{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:10:52Z","timestamp":1793661052030,"version":"4.5.1"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health and Family Planning Commission of the Peoples Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jconrel.2021.03.041","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T17:57:19Z","timestamp":1617127039000},"page":"269-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"special_numbering":"C","title":["Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review"],"prefix":"10.1016","volume":"333","author":[{"given":"Ying","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixin","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2021.03.041_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pdpdt.2017.02.010","article-title":"Effect of laser-assisted scaling and root planing on the expression of pro-inflammatory cytokines in the gingival crevicular fluid of patients with chronic periodontitis: a systematic review","volume":"18","author":"Kellesarian","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s40496-014-0032-9","article-title":"Is periodontitis prevalence declining? A review of the current literature","volume":"1","author":"Holtfreter","year":"2014","journal-title":"Curr. Oral Health Rep."},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0015","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1600-051X.2007.01139.x","article-title":"Epidemiology and preventive direction of periodontology in China","volume":"34","author":"Wang","year":"2007","journal-title":"J. Clin. Periodontol."},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1034\/j.1600-0757.2002.290101.x","article-title":"Global epidemiology of periodontal diseases: an overview","volume":"29","author":"Albandar","year":"2002","journal-title":"Periodontol."},{"issue":"28","key":"10.1016\/j.jconrel.2021.03.041_bb0025","first-page":"7","article-title":"Structure of periodontal tissues in health and disease","volume":"11","author":"Nanci","year":"2006","journal-title":"Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0030","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1902\/jop.2006.050140","article-title":"Local drug delivery in the treatment of periodontal diseases: assessing the clinical significance of the results","volume":"77","author":"Greenstein","year":"2006","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jobcr.2019.04.001","article-title":"Development of Moxifloxacin hydrochloride loaded in-situ gel for the treatment of periodontitis: in-vitro drug release study and antibacterial activity","volume":"9","author":"Swain","year":"2019","journal-title":"J. Oral Biol. Craniofac. Res."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-051X.1979.tb01935.x","article-title":"Subgingival microflora and periodontal disease","volume":"6","author":"Slots","year":"1979","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2710.2000.00261.x","article-title":"Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases","volume":"25","author":"Vyas","year":"2000","journal-title":"J. Clin. Pharm. Ther."},{"issue":"12","key":"10.1016\/j.jconrel.2021.03.041_bb0055","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/JPER.18-0047","article-title":"The impact of caries in combination with periodontitis on oral health-related quality of life in Bahia, Brazil","volume":"89","author":"Passos-Soares","year":"2018","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1601-5037.2008.00332.x","article-title":"Periodontitis from the patient\u2019s perspective, a qualitative study","volume":"7","author":"Karlsson","year":"2009","journal-title":"Int. J. Dent. Hyg."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0065","first-page":"209","article-title":"Patients\u2019 views on periodontal disease; attitudes to oral health and expectancy of periodontal treatment: a qualitative interview study","volume":"6","author":"Abrahamsson","year":"2008","journal-title":"Oral Health Prev. Dent."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/prd.12111","article-title":"Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists","volume":"7","author":"De Geest","year":"2016","journal-title":"Periodontol."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1902\/jop.2012.120069","article-title":"Changes in masticatory performance and quality of life in individuals with chronic periodontitis","volume":"84","author":"Borges Tde","year":"2013","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0080","first-page":"S106","article-title":"Diabetes and periodontal diseases: consensus report of the joint EFP\/AAP workshop on periodontitis and systemic diseases","volume":"84","author":"Chapple","year":"2013","journal-title":"J. Periodontol."},{"issue":"14","key":"10.1016\/j.jconrel.2021.03.041_bb0085","first-page":"S24","article-title":"Periodontitis and atherosclerotic cardiovascular disease: consensus report of the joint EFP\/AAP workshop on periodontitis and systemic diseases","volume":"40","author":"Tonetti","year":"2013","journal-title":"J. Clin. Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0090","first-page":"S164","article-title":"Periodontitis and adverse pregnancy outcomes: consensus report of the joint EFP\/AAP workshop on periodontitis and systemic diseases","volume":"84","author":"Sanz","year":"2013","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cden.2009.08.006","article-title":"Nonsurgical mechanical treatment strategies for periodontal disease","volume":"54","author":"Apatzidou","year":"2010","journal-title":"Dent. