{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:26:09Z","timestamp":1792041969657,"version":"4.4.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2015jcyjBX0100"],"award-info":[{"award-number":["cstc2015jcyjBX0100"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["XDJK2017D150"],"award-info":[{"award-number":["XDJK2017D150"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673376"],"award-info":[{"award-number":["81673376"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803472"],"award-info":[{"award-number":["81803472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jconrel.2021.01.032","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T03:11:37Z","timestamp":1611285097000},"page":"390-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Engineered liposomes targeting the gut\u2013CNS Axis for comprehensive therapy of spinal cord injury"],"prefix":"10.1016","volume":"331","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaicheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2021.01.032_bb0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0168-8227(99)00099-6","article-title":"Injection related anxiety in insulin-treated diabetes","volume":"46","author":"Zambanini","year":"1999","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0010","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2018.08.032","article-title":"Oral peptide delivery: translational challenges due to physiological effects","volume":"287","author":"Tyagi","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2014.03.053","article-title":"An overview of clinical and commercial impact of drug delivery systems","volume":"190","author":"Anselmo","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0020","doi-asserted-by":"crossref","first-page":"104685","DOI":"10.1016\/j.phrs.2020.104685","article-title":"Oral administration of protein nanoparticles: an emerging route to disease treatment","author":"Sadeghi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0025","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.addr.2013.01.002","article-title":"Targeted nanoparticles with novel non-peptidic ligands for oral delivery","volume":"65","author":"Rieux","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0030","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/17425247.2018.1504017","article-title":"Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery","volume":"15","author":"Vllasaliu","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0035","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/acsnano.5b00028","article-title":"Overcoming the diffusion barrier of mucus and absorption barrier of epithelium by self-assembled nanoparticles for oral delivery of insulin","volume":"9","author":"Shan","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s003840050236","article-title":"Gut-liver axis","volume":"15","author":"Zeuzem","year":"2000","journal-title":"Int. J. Color. Dis."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The gut\u2013liver axis and the intersection with the microbiome","volume":"15","author":"Tripathi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0060","doi-asserted-by":"crossref","first-page":"113009","DOI":"10.1016\/j.expneurol.2019.113009","article-title":"Gastrointestinal dysfunction after spinal cord injury","volume":"320","author":"Holmes","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MIB.0000000000000667","article-title":"Enteric glial cells: a new frontier in neurogastroenterology and clinical target for inflammatory bowel diseases","volume":"22","author":"Ochoa-Cortes","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: an systematic analysis for the global burden of disease study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4055\/cios.2017.9.1.1","article-title":"Spinal cord injury and related clinical trials","volume":"9","author":"Kim","year":"2017","journal-title":"Clin. Orthop. Surg."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0080","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm1425","article-title":"Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after apinal cord injury","volume":"12","author":"Okada","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0090","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0095","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41593-017-0033-9","article-title":"The diversity and disparity of the glial scar","volume":"21","author":"Adams","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neures.2017.10.004","article-title":"Astrocyte reactivity and astrogliosis after spinal cord injury","volume":"126","author":"Okada","year":"2018","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jss.2009.07.001","article-title":"Curcumin provides neuroprotection after spinal cord injury","volume":"166","author":"Lin","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2013.11.050","article-title":"Curcumin Promotes the spinal cord repair via inhibition of glial scar formation and inflammation","volume":"560","author":"Wang","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0115","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/glia.20972","article-title":"Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation","volume":"58","author":"Su","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0120","doi-asserted-by":"crossref","first-page":"113009","DOI":"10.1016\/j.expneurol.2019.113009","article-title":"Gastrointestinal dysfunction after spinal cord injury","volume":"320","author":"Holmes","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0125","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0140-6736(96)91487-7","article-title":"Bowel dysfunction in spinal-cord-injury patients","volume":"347","author":"Glickman","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0130","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrgastro.2012.138","article-title":"Novel functional roles for enteric glia in the gastrointestinal tract","volume":"9","author":"Gulbransen","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.gastro.2015.09.038","article-title":"Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with crohn\u2019s disease","volume":"150","author":"Pochard","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0140","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00067.2006","article-title":"Role of enteric Glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function","volume":"291","author":"Nasser","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/gutjnl-2012-302090","article-title":"Enteroglial-Derived S100B protein integrates bacteria-induced toll-like receptor signalling in human enteric Glial cells","volume":"63","author":"Turco","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0150","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1172\/JCI76303","article-title":"Emerging roles for enteric glia in gastrointestinal disorders","volume":"125","author":"Sharkey","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0155","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson Disease\u2014the gut-brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0160","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1021\/mp500393m","article-title":"Apamin-mediated actively targeted drug delivery for treatment of spinal cord injury: more than just a concept","volume":"11","author":"Wu","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0165","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2147\/IJN.S40498","article-title":"Tumor-targeted liposomal drug delivery mediated by a diseleno bond-stabilized cyclic peptide","volume":"8","author":"Li","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9468193","article-title":"The potential of curcumin in treatment of spinal cord injury","volume":"2016","author":"Sanivarapu","year":"2016","journal-title":"Neurol. Res. Int."