{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:19:35Z","timestamp":1784204375455,"version":"3.55.0"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jconrel.2020.12.021","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T18:33:55Z","timestamp":1608834835000},"page":"599-617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Dendrimers against fungi \u2013 A state of the art review"],"prefix":"10.1016","volume":"330","author":[{"given":"Dariusz T.","family":"Mlynarczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Dlugaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Kaluzna-Mlynarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Goslinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2020.12.021_bb0005","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/MOP.0000000000000031","article-title":"Primary immunodeficiencies underlying fungal infections","volume":"25","author":"Lanternier","year":"2013","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0507.2008.01606.x","article-title":"Epidemiological trends in skin mycoses worldwide","volume":"51","author":"Havlickova","year":"2008","journal-title":"Mycoses"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0015","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.clindermatol.2009.12.005","article-title":"Epidemiology of superficial fungal infections","volume":"28","author":"Ameen","year":"2010","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0020","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"390","author":"Vos","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1396-0296.2004.04056.x","article-title":"Subcutaneous fungal infections","volume":"17","author":"Pang","year":"2004","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005534","article-title":"Chromoblastomycosis in India: review of 169 cases","volume":"11","author":"Agarwal","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2165\/00128071-200304080-00003","article-title":"Therapeutic approaches to subcutaneous mycoses","volume":"4","author":"Koga","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2015.10.004","article-title":"The global burden of fungal diseases","volume":"30","author":"Vallabhaneni","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0045","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy187","article-title":"Epidemiology and clinical features of invasive fungal infection in a US health care network","volume":"5","author":"Webb","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0050","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0055","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cmi.2018.01.002","article-title":"Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline","volume":"24","author":"Ullmann","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1086\/321811","article-title":"Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study","volume":"33","author":"Blumberg","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0065","doi-asserted-by":"crossref","first-page":"R287","DOI":"10.1186\/cc10574","article-title":"Risk factors for invasive fungal disease in critically ill adult patients: a systematic review","volume":"15","author":"Muskett","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0070","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.idc.2016.07.008","article-title":"Nosocomial fungal infections","volume":"30","author":"Suleyman","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1439-0507.2009.01691.x","article-title":"The changing face of epidemiology of invasive fungal disease in Europe","volume":"52","author":"Lass-Fl\u00f6rl","year":"2009","journal-title":"Mycoses"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1469-0691.2011.03676.x","article-title":"Adjunctive immunotherapy with recombinant cytokines for the treatment of disseminated candidiasis","volume":"18","author":"van de Veerdonk","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0085","first-page":"181","article-title":"The burden of mucormycosis in HIV-infected patients: a systematic review","volume":"73","author":"Moreira","year":"2016","journal-title":"J. Inf. Secur."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0090","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","article-title":"The biology and chemistry of antifungal agents: a review","volume":"20","author":"Kathiravan","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0095","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1002\/ijc.25255","article-title":"The antitumor activity of the fungicide ciclopirox","volume":"127","author":"Zhou","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0100","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0924-8579(00)00258-2","article-title":"Current and future antifungal therapy: new targets for antifungal therapy","volume":"16","author":"Andriole","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/S0269915X03002064","article-title":"Antifungal agents: their diversity and increasing sophistication","volume":"17","author":"Odds","year":"2003","journal-title":"Mycologist"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0110","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"Fisher","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2016.00011","article-title":"Emerging threats in antifungal-resistant fungal pathogens","volume":"3","author":"Sanglard","year":"2016","journal-title":"Front. Med."