{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:22:32Z","timestamp":1779254552995,"version":"3.51.4"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44DE028713"],"award-info":[{"award-number":["R44DE028713"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1 TR002531"],"award-info":[{"award-number":["TL1 TR002531"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR002529"],"award-info":[{"award-number":["UL1 TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jconrel.2020.09.047","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T22:29:18Z","timestamp":1601936958000},"page":"570-584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Analysis of the bone fracture targeting properties of osteotropic ligands"],"prefix":"10.1016","volume":"329","author":[{"given":"Jeffery J.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart A.","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal T.","family":"Ramseier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul V.","family":"Hadap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-1520","authenticated-orcid":false,"given":"Mingding","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-5528","authenticated-orcid":false,"given":"Philip S.","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.09.047_bb0005","article-title":"By the numbers: musculoskeletal injuries","author":"Bone and Joint Initiative","year":"2012","journal-title":"Bone Jt. Initiat."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.5312\/wjo.v5.i4.402","article-title":"Complications of hip fractures: a review","volume":"5","author":"Carpintero","year":"2014","journal-title":"World J. Orthop."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4103\/0970-0358.118597","article-title":"Unfavourable outcomes in maxillofacial injuries: how to avoid and manage","volume":"46","author":"Parashar","year":"2013","journal-title":"Indian J. Plast. Surg."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0020","series-title":"The Burden of Musculoskeletal Diseases in the United States","author":"The Bone and Joint Initative","year":"2019"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0025","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.exger.2006.09.008","article-title":"Fracture healing in the elderly patient","volume":"41","author":"Gruber","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2106\/JBJS.L.01406","article-title":"Risk factors for continued opioid use one to two months after surgery for musculoskeletal trauma","volume":"96","author":"Helmerhorst","year":"2014","journal-title":"J. Bone Jt. Surg. Ser. A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0035","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1525-1497.2005.00219.x","article-title":"Best practices for elderly hip fracture patients a systematic overview of the evidence","volume":"20","author":"Beaupre","year":"2005","journal-title":"J. Gen. Intern. Med."},{"issue":"2002","key":"10.1016\/j.jconrel.2020.09.047_bb0040","first-page":"40","article-title":"Safety profile for the clinical use of bone morphogenetic proteins in the spine","volume":"27","author":"Poynton","year":"1976","journal-title":"Spine (Phila. Pa.)"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7859184","article-title":"Effect of BMP-2 delivery mode on osteogenic differentiation of stem cells","volume":"2017","author":"Jung","year":"2017","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0050","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1089\/ten.tea.2011.0008","article-title":"The evaluation of ectopic bone formation induced by delivery systems for bone morphogenetic protein-9 or its derived peptide","volume":"18","author":"Bergeron","year":"2012","journal-title":"Tissue Eng. - Part A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0055","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/ten.teb.2015.0357","article-title":"A review of the clinical side effects of bone morphogenetic protein-2","volume":"22","author":"James","year":"2016","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1515\/revneuro-2017-0060","article-title":"Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration","volume":"29","author":"Chung","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0065","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-014-0485-1","article-title":"The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology","volume":"16","author":"Gr\u00e4ssel","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0070","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00018-005-5175-3","article-title":"Neuronal signaling and the regulation of bone remodeling","volume":"62","author":"Elefteriou","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2013.00006","article-title":"Anabolic effects of IGF-1 signaling on the skeleton","volume":"4","author":"Tahimic","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0080","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1021\/jm0001727","article-title":"Structure - function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a","volume":"43","author":"Bednarek","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0085","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.125.4.929","article-title":"SPARC is a source of copper-binding peptides that stimulate angiogenesis","volume":"125","author":"Lane","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0090","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1002\/chem.201802117","article-title":"VEGFR recognition interface of a proangiogenic VEGF-mimetic peptide determined in vitro and in the presence of endothelial cells by NMR spectroscopy","author":"DiStasi","year":"2018","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2013.03.050","article-title":"Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies","volume":"244","author":"Verheyen","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0100","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.drudis.2013.07.015","article-title":"Treating osteoporosis by targeting parathyroid hormone to bone","volume":"19","author":"Ponnapakkam","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0105","first-page":"3757","article-title":"Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys","volume":"84","author":"Brommage","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0110","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/bip.21336","article-title":"C-type natriuretic peptide: structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines","volume":"94","author":"Shaikh","year":"2010","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0115","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1210\/js.2018-00118","article-title":"Osteoanabolic agents for osteoporosis","volume":"2","author":"Haas","year":"2018","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0120","article-title":"A randomized, double-blind, placebo-controlled, comparative phase 3 multicenter study to evaluate the safety and efficacy of BA058 for injection for prevention of fracture in ambulatory postmenopausal women with severe osteoporosis and at risk of fracture","author":"Health","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0125","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1136\/bcr-2017-223035","article-title":"Teriparatide-induced