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0175","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1021\/acs.nanolett.8b02229","article-title":"Nanoparticles targeted against cryptococcal pneumonia by interactions between chitosan and its peptide ligand","volume":"18","author":"Tang","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0180","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1002\/anie.200904550","article-title":"Apamin as a template for structure-based rational design of potent peptide activators of p53","volume":"48","author":"Li","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/(SICI)1097-0282(200006)53:7<550::AID-BIP3>3.0.CO;2-O","article-title":"Synthesis and conformational analysis of apamin analogues with natural and non-natural cystine\/selenocystine connectivities","volume":"53","author":"Fiori","year":"2000","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0190","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/bip.20755","article-title":"Role of Asn2 and Glu7 residues in the oxidative folding and on the conformation of the N-terminal loop of apamin","volume":"86","author":"Le-Nguyen","year":"2007","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0195","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/mp500809f","article-title":"Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0200","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.1016\/j.biomaterials.2012.08.031","article-title":"The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0205","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.cclet.2018.09.006","article-title":"Synthesis of hierarchical sieve-like mesoporous silica nanoparticle aggregates via centrifugal method for drug delivery system","volume":"29","author":"Gao","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0210","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jcc.21224","article-title":"Packmol: a package for building initial configurations for molecular dynamics simulations","volume":"30","author":"Mart\u00ednez","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0215","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0220","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: the biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0225","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"CHARMM: the biomolecular simulation program","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0230","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"4","author":"Hess","year":"1997","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0235","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle Mesh Ewald: An N\u00b7log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0240","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1063\/1.447334","article-title":"A unified formulation of the constant temperature molecular dynamics methods","volume":"81","author":"Nos\u00e9","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0245","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1103\/PhysRevA.31.1695","article-title":"Canonical dynamics: equilibrium phase-space distributions","volume":"31","author":"Hoover","year":"1985","journal-title":"Phys. Rev. A"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0250","doi-asserted-by":"crossref","first-page":"075503","DOI":"10.1103\/PhysRevLett.90.075503","article-title":"Predicting crystal structures: the parrinello-rahman method revisited","volume":"90","author":"Marto\u0148\u00e1k","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0255","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1021\/jf401556u","article-title":"Dual effects of chitosan decoration on the liposomal membrane physicochemical properties as affected by chitosan concentration and molecular conformation","volume":"61","author":"Tan","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0260","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/gut.2010.229237","article-title":"Enteric Glia protect against shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione","volume":"60","author":"Flamant","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0265","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconrel.2018.11.023","article-title":"Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs","volume":"296","author":"Yeap","year":"2019","journal-title":"J. Control.Release"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0270","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/(SICI)1096-9861(19980126)390:4<497::AID-CNE4>3.0.CO;2-W","article-title":"Immunohistochemical localization of nicotinic acetylcholine receptors in the Guinea-Pig bowel and pancreas","volume":"390","author":"Kirchgessner","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/10799890600778821","article-title":"Glutamate receptor subunit expression in primary enteric Glia cultures","volume":"26","author":"von Boyen","year":"2006","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0280","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijpharm.2010.10.017","article-title":"Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion","volume":"403","author":"Li","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0285","doi-asserted-by":"crossref","first-page":"7897","DOI":"10.2147\/IJN.S145988","article-title":"Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers","volume":"12","author":"Tian","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0290","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2012.07.002","article-title":"Biopharmaceutics classification and intestinal absorption study of apigenin","volume":"436","author":"Zhang","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0295","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.intimp.2014.09.007","article-title":"Toll like receptor 4 (TLR4) mediates the stimulating activities of Chitosan Oligosaccharide on macrophages","volume":"23","author":"Zhang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0300","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.cclet.2018.10.012","article-title":"The influence of nanoparticle shape on bilateral exocytosis from Caco-2 Cells","volume":"29","author":"Zhuang","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0305","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1021\/ja043600x","article-title":"Hybrid nanocapsules: interactions of ABA block copolymers with liposomes","volume":"127","author":"Ruysschaert","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0310","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.bpj.2010.04.063","article-title":"Optimizing methods to recover absolute FRET efficiency from immobilized single molecules","volume":"99","author":"McCann","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0315","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1016\/j.biomaterials.2011.05.029","article-title":"MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome","volume":"32","author":"Tagami","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-61779-452-0_7","article-title":"Isolation and culture of spinal cord astrocytes","volume":"814","author":"Kerstetter","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0325","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jneuroim.2006.05.012","article-title":"Isolation and culture of microvascular endothelial cells from murine spinal