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0125","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1289\/ehp.5785","article-title":"Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase","volume":"111","author":"Zarn","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0130","series-title":"Active Antifungal Substances from Natural Sources","first-page":"116","author":"Abad","year":"2007"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0135","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/np058128n","article-title":"Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence","volume":"69","author":"Gunatilaka","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2019.01.002","article-title":"Electrospun polymer biomaterials","volume":"90","author":"Ding","year":"2019","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0145","doi-asserted-by":"crossref","first-page":"1700527","DOI":"10.1002\/advs.201700527","article-title":"Antibacterial hydrogels","volume":"5","author":"Li","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.progpolymsci.2011.08.005","article-title":"Polymeric materials with antimicrobial activity","volume":"37","author":"Mu\u00f1oz-Bonilla","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijfoodmicro.2010.09.012","article-title":"Antimicrobial properties of chitosan and mode of action: a state of the art review","volume":"144","author":"Kong","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0160","series-title":"Nanostructured Mater. - Fabr. Appl","article-title":"Dendrimer structure diversity and tailorability as a way to fight infectious diseases","author":"Mlynarczyk","year":"2017"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0165","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2217\/nnm.11.67","article-title":"Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties","volume":"6","author":"Kaminskas","year":"2011","journal-title":"Nanomed"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0170","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2174\/138920021131400104","article-title":"An overview of the pharmacokinetics of polymer-based nanoassemblies and nanoparticles","volume":"14","author":"Zhao","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0175","series-title":"Search Antibact. Agents","article-title":"Dendrimers as antibacterial agents","author":"Tulu","year":"2012"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0180","series-title":"Full Text View - ClinicalTrials.gov","author":"Retention and Duration of Activity of SPL7013 (VivaGel\u00ae) After Vaginal Dosing","year":"2020"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/nano7020048","article-title":"Antimicrobial polymers in the nano-world","volume":"7","author":"\u00c1lvarez-Paino","year":"2017","journal-title":"Nanomaterials."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0190","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/ma9070599","article-title":"Recent developments in antimicrobial polymers: a review","volume":"9","author":"Santos","year":"2016","journal-title":"Materials"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/polym4010046","article-title":"Antimicrobial polymers in solution and on surfaces: overview and functional principles","volume":"4","author":"Siedenbiedel","year":"2012","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0200","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1021\/am507482y","article-title":"Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure\u2013activity relationship, and membrane-active mode of action","volume":"7","author":"Hoque","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0205","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/ph6121543","article-title":"Antimicrobial peptides","volume":"6","author":"Bahar","year":"2013","journal-title":"Pharmaceuticals"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2020.12.021_bb0210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0005-2736(99)00200-X","article-title":"Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by K-helical antimicrobial and cell non-selective membrane-lytic peptides","volume":"1462","author":"Shai","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0215","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.polymer.2015.03.007","article-title":"Controlling macromolecular structures towards effective antimicrobial polymers","volume":"63","author":"Ganewatta","year":"2015","journal-title":"Polymer"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0220","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","article-title":"The relationship between peptide structure and antibacterial activity","volume":"24","author":"Powers","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0225","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1046\/j.0014-2956.2001.02728.x","article-title":"Antimicrobial dendrimeric peptides: Antimicrobial dendrimeric peptides","volume":"269","author":"Tam","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.18388\/abp.2006_3364","article-title":"Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers","volume":"53","author":"Janiszewska","year":"2006","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0235","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.3390\/molecules14103881","article-title":"Design of antimicrobially active small amphiphilic peptide dendrimers","volume":"14","author":"Polcyn","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0240","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ejmech.2008.06.016","article-title":"Synthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules","volume":"44","author":"Tulu","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0245","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s10570-012-9744-y","article-title":"Preparation, characterization, and antimicrobial property of cotton cellulose fabric grafted with poly (propylene imine) dendrimer","volume":"19","author":"Salimpour Abkenar","year":"2012","journal-title":"Cellulose"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0250","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1021\/mp200549c","article-title":"Biological properties of new viologen-phosphorus dendrimers","volume":"9","author":"Ciepluch","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0255","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijpharm.2005.10.039","article-title":"Biological properties of low molecular mass peptide dendrimers","volume":"309","author":"Klajnert","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0260","first-page":"220","article-title":"Amphiphilic