atrial tachycardia","volume":"2018","author":"Ziffra","year":"2018","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0130","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/oxfordjournals.eurheartj.a014724","article-title":"Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters","volume":"17","author":"Nieminen","year":"1996","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0116462","article-title":"Dexamethasone enhances osteogenic differentiation of bone marrow-and muscle-derived stromal cells and augments ectopic bone formation induced by bone morphogenetic protein-2","volume":"10","author":"Yuasa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0140","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1677\/joe.0.1620371","article-title":"Effects of dexamethasone on proliferation, activity, and cytokine secretion of normal human bone marrow stromal cells: possible mechanisms of glucocorticoid-induced bone loss","volume":"162","author":"Kim","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0145","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1021\/acs.jmedchem.7b00271","article-title":"Inhibitors of 15-prostaglandin dehydrogenase to potentiate tissue repair","volume":"60","author":"Antczak","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa2340","article-title":"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0155","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2106\/JBJS.15.01106","article-title":"Bone morphogenetic protein use and cancer risk among patients undergoing lumbar arthrodesis a case-cohort study using the SEER-medicare database","volume":"98","author":"Beachler","year":"2016","journal-title":"J. Bone Jt. Surg. Am."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0160","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s00198-018-4604-8","article-title":"The Forteo patient registry linkage to multiple state cancer registries: study design and results from the first 8 years","volume":"29","author":"Gilsenan","year":"2018","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms18071345","article-title":"Development of bone targeting drugs","volume":"18","author":"Stapleton","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0170","series-title":"Targeted Delivery to Bone and Mineral Deposits Using Bisphosphonate Ligands","author":"Cole","year":"2016"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13550-016-0161-3","article-title":"177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment","volume":"6","author":"Bergmann","year":"2016","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0180","series-title":"Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis","author":"Xie","year":"2017"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0185","series-title":"Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms","author":"Sedghizadeh","year":"2017"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0190","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.coph.2018.03.010","article-title":"Targeting therapeutics to bone by conjugation with bisphosphonates","volume":"40","author":"Young","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijpharm.2006.11.024","article-title":"Bone targeting potential of bisphosphonate-targeted liposomes. Preparation, characterization and hydroxyapatite binding in vitro","volume":"331","author":"Hengst","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0200","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bmcl.2008.12.051","article-title":"Bioorganic & medicinal chemistry letters bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent","volume":"19","author":"Neale","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0205","first-page":"5671","article-title":"Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system","volume":"10","author":"Chai","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0210","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s11095-008-9706-0","article-title":"Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E1 to promote bone formation in aged, estrogen-deficient rats","volume":"25","author":"Miller","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0215","doi-asserted-by":"crossref","DOI":"10.1007\/s00774-008-0004-z","article-title":"Selective drug delivery to bone using acidic oligopeptides","author":"Ishizaki","year":"2009","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0220","doi-asserted-by":"crossref","DOI":"10.3109\/10611860108997922","article-title":"Novel drug delivery system to bone using acidic oligopeptide: pharmacokinetic characteristics and pharmacological potential","author":"Sekido","year":"2001","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0225","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1166\/jnn.2017.12855","article-title":"Osteotropic nanoscale drug delivery system via a single aspartic acid as the bone-targeting moiety","volume":"17","author":"Carbone","year":"2017","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0230","series-title":"Journal of Molecular Graphics and Modelling a Structural and Functional Model for Human Bone Sialoprotein","author":"Vincent","year":"2013"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0235","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1007\/s11095-008-9605-4","article-title":"Bone-targeting of quinolones conjugated with an acidic oligopeptide","volume":"25","author":"Takahashi","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0240","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.addr.2012.01.012","article-title":"Targeting polymer therapeutics to bone","volume":"64","author":"Low","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0245","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1021\/jm801007z","article-title":"Linking bisphosphonates to the free amino groups in fluoroquinolones: preparation of osteotropic prodrugs for the prevention of osteomyelitis","volume":"51","author":"Houghton","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-14149-7","article-title":"Evaluation of Ga-DOTA-(D-asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone","volume":"7","author":"Ogawa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0255","series-title":"Bisphosphonate Conjugation for Bone Specific Drug Targeting","author":"Farrell","year":"2018"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics10030154","article-title":"Synthesis of a bone-targeted bortezomib with in vivo anti-myeloma effects in mice","volume":"10","author":"Wang","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0265","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/jbmr.2382","article-title":"Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss","volume":"30","author":"Liu","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0270","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.bmc.2012.01.024","article-title":"Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis","volume":"20","author":"Arns","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0275","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.bmc.2009.12.041","article-title":"Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens","volume":"18","author":"Morioka","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0280","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1021\/bc7002132","article-title":"Osteotropic