{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:16:45Z","timestamp":1793402205567,"version":"4.5.0"},"reference-count":177,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431C 2020\/17"],"award-info":[{"award-number":["ED431C 2020\/17"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["RTI2018-094131-A-I00"],"award-info":[{"award-number":["RTI2018-094131-A-I00"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA18125"],"award-info":[{"award-number":["CA18125"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["RYC2014-15239"],"award-info":[{"award-number":["RYC2014-15239"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Government of Spain Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010024","name":"Hungarian Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.jconrel.2021.02.012","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T05:02:04Z","timestamp":1613538124000},"page":"40-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":308,"special_numbering":"C","title":["Aerogels in drug delivery: From design to application"],"prefix":"10.1016","volume":"332","author":[{"given":"Carlos A.","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sosnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Kalm\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Erkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Concheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Alvarez-Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2021.02.012_bb0005","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3390\/ma6030941","article-title":"A special material or a new state of matter: a review and reconsideration of the aerogel","volume":"6","author":"Du","year":"2013","journal-title":"Materials"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0010","first-page":"60","article-title":"Preparation, properties, and applications of natural cellulosic aerogels: a review","volume":"1","author":"Zaman","year":"2020","journal-title":"EBE"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0015","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1021\/acs.nanolett.0c00917","article-title":"An all-ceramic, anisotropic, and flexible aerogel insulation material","volume":"20","author":"An","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/admi.201700065","volume":"4","author":"Deuber","year":"2017","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0025","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1557\/jmr.2017.412","article-title":"Direct solution-based reduction synthesis of Au, Pd, and Pt aerogels","volume":"32","author":"Burpo","year":"2017","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0030","first-page":"195","article-title":"Mesoporous silica\u2013gelatin aerogels for the selective adsorption of aqueous Hg(II), ACS Appl","volume":"3","author":"Herman","year":"2020","journal-title":"Nanostruct. Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0035","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/polym11040726","article-title":"Nanomaterials in advanced, high-performance aerogel composites: a review","volume":"11","author":"Barrios","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0040","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1039\/D0SM01261K","article-title":"Polymeric hybrid aerogels and their biomedical applications","volume":"16","author":"Liu","year":"2020","journal-title":"Soft Matter"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0045","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/smll.201503524","article-title":"3D printing of graphene aerogels","volume":"12","author":"Zhang","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0050","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-020-2594-0","article-title":"Additive manufacturing of silica aerogels","volume":"584","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0055","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1002\/anie.201709014","article-title":"Biopolymer aerogels and foams: chemistry, properties, and applications","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0060","doi-asserted-by":"crossref","first-page":"115744","DOI":"10.1016\/j.carbpol.2019.115744","article-title":"Synthesis of chitosan aerogels as promising carriers for drug delivery: a review","volume":"231","author":"Wei","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0065","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/pharmaceutics12050449","article-title":"New trends in bio-based aerogels","volume":"12","author":"Nita","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0070","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3390\/molecules24091815","article-title":"An opinion paper on aerogels for biomedical and environmental applications","volume":"24","author":"Garc\u00eda-Gonz\u00e1lez","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijpharm.2017.09.002","article-title":"Nanofibrillar cellulose hydrogels and reconstructed hydrogels as matrices for controlled drug release","volume":"532","author":"Paukkonen","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jmatprotec.2007.10.060","article-title":"Silica aerogel; synthesis, properties and characterization","volume":"199","author":"Soleimani Dorcheh","year":"2008","journal-title":"J. Mater. Process. Technol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0085","first-page":"37","article-title":"Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems. Mater","volume":"140","author":"Vakifahmetoglu","year":"2018","journal-title":"Design"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0090","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijpharm.2008.05.014","article-title":"Are pharmaceutics really going supercritical","volume":"364","author":"Pasquali","year":"2008","journal-title":"Int. J.Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0095","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jbm.b.34398","article-title":"A new era for sterilization based on supercritical CO2 technology","volume":"108","author":"Ribeiro","year":"2020","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejps.2013.02.023","article-title":"Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels","volume":"50","author":"Valo","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.micromeso.2012.02.009","article-title":"A novel process for coating of silica aerogel microspheres for controlled drug release applications","volume":"160","author":"Alnaief","year":"2012","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0110","doi-asserted-by":"crossref","first-page":"62362","DOI":"10.1039\/C4RA09089F","article-title":"A novel hybrid material: an inorganic silica aerogel core encapsulated with a tunable organic alginate aerogel layer","volume":"4","author":"Ulker","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0115","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.supflu.2013.01.025","article-title":"Preparation of multi-membrane alginate aerogels used for drug delivery","volume":"79","author":"Veronovski","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/polym12020273","article-title":"Jet cutting technique for the production of chitosan aerogel microparticles loaded with vancomycin","volume":"12","author":"L\u00f3pez-Iglesias","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0125","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejpb.2008.02.003","article-title":"Hydrophilic silica aerogels as dermal drug delivery systems-dithranol as a model drug","volume":"69","author":"Guenther","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0130","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cej.2018.09.159","article-title":"From the printer to the lungs: inkjet-printed aerogel particles for pulmonary delivery","volume":"357","author":"L\u00f3pez-Iglesias","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.supflu.2019.04.013","article-title":"Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery","volume":"150","author":"Athamneh","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1208\/s12249-020-01735-8","article-title":"Development, in vitro characterization, and in vivo toxicity evaluation of chitosan-alginate nanoporous carriers loaded with cisplatin for lung cancer treatment","volume":"21","author":"Alsmadi","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2016.09.086","article-title":"Application of RPMI 2650 as a cell model to evaluate solid formulations for intranasal delivery of drugs","volume":"51","author":"Goncalves","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0150","doi-asserted-by":"crossref","first-page":"1902826","DOI":"10.1002\/smll.201902826","article-title":"Versatile aerogels for sensors","volume":"15","author":"Yang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0155","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.2147\/IJN.S238005","article-title":"Engineering of aerogel-based biomaterials for biomedical applications","volume":"15","author":"Zheng","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0160","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/bc5005922","article-title":"Processing of materials for regenerative medicine using supercritical fluid technology","volume":"26","author":"Garc\u00eda-Gonz\u00e1lez","year":"2015","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2174\/1877912305666150602221739","article-title":"Patent survey on current applications of supercritical fluid technology in regenerative medicine","volume":"5","author":"Garc\u00eda-Gonz\u00e1lez","year":"2015","journal-title":"Recent Patents Nanomed."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2013.12.033","article-title":"An emerging platform for drug delivery: aerogel based systems","volume":"177","author":"Ulker","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0175","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.carbpol.2011.06.066","article-title":"Polysaccharide-based aerogels-Promising biodegradable carriers for drug delivery systems","volume":"86","author":"Garc\u00eda-Gonz\u00e1lez","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0180","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.msec.2018.11.067","article-title":"Porous aerogel and core\/shell nanoparticles for controlled drug delivery: a review","volume":"96","author":"Esquivel-Castro","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0185","doi-asserted-by":"crossref","first-page":"17606","DOI":"10.1039\/C5TA04215A","article-title":"Laser induced instantaneous gelation: aerogels for 3D printing","volume":"3","author":"Saeed","year":"2015","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0190","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s10971-016-3968-5","article-title":"Review of aerogel-based materials in biomedical applications","volume":"77","author":"Stergar","year":"2016","journal-title":"J. Solgel Sci. Technol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0195","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1163\/092050611X566126","article-title":"Synthesis and use of organic biodegradable aerogels as drug carriers","volume":"23","author":"Veronovski","year":"2012","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0200","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.3390\/molecules24213931","article-title":"Diffusion of resveratrol in silica alcogels","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0205","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.supflu.2016.05.033","article-title":"An advantageous technique to load drugs into aerogels: gas antisolvent crystallization inside the pores","volume":"120","author":"Ulker","year":"2017","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0210","doi-asserted-by":"crossref","first-page":"104592","DOI":"10.1016\/j.supflu.2019.104592","article-title":"Development of an integrated one-pot process for the production and impregnation of starch aerogels in supercritical carbon dioxide","volume":"154","author":"Villegas","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0215","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcou.2017.10.006","article-title":"Development of barley and yeast beta-glucan aerogels for drug delivery by supercritical fluids","volume":"22","author":"Salgado","year":"2017","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0220","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1081\/PDT-200035804","article-title":"Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels","volume":"9","author":"Smirnova","year":"2004","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.supflu.2019.04.003","article-title":"Preparation of Balangu (Lallemantia royleana) seed mucilage aerogels loaded with paracetamol: evaluation of drug loading via response surface methodology","volume":"150","author":"Falahati","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0230","doi-asserted-by":"crossref","first-page":"123290","DOI":"10.1016\/j.matchemphys.2020.123290","article-title":"Properties of \u03ba-carrageenan aerogels prepared by using different dissolution media and its application as drug delivery systems","volume":"253","author":"Agostinho","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0235","series-title":"Sec. 184.1240 Carbon dioxide","volume":"vol. 3","author":"US FDA","year":"2019"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cep.2012.06.004","article-title":"Supercritical fluids for pharmaceutical particle engineering: methods, basic fundamentals and modelling","volume":"60","author":"Tabernero","year":"2012","journal-title":"Chem. Eng. Process."