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0100","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4103\/0975-962X.151697","article-title":"Comparison of Periochip (chlorhexidine gluconate 2.5 mg) and Arestin (Minocycline hydrochloride 1 mg) in the management of chronic periodontitis","volume":"6","author":"Jhinger","year":"2015","journal-title":"Ind. J. Dent."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0105","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2710.1992.tb01220.x","article-title":"Antibiotics in periodontal therapy: advantages and disadvantages","volume":"17","author":"Slots","year":"1990","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: an introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0120","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/0972-124X.100905","article-title":"Risk assessment for periodontal disease","volume":"16","author":"Koshi","year":"2012","journal-title":"J. Ind. Soc. Periodontol"},{"issue":"Pt 2","key":"10.1016\/j.jconrel.2021.03.041_bb0125","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1099\/mic.0.26082-0","article-title":"Are dental diseases examples of ecological catastrophes?","volume":"149","author":"Marsh","year":"2003","journal-title":"Microbiology"},{"issue":"8","key":"10.1016\/j.jconrel.2021.03.041_bb0130","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1902\/jop.2008.080173","article-title":"The management of inflammation in periodontal disease","volume":"79","author":"Van Dyke","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0757.2006.00178.x","article-title":"The role of reactive oxygen and antioxidant species in periodontal tissue destruction","volume":"43","author":"Chapple","year":"2007","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0140","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/prd.12074","article-title":"Periodontal microbiology in Latin America","volume":"67","author":"Contreras","year":"2015","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/prd.12010","article-title":"Lessons learned and unlearned in periodontal microbiology","volume":"62","author":"Teles","year":"2013","journal-title":"Periodontol."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0150","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1902\/jop.2000.71.6.981","article-title":"Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/prd.12088","article-title":"Neutrophil activation and periodontal tissue injury","volume":"69","author":"Herrmann","year":"2015","journal-title":"Periodontol."},{"issue":"21\u221222","key":"10.1016\/j.jconrel.2021.03.041_bb0160","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.drudis.2008.07.010","article-title":"Recent approaches for the treatment of periodontitis","volume":"13","author":"Jain","year":"2008","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/prd.12089","article-title":"Local inflammatory reactions in patients with diabetes and periodontitis","volume":"69","author":"Sonnenschein","year":"2015","journal-title":"Periodontol."},{"issue":"12","key":"10.1016\/j.jconrel.2021.03.041_bb0170","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1902\/jop.2005.76.12.2187","article-title":"Strengthening the prevention of periodontal disease: the WHO approach","volume":"76","author":"Petersen","year":"2005","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0175","doi-asserted-by":"crossref","first-page":"104193","DOI":"10.1016\/j.micpath.2020.104193","article-title":"Oral spirochetes: pathogenic mechanisms in periodontal disease","volume":"144","author":"Yousefi","year":"2020","journal-title":"Microb. Pathog."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0180","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3390\/molecules25030516","article-title":"Emerging applications of drug delivery systems in oral infectious diseases prevention and treatment","volume":"25","author":"Liang","year":"2020","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jconrel.2021.03.041_bb0185","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0190","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1128\/AAC.19.5.867","article-title":"Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria","volume":"19","author":"Walker","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.jconrel.2021.03.041_bb0195","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1902\/jop.1981.52.9.545","article-title":"Antibiotics in the treatment of human periodontal diseases","volume":"52","author":"Genco","year":"1981","journal-title":"J. Periodontol."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0200","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13346-013-0171-x","article-title":"A mini-review on novel intraperiodontal pocket drug delivery materials for the treatment of periodontal diseases","volume":"4","author":"Hau","year":"2014","journal-title":"Drug Deliv. Transl. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1902\/annals.1996.1.1.491","article-title":"Non-surgical pocket therapy: pharmacotherapeutics","volume":"1","author":"Drisko","year":"1996","journal-title":"Ann. Periodontol"},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0215","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive nanocarriers for drug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"issue":"5665","key":"10.1016\/j.jconrel.2021.03.041_bb0220","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.1095833","article-title":"Drug delivery systems: entering the mainstream","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-0363-4_1","article-title":"Current status and future prospects of drug delivery systems","volume":"1141","author":"Jain","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"29","key":"10.1016\/j.jconrel.2021.03.041_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201705328","article-title":"Advances in biomaterials for drug delivery","volume":"30","author":"Fenton","year":"2018","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0235","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.copbio.2003.10.007","article-title":"Drug delivery in biotechnology: present and future","volume":"14","author":"Orive","year":"2003","journal-title":"Curr. Opin. Biotechnol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0240","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bit.21301","article-title":"Microparticles and nanoparticles for drug delivery","volume":"96","author":"Kohane","year":"2007","journal-title":"Biotechnol. Bioeng."