{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:01:08Z","timestamp":1791298868091,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2021-1347"],"award-info":[{"award-number":["075-15-2021-1347"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-72-30012"],"award-info":[{"award-number":["19-72-30012"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013666","name":"University at Buffalo Office of the Vice President for Research and Economic Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-29-04012"],"award-info":[{"award-number":["19-29-04012"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jconrel.2022.07.007","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T18:52:19Z","timestamp":1658170339000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging"],"prefix":"10.1016","volume":"349","author":[{"given":"I.V.","family":"Zelepukin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.N.","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.B.","family":"Mirkasymov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.G.","family":"Shevchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.N.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.V.","family":"Kabashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Deyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2022.07.007_bb0005","first-page":"R23","article-title":"Imaging modalities in x-ray computerized tomography and in selected volume tomography","volume":"44","author":"Carlsson","year":"1999","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0010","first-page":"633","article-title":"Molecular body imaging: MR imaging, CT, and US. Part I. principles","volume":"263","author":"Kircher","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0015","first-page":"1055","article-title":"The role of modern molecular imaging techniques in gastroenterology","volume":"135","author":"Basu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0020","first-page":"160","article-title":"Imaging of the gastrointestinal tract-novel technologies","volume":"15","author":"Fr\u00f8kjaer","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0025","first-page":"1538","article-title":"Gastrointestinal cancer imaging: deeper than the eye can see","volume":"128","author":"Kwon","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0030","first-page":"72","article-title":"Revisiting oral barium sulfate contrast agents","volume":"14","author":"O'Connor","year":"2007","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0035","first-page":"53","article-title":"Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy","volume":"9","author":"Curry","year":"2014","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0040","first-page":"2641","article-title":"Nano-sized CT contrast agents","volume":"25","author":"Lee","year":"2013","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0045","first-page":"257","article-title":"Nanoparticles as computed tomography contrast agents: current status and future perspectives","volume":"7","author":"Shilo","year":"2012","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0050","first-page":"10","article-title":"Nanoparticles in the clinic","volume":"1","author":"Anselmo","year":"2016","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0055","first-page":"9841","article-title":"Laser-processed Nanosilicon: a multifunctional nanomaterial for energy and healthcare","volume":"13","author":"Kabashin","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0060","first-page":"565","article-title":"Photon cross sections from 1 keV to 100 MeV for elements Z=1 to Z=100","volume":"7","author":"Storm","year":"1970","journal-title":"At. Data Nucl. Data Tables"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0065","first-page":"10","article-title":"World market of bismuth: a review","volume":"48","author":"Naumov","year":"2007","journal-title":"Russ. J. Non-ferrous Metals"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0070","first-page":"459","article-title":"Review article: safety of bismuth in the treatment of gastrointestinal diseases","volume":"10","author":"Tillman","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0075","first-page":"4540","article-title":"Metallodrugs in medicinal inorganic chemistry","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0080","first-page":"1555","article-title":"Synthesis and characterization of nanostructured powders of Bi2O3, BiOCl and bi","volume":"64","author":"L\u00f3pez-Salinas","year":"2010","journal-title":"Mater. Lett."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0085","first-page":"84","article-title":"Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability","volume":"4","author":"Lamson","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0090","first-page":"434","article-title":"Physicochemical factors that affect metal and metal oxide nanoparticle passage across epithelial barriers, Wiley Interdiscip","volume":"1","author":"Elder","year":"2009","journal-title":"Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0095","first-page":"403","article-title":"Toxicity of MRI and CT contrast agents","volume":"5","author":"Hasebroock","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0100","first-page":"4886","article-title":"Large-scale synthesis of bi(2)S(3) nanodots as a contrast agent for in vivo X-ray computed tomography imaging","volume":"23","author":"Ai","year":"2011","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0105","first-page":"2266","article-title":"Synthesis, X-ray opacity, and biological compatibility of ultra-high payload elemental bismuth nanoparticle X-ray contrast agents","volume":"26","author":"Brown","year":"2014","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0110","first-page":"10189","article-title":"Synthesis, characterization, and X-ray attenuation properties of ultrasmall BiOI nanoparticles: toward renal clearable particulate CT contrast agents","volume":"53","author":"Kandanapitiye","year":"2014","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0115","first-page":"1","article-title":"Bi-DTPA as a high-performance CT contrast agent for in vivo imaging","volume":"203","author":"Liao","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0120","first-page":"9635","article-title":"Computed tomography in color: NanoK-enhanced spectral CT molecular imaging","volume":"49","author":"Pan","year":"2010","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0125","first-page":"118","article-title":"An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles","volume":"5","author":"Rabin","year":"2006","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0130","first-page":"12720","article-title":"Facile