{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:55:50Z","timestamp":1792691750295,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jconrel.2022.08.050","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T19:13:19Z","timestamp":1662059599000},"page":"525-537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["pH-activated nanoplatform for visualized photodynamic and ferroptosis synergistic therapy of tumors"],"prefix":"10.1016","volume":"350","author":[{"given":"Rui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjian","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longguang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2022.08.050_bb0005","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(72)92596-2","article-title":"Photodynamic therapy of malignant tumours","volume":"2","author":"Diamond","year":"1972","journal-title":"Lancet."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0010","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1021\/cr900300p","article-title":"Imaging and photodynamic therapy: mechanisms, monitoring, and optimization","volume":"110","author":"Celli","year":"2010","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0015","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","article-title":"Photodynamic therapy for cancer","volume":"3","author":"Dolmans","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0025","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0030","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.2174\/092986711795843272","article-title":"Mechanisms of resistance to photodynamic therapy","volume":"18","author":"Casas","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0035","doi-asserted-by":"crossref","first-page":"113941","DOI":"10.1016\/j.addr.2021.113941","article-title":"Photodynamic and antibiotic therapy in combination against bacterial infections: efficacy, determinants, mechanisms, and future perspectives","volume":"177","author":"Feng","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0040","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0168-8278(00)80083-5","article-title":"Neoadjuvant photodynamic therapy before curative resection of proximal bile duct carcinoma","volume":"32","author":"Berr","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0045","doi-asserted-by":"crossref","first-page":"12181","DOI":"10.1021\/acsnano.8b05860","article-title":"Ferrous-supply-regeneration Nanoengineering for Cancer-cell-specific Ferroptosis in combination with imaging-guided photodynamic therapy","volume":"12","author":"Liu","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0050","doi-asserted-by":"crossref","first-page":"120456","DOI":"10.1016\/j.biomaterials.2020.120456","article-title":"Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy","volume":"265","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0055","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1073\/pnas.1912220117","article-title":"Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing","volume":"117","author":"Chen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0060","doi-asserted-by":"crossref","first-page":"e2006003","DOI":"10.1002\/adma.202006003","article-title":"Reprogramming the Tumor Microenvironment through Second-Near-Infrared-Window Photothermal Genome Editing of PD-L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy","volume":"33","author":"Tang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0065","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/C7CS00594F","article-title":"Supramolecular photosensitizers rejuvenate photodynamic therapy","volume":"47","author":"Li","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002739","article-title":"Targeting neutrophils for enhanced Cancer Theranostics","volume":"32","author":"Tang","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0075","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1021\/acsnano.9b09426","article-title":"Enhanced Ferroptosis by oxygen-boosted phototherapy based on a 2-in-1 Nanoplatform of ferrous hemoglobin for tumor synergistic therapy","volume":"14","author":"Xu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.trecan.2021.01.013","article-title":"Ferroptosis and photodynamic therapy synergism: enhancing anticancer treatment","volume":"7","author":"Mishchenko","year":"2021","journal-title":"Trends in cancer"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0085","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0090","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0095","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1021\/acs.nanolett.0c03127","article-title":"Self-amplification of tumor oxidative stress with degradable metallic complexes for synergistic Cascade tumor therapy","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202100114","article-title":"A harmless\u2013harmful switchable and uninterrupted laccase-instructed killer for Activatable Chemodynamic therapy","volume":"33","author":"Zhou","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0105","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of Ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of Ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0115","doi-asserted-by":"crossref","first-page":"11088","DOI":"10.1002\/anie.201904880","article-title":"Coordinatively unsaturated Fe3+ based Activatable probes for enhanced MRI and therapy of tumors","volume":"58","author":"Zhang","year":"2019","journal-title":"Angew. Chem. Int. Edit."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202112925","article-title":"Coordinating the mechanisms of action of Ferroptosis and the Photothermal effect for Cancer Theranostics","volume":"61","author":"Zeng","year":"2022","journal-title":"Angew. Chem. Int. Edit."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2019.12.002","article-title":"Immunotherapy for hepatocellular carcinoma","volume":"470","author":"Zongyi","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41575-021-00508-3","article-title":"Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications","volume":"19","author":"Lee","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2018.08.030","article-title":"Exploiting the bioengineering versatility of lactobionic acid in targeted nanosystems and biomaterials","volume":"287","author":"Alonso","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0150","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/acs.molpharmaceut.5b00677","article-title":"Glycyrrhetinic acid mediated drug delivery carriers for hepatocellular carcinoma therapy","volume":"13","author":"Cai","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0155","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00726-017-2517-z","article-title":"Imaging the expression of glypican-3 in hepatocellular carcinoma by PET","volume":"50","author":"Wang","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7150\/thno.64759","article-title":"Smart NIR-II croconaine dye-peptide for enhanced photo-sonotheranostics of hepatocellular carcinoma","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0165","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pharmthera.2017.02.010","article-title":"Recent advances in hepatocellular carcinoma therapy","volume":"173","author":"Dutta","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0170","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhep.2019.09.023","article-title":"Role of locoregional therapies in the wake of systemic therapy","volume":"72","author":"Palmer","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jhep.2019.09.025","article-title":"Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma","volume":"72","author":"Cheng","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jhep.2019.09.028","article-title":"Novel patient-derived preclinical models of liver cancer","volume":"72","author":"Bresnahan","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0185","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/2159-8290.CD-14-0001","article-title":"Patient-derived xenograft models: an emerging platform for translational cancer research","volume":"4","author":"Hidalgo","year":"2014","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0190","article-title":"A systematic strategy of combinational blow for overcoming Cascade drug resistance via NIR-light-triggered hyperthermia","volume":"33","author":"Wang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0195","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.apsb.2021.02.001","article-title":"Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0200","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/gutjnl-2011-301862","article-title":"Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma","volume":"61","author":"Tremosini","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0205","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/gut.2010.231993","article-title":"EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies","volume":"60","author":"Cai","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0210","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhep.2008.11.014","article-title":"The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma","volume":"50","author":"Di Tommaso","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2022.08.050_bb0215","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/gut.48.4.558","article-title":"Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders","volume":"48","author":"Zhu","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biomaterials.2017.03.009","article-title":"Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics","volume":"129","author":"Tang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0225","article-title":"A highly selective optical probe for sensing of Fe3+ based on a water-soluble croconaine","volume":"S1010603017306032","author":"Ye","year":"2017","journal-title":"J. Photoch. Photobio. A"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0230","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1016\/j.tet.2015.06.081","volume":"71","year":"2015","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0235","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jconrel.2012.11.012","article-title":"Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy","volume":"169","author":"Gao","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0240","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jconrel.2012.06.027","article-title":"pH-sensitive drug loading\/releasing in amphiphilic copolymer PAE-PEG: integrating molecular dynamics and dissipative particle dynamics simulations","volume":"162","author":"Luo","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2022.08.050_bb0245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jconrel.2010.02.024","article-title":"Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy","volume":"144","author":"Min","year":"2010","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922005570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365922005570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:33:24Z","timestamp":1759163604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365922005570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":49,"alternative-id":["S0168365922005570"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.08.050","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH-activated nanoplatform for visualized photodynamic and ferroptosis synergistic therapy of tumors","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2022.08.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}