},{"issue":"4976","key":"10.1016\/j.jconrel.2021.03.041_bb0245","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.2218494","article-title":"New methods of drug delivery","volume":"249","author":"Langer","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0250","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0757.1996.tb00069.x","article-title":"The acquisition of antibiotic resistance in the periodontal microflora","volume":"10","author":"Walker","year":"1996","journal-title":"Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0255","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0757.1994.tb00022.x","article-title":"Antimicrobial strategies for treatment of periodontal diseases","volume":"5","author":"Goodson","year":"1994","journal-title":"Periodontol."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0260","doi-asserted-by":"crossref","first-page":"55","DOI":"10.17096\/jiufd.90144","article-title":"Adjunctive use of antibiotics in periodontal therapy","volume":"49","author":"Barca","year":"2015","journal-title":"J. Istanb Univ. Fac. Dent."},{"issue":"Pt B","key":"10.1016\/j.jconrel.2021.03.041_bb0265","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jconrel.2015.09.008","article-title":"Current strategies for sustaining drug release from electrospun nanofibers","volume":"220","author":"Chou","year":"2015","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0270","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-051X.1979.tb02186.x","article-title":"Periodontal therapy by local delivery of tetracycline","volume":"6","author":"Goodson","year":"1979","journal-title":"J. Clin. Periodontol."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0275","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1600-0765.1991.tb01734.x","article-title":"Multicenter evaluation of tetracycline fiber therapy. III. Microbiological response","volume":"26","author":"Goodson","year":"1991","journal-title":"J. Periodontal Res."},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0280","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1902\/jop.1994.65.7.685","article-title":"A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: clinical results","volume":"65","author":"Newman","year":"1994","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0285","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1600-0765.1990.tb00911.x","article-title":"Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers","volume":"25","author":"Tonetti","year":"1990","journal-title":"J. Periodontal Res."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0290","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1902\/jop.1997.68.4.353","article-title":"The use of tetracycline-containing controlled-release fibers in the treatment of refractory periodontitis","volume":"68","author":"Vandekerckhove","year":"1997","journal-title":"J. Periodontol."},{"issue":"8","key":"10.1016\/j.jconrel.2021.03.041_bb0295","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1600-0765.1996.tb00518.x","article-title":"Use of the polymeric matrix as internal standard for quantitation of in vivo delivery of tetracycline HCl from Actisite tetracycline fiber during periodontal treatment","volume":"31","author":"Litch","year":"1996","journal-title":"J. Periodontal Res."},{"issue":"10","key":"10.1016\/j.jconrel.2021.03.041_bb0300","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.2042-7158.1989.tb06343.x","article-title":"Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease","volume":"41","author":"Deasy","year":"1989","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0305","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1902\/jop.1990.61.1.30","article-title":"In vitro release of doxycycline from bioabsorbable materials and acrylic strips","volume":"61","author":"Larsen","year":"1990","journal-title":"J. Periodontol."},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0310","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1600-051X.1995.tb01785.x","article-title":"Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide\/glycolide) film strips in SPT patients","volume":"22","author":"Maze","year":"1995","journal-title":"J. Clin. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0315","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1902\/jop.1989.60.2.113","article-title":"Application of a local drug delivery system to periodontal therapy: I. development of collagen preparations with immobilized tetracycline","volume":"60","author":"Minabe","year":"1989","journal-title":"J. Periodontol."