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0245","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/anie.200462468","article-title":"Supercritical water as a solvent","volume":"44","author":"Weing\u00e4rtner","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0250","doi-asserted-by":"crossref","first-page":"1700433","DOI":"10.1002\/adhm.201700433","article-title":"Supercritical fluid technology: an emphasis on drug delivery and related biomedical applications","volume":"6","author":"Kankala","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0255","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.addr.2018.07.010","article-title":"Supercritical carbon dioxide-based technologies for the production of drug nanoparticles\/nanocrystals \u2013 a comprehensive review","volume":"131","author":"Padrela","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0260","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.carbpol.2014.10.045","article-title":"Polysaccharide-based aerogel microspheres for oral drug delivery","volume":"117","author":"Garc\u00eda-Gonz\u00e1lez","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0265","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.supflu.2017.03.005","article-title":"Amorphization of drugs by adsorptive precipitation from supercritical solutions: a review","volume":"132","author":"Gurikov","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0270","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.cherd.2011.11.011","article-title":"Nimesulide adsorbed on silica aerogel using supercritical carbon dioxide","volume":"90","author":"Caputo","year":"2012","journal-title":"Chem. Eng. Res. Design"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0280","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chroma.2012.04.052","article-title":"Determination of diffusion coefficients for supercritical fluids","volume":"1250","author":"Medina","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0285","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1021\/ie503867p","article-title":"Silica aerogel microparticles from rice husk ash for drug delivery","volume":"54","author":"Rajanna","year":"2015","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0290","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jddst.2017.12.017","article-title":"Synthesis and characterization of silica aerogel as a promising drug carrier system","volume":"44","author":"Mohammadian","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0295","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/03639045.2020.1742141","article-title":"Mesoporous silica particles as potential carriers for protein drug delivery: protein immobilization and the effect of displacer on \u03b3-globulin release","volume":"46","author":"Ajiboye","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0300","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.jnoncrysol.2010.06.027","article-title":"Effect of surface functionalization of silica aerogel on their adsorptive and release properties","volume":"356","author":"Alnaief","year":"2010","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0305","doi-asserted-by":"crossref","first-page":"109759","DOI":"10.1016\/j.micromeso.2019.109759","article-title":"Molecularly imprinted phenyl-functionalized silica aerogels: selective adsorbents for methylxanthines and PAHs","volume":"292","author":"Saad","year":"2020","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0310","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0315","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jconrel.2011.10.006","article-title":"Modeling of diffusion controlled drug delivery","volume":"161","author":"Siepmann","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0320","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2013.04.044","article-title":"Mathematical modeling of drug dissolution","volume":"453","author":"Siepmann","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0325","doi-asserted-by":"crossref","first-page":"107237","DOI":"10.1039\/C5RA21353C","article-title":"The pore network and the adsorption characteristics of mesoporous silica aerogel: adsorption kinetics on a timescale of seconds","volume":"5","author":"Kalm\u00e1r","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0330","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejps.2018.07.031","article-title":"Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules","volume":"123","author":"Janov\u00e1k","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0335","doi-asserted-by":"crossref","first-page":"9493","DOI":"10.1007\/s10570-020-03426-w","article-title":"Temperature-responsive hydroxypropyl methylcellulose-N-isopropylacrylamide aerogels for drug delivery systems","volume":"27","author":"Liu","year":"2020","journal-title":"Cellulose"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0340","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3390\/molecules25051187","article-title":"Preparation and characterization of chitosan-coated pectin aerogels: curcumin case study","volume":"25","author":"Pantic","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0345","doi-asserted-by":"crossref","first-page":"147232","DOI":"10.1016\/j.apsusc.2020.147232","article-title":"Mechanism of hydration of biocompatible silica-casein aerogels probed by NMR and SANS reveal backbone rigidity","volume":"531","author":"L\u00e1z\u00e1r","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0350","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.colsurfb.2017.01.019","article-title":"Mechanism