dendrimeric peptides as model non-sequential pharmacophores with antimicrobial properties","volume":"13","author":"Janiszewska","year":"2007","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0265","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bmcl.2011.12.051","article-title":"Novel dendrimeric lipopeptides with antifungal activity","volume":"22","author":"Janiszewska","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0270","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.tet.2014.12.083","article-title":"Synthesis and spectral characterization of a new PPA dendrimer modified with 4-bromo-1,8-naphthalimide and in vitro antimicrobial activity of its Cu(II) and Zn(II) metal complexes","volume":"71","author":"Staneva","year":"2015","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0275","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ica.2015.09.010","article-title":"Poly(propylenamine) dendrimers modified with 4-amino-1,8-naphthalimide: synthesis, characterization and in vitro microbiological tests of their Cu(II) and Zn(II) complexes","volume":"438","author":"Grabchev","year":"2015","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0280","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1039\/b414241a","article-title":"Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes","author":"Wu","year":"2005","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0285","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.peptides.2010.04.022","article-title":"Synthesis, characterization, antimicrobial activity and LPS-interaction properties of SB041, a novel dendrimeric peptide with antimicrobial properties","volume":"31","author":"Bruschi","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0290","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1021\/nn303472r","article-title":"Cationic PAMAM dendrimers aggressively initiate blood clot formation","volume":"6","author":"Jones","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0295","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/AAC.43.6.1317","article-title":"Peptide antibiotics","volume":"43","author":"Hancock","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0300","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpharm.2006.07.018","article-title":"DSC studies on interactions between low molecular mass peptide dendrimers and model lipid membranes","volume":"327","author":"Klajnert","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0305","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/ja.2014.25","article-title":"The in vitro effects of new D186 dendrimer on virulence factors of Candida albicans","volume":"67","author":"Staniszewska","year":"2014","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0310","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejmech.2015.10.013","article-title":"Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers","volume":"105","author":"Zieli\u0144ska","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3226","article-title":"Peptide dendrimers as antifungal agents and carriers for potential antifungal agent\u2014 N 3 -(4-methoxyfumaroyl)-( S )-2,3-diaminopropanoic acid\u2014synthesis and antimicrobial activity","volume":"26","author":"Stolarska","year":"2020","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0320","doi-asserted-by":"crossref","first-page":"112506","DOI":"10.1016\/j.jphotochem.2020.112506","article-title":"Synthesis of a new fluorescent poly(propylene imine) dendrimer modified with 4-nitrobenzofurazan. Sensor and antimicrobial activity","volume":"395","author":"Staneva","year":"2020","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0325","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1039\/c2nj40421d","article-title":"Antimicrobial activity of poly(propylene imine) dendrimers","volume":"36","author":"Felczak","year":"2012","journal-title":"New J. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0330","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.eurpolymj.2016.04.002","article-title":"Antimicrobial and anticancer activities of organoiron melamine dendrimers capped with piperazine moieties","volume":"82","author":"Abd-El-Aziz","year":"2016","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0335","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1021\/acs.biomac.5b01207","article-title":"Antimicrobial organometallic dendrimers with tunable activity against multidrug-resistant bacteria","volume":"16","author":"Abd-El-Aziz","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0340","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1039\/C6NJ01120A","article-title":"Synthesis, characterization, optical and electrochemical properties and antifungal and anticancer activities of ferrocenyl conjugated novel dendrimers","volume":"41","author":"Saravanan","year":"2017","journal-title":"New J. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0345","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/aoc.1202","article-title":"On the medicinal chemistry of ferrocene","volume":"21","author":"Fouda","year":"2007","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0350","doi-asserted-by":"crossref","first-page":"10167","DOI":"10.1002\/slct.201701953","article-title":"Synthesis, photophysical, electrochemical properties and anticancer, antimicrobial activity of N -n-hexyl- N -phenylanilinochalcone-capped dendrimers","volume":"2","author":"Ravivarma","year":"2017","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0355","doi-asserted-by":"crossref","first-page":"19994","DOI":"10.1021\/acsami.5b04780","article-title":"Biological activity of mesoporous dendrimer-coated titanium dioxide: insight on the role of the surface\u2013interface composition and the framework crystallinity","volume":"7","author":"Milowska","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0360","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/pola.27501","article-title":"Theoretical and experimental characterization of amino-PEG-phosphonate-terminated