},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0320","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1902\/jop.1990.61.7.393","article-title":"A new degradable controlled release device for treatment of periodontal disease: in vitro release study","volume":"61","author":"Steinberg","year":"1990","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0325","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1902\/jop.2008.070308","article-title":"Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study","volume":"79","author":"Paolantonio","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0330","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2014.06.021","article-title":"Recent advances in micro\/nanoscale biomedical implants","volume":"189","author":"Arsiwala","year":"2014","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0335","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/02652049709015331","article-title":"Biodegradable microparticles for sustained delivery of tetracycline to the periodontal pocket: formulatory and drug release studies","volume":"14","author":"Esposito","year":"1997","journal-title":"J. Microencapsul."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0340","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconrel.2007.01.008","article-title":"Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(epsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies","volume":"119","author":"Mundargi","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0345","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jddst.2019.04.031","article-title":"Influence of formulation parameters on encapsulation of doxycycline in PLGA microspheres prepared by double emulsion technique for the treatment of periodontitis","volume":"52","author":"Ali","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0350","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0501.2006.01269.x","article-title":"Antimicrobial therapy using a local drug delivery system (Arestin) in the treatment of peri-implantitis. I: microbiological outcomes","volume":"17","author":"Persson","year":"2006","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0355","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0757.2005.00143.x","article-title":"Nanotechnology and its role in the management of periodontal diseases","volume":"40","author":"Kong","year":"2006","journal-title":"Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0360","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2016.01.008","article-title":"Current applications of nanoparticles in infectious diseases","volume":"224","author":"Zazo","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0365","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jphotobiol.2016.01.002","article-title":"Green and ecofriendly synthesis of silver nanoparticles: characterization, biocompatibility studies and gel formulation for treatment of infections in burns","volume":"155","author":"Jadhav","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0370","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jconrel.2019.06.038","article-title":"Local drug delivery systems in the management of periodontitis: A scientific review","volume":"307","author":"Rajeshwari","year":"2019","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0375","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.tiv.2009.12.001","article-title":"Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism","volume":"24","author":"Park","year":"2010","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0380","first-page":"1677","article-title":"Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride","volume":"9","author":"Inkielewicz-Stepniak","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0385","first-page":"3963","article-title":"Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs","volume":"9","author":"Yao","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0390","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.msec.2014.09.004","article-title":"Physicochemical comparison of chitin and chitosan obtained from larvae and adult Colorado potato beetle (Leptinotarsa decemlineata)","volume":"45","author":"Kaya","year":"2014","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"8","key":"10.1016\/j.jconrel.2021.03.041_bb0395","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1517\/17425247.2011.586334","article-title":"Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale","volume":"8","author":"das Neves","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0400","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/157016311796799035","article-title":"Chitosan formulations as carriers for therapeutic proteins","volume":"8","author":"Andrade","year":"2011","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116163","article-title":"The effect of doxycycline-containing chitosan\/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease","volume":"237","author":"Xu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0410","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.ijbiomac.2018.09.057","article-title":"A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment","volume":"129","author":"Hu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.jconrel.2021.03.041_bb0415","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1002\/jbm.b.32788","article-title":"Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis","volume":"100","author":"Qin","year":"2012","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0420","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jbm.b.30596","article-title":"Application of chitosan gel in the treatment of chronic periodontitis","volume":"80","author":"Akncbay","year":"2007","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0425","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/10717544.2014.929195","article-title":"Preparation and characteristics of thermoresponsive gel of minocycline hydrochloride and evaluation of its effect on experimental periodontitis models","volume":"23","author":"Ruan","year":"2016","journal-title":"Drug Deliv."