of drug release from silica-gelatin aerogel-Relationship between matrix structure and release kinetics","volume":"152","author":"Veres","year":"2017","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0355","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.actbio.2020.01.016","article-title":"Gelatin content governs hydration induced structural changes in silica-gelatin hybrid aerogels - Implications in drug delivery","volume":"105","author":"Keri","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0360","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnoncrysol.2004.06.031","article-title":"Feasibility study of hydrophilic and hydrophobic silica aerogels as drug delivery systems","volume":"350","author":"Smirnova","year":"2004","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0365","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.supflu.2019.02.026","article-title":"3D aerogel of cellulose triacetate with supercritical antisolvent process for drug delivery","volume":"148","author":"Wang","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0370","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijpharm.2015.10.045","article-title":"Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs","volume":"496","author":"Veres","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0375","doi-asserted-by":"crossref","first-page":"86","DOI":"10.14356\/kona.2005012","article-title":"Aerogels: Tailor-made carriers for immediate and prolonged drug release","volume":"23","author":"Smirnova","year":"2005","journal-title":"KONA"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0380","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1021\/am4059217","article-title":"Evaluation of dysprosia aerogels as drug delivery systems: a comparative study with random and ordered mesoporous silicas","volume":"6","author":"Bang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0385","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1517\/17425241003602259","article-title":"Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems","volume":"7","author":"Fu","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0390","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/masy.201000008","article-title":"Loading of bacterial cellulose aerogels with bioactive compounds by antisolvent precipitation with supercritical carbon dioxide","volume":"294-II","author":"Haimer","year":"2010","journal-title":"Macromol. Symp."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0395","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/polb.1986.090240214","article-title":"Solute and penetrant diffusion in swellable polymers. I. Mathematical modelling","volume":"24","author":"Korsmeyer","year":"1986","journal-title":"J. Polym. Sci. Part A-2 Polym. Phys."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0400","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.supflu.2017.10.026","article-title":"Comparative study of PVDF-HFP-curcumin porous structures produced by supercritical assisted processes","volume":"133","author":"Cardea","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0405","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.supflu.2014.04.014","article-title":"Silk fibroin aerogels for drug delivery applications","volume":"91","author":"Marin","year":"2014","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0410","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.supflu.2016.06.002","article-title":"Impregnation of medicinal plant phytochemical compounds into silica and alginate aerogels","volume":"116","author":"Mustapa","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0415","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijpharm.2011.03.051","article-title":"Higuchi equation: derivation, applications, use and misuse","volume":"418","author":"Siepmann","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0420","series-title":"Controlled Release Polymeric Formulations","first-page":"26","article-title":"Controlled release from erodible slabs, cylinders, and spheres","author":"Hopfenberg","year":"1976"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0425","first-page":"818","article-title":"In-vitro study of ketoprofen release from synthesized silica aerogels (as drug carriers) and evaluation of mathematical kinetic release models","volume":"17","author":"Mohammadian","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0430","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jconrel.2011.06.038","article-title":"Understanding controlled drug release from mesoporous silicates: theory and experiment","volume":"155","author":"Ukmar","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0435","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1039\/C1JM13493K","article-title":"Guest\u2013host van der Waals interactions decisively affect the molecular transport in mesoporous media","volume":"22","author":"Ukmar","year":"2012","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0440","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijpharm.2019.05.041","article-title":"The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): beyond guidelines","volume":"566","author":"Charalabidis","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0445","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fphar.2020.00524","article-title":"Advances in oral drug delivery for regional targeting in the gastrointestinal tract - influence of physiological, pathophysiological and pharmaceutical factors","volume":"11","author":"Hua","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0450","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/17425247.2020.1750593","article-title":"Oral controlled release dosage forms: dissolution versus diffusion","volume":"17","author":"Bermejo","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0455","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1039\/C8CS00948A","article-title":"Molecular and cellular cues governing nanomaterials-mucosae interactions: from nanotherapeutics to nanotoxicology","volume":"49","author":"das Neves","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0460","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0465","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijpharm.2012.04.066","article-title":"Emerging trends in the stabilization of