{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:31:19Z","timestamp":1786318279057,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jconrel.2023.03.034","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:37:12Z","timestamp":1680741432000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Transdermal carbon monoxide delivery"],"prefix":"10.1016","volume":"357","author":[{"given":"Matthias","family":"Ruopp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Reil\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Caruana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schmehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Stange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Meinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jconrel.2023.03.034_bb0005","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0749-8063(98)70021-0","article-title":"Overuse tendon conditions: time to change a confusing terminology","volume":"14","author":"Maffulli","year":"1998","journal-title":"Arthrosc. J. Arthroscop. Relat. Surg."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/ageing\/18.4.263","article-title":"Sports injuries in elderly athletes: a three-year prospective, controlled study","volume":"18","author":"Kannus","year":"1989","journal-title":"Age Ageing"},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0015","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2165\/00007256-198603020-00003","article-title":"Achilles tendon lesions in sport","volume":"3","author":"Williams","year":"1986","journal-title":"Sports Med."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0020","series-title":"Sports Medicine","first-page":"307","article-title":"Prevention of sports injuries","author":"Renstr\u00f6m","year":"1991"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0025","series-title":"The Olympic Book of Sports Medicine","first-page":"376","article-title":"Causes of injuries: Intrinsic factors","author":"Lorentzon","year":"1988"},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0030","first-page":"100","article-title":"Surgical treatment of overuse injuries to the Achilles Tendon","volume":"4","author":"Leppilahti","year":"1994"},{"issue":"5","key":"10.1016\/j.jconrel.2023.03.034_bb0035","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/03635465000280050301","article-title":"Long-term prognosis of patients with achilles tendinopathy. An observational 8-year follow-up study","volume":"28","author":"Paavola","year":"2000","journal-title":"Am. J. Sports Med."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0040","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2165\/00007256-198908060-00005","article-title":"Prevention and treatment of overuse tendon injuries","volume":"8","author":"Hess","year":"1989","journal-title":"Sports Med."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0838.1997.tb00125.x","article-title":"Diagnosis and treatment of chronic tendon disorders in sports","volume":"7","author":"Sandmeier","year":"1997","journal-title":"Scand. J. Med. Sci. Sports"},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0050","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2165\/00007256-200029020-00005","article-title":"Chronic Achilles tendinosis: recommendations for treatment and prevention","volume":"29","author":"Alfredson","year":"2000","journal-title":"Sports Med."},{"issue":"7","key":"10.1016\/j.jconrel.2023.03.034_bb0055","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s11999-008-0260-1","article-title":"Treatment of tendinopathy: what works, what does not, and what is on the horizon","volume":"466","author":"Andres","year":"2008","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"8","key":"10.1016\/j.jconrel.2023.03.034_bb0060","first-page":"1183","article-title":"Etiology, diagnosis, and treatment of tendonitis: an analysis of the literature","volume":"30","author":"Almekinders","year":"1998"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0065","first-page":"9534125","article-title":"Achilles tendinopathy: from the basic science to the clinic","volume":"2017","author":"Li","year":"2017","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0070","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/01.jsm.0000407929.35973.b9","article-title":"Corticosteroid and other injections in the management of tendinopathies: a review","volume":"21","author":"Hart","year":"2011","journal-title":"Clin. J. Sport Med."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0075","series-title":"Human Tendons: Anatomy, Physiology, and Pathology","author":"Jozsa","year":"1997"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.646554","article-title":"Enhancing permeation of drug molecules across the skin via delivery in Nanocarriers: novel strategies for effective transdermal applications","volume":"9","author":"Yu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0085","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.biopha.2018.07.027","article-title":"Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: an overview","volume":"106","author":"Thakur","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1113\/jphysiol.1919.sp001838","article-title":"The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion","volume":"52","author":"Krogh","year":"1919","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0095","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jnr.24077","article-title":"Gas diffusion in the CNS","volume":"96","author":"Rodriguez-Grande","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-3-030-34461-0_23","article-title":"Pathways of oxygen diffusion in cells and tissues\u202f: hydrophobic channeling via networked lipids","volume":"1232","author":"Pias","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"9","key":"10.1016\/j.jconrel.2023.03.034_bb0105","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0110","first-page":"63","article-title":"Identification and assessment of carbon monoxide in gas emanated from human skin","volume":"27","author":"Nose","year":"2006"},{"issue":"Suppl. 6","key":"10.1016\/j.jconrel.2023.03.034_bb0115","first-page":"9","article-title":"Exhaled carbon monoxide as a new marker of respiratory diseases in children","volume":"59","author":"Babusikova","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0120","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","article-title":"Anti-inflammatory cytokines","volume":"117","author":"Opal","year":"2000","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0125","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1189\/jlb.0412214","article-title":"Regulation of inflammation by interleukin-4: a review of \u201calternatives\u201d","volume":"92","author":"Luzina","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/3-540-26811-1_13","article-title":"Pro- and anti-inflammatory effects of IL-4: from studies in mice to therapy of autoimmune diseases in humans","volume":"50","author":"Biedermann","year":"2005","journal-title":"Ernst Schering Res Found