{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:38:01Z","timestamp":1787013481395,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016615","name":"Curing Kids Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008221","name":"Cure Starts Now Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jconrel.2020.11.010","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T15:37:14Z","timestamp":1605109034000},"page":"1034-1045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma"],"prefix":"10.1016","volume":"330","author":[{"given":"Joji","family":"Ishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Alli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bondoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Golbourn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Sabha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Mikloska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Krumholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilakshan","family":"Srikanthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Luck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Maslink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kullervo","family":"Hynynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rutka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jconrel.2020.11.010_bb0005","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(06)70615-5","article-title":"Diffuse brainstem glioma in children: critical review of clinical trials","volume":"7","author":"Hargrave","year":"2006","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.jconrel.2020.11.010_bb0010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of Tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11060-014-1448-8","article-title":"Diffuse intrinsic pontine glioma: a reassessment","volume":"119","author":"Robison","year":"2014","journal-title":"J. Neuro-Oncol."},{"issue":"3","key":"10.1016\/j.jconrel.2020.11.010_bb0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng.1102","article-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","volume":"44","author":"Wu","year":"2012","journal-title":"Nat. Genet."},{"issue":"519","key":"10.1016\/j.jconrel.2020.11.010_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw0064","article-title":"Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening","volume":"11","author":"Lin","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2020.11.010_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/nm.3855","article-title":"Functionally defined therapeutic targets in diffuse intrinsic pontine glioma","volume":"21","author":"Grasso","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2017.10.JNS171845","article-title":"First-in-human evaluation of the Cleveland multiport catheter for convection-enhanced delivery of topotecan in recurrent high-grade glioma: results of pilot trial 1","volume":"1","author":"Vogelbaum","year":"2018","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0040","first-page":"1","article-title":"Blood-brain barrier opening in primary brain Tumors with non- invasive MR-guided focused ultrasound\u202f: a clinical safety and feasibility study","volume":"2019","author":"Mainprize","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/17425247.2019.1676227","article-title":"Novel therapeutics for brain tumors: current practice and future prospects","volume":"17","author":"El Demerdash","year":"2020","journal-title":"Expert. Opin. Drug Deliv."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroimage.2004.06.046","article-title":"Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications","volume":"24","author":"Hynynen","year":"2005","journal-title":"Neuroimage."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0055","article-title":"Neuropharmacology noninvasive and targeted delivery of therapeutics to the brain using focused","volume":"120","author":"Poon","year":"2017","journal-title":"ultrasound."},{"issue":"November 2017","key":"10.1016\/j.jconrel.2020.11.010_bb0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2018.05.005","article-title":"Brainstem blood brain barrier disruption using focused ultrasound\u202f: A demonstration of feasibility and enhanced doxorubicin delivery","volume":"281","author":"Alli","year":"2018","journal-title":"J. Control. Release"},{"issue":"OCT","key":"10.1016\/j.jconrel.2020.11.010_bb0065","first-page":"1","article-title":"Effective drug delivery in diffuse intrinsic pontine glioma: a theoretical model to identify potential candidates","volume":"7","author":"El-Khouly","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-018-0086-7","article-title":"Functional diversity and cooperativity between and diffuse intrinsic pontine glioma cells","author":"Vinci","year":"2018","journal-title":"Nat. Med."},{"issue":"13","key":"10.1016\/j.jconrel.2020.11.010_bb0075","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1158\/1541-7786.MCR-16-0389","article-title":"Histone H3 . 