{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:07:14Z","timestamp":1793326034847,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jconrel.2020.08.053","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:12:19Z","timestamp":1598746339000},"page":"276-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents"],"prefix":"10.1016","volume":"328","author":[{"given":"Dezhuang","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-0641","authenticated-orcid":false,"given":"Arash","family":"Nazeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.08.053_bb0005","doi-asserted-by":"crossref","unstructured":"K. Hynynen, N. McDannold, N. Vykhodtseva, F.A. Jolesz, Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits., Radiology. 220 (2001) 640\u2013646. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11526261.","DOI":"10.1148\/radiol.2202001804"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0010","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.106.034301","article-title":"Blood vessel deformations on microsecond time scales by ultrasonic cavitation","volume":"106","author":"Chen","year":"2011","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2016.10.011","article-title":"Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption","volume":"250","author":"Park","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010549","article-title":"Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer\u2019s disease","volume":"5","author":"Jord\u00e3o","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0025","doi-asserted-by":"crossref","unstructured":"Manabu Kinoshita, N. McDannold, F.A. Jolesz, Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption., Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 11719\u201323. doi:https:\/\/doi.org\/10.1073\/pnas.0604318103.","DOI":"10.1073\/pnas.0604318103"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2012.64","article-title":"Focal delivery of AAV2\/1-transgenes into the rat brain by localized ultrasound-induced BBB opening","volume":"2","author":"Alonso","year":"2013","journal-title":"Mol. Ther. Nucleic Acids."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0035","doi-asserted-by":"crossref","first-page":"39955","DOI":"10.1038\/srep39955","article-title":"Non-invasive, focused ultrasound-facilitated gene delivery for Optogenetics","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/gt.2014.91","article-title":"Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus","volume":"22","author":"Wang","year":"2014","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027877","article-title":"Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier","volume":"6","author":"Burgess","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0050","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/0963689717715824","article-title":"Magnetic enhancement of stem cell\u2013targeted delivery into the brain following MR-guided focused ultrasound for opening the blood\u2013brain barrier","volume":"26","author":"Shen","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0055","doi-asserted-by":"crossref","unstructured":"A. Carpentier, M. Canney, A. Vignot, V. Reina, K. Beccaria, C. Horodyckid, C. Karachi, D. Leclercq, C. Lafon, J.Y. Chapelon, L. Capelle, P. Cornu, M. Sanson, K. Hoang-Xuan, J.Y. Delattre, A. Idbaih, Clinical trial of blood-brain barrier disruption by pulsed ultrasound, Sci. Transl. Med. 8 (2016) 343re2\u2013343re2. doi:https:\/\/doi.org\/10.1126\/scitranslmed.aaf6086.","DOI":"10.1126\/scitranslmed.aaf6086"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0060","first-page":"1","article-title":"Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy","author":"Park","year":"2020","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0065","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41598-018-36340-0","article-title":"Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: A clinical safety and feasibility study","volume":"9","author":"Mainprize","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0070","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1038\/s41467-018-04529-6","article-title":"Blood\u2013brain barrier opening in Alzheimer\u2019s disease using MR-guided focused ultrasound","volume":"9","author":"Lipsman","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0075","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/ana.25604","article-title":"Glymphatics visualization after focused ultrasound-induced blood\u2013brain barrier opening in humans","volume":"86","author":"Meng","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0080","article-title":"Noninvasive hippocampal blood\u2212brain barrier opening in Alzheimer\u2019s disease with focused ultrasound","volume":"202002571","author":"Rezai","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0085","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1038\/s41467-019-12426-9","article-title":"First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound","volume":"10","author":"Abrahao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0090","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0095","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI67677","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"Iliff","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0100","doi-asserted-by":"crossref","unstructured":"J.J. Iliff, M. Wang, Y. Liao, B.A. Plogg, W. Peng, G.A. Gundersen, H. Benveniste, G.E. Vates, R. Deane, S.A. Goldman, E.A. Nagelhus, M. Nedergaard, A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2, Sci. Transl. Med. 