{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:58:28Z","timestamp":1791903508803,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["JPMJPR19K8"],"award-info":[{"award-number":["JPMJPR19K8"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jconrel.2022.06.017","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T05:51:22Z","timestamp":1655531482000},"page":"648-659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"special_numbering":"C","title":["On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device"],"prefix":"10.1016","volume":"348","author":[{"given":"Kento","family":"Okuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Iwakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Maeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tokeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyoshi","family":"Harashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2022.06.017_bb0005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd4278","article-title":"mRNA-based therapeutics--developing a new class of drugs","volume":"13","author":"Sahin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0015","first-page":"1","article-title":"Drug delivery systems for RNA therapeutics, nature reviews","author":"Paunovska","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0020","article-title":"Nanomaterial delivery systems for mRNA vaccines","volume":"9","author":"Buschmann","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0025","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s40265-018-0983-6","article-title":"Patisiran: first global approval","volume":"78","author":"Hoy","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s40265-021-01480-7","article-title":"BNT162b2 mRNA COVID-19 vaccine: first approval","volume":"81","author":"Lamb","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0035","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1248\/cpb.c21-00705","article-title":"Development of lipid nanoparticles for the delivery of macromolecules based on the molecular design of pH-sensitive cationic lipids","volume":"69","author":"Sato","year":"2021","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2020.03.006","article-title":"Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E\/low density lipoprotein receptor and the N-acetyl-d-galactosamine\/asialoglycoprotein receptor pathway","volume":"322","author":"Sato","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0045","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/mt.2010.85","article-title":"Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms","volume":"18","author":"Akinc","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0050","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1021\/acsnano.7b04734","article-title":"Next-generation lipids in RNA interference therapeutics","volume":"11","author":"Rietwyk","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nbt.1602","article-title":"Rational design of cationic lipids for siRNA delivery","volume":"28","author":"Semple","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature04688","article-title":"RNAi-mediated gene silencing in non-human primates","volume":"441","author":"Zimmermann","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0065","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jconrel.2019.01.001","article-title":"Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo","volume":"295","author":"Sato","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0070","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/mt.2013.124","article-title":"Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics","volume":"21","author":"Maier","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0075","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1002\/anie.201203263","article-title":"Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo","volume":"51","author":"Jayaraman","year":"2012","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120826","article-title":"Microfluidic formulation of nanoparticles for biomedical applications","volume":"274","author":"Shepherd","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0085","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1021\/la204833h","article-title":"Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing","volume":"28","author":"Zhigaltsev","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0090","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1021\/acsomega.8b00341","article-title":"Development of the iLiNP device: fine tuning the lipid nanoparticle size within 10 nm for drug delivery","volume":"3","author":"Kimura","year":"2018","journal-title":"Acs Omega"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0095","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1021\/acsnano.8b01516","article-title":"On the formation and morphology of lipid nanoparticles containing Ionizable cationic lipids and siRNA","volume":"12","author":"Kulkarni","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0100","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1039\/C9NR02004G","article-title":"Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads","volume":"11","author":"Kulkarni","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0105","doi-asserted-by":"crossref","first-page":"E3351","DOI":"10.1073\/pnas.1720542115","article-title":"Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles","volume":"115","author":"Yanez Arteta","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2012.28","article-title":"Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA","volume":"1","author":"Belliveau","year":"2012","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2016.03.019","article-title":"Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery","volume":"229","author":"Sato","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0120","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.actbio.2019.11.022","article-title":"Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles","volume":"102","author":"Sato","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0125","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1016\/S0006-3495(98)77732-X","article-title":"Experimental and Monte Carlo simulation studies of the thermodynamics of polyethyleneglycol chains grafted to lipid bilayers","volume":"75","author":"Rex","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0130","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1021\/jp101415g","article-title":"A