Peptide that differentiates functional domains of the skeleton","volume":"18","author":"Wang","year":"2007","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0285","doi-asserted-by":"crossref","DOI":"10.1021\/acs.biomac.5b00777","article-title":"Biodistribution of fracture-targeted GSK3\u03b2 inhibitor-loaded micelles for improved fracture healing","author":"Low","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0290","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1021\/acs.bioconjchem.8b00660","article-title":"Bone-fracture-targeted Dasatinib-Oligoaspartic acid conjugate potently accelerates fracture repair","volume":"29","author":"Wang","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0295","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2217\/nnm-2016-0340","article-title":"Healing efficacy of fracture-targeted GSK3\u03b2 inhibitor-loaded micelles for improved fracture repair","volume":"12","author":"Low","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0300","series-title":"Drug Delivery Systems Functionalized with Bone Mineral Seeking Agents for Bone Targeted Therapeutics","author":"Rotman","year":"2018"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071345","article-title":"Development of bone targeting drugs","author":"Stapleton","year":"2017","journal-title":"J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0310","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11914-020-00604-4","article-title":"Bone targeting systems to systemically deliver therapeutics to bone fractures for accelerated healing","author":"Nielsen","year":"2020","journal-title":"Curr. Osteoporsis Reportssteoporsis Reports"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0315","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/bc0200430","article-title":"Synthesis and biological evaluation of EC20: a new folate-derived, 99mTc-based radiopharmaceutical","volume":"13","author":"Leamon","year":"2002","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0320","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1172\/JCI107153","article-title":"Studies on mono- and diiodohistidine. I. The identification of iodohistidines from thyroidal iodoproteins and their peripheral metabolism in the normal man and rat","volume":"52","author":"Savoie","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0325","first-page":"274","article-title":"Tumor model studies of 131I-tetracycline and other compounds","volume":"17","author":"Chauncey","year":"1976","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0330","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/208787a0","article-title":"Binding of Tetracyclines to bone","volume":"208","author":"Perrin","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0335","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00244-001-0017-2","article-title":"Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria","volume":"42","author":"Halling-S\u00f8rensen","year":"2002","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0340","first-page":"3","article-title":"A restorative challenge: tetracycline-stained teeth","author":"Cutbirth","year":"2015","journal-title":"Denistry Today"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0345","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/rb\/rbx011","article-title":"The use of bioactive peptides to modify materials for bone tissue repair","volume":"4","author":"Wang","year":"2017","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0350","series-title":"Orthopedic Tissue Regeneration: Cells, Scaffolds, and Small Molecules","author":"Jeon","year":"2016"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0355","series-title":"Peptides for Bone Tissue Engineering","author":"Visser","year":"2016"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0360","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s11999-010-1722-9","article-title":"Anabolic agents and bone quality","volume":"469","author":"Sibai","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0365","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/med.21388","article-title":"Short anabolic peptides for bone growth","volume":"36","author":"Amso","year":"2016","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0370","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/14712598.2015.977249","article-title":"The effect of parathyroid hormone and teriparatide on fracture healing","volume":"15","author":"Campbell","year":"2015","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0375","doi-asserted-by":"crossref","first-page":"9935","DOI":"10.1021\/bi1014437","article-title":"Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities","volume":"49","author":"Choi","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0380","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/154405910708600917","article-title":"Inorganic polyphosphate: a possible stimulant of bone formation","volume":"86","author":"Hacchou","year":"2007","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0385","first-page":"324","article-title":"Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays","volume":"60","author":"Brown","year":"2014","journal-title":"Can. Fam. Physician"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0390","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/med.21388","article-title":"Short anabolic peptides for bone growth","volume":"36","author":"Amso","year":"2016","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0395","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0142-9612(03)00602-1","article-title":"Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide","volume":"25","author":"Shin","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0400","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1089\/ten.tea.2011.0257","article-title":"An isolated cryptic peptide influences osteogenesis and bone Remodeling in an adult mammalian model of digit amputation","volume":"17","author":"Agrawal","year":"2011","journal-title":"Tissue Eng. Part A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0405","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1089\/ten.tea.2011.0036","article-title":"Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation","volume":"17","author":"Agrawal","year":"2011","journal-title":"Tissue Eng. Part A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0410","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cjce.20453","article-title":"Combination of synthetic peptides derived from bone morphogenetic proteins and biomaterials for medical applications","volume":"89","author":"Senta","year":"2011","journal-title":"Can. J. Chem. Eng."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0415","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/jbm.a.30833","article-title":"Elastin blends for tissue engineering scaffolds","volume":"79","author":"Li","year":"2006","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0420","first-page":"963","article-title":"2 Yoon-Jeong Park1, characterization of the surface immobilized synthetic heparin binding domain derived from human fibroblast growth factor-2 and its effect on osteoblast differentiation","volume":"83","author":"Lee","year":"2007","journal-title":"J. Biomed. Mater. Res. Part A."