amorphous drugs","volume":"453","author":"Laitinen","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0470","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/pharmaceutics12030214","article-title":"Crystallisation behaviour of pharmaceutical compounds confined within mesoporous silicon","volume":"12","author":"Jones","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0475","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jnoncrysol.2015.09.015","article-title":"Mechanism for formation of hollow and granular silica aerogel microspheres from rice husk ash for drug delivery","volume":"429","author":"Rajanna","year":"2015","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0480","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/00986445.2016.1263618","article-title":"Robust silica aerogel microspheres from rice husk ash to enhance the dissolution rate of poorly water-soluble drugs","volume":"204","author":"Rajanna","year":"2017","journal-title":"Chem. Eng. Commun."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0485","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1021\/acs.chemmater.9b00221","article-title":"Degradable drug carriers: vanishing mesoporous silica nanoparticles","volume":"31","author":"M\u00f6ller","year":"2019","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0490","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.supflu.2012.11.006","article-title":"Nanostructured silica-based drug delivery vehicles for hydrophobic and moisture sensitive drugs","volume":"73","author":"Murillo-Cremaes","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0495","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1208\/s12249-018-1021-4","article-title":"Investigation of carrageenan aerogel microparticles as a potential drug carrier","volume":"19","author":"Obaidat","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0500","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jps.23361","article-title":"Design of alginate-based aerogel for nonsteroidal anti-inflammatory drugs controlled delivery systems using prilling and supercritical-assisted drying","volume":"102","author":"Del Gaudio","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0505","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/ma13020329","article-title":"Alginate-based aerogel particles as drug delivery systems: investigation of the supercritical adsorption and in vitro evaluations","volume":"13","author":"Lovskaya","year":"2020","journal-title":"Materials"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0510","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jcou.2019.11.001","article-title":"Supercritical CO2 adsorption of non-steroidal anti-inflammatory drugs into biopolymer aerogels","volume":"36","author":"Franco","year":"2020","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0515","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.supflu.2015.07.011","article-title":"Aerogels as drug delivery systems: in vitro and in vivo evaluations","volume":"106","author":"Lovskaya","year":"2015","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0520","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2174\/1567201813666160920154209","article-title":"Biodegradable porous starch spheres as a novel carrier for enhancement of dissolution rate and oral bioavailability of itraconazole","volume":"14","author":"Pawar","year":"2017","journal-title":"Current Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0525","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/1750-3841.14673","article-title":"In vitro bioaccessibility of low-crystallinity phytosterol nanoparticles generated using nanoporous starch bioaerogels","volume":"84","author":"Ubeyitogullari","year":"2019","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0530","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cherd.2017.01.024","article-title":"Starch aerogel loaded with poorly water-soluble vitamins through supercritical CO2 adsorption","volume":"119","author":"De Marco","year":"2017","journal-title":"Chem. Eng. Res. Des."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0535","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jconrel.2005.08.017","article-title":"Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs","volume":"108","author":"Salonen","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0540","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.carbon.2020.02.028","article-title":"Crystalline loading of lipophilic Coenzyme Q(10) pharmaceuticals within conjugated carbon aerogel derivatives","volume":"164","author":"Lim","year":"2020","journal-title":"Carbon"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0545","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.jnoncrysol.2009.08.038","article-title":"Polysaccharide-based aerogels as drug carriers","volume":"355","author":"Mehling","year":"2009","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0550","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.supflu.2013.03.001","article-title":"Use of supercritical fluid technology for the production of tailor-made aerogel particles for delivery systems","volume":"79","author":"Garc\u00eda-Gonz\u00e1lez","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0555","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ijbiomac.2019.04.148","article-title":"Bioinspired aerogel based on konjac glucomannan and functionalized carbon nanotube for controlled drug release","volume":"133","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0560","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijpharm.2016.10.008","article-title":"Evaluation of mesoporous carbon aerogels as carriers of the non-steroidal anti-inflammatory drug ibuprofen","volume":"515","author":"Eleftheriadis","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0565","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.2147\/IJN.S124318","article-title":"Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery","volume":"12","author":"Bhandari","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0570","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.micromeso.2015.11.048","article-title":"pH sensitive mesoporous materials for immediate or controlled release of