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0430","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2006.07.013","article-title":"Stability of poly(D,L-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems","volume":"115","author":"Dong","year":"2006","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0435","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/03639045.2012.660952","article-title":"Injectable PLA-based in situ forming implants for controlled release of Ivermectin a BCS class II drug: solvent selection based on physico-chemical characterization","volume":"39","author":"Camargo","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0440","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s11095-007-9478-y","article-title":"In vitro and in vivo drug release from a novel in situ forming drug delivery system","volume":"25","author":"Kranz","year":"2008","journal-title":"Pharm. Res."},{"issue":"2\u20133","key":"10.1016\/j.jconrel.2021.03.041_bb0445","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejps.2008.03.004","article-title":"Structure formation and characterization of injectable drug loaded biodegradable devices: in situ implants versus in situ microparticles","volume":"34","author":"Kranz","year":"2008","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0450","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/03639045.2012.746360","article-title":"Development of meloxicam in situ implant formulation by quality by design principle","volume":"40","author":"Ibrahim","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0455","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2174\/1567201814666171120120421","article-title":"Minocycline-loaded in situ hydrogel for periodontitis treatment","volume":"15","author":"Wang","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0460","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/molecules23092275","article-title":"Development and evaluation of minocycline hydrochloride-loaded in situ cubic liquid crystal for intra-periodontal pocket administration","volume":"23","author":"Yang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0465","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2020.05.004","article-title":"A tunable and injectable local drug delivery system for personalized periodontal application","volume":"324","author":"Wang","year":"2020","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0470","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10717544.2019.1571121","article-title":"Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation","volume":"26","author":"Mou","year":"2019","journal-title":"Drug Deliv."},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0475","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1080\/17425247.2017.1329297","article-title":"Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation","volume":"14","author":"Gad","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0480","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/08982104.2019.1566243","article-title":"Lycopene solid lipid microparticles with enhanced effect on gingival crevicular fluid protein carbonyl as a biomarker of oxidative stress in patients with chronic periodontitis","volume":"29","author":"Tawfik","year":"2019","journal-title":"J. Liposome Res."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0485","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1208\/s12249-019-1613-7","article-title":"Stimuli responsive in situ gelling systems loaded with PLGA nanoparticles of Moxifloxacin hydrochloride for effective treatment of periodontitis","volume":"21","author":"Beg","year":"2020","journal-title":"AAPS PharmSciTech"},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0490","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1902\/jop.1999.70.5.490","article-title":"Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis","volume":"70","author":"Garrett","year":"1999","journal-title":"J. Periodontol."},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0495","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1902\/jop.1993.64.7.637","article-title":"Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study","volume":"64","author":"van Steenberghe","year":"1993","journal-title":"J. Periodontol."},{"issue":"34","key":"10.1016\/j.jconrel.2021.03.041_bb0500","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.2174\/1381612826666200513112607","article-title":"Curcumin for the management of periodontal diseases: a review","volume":"26","author":"Forouzanfar","year":"2020","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0505","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0765.2010.01342.x","article-title":"Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo","volume":"46","author":"Guimaraes","year":"2011","journal-title":"J. Periodontal Res."},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0510","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1080\/03639045.2018.1439501","article-title":"Development, optimization and evaluation of curcumin loaded biodegradable crosslinked gelatin film for the effective treatment of periodontitis","volume":"44","author":"Chauhan","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0515","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1038\/s41598-018-24866-2","article-title":"Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease","volume":"8","author":"Zambrano","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0520","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0525","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4103\/0253-7613.115017","article-title":"Evaluation of anti-inflammatory effect of statins in chronic periodontitis","volume":"45","author":"Suresh","year":"2013","journal-title":"Ind. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0530","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejps.2018.08.037","article-title":"Development and in vitro evaluation of chitosan based system for local delivery of atorvastatin for treatment of periodontitis","volume":"124","author":"Isilay Ozdogan","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0535","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1166\/jnn.2017.13745","article-title":"Lipid nanostructures containing atorvastatin decrease lipopolysaccharide-induced inflammation in macrophages","volume":"17","author":"Moisei","year":"2017","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0540","doi-asserted-by":"crossref","first-page":"118860","DOI":"10.1016\/j.ijpharm.2019.118860","article-title":"Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases","volume":"573","author":"Lim","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0545","doi-asserted-by":"crossref","first-page":"118833","DOI":"10.1016\/j.ijpharm.2019.118833","article-title":"In-situ forming implants for the treatment of periodontal diseases: simultaneous controlled release of an antiseptic and an anti-inflammatory drug","volume":"572","author":"Lizambard","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0550","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jsps.2019.04.014","article-title":"A novel nanoformulation development of Eugenol and their treatment in inflammation and periodontitis","volume":"27","author":"Ahmad","year":"2019","journal-title":"Saudi Pharm. J."},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0555","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0022034518810213","article-title":"A novel thermoresponsive gel as a potential delivery system for lipoxin","volume":"98","author":"Wang","year":"2019","journal-title":"J. Dent. Res."},{"issue":"35","key":"10.1016\/j.jconrel.2021.03.041_bb0560","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1039\/C7NR02546G","article-title":"Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells","volume":"9","author":"Li","year":"2017","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0565","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0570","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2019.01.001","article-title":"An injectable and thermosensitive hydrogel: promoting periodontal regeneration by controlled-release of aspirin and erythropoietin","volume":"86","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0575","doi-asserted-by":"crossref","first-page":"118659","DOI":"10.1016\/j.ijpharm.2019.118659","article-title":"A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis","volume":"570","author":"Aminu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0580","doi-asserted-by":"crossref","first-page":"118564","DOI":"10.1016\/j.ijpharm.2019.118564","article-title":"In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: proof of concept study in vivo","volume":"569","author":"Batool","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0585","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1601-6343.2005.00352.x","article-title":"Current concepts in periodontal bioengineering","volume":"8","author":"Taba","year":"2005","journal-title":"Orthod. Craniofacial Res."},{"issue":"8 Suppl","key":"10.1016\/j.jconrel.2021.03.041_bb0590","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-051X.2008.01263.x","article-title":"Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials - biological foundation and preclinical evidence: a systematic review","volume":"35","author":"Sculean","year":"2008","journal-title":"J. Clin. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0595","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1708-8208.2007.00067.x","article-title":"Histopathological observations of a polylactic acid-based device intended for guided bone\/tissue regeneration","volume":"10","author":"Polimeni","year":"2008","journal-title":"Clin. Implant. Dent. Relat. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0600","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/app9061046","article-title":"Past, present, and future of regeneration therapy in Oral and periodontal tissue: a review","volume":"9","author":"Lee","year":"2019","journal-title":"Appl. Sci."},{"issue":"2\u20133","key":"10.1016\/j.jconrel.2021.03.041_bb0605","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0168-3659(97)00169-7","article-title":"Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration","volume":"51","author":"Park","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0610","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2020.01.045","article-title":"One-step treatment of periodontitis based on a core-shell micelle-in-nanofiber membrane with time-programmed drug release","volume":"320","author":"Liu","year":"2020","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2021.03.041_bb0615","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/0022034517736255","article-title":"Chitosan-based Trilayer scaffold for multitissue periodontal regeneration","volume":"97","author":"Varoni","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0620","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.colsurfb.2017.09.059","article-title":"Chitosan\/hydroxyapatite (HA)\/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes","volume":"160","author":"Iqbal","year":"2017","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0625","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1834-7819.2008.00019.x","article-title":"Stem cells and periodontal regeneration","volume":"53","author":"Lin","year":"2008","journal-title":"Aust. Dent. J."