{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:29:30Z","timestamp":1793212170002,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jconrel.2022.05.017","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T12:48:39Z","timestamp":1652878119000},"page":"356-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant"],"prefix":"10.1016","volume":"347","author":[{"given":"Matthew D.","family":"Gallovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Junkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Sandor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Sample","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel K.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslee C.","family":"Arwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Sahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Bachelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy M.","family":"Ainslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Sempowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny P.-Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2022.05.017_bb0005","series-title":"Up to 650 000 people die of respiratory diseases linked to seasonal flu each year","author":"World Health Organization","year":"2017"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0010","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.vaccine.2007.03.046","article-title":"The annual impact of seasonal influenza in the US: measuring disease burden and costs","volume":"25","author":"Molinari","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0015","series-title":"Influenza (flu)","author":"Centers for Disease Control and Prevention","year":"2018"},{"issue":"1","key":"10.1016\/j.jconrel.2022.05.017_bb0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMp1714916","article-title":"Chasing seasonal influenza - the need for a universal influenza vaccine","volume":"378","author":"Paules","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006682","article-title":"A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine","volume":"13","author":"Wu","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0030","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1073\/pnas.1712377114","article-title":"Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains","volume":"114","author":"Zost","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0035","article-title":"Low and decreasing vaccine effectiveness against influenza A(H3) in 2011\/12 among vaccination target groups in Europe: results from the I-MOVE multicentre case-control study, euro surveillance\u202f: bulletin Europeen sur les maladies transmissibles =","volume":"18","author":"Kissling","year":"2013","journal-title":"Eur. Commun. Dis. Bull."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0040","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/infdis\/jix478","article-title":"Randomized comparison of immunogenicity and safety of Quadrivalent recombinant versus inactivated influenza vaccine in healthy adults 18-49 years of age","volume":"216","author":"Dunkle","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0045","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1016\/j.vaccine.2011.09.061","article-title":"The mechanism of action of MF59\u2013an innately attractive adjuvant formulation","volume":"30","author":"O\u2019Hagan","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0050","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1586\/14760584.6.5.699","article-title":"MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection","volume":"6","author":"O\u2019Hagan","year":"2007","journal-title":"Expert review of vaccines"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0055","series-title":"Seminars in immunology","article-title":"Correlates of adjuvanticity: A review on adjuvants in licensed vaccines","author":"Del Giudice","year":"2018"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0060","doi-asserted-by":"crossref","first-page":"12294","DOI":"10.1073\/pnas.1400478111","article-title":"Unleashing the potential of NOD-and toll-like agonists as vaccine adjuvants","volume":"111","author":"Maisonneuve","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003188","article-title":"Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia","volume":"9","author":"Hogner","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of toll-like receptors\u2014redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.it.2016.12.004","article-title":"Crosstalk between cytoplasmic RIG-I and STING sensing pathways","volume":"38","author":"Zevini","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0080","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1172\/JCI79915","article-title":"Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants","volume":"125","author":"Hanson","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jconrel.2022.05.017_bb0085","doi-asserted-by":"crossref","first-page":"1600013","DOI":"10.1002\/adbi.201600013","article-title":"Liposomal delivery enhances immune activation by STING agonists for Cancer immunotherapy, advanced","volume":"Feb","author":"Koshy","year":"2017","journal-title":"Biosystems"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.actbio.2015.10.025","article-title":"Submicron-sized hydrogels incorporating cyclic dinucleotides for selective delivery and elevated cytokine release in macrophages","volume":"29","author":"Lee","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2015.08.026","article-title":"Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma","volume":"216","author":"Nakamura","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0100","first-page":"237","article-title":"Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy, Nanomedicine: nanotechnology","volume":"14","author":"Wilson","year":"2018","journal-title":"Biol. and Med."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0105","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.vaccine.2017.03.067","article-title":"Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis","volume":"35","author":"Goodwin","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2017.11.030","article-title":"A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination","volume":"270","author":"Junkins","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114020","article-title":"Delivery of STING agonists for adjuvanting subunit vaccines","volume":"179","author":"Van Herck","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.753472","article-title":"Pharmacological activation of cGAS for Cancer immunotherapy","volume":"12","author":"Garland","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imr.12765","article-title":"STING pathway agonism as a cancer therapeutic","volume":"290","author":"Flood","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0130","doi-asserted-by":"crossref","first-page":"11109","DOI":"10.1021\/acs.chemrev.5b00109","article-title":"Synthetic nanoparticles for vaccines and immunotherapy","volume":"115","author":"Irvine","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bit.21301","article-title":"Microparticles and nanoparticles for drug delivery","volume":"96","author":"Kohane","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0140","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1021\/ja803947s","article-title":"Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications","volume":"130","author":"Bachelder","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0145","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1073\/pnas.0901592106","article-title":"Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy","volume":"106","author":"Broaders","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0150","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/am3008888","article-title":"Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product","volume":"4","author":"Kauffman","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0155","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1021\/acs.chemrev.6b00532","article-title":"Acetalated dextran: a tunable and acid-labile biopolymer with facile synthesis and a range of applications","volume":"117","author":"Bachelder","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0160","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1021\/mp300643d","article-title":"Efficient delivery of the toll-like receptor agonists polyinosinic:polycytidylic acid and CpG to macrophages by acetalated dextran microparticles","volume":"10","author":"Peine","year":"2013","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.jconrel.2022.05.017_bb0165","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1021\/acs.molpharmaceut.8b00579","article-title":"Acetalated dextran microparticles for co-delivery of STING and TLR7\/8 agonists","volume":"15","author":"Collier","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0170","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2012.04.043","article-title":"Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions","volume":"431","author":"Kanthamneni","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.biomaterials.2019.03.011","article-title":"A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8(+) T