{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:45Z","timestamp":1791406965304,"version":"4.3.3"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA257958-01A1"],"award-info":[{"award-number":["R01CA257958-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS106379"],"award-info":[{"award-number":["R01NS106379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS122395"],"award-info":[{"award-number":["R01NS122395"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jconrel.2022.07.008","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T20:14:36Z","timestamp":1657829676000},"page":"413-424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Indocarbocyanine nanoparticles extravasate and distribute better than liposomes in brain tumors"],"prefix":"10.1016","volume":"349","author":[{"given":"Irina V.","family":"Balyasnikova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markella","family":"Zannikou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guankui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca N.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Seblani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmant","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Simberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2022.07.008_bb0005","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0010","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/neuonc\/now182","article-title":"Tumor treating fields: a novel treatment modality and its use in brain tumors","volume":"18","author":"Hottinger","year":"2016","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00006123-199608000-00001","article-title":"Glioma invasion in the central nervous system","volume":"39","author":"Giese","year":"1996","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2015.03.015","article-title":"Mechanisms regulating glioma invasion","volume":"362","author":"Paw","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/pr.117.014944","article-title":"Current challenges and opportunities in treating glioblastoma","volume":"70","author":"Shergalis","year":"2018","journal-title":"Pharmacol. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.jconrel.2022.07.008_bb0030","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/neuonc\/nox237.013","article-title":"Irradiation of glioblastoma cells can promote enhanced motility and invasiveness, both in vitro and in vivo through activation of MRCK","volume":"20","author":"Birch","year":"2018","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1667\/RR2773.1","article-title":"Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS)","volume":"177","author":"Park","year":"2012","journal-title":"Radiat. Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0040","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1158\/2326-6066.CIR-16-0376","article-title":"Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen loss variants","volume":"5","author":"Krenciute","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11060-011-0564-y","article-title":"Tissue concentration of systemically administered antineoplastic agents in human brain tumors","volume":"104","author":"Pitz","year":"2011","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0055","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1158\/1078-0432.CCR-10-1564","article-title":"Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer","volume":"16","author":"Lockman","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0060","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/neuonc\/nox175","article-title":"Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data","volume":"20","author":"Sarkaria","year":"2018","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41568-019-0205-x","article-title":"The blood-brain barrier and blood-tumour barrier in brain tumours and metastases","volume":"20","author":"Arvanitis","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3171\/2016.1.JNS151591","article-title":"Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies","volume":"126","author":"Jahangiri","year":"2017","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0075","doi-asserted-by":"crossref","first-page":"E8717","DOI":"10.1073\/pnas.1807105115","article-title":"Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption","volume":"115","author":"Arvanitis","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0080","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1039\/C8CS00805A","article-title":"Emerging blood-brain-barrier-crossing nanotechnology for brain cancer theranostics","volume":"48","author":"Tang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0085","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1080\/10717544.2017.1378940","article-title":"Glioma and microenvironment dual targeted nanocarrier for improved antiglioblastoma efficacy","volume":"24","author":"Wang","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0090","first-page":"1629","article-title":"C(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma","volume":"11","author":"Huang","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0095","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1080\/10717544.2018.1509907","article-title":"PD-1\/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer","volume":"25","author":"Sun","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0100","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1158\/0008-5472.CAN-10-0339","article-title":"Targeted nanoparticles that deliver a sustained, specific release of paclitaxel to irradiated tumors","volume":"70","author":"Passarella","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0105","article-title":"Sequential targeting in crosslinking nanotheranostics for tackling the multibarriers of brain tumors","volume":"32","author":"Wu","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0110","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1158\/0008-5472.CAN-13-2787","article-title":"Future opportunities in cancer nanotechnology--NCI strategic workshop report","volume":"74","author":"Grodzinski","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0115","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biotechadv.2013.08.003","article-title":"Highlights of recent developments and trends in cancer nanotechnology research--view from NCI alliance for nanotechnology in cancer","volume":"32","author":"Hull","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0120","first-page":"20130001","article-title":"From seeing to believing: labelling strategies for in vivo cell-tracking experiments, Interface","volume":"3","author":"Progatzky","year":"2013","journal-title":"Focus"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0125","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1113\/jphysiol.2010.202820","article-title":"Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung\u2019s disease","volume":"589","author":"Zagorodnyuk","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0130","doi-asserted-by":"crossref","DOI":"10.1117\/1.2364903","article-title":"Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing","volume":"11","author":"Kalchenko","year":"2006","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature07434","article-title":"Live-animal tracking of individual haematopoietic stem\/progenitor cells in their niche","volume":"457","author":"Lo Celso","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jconrel.2020.07.019","article-title":"Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles","volume":"326","author":"Yang","year":"2020","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0145","doi-asserted-by":"crossref","first-page":"11880","DOI":"10.1021\/acsnano.1c02982","article-title":"Liposomal extravasation and accumulation in tumors as studied by fluorescence microscopy and imaging depend on the fluorescent label","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.605255","article-title":"Organoid models of glioblastoma and their role in drug discovery","volume":"15","author":"Rybin","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0155","doi-asserted-by":"crossref","first-page":"21162","DOI":"10.1021\/acsomega.0c02879","article-title":"Head-to-head comparison of the penetration efficiency of lipid-based nanoparticles into tumor spheroids","volume":"5","author":"Niora","year":"2020","journal-title":"ACS Omega."