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0630","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/j.1582-4934.2010.01251.x","article-title":"Future dentistry: cell therapy meets tooth and periodontal repair and regeneration","volume":"15","author":"Caton","year":"2011","journal-title":"J. Cell. Mol. Med."},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0635","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2217\/nnm.12.146","article-title":"Nanodentistry: combining nanostructured materials and stem cells for dental tissue regeneration","volume":"7","author":"Mitsiadis","year":"2012","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0640","doi-asserted-by":"crossref","first-page":"6205910","DOI":"10.1155\/2016\/6205910","article-title":"Phase I\/II trial of autologous bone marrow stem cell transplantation with a three-dimensional woven-fabric scaffold for periodontitis","author":"Baba","year":"2016","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0645","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/prd.12062","article-title":"Cementum proteins: role in cementogenesis, biomineralization, periodontium formation and regeneration","volume":"67","author":"Arzate","year":"2015","journal-title":"Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0650","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/CBI20110168","article-title":"Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions","volume":"36","author":"Hoz","year":"2012","journal-title":"Cell Biol. Int."},{"issue":"38","key":"10.1016\/j.jconrel.2021.03.041_bb0655","doi-asserted-by":"crossref","first-page":"9990","DOI":"10.1016\/j.biomaterials.2013.09.030","article-title":"Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo","volume":"34","author":"Chang","year":"2013","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.jconrel.2021.03.041_bb0660","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1002\/jbm.a.34244","article-title":"Biocompatibility of PDGF-simvastatin double-walled PLGA (PDLLA) microspheres for dentoalveolar regeneration: a preliminary study","volume":"100","author":"Chang","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0665","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/jcpe.12406","article-title":"Human intrabony defect regeneration with rhFGF-2 and hyaluronic acid - a randomized controlled clinical trial","volume":"42","author":"de Santana","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0670","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.archoralbio.2017.05.022","article-title":"Effect of 1.2% of simvastatin gel as a local drug delivery system on gingival crevicular fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients","volume":"82","author":"Gunjiganur Vemanaradhya","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0675","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.2147\/IJN.S111701","article-title":"Fabrication of gelatin methacrylate\/nanohydroxyapatite microgel arrays for periodontal tissue regeneration","volume":"11","author":"Chen","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0680","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2147\/IJN.S184396","article-title":"Preparation and biological characterization of the mixture of poly(lactic-co-glycolic acid)\/chitosan\/Ag nanoparticles for periodontal tissue engineering","volume":"14","author":"Xue","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0685","first-page":"285","article-title":"Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs","volume":"11","author":"Lee","year":"2016","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0690","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0695","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/WCO.0000000000000797","article-title":"Linking mechanisms of periodontitis to Alzheimer\u2019s disease","volume":"33","author":"Sadrameli","year":"2020","journal-title":"Curr. Opin. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2021.03.041_bb0700","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000458411","article-title":"Is periodontal disease associated with Alzheimer\u2019s disease? A systematic review with meta-analysis","volume":"48","author":"Leira","year":"2017","journal-title":"Neuroepidemiology"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0705","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/prd.12304","article-title":"Mechanisms underlying the association between periodontitis and atherosclerotic disease","volume":"83","author":"Schenkein","year":"2020","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0710","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/prd.12326","article-title":"The association of periodontal diseases with metabolic syndrome and obesity","volume":"83","author":"Jepsen","year":"2020","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0715","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/prd.12300","article-title":"Periodontitis and rheumatoid arthritis: an update 2012-2017","volume":"83","author":"Bartold","year":"2020","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0720","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: a systematic review and meta-analysis","volume":"116","author":"Munoz Aguilera","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0725","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/prd.12295","article-title":"Periodontal diseases and adverse pregnancy outcomes: mechanisms","volume":"83","author":"Figuero","year":"2020","journal-title":"Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0730","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12299","article-title":"Periodontal therapy and cardiovascular risk","volume":"83","author":"Orlandi","year":"2020","journal-title":"Periodontol."