4 (2012) 147ra111. doi:https:\/\/doi.org\/10.1126\/scitranslmed.3003748.","DOI":"10.1126\/scitranslmed.3003748"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0105","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1208\/s12248-015-9719-7","article-title":"Intranasal delivery of proteins and peptides in the treatment of neurodegenerative diseases","volume":"17","author":"Meredith","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jconrel.2016.01.017","article-title":"Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model","volume":"224","author":"Zhao","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0115","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/mt.2011.291","article-title":"Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain","volume":"20","author":"Kim","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0120","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/s41598-017-01819-9","article-title":"Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation","volume":"7","author":"Rodriguez","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jconrel.2017.06.032","article-title":"A potential non-invasive glioblastoma treatment: nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles","volume":"261","author":"Sekerdag","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.colsurfb.2017.01.031","article-title":"Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer\u2019s therapy","volume":"152","author":"Rassu","year":"2017","journal-title":"Colloids Surfaces B Biointerfaces."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0135","doi-asserted-by":"crossref","unstructured":"S. Wu, K. Li, Y. Yan, B. Gran, Y. Han, F. Zhou, Y.-T. Guan, A. Rostami, G.-X. Zhang, Intranasal delivery of neural stem cells: A CNS-specific, non-invasive cell-based therapy for experimental autoimmune encephalomyelitis., J. Clin. Cell. Immunol. 4 (2013). doi:https:\/\/doi.org\/10.4172\/2155-9899.1000142.","DOI":"10.4172\/2155-9899.1000142"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40263-013-0076-8","article-title":"Intranasal insulin as a treatment for Alzheimer\u2019s disease: a review of basic research and clinical evidence","volume":"27","author":"Freiherr","year":"2013","journal-title":"CNS Drugs."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0168-3659(02)00363-2","article-title":"Nasal drug delivery - possibilities, problems and solutions","volume":"87","author":"Illum","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jconrel.2014.06.053","article-title":"Quantitative analysis of drug delivery to the brain via nasal route","volume":"189C","author":"Kozlovskaya","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0155","article-title":"A new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug delivery","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0160","doi-asserted-by":"crossref","first-page":"28599","DOI":"10.1038\/srep28599","article-title":"Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2018.07.020","article-title":"Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain","volume":"286","author":"Ye","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0170","doi-asserted-by":"crossref","first-page":"19402","DOI":"10.1038\/s41598-019-55294-5","article-title":"Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson\u2019s disease mouse model","volume":"9","author":"Ji","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ultras.2008.09.010","article-title":"High-speed observation of cavitation bubble clouds near a tissue boundary in high-intensity focused ultrasound fields","volume":"49","author":"Chen","year":"2009","journal-title":"Ultrasonics."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0180","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1039\/c2ra20546g","article-title":"Serum albumin reduces the antibacterial and cytotoxic effects of hydrogel-embedded colloidal silver nanoparticles","volume":"2","author":"Grade","year":"2012","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40262-017-0549-x","article-title":"A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients","volume":"57","author":"T\u2019jollyn","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0190","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jneumeth.2005.08.006","article-title":"Fluorescence imaging of blood-brain barrier disruption","volume":"151","author":"Hawkins","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2010.08.045","article-title":"A novel quantification of blood-brain barrier damage and histochemical typing after embolic stroke in rats","volume":"1359","author":"Michalski","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0200","doi-asserted-by":"crossref","unstructured":"J. a Falcone, T.S. Salameh, X. Yi, B.J. Cordy, W.G. Mortell, A. V Kabanov, W. a Banks, Intranasal administration as a route for drug delivery to the brain: Evidence for a unique pathway for albumin., J. Pharmacol. Exp. Ther. 98108 (2014) 54\u201360. doi:https:\/\/doi.org\/10.1124\/jpet.114.216705.","DOI":"10.1124\/jpet.114.216705"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1088\/0031-9155\/58\/1\/127","article-title":"Gauging the