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A."},{"key":"10.1016\/j.jconrel.2022.10.055_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jconrel.2022.10.055_bb0370","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ars.2015.6577","article-title":"Hydrogen sulfide mitigates myocardial infarction via promotion of mitochondrial biogenesis-dependent M2 polarization of macrophages","volume":"25","author":"Miao","year":"2016","journal-title":"Antioxid. 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Sci."},{"key":"10.1016\/j.jconrel.2022.10.055_bb0480","article-title":"ZnS@BSA nanoclusters potentiate efficacy of cancer immunotherapy","author":"Cen","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2022.10.055_bb0485","doi-asserted-by":"crossref","first-page":"11562","DOI":"10.1039\/D0NR02543G","article-title":"A continuous stimuli-responsive system for NIR-II fluorescence\/photoacoustic imaging guided photothermal\/gas synergistic therapy","volume":"12","author":"Zheng","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2022.10.055_bb0490","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12951-021-01023-y","article-title":"Laser-triggered combination therapy by iron sulfide-doxorubicin@functionalized nanozymes for breast cancer therapy","volume":"19","author":"Ning","year":"2021","journal-title":"J. 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