},{"issue":"5","key":"10.1016\/j.jconrel.2021.03.041_bb0735","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1902\/jop.2008.070250","article-title":"Effects of periodontal therapy on glycemic control and inflammatory markers","volume":"79","author":"O\u2019Connell","year":"2008","journal-title":"J. Periodontol."},{"issue":"12","key":"10.1016\/j.jconrel.2021.03.041_bb0740","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1902\/jop.1988.59.12.816","article-title":"CPITN assessment of periodontal disease in diabetic patients","volume":"59","author":"Bacic","year":"1988","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0745","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1902\/jop.1991.62.2.123","article-title":"Periodontal disease in non-insulin-dependent diabetes mellitus","volume":"62","author":"Emrich","year":"1991","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0750","doi-asserted-by":"crossref","first-page":"532","DOI":"10.14219\/jada.archive.1990.0211","article-title":"Type 2 diabetes mellitus and periodontal disease","volume":"121","author":"Shlossman","year":"1990","journal-title":"J. Am. Dent. Assoc."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0755","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-051X.1993.tb00384.x","article-title":"Long-term control of diabetes mellitus and periodontitis","volume":"20","author":"Tervonen","year":"1993","journal-title":"J. Clin. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0760","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1208\/s12249-013-9978-5","article-title":"25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models","volume":"14","author":"Li","year":"2013","journal-title":"AAPS PharmSciTech"},{"issue":"10","key":"10.1016\/j.jconrel.2021.03.041_bb0765","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1902\/jop.2012.110292","article-title":"Local drug delivery of alendronate gel for the treatment of patients with chronic periodontitis with diabetes mellitus: a double-masked controlled clinical trial","volume":"83","author":"Pradeep","year":"2012","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0770","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ijms19113488","article-title":"Metformin hydrochloride-loaded PLGA nanoparticle in periodontal disease experimental model using diabetic rats","volume":"19","author":"Pereira","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2021.03.041_bb0775","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/molecules22071180","article-title":"Resveratrol improves glycemic control in type 2 diabetic obese mice by regulating glucose transporter expression in skeletal muscle and liver","volume":"22","author":"Yonamine","year":"2017","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jconrel.2021.03.041_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042271","article-title":"Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun","volume":"7","author":"Martinez-Mora","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2021.03.041_bb0785","first-page":"1","article-title":"Chemoprevention of experimental periodontitis in diabetic rats with silk fibroin nanoparticles loaded with resveratrol","volume":"9","author":"Gimenez-Siurana","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0790","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0528.1999.tb01987.x","article-title":"Cigarette smoking and periodontitis: methodology to assess the strength of evidence in support of a causal association","volume":"27","author":"Gelskey","year":"1999","journal-title":"Community Dent. Oral Epidemiol."},{"issue":"8","key":"10.1016\/j.jconrel.2021.03.041_bb0795","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1902\/jop.2012.120298","article-title":"Locally delivered 1% metformin gel in the treatment of smokers with chronic periodontitis: a randomized controlled clinical trial","volume":"84","author":"Rao","year":"2013","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.jconrel.2021.03.041_bb0800","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/adj.12042","article-title":"Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial","volume":"58","author":"Rao","year":"2013","journal-title":"Aust. Dent. J."},{"issue":"6","key":"10.1016\/j.jconrel.2021.03.041_bb0805","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s00784-019-03067-9","article-title":"Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats","volume":"24","author":"de Souza Malta","year":"2020","journal-title":"Clin. Oral Investig."},{"issue":"4","key":"10.1016\/j.jconrel.2021.03.041_bb0810","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jre.12442","article-title":"Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats","volume":"52","author":"Messora","year":"2017","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.jconrel.2021.03.041_bb0815","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3920\/BM2019.0038","article-title":"Effects of Bifidobacterium animalis subsp. lactis HN019 on ligature-induced periodontitis in rats with experimental rheumatoid arthritis","volume":"11","author":"Cardoso","year":"2020","journal-title":"Benefic. Microbes"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921001528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365921001528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:57:56Z","timestamp":1759161476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365921001528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":163,"alternative-id":["S0168365921001528"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.03.041","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2021.03.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}