likelihood of stable cavitation from ultrasound contrast agents","volume":"58","author":"Bader","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0210","doi-asserted-by":"crossref","first-page":"33264","DOI":"10.1038\/srep33264","article-title":"Focused ultrasound-induced blood-brain barrier opening: association with mechanical index and cavitation index analyzed by dynamic contrast-enhanced magnetic-resonance imaging","volume":"6","author":"Chu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0215","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1121\/1.3646905","article-title":"The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice","volume":"130","author":"Tung","year":"2011","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0220","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/jcbfm.2014.71","article-title":"The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure","volume":"34","author":"Chen","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0225","first-page":"1","article-title":"Delivery of liposomes with different sizes to mice brain after sonication by focused ultrasound in the presence of microbubbles","author":"Shen","year":"2016","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0230","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1088\/0031-9155\/60\/6\/2511","article-title":"Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model","volume":"60","author":"Aryal","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0235","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/jcbfm.2010.155","article-title":"Noninvasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies","volume":"31","author":"Choi","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2018.05.005","article-title":"Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery","volume":"281","author":"Alli","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0245","doi-asserted-by":"crossref","unstructured":"S. Mahesh, K.C. Tang, M. Raj, Amide bond activation of biological molecules, Molecules. 23 (2018). doi:https:\/\/doi.org\/10.3390\/molecules23102615.","DOI":"10.3390\/molecules23102615"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0250","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11307-011-0499-x","article-title":"Albumin-binding domain conjugate for near-infrared fluorescence lymphatic imaging","volume":"14","author":"Davies-Venn","year":"2012","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0255","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3109\/02688697.2015.1056090","article-title":"Fluorescence-guided resection of experimental malignant glioma using cetuximab-IRDye 800CW","volume":"29","author":"Warram","year":"2015","journal-title":"Br. J. Neurosurg."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0260","series-title":"Personalized Medicine and Imaging Sensitivity and Specificity of Cetuximab-IRDye800CW to Identify Regional Metastatic Disease in Head and Neck Cancer","author":"Rosenthal","year":"2017"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0265","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00259-012-2080-5","article-title":"Nanocolloidal albumin-IRDye 800CW: A near-infrared fluorescent tracer with optimal retention in the sentinel lymph node","volume":"39","author":"Heuveling","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0270","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ejpb.2016.05.008","article-title":"Development, preclinical safety, formulation, and stability of clinical grade bevacizumab-800CW, a new near infrared fluorescent imaging agent for first in human use","volume":"104","author":"Ter Weele","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0275","unstructured":"K. Leung, IRDye 800CW-Epidermal growth factor, in: Mol. Imaging Contrast Agent Database, National Center for Biotechnology Information (US), Bethesda (MD), 2004."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0280","doi-asserted-by":"crossref","unstructured":"F. Kazazi-Hyseni, S.H. Van Vuuren, D.M. Van Der Giezen, E.H. Pieters, F. Ramazani, S. Rodriguez, G.J. Veldhuis, R. Goldschmeding, C.F. Van Nostrum, W.E. Hennink, R.J. Kok, Release and pharmacokinetics of near-infrared labeled albumin from monodisperse poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcapsular renal injection, Acta Biomater. 22 (2015) 141\u2013154. doi:https:\/\/doi.org\/10.1016\/j.actbio.2015.04.030.","DOI":"10.1016\/j.actbio.2015.04.030"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ultrasmedbio.2006.07.018","article-title":"Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice","volume":"33","author":"Choi","year":"2007","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/smll.201703115","article-title":"Focused ultrasound enabled trans-blood brain barrier delivery of gold nanoclusters: effect of surface charges and quantification using positron emission tomography","volume":"14","author":"Sultan","year":"2018","journal-title":"Small."