{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:57:40Z","timestamp":1781175460217,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017M3A9C6061360"],"award-info":[{"award-number":["NRF-2017M3A9C6061360"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2019R1A6A1A03032888"],"award-info":[{"award-number":["NRF-2019R1A6A1A03032888"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2020R1A2C3009783"],"award-info":[{"award-number":["NRF-2020R1A2C3009783"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jconrel.2020.08.057","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T09:45:50Z","timestamp":1599385550000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["In situ pocket-type microcarrier (PMc) as a therapeutic composite: Regeneration of cartilage with stem cells, genes, and drugs"],"prefix":"10.1016","volume":"332","author":[{"given":"Hye Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Jun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-In","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-2202","authenticated-orcid":false,"given":"Hee Seok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-5578","authenticated-orcid":false,"given":"Keun-Hong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.08.057_bb0005","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1039\/c3tb00021d","article-title":"Nanoporous microspheres: from controllable synthesis to healthcare applications","volume":"1","author":"Fan","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0010","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1039\/C5TB00086F","article-title":"Recent developments in multilayered polymeric particles \u2013 from fabrication techniques to therapeutic formulations","author":"Saha","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0015","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1021\/acs.molpharmaceut.9b00344","article-title":"Goserelin acetate loaded Poloxamer hydrogel in PLGA microspheres: core\u2013shell Di-Depot intramuscular sustained release delivery system","volume":"16","author":"Qi","year":"2019","journal-title":"Mol. Pham."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0020","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1039\/C4PY00039K","article-title":"Pluronic\u00ae block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances","volume":"6","author":"Pitto-Barry","year":"2014","journal-title":"Polym. Chem."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2018.06.015","article-title":"Porous microspheres: synthesis, characterisation and applications in pharmaceutical & medical fields","volume":"548","author":"Dastidar","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2018.11.017","article-title":"An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration","volume":"192","author":"Zhu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biomaterials.2019.01.005","article-title":"Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model","volume":"197","author":"Ingavle","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0040","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.7150\/thno.33904","article-title":"Enrichment of CD146+ adipose-derived stem cells in combination with articular cartilage extracellular matrix scaffold promotes cartilage regeneration","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0045","doi-asserted-by":"crossref","first-page":"24607","DOI":"10.1039\/C7RA01445G","article-title":"Strontium ranelate-loaded PLGA porous microspheres enhancing the osteogenesis of MC3T3-E1 cells","volume":"7","author":"Mao","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201802273","article-title":"A micro-ark for cells: highly open porous Polyhydroxyalkanoate microspheres as injectable scaffolds for tissue regeneration","volume":"30","author":"Wei","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.actbio.2019.01.044","article-title":"Porous PolyHIPE microspheres for protein delivery from an injectable bone graft","volume":"95","author":"Whitely","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0060","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-3-319-76711-6_8","article-title":"Porous scaffolds for regeneration of cartilage, bone and osteochondral tissue","volume":"1058","author":"Chen","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0065","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1039\/C4NR02756F","article-title":"Nitrogen-enriched, double-shelled carbon\/layered double hydroxide hollow microspheres for excellent electrochemical performance","volume":"6","author":"Xu","year":"2014","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.12.031","article-title":"Calcium phosphate-phosphorylated adenosine hybrid microspheres for anti-osteosarcoma drug delivery and osteogenic differentiation","volume":"121","author":"Zhou","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0075","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.2217\/nnm-2016-0074","article-title":"Nanometric emulsions encapsulating solid particles as alternative carriers for intracellular delivery","volume":"11","author":"Quignard","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0080","doi-asserted-by":"crossref","first-page":"14728","DOI":"10.1038\/s41598-017-15225-8","article-title":"Bioinspired synthesis of mesoporous gold-silica hybrid microspheres as recyclable colloidal SERS substrates","volume":"7","author":"Son","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0085","doi-asserted-by":"crossref","first-page":"32613","DOI":"10.1021\/acsami.9b09123","article-title":"Porous chitosan films support stem cells and facilitate sutureless tissue repair","author":"Ruprai","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0090","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijpharm.2016.10.040","article-title":"Porous microscaffolds for 3D culture of dental pulp mesenchymal stem cells","volume":"515","author":"Bhiptani","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0095","article-title":"Mesenchymal stem cell capping on ECM-anchored caspase inhibitor\u2013loaded PLGA microspheres for intraperitoneal injection in DSS-induced murine colitis","author":"Pathak","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0100","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/5\/055003","article-title":"Stem cell differentiation-related protein-loaded PLGA microspheres as a novel platform microtyped scaffold for chondrogenesis","volume":"11","author":"Park","year":"2016","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0105","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1021\/acsami.8b03445","article-title":"Multilayered scaffold with a compact interfacial layer enhances osteochondral defect repair","volume":"10","author":"Jia","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060636","article-title":"BMP2 and TGF-\u03b2 cooperate differently during synovial-derived stem-cell chondrogenesis in a dexamethasone-dependent manner","volume":"8","author":"Kovermann","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0115","doi-asserted-by":"crossref","first-page":"11587","DOI":"10.1021\/acsami.8b20372","article-title":"Drug delivery system based on near-infrared light-responsive molybdenum disulfide nanosheets controls the high-efficiency release of dexamethasone to inhibit inflammation and treat osteoarthritis","volume":"11","author":"Zhao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0120","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1021\/bc070012a","article-title":"Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier","volume":"15","author":"Bae","year":"2007","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0125","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jcb.22587","article-title":"Synthesis and characterization of dexamethasone-conjugated linear polyethylenimine as a gene carrier","volume":"110","author":"Kim","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.msec.2017.02.103","article-title":"Fabrication of novel biodegradable porous bone scaffolds based on amphiphilic hydroxyapatite nanorods","volume":"75","author":"Zheng","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0135","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1039\/C6NR09090G","article-title":"Multi-functional nanotracers for image-guided stem cell gene therapy","volume":"9","author":"Park","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0140","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.7150\/thno.34487","article-title":"Multiply clustered gold-based nanoparticles complexed with exogenous pDNA achieve prolonged gene expression in stem cells","volume":"9","author":"Yi","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.clinimag.2019.07.004","article-title":"MR imaging of cartilage repair surgery of the knee","volume":"58","author":"Liu","year":"2019","journal-title":"Clin. Imag."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2018.12.025","article-title":"Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone","volume":"295","author":"Formica","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2020.08.057_bb0155","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.09.010","article-title":"Glutamic acid-based dendritic peptides for scaffold-free cartilage tissue engineering","author":"Sivadas","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2020.08.057_bb0160","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.7150\/thno.38061","article-title":"3D-bioprinting a genetically inspired cartilage scaffold with GDF5-conjugated BMSC-laden hydrogel and polymer for cartilage repair","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920304983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920304983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:57:23Z","timestamp":1759161443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920304983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":32,"alternative-id":["S0168365920304983"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.08.057","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In situ pocket-type microcarrier (PMc) as a therapeutic composite: Regeneration of cartilage with stem cells, genes, and drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}