cord","volume":"177","author":"Ge","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0330","doi-asserted-by":"crossref","first-page":"9691","DOI":"10.1038\/srep09691","article-title":"In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0335","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/stem.1083","article-title":"Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial- like stem cells","volume":"30","author":"Fujimoto","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0340","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1139\/y2012-004","article-title":"Characteristics of emodin on modulating the contractility of Jejunal smooth muscle","volume":"90","author":"Chen","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0345","doi-asserted-by":"crossref","first-page":"15140","DOI":"10.1021\/ja077498q","article-title":"Selenium becomes metallic in Ru-Se Fuel Cell catalysts: an EC-NMR and XPS investigation","volume":"129","author":"Babu","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0350","doi-asserted-by":"crossref","first-page":"e24978","DOI":"10.4161\/tisb.24978","article-title":"Claudins in intestines: distribution and functional significance in health and diseases","volume":"1","author":"Lu","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0355","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","article-title":"Adapting liposomes for oral drug delivery","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2006.10.022","article-title":"Chitin\/Chitosan: modifications and their unlimited application potential\u2014an overview","volume":"18","author":"Harish Prashanth","year":"2007","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0365","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpharm.2010.10.013","article-title":"Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system","volume":"403","author":"Luo","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0370","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejpb.2011.10.011","article-title":"Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and Chitosan Oligosaccharide as effective surface modifiers","volume":"80","author":"Murata","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0375","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/acs.biomac.6b00146","article-title":"Adsorption of plasma proteins onto PEGylated Lipid Bilayers: the effect of PEG size and grafting density","volume":"17","author":"Lee","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0380","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6","article-title":"Caco-2 versus Caco-2\/HT29-MTX Co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport","volume":"89","author":"Hilgendorf","year":"2000","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0385","first-page":"C1727","article-title":"Expression of Ca(2+)-Activated K(+) Channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract","volume":"281","author":"Fujita","year":"2001","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0390","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.2001.281.4.G964","article-title":"molecular properties of small-conductance ca2+-activated k+ channels expressed in murine colonic smooth muscle","volume":"281","author":"Ro","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0395","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1016\/j.biomaterials.2013.08.048","article-title":"Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0400","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.2147\/IJN.S209987","article-title":"Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical \"Apocynin\"","volume":"14","author":"Anter","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0405","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.apmr.2007.08.004","article-title":"Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury","volume":"88","author":"Davies","year":"2007","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0410","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1089\/08977150260139129","article-title":"Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury","volume":"19","author":"Hayes","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0415","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0420","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1073\/pnas.1300378110","article-title":"Calcium-dependent N-Cadherin Up-regulation mediates reactive astrogliosis and neuroprotection after brain injury","volume":"110","author":"Kanemaru","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0425","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sc.2008.121","article-title":"International standards to document remaining autonomic function after spinal cord injury","volume":"47","author":"Alexander","year":"2009","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0430","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2982.2009.01410.x","article-title":"Upper gastrointestinal motility changes following spinal cord injury","volume":"22","author":"Gondim","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0435","first-page":"R146","article-title":"Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury","volume":"312","author":"Besecker","year":"2017","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0440","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/labinvest.3700564","article-title":"Enteric Glial cells: new players in gastrointestinal motility?","volume":"87","author":"Bassotti","year":"2007","journal-title":"Lab. Investig."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0445","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/gutjnl-2013-305005","article-title":"palmitoylethanolamide improves colon inflammation through an enteric Glia\/Toll Like Receptor 4-Dependent PPAR-\u03b1 activation","volume":"63","author":"Esposito","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2021.01.032_bb0450","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1097\/01.ASN.0000025786.87646.B1","article-title":"PPAR agonists amplify iNOS expression while inhibiting NF-KappaB: implications for mesangial cell activation by cytokines","volume":"13","author":"Cernuda-Moroll\u00f3n","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0455","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1167\/iovs.13-11796","article-title":"Regulation of iNOS expression by NF-\u03baB in Human lens epithelial cells treated with high levels of glucose","volume":"54","author":"jia","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0460","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0891-5849(01)00565-2","article-title":"Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis","volume":"31","author":"Hokari","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2021.01.032_bb0465","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jconrel.2019.03.026","article-title":"Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury","volume":"302","author":"Gao","year":"2019","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921000419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921000419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:56:54Z","timestamp":1759161414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365921000419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":93,"alternative-id":["S0168365921000419"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.01.032","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered liposomes targeting the gut\u2013CNS Axis for comprehensive therapy of spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}