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0295","doi-asserted-by":"crossref","unstructured":"J. a Feshitan, C.C. Chen, J.J. Kwan, M. a Borden, Microbubble size isolation by differential centrifugation., J. Colloid Interface Sci. 329 (2009) 316\u201324. doi:https:\/\/doi.org\/10.1016\/j.jcis.2008.09.066.","DOI":"10.1016\/j.jcis.2008.09.066"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0300","doi-asserted-by":"crossref","unstructured":"K. Liu, Y. Wang, X. Kong, X. Liu, Y. Zhang, L. Tu, V. Validation, O. Probes, N. Fluorescent, F. Leblond, Z. Ovanesyan, S.C. Davis, P.A. Vald\u00e9s, A. Kim, A. Hartov, B.C. Wilson, B.W. Pogue, K.D. Paulsen, D.W. Roberts, J.P. Miller, D. Maji, J. Lam, B.J. Tromberg, S. Achilefu, K. Liu, Y. Wang, X. Kong, X. Liu, Y. Zhang, L. Tu, Y. Ding, M.C.G. Aalders, W.J. Buma, H. Zhang, D. Wirth, K. Kolste, S. Kanick, D.W. Roberts, F. Leblond, K.D. Paulsen, J. Swartling, J. Svensson, D. Bengtsson, K. Terike, S. Andersson-Engels, Pearl Trilogy, Biomed. Opt. Express. 8 (2017) 3095. doi:https:\/\/doi.org\/10.1364\/BOE.8.003656.","DOI":"10.1364\/BOE.8.003656"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0305","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1016\/S0006-3495(03)74770-5","article-title":"Interactions of inertial cavitation bubbles with stratum Corneum lipid bilayers during low-frequency Sonophoresis","volume":"85","author":"Tezel","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0310","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jps.10299","article-title":"Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model","volume":"92","author":"Tezel","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0315","series-title":"Topical Delivery of Anti-Sense Oligonucleotides Using Low-Frequency Sonophoresis","author":"Tezel","year":"2004"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0325","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2012.06.012","article-title":"The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound","volume":"162","author":"Park","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0330","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ultrasmedbio.2010.02.009","article-title":"Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles","volume":"36","author":"Tung","year":"2010","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0335","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1016\/j.ultrasmedbio.2019.07.004","article-title":"Correlation between brain tissue damage and inertial cavitation dose quantified using passive cavitation imaging","volume":"45","author":"Xu","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0340","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1038\/s41598-018-24516-7","article-title":"Focused ultrasound-enabled brain tumor liquid biopsy","volume":"8","author":"Zhu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0345","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2011.07.006","article-title":"Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells","volume":"1411","author":"Alonso","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0350","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.7150\/thno.22069","article-title":"Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased in vivo anti-tumor efficacy","volume":"8","author":"Feng","year":"2018","journal-title":"Theranostics."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0355","first-page":"140","article-title":"Intranasal delivery\u00a0: An approach to bypass the blood brain barrier","volume":"36","author":"Talegaonkar","year":"2004","journal-title":"Indian J Pharmacol."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0360","doi-asserted-by":"crossref","unstructured":"D. Ye, X. Zhuang, Y. Yue, S. Taylor, Y.C. Tai, J.B. Rubin, Y. Liu, H. Chen, Comparison of Focused Ultrasound-Mediated Intranasal Delivery and Focused Ultrasound-Induced Blood-Brain Barrier Disruption in the Delivery of Gold Nanoclusters to the Brainstem, IEEE Int. Ultrason. Symp. IUS. 2018-Janua (2018) 5\u20138. doi:https:\/\/doi.org\/10.1109\/ULTSYM.2018.8580097.","DOI":"10.1109\/ULTSYM.2018.8580097"},{"key":"10.1016\/j.jconrel.2020.08.053_bb0365","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1073\/pnas.192442999","article-title":"Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice","volume":"99","author":"Capsoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0370","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jps.1122","article-title":"Direct nose-brain transport of benzoylecgonine following intranasal administration in rats","volume":"90","author":"Sherry Chow","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0380","first-page":"26","article-title":"Intranasal delivery to the central nervous system: mechanisms and experimental considerations","volume":"3","author":"Dhuria","year":"2011","journal-title":"Int. J. Drug Dev. Res."},{"key":"10.1016\/j.jconrel.2020.08.053_bb0385","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13346-012-0108-9","article-title":"Nasal drug delivery devices: characteristics and performance in a clinical perspective-a review","volume":"3","author":"Djupesland","year":"2013","journal-title":"Drug Deliv. Transl. Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920304946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920304946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T03:15:16Z","timestamp":1718421316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920304946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":75,"alternative-id":["S0168365920304946"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.08.053","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.08.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}