cell-mediated anti-tumor immunity","volume":"205","author":"Watkins-Schulz","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0180","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1242\/dmm.007823","article-title":"The ferret as a model organism to study influenza a virus infection","volume":"4","author":"Belser","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0185","first-page":"15G.2.1","article-title":"The ferret model for influenza","volume":"13","author":"Matsuoka","year":"2009","journal-title":"Curr. Protoc. Microbiol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0190","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/laban1004-50","article-title":"The ferret: an animal model to study influenza virus","volume":"33","author":"Maher","year":"2004","journal-title":"Lab Anim (NY)"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0195","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0810","article-title":"Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity","volume":"367","author":"Wang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0200","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0205","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.4049\/jimmunol.1402071","article-title":"MF59 mediates its B cell Adjuvanticity by promoting T follicular helper cells and thus germinal center responses in adult and early life","volume":"194","author":"Mastelic Gavillet","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0210","first-page":"746","article-title":"Factors associated with the uptake of seasonal influenza vaccination in adults: a systematic review","volume":"38","author":"Yeung","year":"2016","journal-title":"J Public Health (Oxf)"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0215","first-page":"1235","article-title":"Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge","volume":"11","author":"Major","year":"2015","journal-title":"Hum. Vacc. & Immunother."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0220","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molcel.2013.05.022","article-title":"Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110150","article-title":"Cyclic GMP-AMP displays mucosal adjuvant activity in mice","volume":"9","author":"Skrnjug","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jconrel.2022.05.017_bb0230","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.jid.2016.05.105","article-title":"Natural STING agonist as an \u201cideal\u201d adjuvant for cutaneous vaccination","volume":"136","author":"Wang","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jconrel.2014.04.004","article-title":"A new adjuvant delivery system 'cyclic di-GMP\/YSK05 liposome' for cancer immunotherapy","volume":"184","author":"Miyabe","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0240","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jconrel.2018.09.020","article-title":"Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy","volume":"289","author":"Chen","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0245","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0250","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1073\/pnas.0600997103","article-title":"Role of target geometry in phagocytosis","volume":"103","author":"Champion","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0255","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41565-018-0274-0","article-title":"Physical activation of innate immunity by spiky particles","volume":"13","author":"Wang","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0260","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fimmu.2017.01223","article-title":"Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against influenza H5N1 in mice","volume":"8","author":"Ebensen","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0265","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1016\/j.vaccine.2011.04.094","article-title":"Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice","volume":"29","author":"Madhun","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0270","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1016\/j.vaccine.2014.04.011","article-title":"A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung","volume":"32","author":"Neuhaus","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026973","article-title":"Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP","volume":"6","author":"Pedersen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104824","article-title":"Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellular immune responses and provides protection against virus challenge","volume":"9","author":"Sanchez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0285","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.nano.2017.05.012","article-title":"Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice","volume":"13","author":"Schulze","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0290","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/irv.12056","article-title":"A study of chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine","volume":"7","author":"Svindland","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0295","article-title":"cGAMP promotes germinal center formation and production of IgA in nasal-associated lymphoid tissue","volume":"5","author":"Takaki","year":"2017","journal-title":"Med Sci (Basel)"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0300","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1016\/j.vaccine.2017.05.053","article-title":"Nontoxic outer membrane vesicles efficiently increase the efficacy of an influenza vaccine in mice and ferrets","volume":"35","author":"Shim","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0305","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1016\/j.vaccine.2017.04.055","article-title":"Carbohydrate fatty acid monosulphate esters are safe and effective adjuvants for humoral responses","volume":"35","author":"Hilgers","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0310","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0315","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1039\/C5BM00451A","article-title":"Chemically modified inulin microparticles serving dual function as a protein antigen delivery vehicle and immunostimulatory adjuvant","volume":"4","author":"Gallovic","year":"2016","journal-title":"Biomaterials Sci."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0320","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0166-0934(89)90004-9","article-title":"Assessment of signs of influenza illness in the ferret model","volume":"24","author":"Reuman","year":"1989","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027512","article-title":"Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2022.05.017_bb0330","first-page":"24","article-title":"Different receptor specificity of influence viruses from ducks and chickens and its reflection in the composition of sialosides on host cells and mucins","volume":"51","author":"Gambarian","year":"2006","journal-title":"Vopr. Virusol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0335","first-page":"191","article-title":"Influenza-mediated lung infection models","volume":"2019","author":"McGee","year":"1960","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0340","unstructured":"Immunology and Pathogenesis Branch\/Influenza Division\/CDC. Influenza virus microneutralization assay. Updated September 2007."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0345","unstructured":"World Health Organization. Serological diagnosis of influenza by microneutralization assay. Updated December 2010."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0350","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/srep00357","article-title":"Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection","volume":"2","author":"Koutsonanos","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2022.05.017_bb0355","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.vaccine.2016.01.024","article-title":"Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface","volume":"34","author":"Samo","year":"2016","journal-title":"Vaccine"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922002796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922002796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:25:34Z","timestamp":1759163134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365922002796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":71,"alternative-id":["S0168365922002796"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.05.017","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STING agonist-containing microparticles improve seasonal influenza vaccine efficacy and durability in ferrets over standard adjuvant","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}