Polyphosphorhydrazone dendrimers: influence of size and PEG capping on cytotoxicity profiles","volume":"53","author":"Hameau","year":"2015","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0365","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1002\/(SICI)1521-3765(19991203)5:12<3644::AID-CHEM3644>3.0.CO;2-I","article-title":"Preparation of water-soluble cationic phosphorus-containing dendrimers as DNA transfecting agents","volume":"5","author":"Loup","year":"1999","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0370","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/acs.molpharmaceut.7b00771","article-title":"Original multivalent gold(III) and dual gold(III)\u2013copper(II) conjugated phosphorus dendrimers as potent antitumoral and antimicrobial agents","volume":"14","author":"Mignani","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0375","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijpharm.2017.05.067","article-title":"Antibacterial and antifungal properties of dendronized silver and gold nanoparticles with cationic carbosilane dendrons","volume":"528","author":"Pe\u00f1a-Gonz\u00e1lez","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0380","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.addr.2005.09.012","article-title":"Dendrimer\u2013drug interactions","volume":"57","author":"Demanuele","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0385","doi-asserted-by":"crossref","first-page":"328","DOI":"10.22270\/jddt.v8i6-s.2083","article-title":"Unique structures, properties and applications of dendrimers","volume":"8","author":"Gupta","year":"2018","journal-title":"J. Drug Deliv. Ther."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0390","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1021\/ja8100227","article-title":"PAMAM dendrimers undergo pH responsive conformational changes without swelling","volume":"131","author":"Liu","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0395","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/C4TB00171K","article-title":"Dendrimers for drug delivery","volume":"2","author":"Caminade","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0400","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1021\/ja00120a032","article-title":"The dendritic box: shape-selective liberation of encapsulated guests","volume":"117","author":"Jansen","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0405","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.nano.2014.11.008","article-title":"Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers","volume":"11","author":"Jain","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0410","first-page":"171","article-title":"Solubility enhancement of an antifungal agent by association with dendrimers","volume":"3","author":"Jose","year":"2015","journal-title":"Indian J. Res. Pharm. Biotechnol."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0415","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/infdis\/jit378","article-title":"A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis","volume":"208","author":"Daftarian","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0420","first-page":"213","article-title":"Performance evaluation of pamam dendrimer with an antifungal agent","volume":"7","author":"Jose","year":"2015","journal-title":"Pharm. Lett."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0425","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/2230-973X.177833","article-title":"Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers","volume":"6","author":"Jose","year":"2016","journal-title":"Int. J. Pharm. Invest."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0430","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1128\/AAC.04213-14","article-title":"Surface-engineered dendrimeric nanoconjugates for macrophage-targeted delivery of amphotericin B: formulation development and in vitro and in vivo evaluation","volume":"59","author":"Jain","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0435","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/S0040-4039(98)02680-X","article-title":"The synthesis of water soluble dendrimers, and their application as possible drug delivery systems","volume":"40","author":"Twyman","year":"1999","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0440","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1016\/S0040-4020(03)00437-X","article-title":"Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives","volume":"59","author":"Beezer","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0445","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/14756360802205257","article-title":"PAMAM dendrimers for the delivery of the antibacterial Triclosan","volume":"23","author":"Gardiner","year":"2008","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0450","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.colsurfb.2013.11.045","article-title":"Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine","volume":"115","author":"Zhou","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0455","first-page":"736","article-title":"Dendrimers: potential tool for enhancement of antifungal activity","volume":"2","author":"Khairnar","year":"2010","journal-title":"Int. J. PharmTech Res."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0460","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1248\/bpb.34.1129","article-title":"Poly(amidoamine) dendrimers increase antifungal activity of clotrimazole","volume":"34","author":"Winnicka","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0465","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.3390\/molecules17044612","article-title":"Hydrogel of ketoconazole and PAMAM dendrimers: formulation and antifungal activity","volume":"17","author":"Winnicka","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0470","first-page":"790","article-title":"Performance evaluation of pamam dendrimer based clotrimazole formulations","volume":"2","author":"Verma","year":"2012","journal-title":"Am. J. PharmTech Res."