NSAID","volume":"224","author":"Tkalec","year":"2016","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0575","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.carbpol.2018.01.098","article-title":"A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery","volume":"188","author":"Veres","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0580","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.supflu.2015.06.009","article-title":"Fast production of high-methoxyl pectin aerogels for enhancing the bioavailability of low-soluble drugs","volume":"106","author":"Tkalec","year":"2015","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0585","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jnoncrysol.2017.11.037","article-title":"Encapsulation and drug release of poorly water soluble nifedipine from bio-carriers","volume":"481","author":"Horvat","year":"2018","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0590","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.carbpol.2014.06.054","article-title":"Characterisation of biodegradable pectin aerogels and their potential use as drug carriers","volume":"113","author":"Veronovski","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0595","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijbiomac.2017.05.064","article-title":"pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier","volume":"103","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0600","doi-asserted-by":"crossref","first-page":"110712","DOI":"10.1016\/j.colsurfb.2019.110712","article-title":"Graphene aerogel nanoparticles for in-situ loading\/pH sensitive releasing anticancer drugs","volume":"186","author":"Ayazi","year":"2020","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0605","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1166\/jbn.2019.2763","article-title":"Nano-porous silica aerogels as promising biomaterials for oral drug delivery of paclitaxel","volume":"15","author":"Wang","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0610","doi-asserted-by":"crossref","first-page":"105333","DOI":"10.1088\/2053-1591\/ab3a74","article-title":"Aerogel fabricated with halloysite nanoclay as ibuprofen and dexamethasone carrier for dual drugs release","volume":"6","author":"Li","year":"2019","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0615","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.ijbiomac.2018.03.166","article-title":"Dual responsive aerogel made from thermo\/pH sensitive graft copolymer alginate-g-P(NIPAM-co-NHMAM) for drug controlled release","volume":"114","author":"Shao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0620","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1021\/acssuschemeng.6b00814","article-title":"Mechanically strong and thermally responsive cellulose nanofibers\/poly(N-isopropylacrylamide) composite aerogels","volume":"4","author":"Zhang","year":"2016","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0625","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.supflu.2012.08.019","article-title":"Preparation of novel whey protein-based aerogels as drug carriers for life science applications","volume":"72","author":"Betz","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0630","doi-asserted-by":"crossref","first-page":"105534","DOI":"10.1016\/j.foodhyd.2019.105534","article-title":"In-vitro-digestion and swelling kinetics of whey protein, egg white protein and sodium caseinate aerogels","volume":"101","author":"Kleemann","year":"2020","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0635","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/jbm.a.34056","article-title":"Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system","volume":"100A","author":"Giray","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0640","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.supflu.2018.07.007","article-title":"An emulsification\/internal setting technique for the preparation of coated and uncoated hybrid silica\/alginate aerogel beads for controlled drug delivery","volume":"142","author":"Bugnone","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0645","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.powtec.2015.05.004","article-title":"Influence of coating and wetting on the mechanical behaviour of highly porous cylindrical aerogel particles","volume":"285","author":"Antonyuk","year":"2015","journal-title":"Powder Technol."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0650","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1007\/s00396-014-3260-6","article-title":"Compressed antisolvent process for polymer coating of drug-loaded aerogel nanoparticles and study of the release behavior","volume":"292","author":"Murillo-Cremaes","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0655","doi-asserted-by":"crossref","first-page":"101517","DOI":"10.1016\/j.jddst.2020.101517","article-title":"Novel organic\/inorganic hybrid nanoparticles as enzyme-triggered drug delivery systems: dextran and dextran aldehyde coated silica aerogels","volume":"56","author":"Tiryaki","year":"2020","journal-title":"J. Drug Deliv. Sci. Tech."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0660","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.carbpol.2016.04.031","article-title":"Prilling and supercritical drying: A successful duo to produce core-shell polysaccharide aerogel beads for wound healing","volume":"147","author":"De Cicco","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0665","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/03639045.2013.828219","article-title":"Recent advances in gel technologies for topical and transdermal drug delivery","volume":"40","author":"Rehman","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0670","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/antibiotics9100648","article-title":"A review on revolutionary natural biopolymer-based aerogels for antibacterial delivery","volume":"9","author":"Yahya","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0675","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/ab3097","article-title":"Novel multi-layer silica aerogel\/PVA composite for controlled drug delivery","volume":"6","author":"Afrashi","year":"2019","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0680","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jnoncrysol.2018.09.045","article-title":"Comparing the drug loading and release of silica aerogel and PVA nano fibers","volume":"503\u2013504","author":"Afrashi","year":"2019","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0685","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/pen.24834","article-title":"Supercritical CO2 drying and impregnation with thymol","volume":"58","author":"Terzic","year":"2018","journal-title":"Polym. Eng. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0690","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.msec.2018.10.044","article-title":"A facile restructuring of 3D high water absorption aerogels from methoxy polyethylene glycol-polycaprolactone (mPEG-PCL) nanofibers","volume":"94","author":"Jia","year":"2019","journal-title":"Mat. Sci. Eng. C-Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0695","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1021\/acsami.7b16084","article-title":"Development development of graphene oxide composite aerogel with proanthocyanidins with hemostatic properties as a delivery system","volume":"10","author":"Mellado","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0700","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1039\/C7NR08464A","article-title":"Multifunctional hybrid aerogels: hyperbranched polymer-trapped mesoporous silica nanoparticles for sustained and prolonged drug release","volume":"10","author":"Follmann","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0705","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.2174\/1381612821666150416100201","article-title":"Supercritical fluid particle design of dpi formulations (Review)","volume":"21","author":"Sun","year":"2015","journal-title":"Curr. Pharm. Design"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0710","doi-asserted-by":"crossref","first-page":"1800910","DOI":"10.1002\/adhm.201800910","article-title":"Supercritical fluid-assisted porous microspheres for efficient delivery of insulin and inhalation therapy of diabetes","volume":"8","author":"Lin","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0715","first-page":"100053","article-title":"Xyloglucan based mucosal nanovaccine for immunological protection against brucellosis developed by supercritical fluid technology","volume":"2","author":"Vyas","year":"2020","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0720","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejpb.2016.07.003","article-title":"Alginate-based hybrid aerogel microparticles for mucosal drug delivery","volume":"107","author":"Gon\u00e7alves","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0725","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1208\/s12249-015-0312-2","article-title":"Drying using supercritical fluid technology as a potential method for preparation of chitosan aerogel microparticles","volume":"16","author":"Obaidat","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0730","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3390\/polym12102223","article-title":"Preparation of hybrid alginate-chitosan aerogel as potential carriers for pulmonary drug delivery","volume":"12","author":"Alnaief","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0735","doi-asserted-by":"crossref","first-page":"56992","DOI":"10.1039\/C4RA09470K","article-title":"A comparative study of antioxidant-loaded carbon nanoparticles as drug delivery vehicles","volume":"4","author":"Li","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0740","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.supflu.2008.09.010","article-title":"Adsorption and thermal release of highly volatile compounds in silica aerogels","volume":"48","author":"Gorle","year":"2009","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0745","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.foodchem.2016.10.072","article-title":"Structure of starch aerogel as affected by crosslinking and feasibility assessment of the aerogel for an anti-fungal volatile release","volume":"221","author":"Abhari","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0750","doi-asserted-by":"crossref","first-page":"100074","DOI":"10.1016\/j.fochx.2019.100074","article-title":"Active food packaging through controlled in situ production and release of hexanal","volume":"5","author":"Lehtonen","year":"2020","journal-title":"Food Chem. X"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0755","doi-asserted-by":"crossref","first-page":"e50686","DOI":"10.1371\/journal.pone.0050686","article-title":"Histological evaluation of the biocompatibility of polyurea crosslinked silica aerogel implants in a rat model: A pilot study","volume":"7","author":"Sabri","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0760","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijpharm.2019.01.024","article-title":"Controlled release of methotrexate from functionalized silica-gelatin aerogel microparticles applied against tumor cell growth","volume":"558","author":"Nagy","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0765","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1080\/17425247.2019.1660318","article-title":"Shaping the future: recent advances of 3D printing in drug delivery and healthcare","volume":"16","author":"Trenfield","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0770","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1038\/s41598-017-07771-y","article-title":"Direct ink write (DIW) 3D printed cellulose nanocrystal aerogel structures","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0775","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mattod.2019.09.021","article-title":"Entrapment of enzymes in silica aerogels","volume":"33","author":"Ganonyan","year":"2020","journal-title":"Mater. Today"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0780","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.supflu.2017.12.010","article-title":"Synthesis of supported nanoparticles in supercritical fluids by supercritical fluid reactive deposition: current state, further perspectives and needs","volume":"134","author":"T\u00fcrk","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0785","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10853-014-8626-0","article-title":"Supercritical impregnation of drugs and supercritical fluid deposition of metals into aerogels","volume":"50","author":"Tkalec","year":"2015","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0790","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.supflu.2010.10.045","article-title":"Adsorption of Pt(cod)me2 onto organic aerogels from supercritical solutions for the synthesis of supported platinum nanoparticles","volume":"56","author":"Bozbag","year":"2011","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0795","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fmats.2020.00018","article-title":"A remarkable class of nanocomposites: aerogel supported bimetallic nanoparticles","volume":"7","author":"Gunes","year":"2020","journal-title":"Front. Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0800","doi-asserted-by":"crossref","first-page":"13076","DOI":"10.1021\/acsami.5b11582","article-title":"Direct cross-linking of Au\/Ag alloy nanoparticles into monolithic aerogels for application in surface-enhanced raman scattering","volume":"8","author":"Gao","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0805","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.7150\/thno.42601","article-title":"Point-of-care assay for drunken driving with Pd@Pt core-shell nanoparticles-decorated ploy(vinyl alcohol) aerogel assisted by portable pressure meter","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0810","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aca.2020.04.077","article-title":"Highly sensitive electrochemical detection of circulating tumor DNA in human blood based on urchin-like gold nanocrystal-multiple graphene aerogel and target DNA-induced recycling double amplification strategy","volume":"1121","author":"Peng","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0815","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1021\/acsnano.9b00428","article-title":"Millisecond response of shape memory polymer nanocomposite aerogel powered by stretchable graphene framework","volume":"13","author":"Guo","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0820","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1039\/C9TB02383F","article-title":"A novel multifunctional carbon aerogel-coated platform for osteosarcoma therapy and enhanced bone regeneration","volume":"8","author":"Dong","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0825","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1021\/am507601m","article-title":"Polyethylenimine-grafted cellulose nanofibril aerogels as versatile vehicles for drug delivery","volume":"7","author":"Zhao","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0830","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1002\/pola.27297","article-title":"A novel solventless coating method to graft low-molecular weight polyethyleneimine on silica fine powders","volume":"52","author":"Murillo-Cremaes","year":"2014","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0835","doi-asserted-by":"crossref","first-page":"57950","DOI":"10.1039\/C5RA01810B","article-title":"Calf thymus DNA characterization and its adsorption on different silica surfaces","volume":"5","author":"Yetgin","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0840","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1021\/ac0516638","article-title":"Adsorption of duplex DNA on mesoporous silicas: possibility of inclusion of DNA into their mesopores","volume":"77","author":"Fujiwara","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0845","doi-asserted-by":"crossref","first-page":"1700630","DOI":"10.1002\/adhm.201700630","article-title":"Monodispersed bioactive glass nanoclusters with ultralarge pores and intrinsic exceptionally high miRNA loading for efficiently enhancing bone regeneration","volume":"6","author":"Xue","year":"2017","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0850","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.actbio.2009.10.001","article-title":"A novel three-dimensional aerogel biochip for molecular recognition of nucleotide acids","volume":"6","author":"Li","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0855","series-title":"Pharmaceutical process scale-up","author":"Levin","year":"2001"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0860","first-page":"1296","article-title":"Production of sodium alginate-based aerogel particles using supercritical drying in units with different volumes, Russian","volume":"11","author":"Menshutina","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0865","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.colsurfa.2018.12.055","article-title":"A continuous approach to the emulsion gelation method for the production of aerogel micro-particle","volume":"566","author":"Baudron","year":"2019","journal-title":"Colloid Surf. A"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0870","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1007\/s11367-017-1351-6","article-title":"An environmental study on starch aerogel for drug delivery applications: effect of plant scale up","volume":"23","author":"De Marco","year":"2018","journal-title":"Int. J. Life Cycle Assess."},{"key":"10.1016\/j.jconrel.2021.02.012_bb0875","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.supflu.2018.09.003","article-title":"Life cycle assessment of supercritical impregnation: Starch aerogel plus alpha-tocopherol tablets","volume":"143","author":"De Marco","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0880","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jnoncrysol.2017.07.016","article-title":"Biocompatible silica-gelatin hybrid aerogels covalently labeled with fluorescein","volume":"473","author":"Veres","year":"2017","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jconrel.2021.02.012_bb0885","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s10971-019-04946-z","article-title":"Preparation and characterization of hydroxyapatite incorporated silica aerogel and its effect on normal human dermal fibroblast cells","volume":"90","author":"Sani","year":"2019","journal-title":"J. Sol-Gel Sci. Technol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921000754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921000754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:39:39Z","timestamp":1777509579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365921000754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":177,"alternative-id":["S0168365921000754"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.02.012","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerogels in drug delivery: From design to application","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}