3K27M represses p16 to accelerate gliomagenesis in a murine model of DIPG","volume":"2","author":"Cordero","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0080","first-page":"1","article-title":"Pre-clinical study of panobinostat in xenograft and genetically engineered murine diffuse intrinsic pontine glioma models","author":"Hennika","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0085","first-page":"1","article-title":"MR-guided focused ultrasound facilitates Sonodynamic therapy with 5-Aminolevulinic acid in a rat Glioma model","volume":"9","author":"Wu","year":"2019","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jconrel.2020.11.010_bb0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1182\/blood-2012-10-464677","article-title":"e- Blood MYELOID NEOPLASIA AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model","volume":"121","author":"Wunderlich","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2020.11.010_bb0095","first-page":"1","article-title":"Systemic and cardiac susceptibility of immune compromised mice to doxorubicin","volume":"6","author":"Favreau-lessard","year":"2019","journal-title":"Cardio-Oncology"},{"issue":"8","key":"10.1016\/j.jconrel.2020.11.010_bb0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11940-019-0577-y","article-title":"Diffuse intrinsic Pontine Glioma: from diagnosis to next-generation clinical trials","volume":"21","author":"Vitanza","year":"2019","journal-title":"Curr. Treat. Options Neurol."},{"issue":"May","key":"10.1016\/j.jconrel.2020.11.010_bb0105","first-page":"153","article-title":"Neuro-oncology in need of new","volume":"19","author":"Jones","year":"2018","journal-title":"thinking."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0110","series-title":"Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma","first-page":"104","author":"Bredlau","year":"2017"},{"issue":"4","key":"10.1016\/j.jconrel.2020.11.010_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1546-9","article-title":"Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy","volume":"10","author":"Pfitzer","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and Cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"FEB","key":"10.1016\/j.jconrel.2020.11.010_bb0125","first-page":"1","article-title":"Treatment strategies in diffuse midline gliomas with the H3K27M mutation: the role of convection-enhanced delivery in overcoming anatomic challenges","volume":"9","author":"Himes","year":"2019","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2020.11.010_bb0130","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.nano.2018.01.021","article-title":"Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound","volume":"14","author":"Coluccia","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol Med."},{"key":"10.1016\/j.jconrel.2020.11.010_bb0135","series-title":"ABCG2 and ABCB1 Limit the Ef fi cacy of Dasatinib in a PDGF-B \u2013 Driven Brainstem Glioma Model","first-page":"819","author":"Mittapalli","year":"2016"},{"key":"10.1016\/j.jconrel.2020.11.010_bb0140","series-title":"Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.","first-page":"1","volume":"1700474","author":"Wu","year":"2018"},{"key":"10.1016\/j.jconrel.2020.11.010_bb0145","series-title":"Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier Opening in a Patient-Derived Glioblastoma Model","volume":"3","author":"Sulheim","year":"2019"},{"issue":"33","key":"10.1016\/j.jconrel.2020.11.010_bb0150","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/aac7dd","article-title":"Nanoformulations of doxorubicin: how far have we come and where do we go from here?","volume":"29","author":"Bori\u0161ev","year":"2018","journal-title":"Nanotechnology."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40959-019-0050-9","article-title":"Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children\u2019s oncology group","volume":"5","author":"Kopp","year":"2019","journal-title":"Cardio-Oncology."},{"issue":"3","key":"10.1016\/j.jconrel.2020.11.010_bb0160","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ijrobp.2006.06.043","article-title":"Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes","volume":"66","author":"Yuan","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"6","key":"10.1016\/j.jconrel.2020.11.010_bb0165","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrclinonc.2012.61","article-title":"Patient-derived tumour xenografts as models for oncology drug development","volume":"9","author":"Tentler","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-14642-0","article-title":"Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas","volume":"11","author":"Aslan","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2020.11.010_bb0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-018-0553-x","article-title":"Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma","volume":"6","author":"Lin","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"16","key":"10.1016\/j.jconrel.2020.11.010_bb0180","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.7150\/thno.21630","article-title":"Acute inflammatory response following increased blood-brain barrier permeability induced by focused ultrasound is dependent on microbubble dose","volume":"7","author":"McMahon","year":"2017","journal-title":"Theranostics."},{"issue":"21","key":"10.1016\/j.jconrel.2020.11.010_bb0185","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.7150\/thno.35892","article-title":"Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model","volume":"9","author":"McDannold","year":"2019","journal-title":"Theranostics."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920306593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920306593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:07:52Z","timestamp":1759162072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920306593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":37,"alternative-id":["S0168365920306593"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.11.010","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}