":"22","author":"Preus","year":"1995","journal-title":"J. Clin. Periodontol."},{"issue":"7","key":"10.1016\/j.jconrel.2020.05.004_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182381","article-title":"Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers","volume":"12","author":"Reis","year":"2017","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2020.05.004_bb0235","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijpharm.2016.09.077","article-title":"Immobilization and delivery of biologically active Lipoxin A4 using electrospinning technology","volume":"515","author":"Cianci","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.jconrel.2020.05.004_bb0240","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1021\/acsnano.8b02365","article-title":"Modified magnesium hydroxide nanoparticles inhibit the inflammatory response to biodegradable poly(lactide-co-glycolide) implants","volume":"12","author":"Lih","year":"2018","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2020.05.004_bb0245","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1600-0765.1978.tb00178.x","article-title":"Subcutaneous implants for assessements of dental materials with emphasis on periodontal dressings","volume":"13","author":"Haugen","year":"1978","journal-title":"J. Periodontal Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920302790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920302790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:38:51Z","timestamp":1777509531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920302790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":48,"alternative-id":["S0168365920302790"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.05.004","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A tunable and injectable local drug delivery system for personalized periodontal application","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}