molecular view of the cholesterol condensing effect in DOPC lipid bilayers","volume":"114","author":"Alwarawrah","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12111095","article-title":"Manufacturing considerations for the development of lipid nanoparticles using microfluidics","volume":"12","author":"Roces","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0140","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1021\/acs.langmuir.0c03039","article-title":"Characterization of lipid nanoparticles containing Ionizable cationic lipids using design-of-experiments approach","volume":"37","author":"Terada","year":"2021","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0145","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jconrel.2021.05.021","article-title":"Impact of lipid nanoparticle size on mRNA vaccine immunogenicity","volume":"335","author":"Hassett","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijpharm.2014.10.030","article-title":"High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization","volume":"477","author":"Kastner","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0155","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/mt.2015.222","article-title":"Relationship between the physicochemical properties of lipid nanoparticles and the quality of siRNA delivery to liver cells","volume":"24","author":"Sato","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2353\/ajpath.2010.090136","article-title":"The role of liver sinusoidal cells in hepatocyte-directed gene transfer","volume":"176","author":"Jacobs","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/gt.2011.17","article-title":"Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation","volume":"18","author":"Diken","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0170","article-title":"Macropinocytosis in different cell types: similarities and differences","volume":"10","author":"Lin","year":"2020","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1021\/mp3005337","article-title":"Assessing the heterogeneity level in lipid nanoparticles for siRNA delivery: size-based separation, compositional heterogeneity, and impact on bioperformance","volume":"10","author":"Zhang","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cis.2011.06.003","article-title":"The model of hydrophobic attraction in the framework of classical DLVO forces","volume":"168","author":"Mishchuk","year":"2011","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jconrel.2020.08.031","article-title":"The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery","volume":"327","author":"Hashiba","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0190","doi-asserted-by":"crossref","first-page":"7610","DOI":"10.1021\/cr400544s","article-title":"Mechanisms of nucleation and growth of nanoparticles in solution","volume":"114","author":"Thanh","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0195","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/gt.2008.60","article-title":"The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer","volume":"15","author":"Wisse","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0200","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jconrel.2020.12.013","article-title":"Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition","volume":"330","author":"Suzuki","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.abb.2014.07.031","article-title":"Toward understanding driving forces in membrane protein folding","volume":"564","author":"Hong","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0210","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2012.09.009","article-title":"A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo","volume":"163","author":"Sato","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0215","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.1021\/jp004576m","article-title":"A definition of the degree of ionization of a micelle based on its aggregation number","volume":"105","author":"Bales","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0220","doi-asserted-by":"crossref","first-page":"5696","DOI":"10.1021\/jp0216981","article-title":"Hofmeister effects in the stability and electrophoretic mobility of polystyrene latex particles","volume":"107","author":"L\u00f3pez-Le\u00f3n","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0225","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cocis.2004.05.005","article-title":"\u2018Zur Lehre von der Wirkung der Salze\u2019 (about the science of the effect of salts): Franz Hofmeister\u2019s historical papers","volume":"9","author":"Kunz","year":"2004","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0230","doi-asserted-by":"crossref","first-page":"16060","DOI":"10.1021\/jp803796a","article-title":"Hofmeister effects in colloidal systems: influence of the surface nature","volume":"112","author":"L\u00f3pez-Le\u00f3n","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0235","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature18300","article-title":"Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy","volume":"534","author":"Kranz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0240","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8","volume":"303","author":"Heil","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2022.06.017_bb0245","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.4049\/jimmunol.1400840","article-title":"Stimulation of the RIG-I\/MAVS pathway by polyinosinic:polycytidylic acid upregulates IFN-\u03b2 in airway epithelial cells with minimal costimulation of IL-8","volume":"195","author":"Dauletbaev","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2022.06.017_bb0250","doi-asserted-by":"crossref","first-page":"eaaz6893","DOI":"10.1126\/sciadv.aaz6893","article-title":"Impact of mRNA chemistry and manufacturing process on innate immune activation","volume":"6","author":"Nelson","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922003467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922003467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:34:54Z","timestamp":1759163694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365922003467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":50,"alternative-id":["S0168365922003467"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.06.017","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}