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0425","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12031-014-0389-1","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) signalling enhances osteogenesis in UMR-106 cell line","volume":"54","author":"Juh\u00e1sz","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0430","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1021\/j100653a014","article-title":"Structural investigations of calcium binding molecules. II. The crystal and molecular structures of calcium dihydrogen ethane-1-hydroxy-1,1-diphosphonate dihydrate, CaC(CH3)(OH)(PO3H)2\u00b72H2O; implications for polynuclear complex formation","volume":"76","author":"Uchtman","year":"1972","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0435","doi-asserted-by":"crossref","first-page":"20160462","DOI":"10.1098\/rsif.2016.0462","article-title":"The role of amino acids in hydroxyapatite mineralization","volume":"13","author":"Tavafoghi","year":"2016","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0440","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/psc.941","article-title":"Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid Jaros\u0142aw","author":"Ruczynski","year":"2008","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0445","first-page":"6","article-title":"Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time","volume":"1","author":"Tam","year":"1988","journal-title":"Pept. Res."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0450","first-page":"189","article-title":"Oral protein and peptide drug delivery","volume":"70","author":"Shaji","year":"2005","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0455","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10865-007-9147-y","article-title":"The impact of medication regimen factors on adherence to chronic treatment: a review of literature","volume":"31","author":"Ingersoll","year":"2008","journal-title":"J. Behav. Med."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0460","first-page":"527","article-title":"Dosing frequency and medication adherence in chronic disease","volume":"18","author":"Coleman","year":"2012","journal-title":"J. Manag. Care Pharm."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0465","first-page":"60","article-title":"Skeletal drug delivery system: a review","volume":"4","author":"Kar","year":"2014","journal-title":"J. Drug Deliv. Ther."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0470","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bonr.2018.06.007","article-title":"Bisphosphonate conjugation for bone specific drug targeting","volume":"9","author":"Farrell","year":"2018","journal-title":"Bone Reports"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0475","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.addr.2015.10.005","article-title":"Targeted delivery to bone and mineral deposits using bisphosphonate ligands","volume":"99","author":"Cole","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0480","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0020-1383(88)90166-0","article-title":"99Tcm-MDP bone scanning of injuries of the carpal scaphoid","volume":"19","author":"Young","year":"1988","journal-title":"Injury"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0485","first-page":"2271","article-title":"Bone-targeting liposome formulation of salvianic acid a accelerates the healing of delayed fracture Union in Mice, nanomedicine nanotechnology","volume":"14","author":"Liu","year":"2018","journal-title":"Biol. Med."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0490","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/bj3000723","article-title":"Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation","volume":"300","author":"Hunter","year":"1994","journal-title":"Biochem. J."},{"issue":"Pt 1","key":"10.1016\/j.jconrel.2020.09.047_bb0495","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj3020175","article-title":"Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein","volume":"302","author":"Hunter","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0500","doi-asserted-by":"crossref","first-page":"7927","DOI":"10.1039\/c1sm05329a","article-title":"Collagen mimetic peptides: progress towards functional applications","volume":"7","author":"Michael Yua","year":"2011","journal-title":"Soft Matter"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0505","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/bip.21536","article-title":"Template-tethered collagen mimetic peptides for studying heterotrimeric triple-helical interactions","volume":"95","author":"Li","year":"2011","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0510","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00223-011-9485-1","article-title":"Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice","volume":"88","author":"Ponnapakkam","year":"2011","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0515","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1021\/acsnano.5b07828","article-title":"Osteoblast-targeting-peptide modified nanoparticle for siRNA\/microRNA delivery","volume":"10","author":"Sun","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0520","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.7b05103","article-title":"Fracture-targeted delivery of \u03b2-catenin agonists via peptide-functionalized nanoparticles augments fracture healing","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0525","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1021\/acsnano.7b05103","article-title":"Fracture-targeted delivery of \u03b2-catenin agonists via peptide-functionalized nanoparticles augments fracture healing","volume":"11","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0530","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/acs.biomac.7b01193","article-title":"Multivalent presentation of peptide targeting groups alters polymer biodistribution to target tissues","volume":"19","author":"Newman","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2020.09.047_bb0535","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1021\/acs.chemrev.7b00013","article-title":"Ligand-targeted drug delivery","volume":"117","author":"Srinivasarao","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2020.09.047_bb0540","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.addr.2004.12.017","article-title":"Skeletal function and structure: implications for tissue-targeted therapeutics","volume":"57","author":"Shea","year":"2005","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920305630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920305630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:06:29Z","timestamp":1759161989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920305630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":108,"alternative-id":["S0168365920305630"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.09.047","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the bone fracture targeting properties of osteotropic ligands","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}