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0160","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1021\/acsnano.2c00423","article-title":"PEGylated liposomes accumulate in the areas relevant to skin toxicities via passive extravasation across \u201cLeaky\u201d endothelium","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0165","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/cpns.25","article-title":"Fluorescein isothiocyanate (FITC)-dextran extravasation as a measure of blood-brain barrier permeability","volume":"79","author":"Natarajan","year":"2017","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0175","doi-asserted-by":"crossref","first-page":"12281","DOI":"10.1021\/acsnano.9b09713","article-title":"What went wrong with anticancer nanomedicine design and how to make it right","volume":"14","author":"Sun","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0180","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.jocn.2011.02.026","article-title":"Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy","volume":"18","author":"Ananda","year":"2011","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0185","article-title":"A new mouse model of diffuse midline glioma to test targeted immunotherapies","author":"Seblani","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0190","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41563-022-01251-z","article-title":"STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity","volume":"21","author":"Dane","year":"2022","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0195","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0002-9440(10)65006-7","article-title":"Openings between defective endothelial cells explain tumor vessel leakiness","volume":"156","author":"Hashizume","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0200","first-page":"4129","article-title":"Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor","volume":"59","author":"Monsky","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0205","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3389\/fonc.2020.00739","article-title":"Blood-brain barrier, blood-brain tumor barrier, and fluorescence-guided neurosurgical oncology: delivering optical labels to brain tumors","volume":"10","author":"Belykh","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0210","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1073\/pnas.95.8.4607","article-title":"Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment","volume":"95","author":"Hobbs","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0215","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/cam4.491","article-title":"Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients","volume":"4","author":"Golan","year":"2015","journal-title":"Cancer Med."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0220","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejpb.2018.04.003","article-title":"Pharmacokinetics of lipid-drug conjugates loaded into liposomes","volume":"128","author":"Signorell","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0225","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v26.i6.10","article-title":"Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic","volume":"26","author":"Puri","year":"2009","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0230","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1021\/acs.molpharmaceut.6b01027","article-title":"Lipid-drug conjugate for enhancing drug delivery","volume":"14","author":"Irby","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0235","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1172\/JCI965","article-title":"Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice","volume":"101","author":"Thurston","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0240","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1172\/JCI92284","article-title":"Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer","volume":"127","author":"Liu","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0245","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41563-019-0566-2","article-title":"The entry of nanoparticles into solid tumours","volume":"19","author":"Sindhwani","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0250","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1021\/acs.nanolett.9b03211","article-title":"Transcytosis of nanomedicine for tumor penetration","volume":"19","author":"Liu","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0255","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3892\/ijmm.2014.1663","article-title":"Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging","volume":"33","author":"Grange","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0260","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1182\/blood-2004-03-0824","article-title":"Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells","volume":"104","author":"Morelli","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0265","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1126\/science.556653","article-title":"Lateral transport of a lipid probe and labeled proteins on a cell membrane","volume":"195","author":"Schlessinger","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0270","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0197-4580(90)90031-T","article-title":"Tracing neuronal connections in postmortem human hippocampal complex with the carbocyanine dye DiI","volume":"11","author":"Mufson","year":"1990","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0275","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/38.5.2185313","article-title":"Neuronal tracing with DiI: decalcification, cryosectioning, and photoconversion for light and electron microscopic analysis","volume":"38","author":"von Bartheld","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0280","series-title":"Brain Tumors","first-page":"133","article-title":"Human glioblastoma organoids to model brain tumor heterogeneity ex vivo","author":"Pontius","year":"2021"},{"key":"10.1016\/j.jconrel.2022.07.008_bb0285","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ymthe.2018.02.001","article-title":"Adoptive transfer of IL13Ralpha2-specific chimeric antigen receptor T cells creates a pro-inflammatory environment in glioblastoma","volume":"26","author":"Pituch","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0290","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2015800118","article-title":"Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity","volume":"118","author":"Pituch","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0295","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1158\/1078-0432.CCR-21-0361","article-title":"IL13Ralpha2 promotes proliferation and outgrowth of breast cancer brain metastases","volume":"27","author":"Marquez-Ortiz","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0300","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.celrep.2017.10.030","article-title":"Single-cell RNA-Seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma","volume":"21","author":"Darmanis","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0305","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.779319","article-title":"Single-cell transcriptomic analysis revealed a critical role of SPP1\/CD44-mediated crosstalk between macrophages and cancer cells in glioma","volume":"9","author":"He","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.jconrel.2022.07.008_bb0320","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1158\/0008-5472.CAN-16-2310","article-title":"Cellular and molecular identity of tumor-associated macrophages in glioblastoma","volume":"77","author":"Chen","year":"2017","journal-title":"Cancer Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922004187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922004187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:26:57Z","timestamp":1759163217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365922004187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":63,"alternative-id":["S0168365922004187"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.07.008","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indocarbocyanine nanoparticles extravasate and distribute better than liposomes in brain tumors","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}