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0475","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5897\/AJPP2013.3470","article-title":"PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state","volume":"7","author":"Sosnowska","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0480","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14314\/polimery.2016.322","article-title":"The effect of PAMAM dendrimers with amine or hydroxyl terminal groups on the bioadhesive properties of hydrogels with clotrimazole","volume":"61","author":"Sosnowska","year":"2016","journal-title":"Polimery"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0485","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1021\/acs.biomac.6b01436","article-title":"PEGylated dendrimers as drug delivery vehicles for the photosensitizer silicon phthalocyanine pc 4 for candidal infections","volume":"18","author":"Hutnick","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0490","series-title":"ClinicalTrials.gov","author":"NIH U.S. National Library of Medicine","year":"2020"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micres.2007.08.001","article-title":"Antifungal photodynamic therapy","volume":"163","author":"Donnelly","year":"2008","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0500","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1039\/C7OB02270K","article-title":"Cationic phthalocyanine dendrimers as potential antimicrobial photosensitisers","volume":"15","author":"Ruiz-Gonz\u00e1lez","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0505","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/ma12091446","article-title":"Origanum majorana L. essential oil-associated polymeric nano dendrimer for antifungal activity against Phytophthora infestans","volume":"12","author":"Thanh","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0510","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/masy.200900078","article-title":"Simulation of itraconazole encapsulation by novel biocampatible dendritic compounds","volume":"297","author":"Elkin","year":"2010","journal-title":"Macromol. Symp."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0515","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/macp.201500211","article-title":"Influence of hydrophobic dendrimer core structure on the itraconazole encapsulation efficiency","volume":"216","author":"Elkin","year":"2015","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0520","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7324\/JAPS.2016.601213","article-title":"Novel citric acid dendritic hydrogels for the delivery of econazole nitrate and its antifungal activity","volume":"6","author":"Rao","year":"2016","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0525","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ijpharm.2017.03.032","article-title":"Preparation of core-crosslinked linear-dendritic copolymer micelles with enhanced stability and their application for drug solubilisation","volume":"523","author":"Zhou","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0530","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1021\/ac034914q","article-title":"Real-time detection of bacterial contamination in dynamic aqueous environments using optical sensors","volume":"76","author":"Ji","year":"2004","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0535","series-title":"2015 XVIII AISEM Annu. Conf., IEEE, Trento, Italy","first-page":"1","article-title":"Development of electrochemical aptasensor using dendrimers as an immobilization platform for detection of Aflatoxin B1 in food samples","author":"Castillo","year":"2015"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0540","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodcont.2014.12.008","article-title":"Detection of aflatoxin B 1 by aptamer-based biosensor using PAMAM dendrimers as immobilization platform","volume":"52","author":"Castillo","year":"2015","journal-title":"Food Control"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0545","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aca.2016.03.038","article-title":"Direct detection of OTA by impedimetric aptasensor based on modified polypyrrole-dendrimers","volume":"920","author":"Mejri-Omrani","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0550","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10096-007-0451-9","article-title":"Will resistance in fungi emerge on a scale similar to that seen in bacteria?","volume":"27","author":"Hof","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0555","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3390\/nano10102022","article-title":"From nanobiotechnology, positively charged biomimetic dendrimers as novel antibacterial agents: a review","volume":"10","author":"Alfei","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jconrel.2020.12.021_bb0560","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/mabi.200800121","article-title":"Amphiphilic branched polymers as antimicrobial agents","volume":"8","author":"Pasquier","year":"2008","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2020.12.021_bb0565","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2217\/17435889.3.5.703","article-title":"Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats","volume":"3","author":"Longmire","year":"2008","journal-title":"Nanomed"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920307458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365920307458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:00:09Z","timestamp":1759161609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365920307458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":113,"alternative-id":["S0168365920307458"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.12.021","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrimers against fungi \u2013 A state of the art review","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2020.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}