synthesis of uniform-sized bismuth nanoparticles for CT visualization of gastrointestinal tract in vivo","volume":"8","author":"Wei","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0135","first-page":"1718","article-title":"Metabolizable bi 2 se 3 Nanoplates: biodistribution, toxicity, and uses for Cancer radiation therapy and imaging","volume":"24","author":"Zhang","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0140","first-page":"1599","article-title":"pH-dependent synthesis and stability of aqueous, elemental bismuth Glyconanoparticle colloids: potentially biocompatible X-ray contrast agents","volume":"24","author":"Brown","year":"2012","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0145","first-page":"20831","article-title":"Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0150","article-title":"Allicin alleviates dextran sodium sulfate- (DSS-) induced ulcerative colitis in BALB\/c mice","volume":"2015","author":"Pandurangan","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0155","first-page":"541","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0160","first-page":"479","article-title":"Citric acid modulated electrochemical synthesis and photocatalytic behavior of BiOCl nanoplates with exposed {001} facets","volume":"43","author":"Xu","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0165","first-page":"238","article-title":"Controllable synthesis of {001} facet dependent foursquare BiOCl nanosheets: a high efficiency photocatalyst for degradation of methyl orange","volume":"695","author":"Li","year":"2017","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0170","first-page":"6740","article-title":"Visible-light photocatalytic removal of NO in air over BiOX (X = cl, Br, I) single-crystal Nanoplates prepared at room temperature","volume":"52","author":"Zhang","year":"2013","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0175","first-page":"50701","article-title":"Facile one-step hydrothermal synthesis of noble-metal-free hetero-structural ternary composites and their application in photocatalytic water purification","volume":"7","author":"Zhang","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0180","article-title":"Silica nanoparticles in Transmucosal drug delivery","volume":"12","author":"Ways","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0185","first-page":"289","article-title":"Emerging technologies to increase gastrointestinal transit times of drug delivery systems","volume":"346","author":"Kali","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0190","article-title":"Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles","author":"Zhang","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0195","first-page":"10187","article-title":"Dextran-coated cerium oxide nanoparticles: a computed tomography contrast agent for imaging the gastrointestinal tract and inflammatory bowel disease","volume":"14","author":"Naha","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0200","first-page":"328","article-title":"Effect of pH on the association behavior in aqueous solutions of pig gastric mucin","volume":"343","author":"Maleki","year":"2008","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0205","first-page":"65","article-title":"Effects of isoflurane on gastrointestinal motility after brief exposure in rats","volume":"294","author":"Torjman","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0210","first-page":"272ra11","article-title":"Regulation of dendrimer\/dextran material performance by altered tissue microenvironment in inflammation and neoplasia","volume":"7","author":"Oliva","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0215","first-page":"261","article-title":"Dextran and carrageenan evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin","volume":"221","author":"Lo","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0220","article-title":"The Hemocompatibility of nanoparticles: a review of cell-nanoparticle interactions and hemostasis","volume":"8","author":"de La Harpe","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0225","first-page":"5080","article-title":"BiVO4@Bi2S3 heterojunction Nanorods with enhanced charge separation efficiency for multimodal imaging and synergy therapy of tumor","volume":"3","author":"Wang","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0230","first-page":"4235","article-title":"Size-controlled synthesis of BiPO4 nanocrystals for enhanced photocatalytic performance","volume":"21","author":"Pan","year":"2011","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0235","article-title":"Long-term fate of magnetic particles in mice: a comprehensive study","author":"Zelepukin","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0240","first-page":"1930","article-title":"Diffusion of macromolecules and virus-like particles in human cervical mucus","volume":"81","author":"Olmsted","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0245","first-page":"16631","article-title":"Shape effect in cellular uptake of PEGylated nanoparticles: comparison between sphere, rod, cube and disk","volume":"7","author":"Li","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0250","first-page":"315","article-title":"The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration","volume":"18","author":"Tob\u0131\u0301o","year":"2000","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2022.07.007_bb0255","first-page":"280","article-title":"In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration","volume":"97","author":"Inchaurraga","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0260","first-page":"1832","article-title":"Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass index","volume":"21","author":"Hellmig","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0265","first-page":"269","article-title":"Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH","volume":"86","author":"Charman","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2022.07.007_bb0270","first-page":"48","article-title":"Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse","volume":"197","author":"Maisel","year":"2015","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922004175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922004175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:28:15Z","timestamp":1759163295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365922004175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":54,"alternative-id":["S0168365922004175"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.07.007","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}