Workshop"},{"issue":"1","key":"10.1016\/j.jconrel.2023.03.034_bb0135","first-page":"S58","article-title":"Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug","volume":"30","author":"Oberholzer","year":"2002"},{"issue":"1","key":"10.1016\/j.jconrel.2023.03.034_bb0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1021\/acs.bioconjchem.1c00495","article-title":"Chemo-enzymatic PEGylation\/POxylation of murine Interleukin-4","volume":"33","author":"Haas","year":"2022","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2014.06.025","article-title":"Oral drug delivery of therapeutic gases - carbon monoxide release for gastrointestinal diseases","volume":"189","author":"Steiger","year":"2014","journal-title":"J. Control. Release"},{"issue":"Pt A","key":"10.1016\/j.jconrel.2023.03.034_bb0150","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejpb.2015.10.009","article-title":"Controlled therapeutic gas delivery systems for quality-improved transplants","volume":"97","author":"Steiger","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2016.08.030","article-title":"Prevention of colitis by controlled oral drug delivery of carbon monoxide","volume":"239","author":"Steiger","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejpb.2016.11.002","article-title":"Localized delivery of carbon monoxide","volume":"118","author":"Steiger","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"20","key":"10.1016\/j.jconrel.2023.03.034_bb0165","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.2174\/1381612824666180723161811","article-title":"Where is the clinical breakthrough of Heme Oxygenase-1 \/ carbon monoxide therapeutics?","volume":"24","author":"Hopper","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0170","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jconrel.2018.04.017","article-title":"Overcoming safety challenges in CO therapy - extracorporeal CO delivery under precise feedback control of systemic carboxyhemoglobin levels","volume":"279","author":"Wollborn","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0175","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejpb.2018.07.009","article-title":"Investigation of orally delivered carbon monoxide for postoperative ileus","volume":"130","author":"Van Dingenen","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0180","doi-asserted-by":"crossref","first-page":"F1572","DOI":"10.1152\/ajprenal.00241.2019","article-title":"Extracorporeal resuscitation with carbon monoxide improves renal function by targeting inflammatory pathways in cardiac arrest in pigs","volume":"317","author":"Wollborn","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0185","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1097\/CCM.0000000000004242","article-title":"Carbon monoxide exerts functional neuroprotection after cardiac arrest using extracorporeal resuscitation in pigs","volume":"48","author":"Wollborn","year":"2020","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.jconrel.2023.03.034_bb0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cvr\/cvz075","article-title":"Carbon monoxide improves haemodynamics during extracorporeal resuscitation in pigs","volume":"116","author":"Wollborn","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"651","key":"10.1016\/j.jconrel.2023.03.034_bb0195","doi-asserted-by":"crossref","first-page":"eabl4135","DOI":"10.1126\/scitranslmed.abl4135","article-title":"Delivery of therapeutic carbon monoxide by gas-entrapping materials","volume":"14","author":"Byrne","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2023.03.034_bb0200","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40635-020-0292-8","article-title":"Carbon monoxide in intensive care medicine-time to start the therapeutic application?!","volume":"8","author":"Goebel","year":"2020","journal-title":"Intensive Care Med. Exp."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0205","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ab.2005.03.019","article-title":"Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure","volume":"341","author":"Vreman","year":"2005","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0210","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/jappl.1975.39.4.633","article-title":"Predicting the carboxyhemoglobin levels resulting from carbon monoxide exposures","volume":"39","author":"Peterson","year":"1975","journal-title":"J. Appl. Physiol."},{"issue":"5","key":"10.1016\/j.jconrel.2023.03.034_bb0215","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1042\/bj0211068","article-title":"Carbon Monoxide as a Tissue Poison","volume":"21","author":"Haldane","year":"1927","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0220","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1113\/jphysiol.1912.sp001517","article-title":"The laws of combination of haemoglobin with carbon monoxide and oxygen","volume":"44","author":"Douglas","year":"1912","journal-title":"J. Physiol."},{"issue":"7","key":"10.1016\/j.jconrel.2023.03.034_bb0225","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1128\/AAC.00703-16","article-title":"Bactericidal effect of a Photoresponsive carbon monoxide-releasing nonwoven against Staphylococcus aureus biofilms","volume":"60","author":"Klinger-Strobel","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0230","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2014.05.018","article-title":"Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease","volume":"187","author":"Yin","year":"2014","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2023.03.034_bb0235","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1039\/C3TB21649G","article-title":"Light-triggered CO release from nanoporous non-wovens","volume":"2","author":"Bohlender","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/00365516109137244","article-title":"Postmortem absorption of carbon monoxide in rats","volume":"13","author":"Asvall","year":"1961","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0245","first-page":"315","article-title":"Skin absorption of certain gases","volume":"26","author":"Walton","year":"1925"},{"issue":"1","key":"10.1016\/j.jconrel.2023.03.034_bb0250","first-page":"37","article-title":"Post mortem diffusion of carbon monoxide to muscles and blood--preliminary examinations","volume":"54","author":"Teresi\u0144ski","year":"2004","journal-title":"Archiwum Medycyny Sadowej i Kryminologii"},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0255","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1073\/pnas.69.4.868","article-title":"Carbon monoxide binding by hemoglobin and myoglobin under photodissociating conditions","volume":"69","author":"Brunori","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0260","article-title":"Oral use of therapeutic carbon monoxide for anyone, anywhere, and anytime","author":"Reilander","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0265","author":"AbnovaCorporation AbVideo\u2122 - H&E Staining"},{"issue":"12","key":"10.1016\/j.jconrel.2023.03.034_bb0270","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20051047","article-title":"Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway","volume":"202","author":"Hegazi","year":"2005","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0275","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/S0002-9440(10)63610-3","article-title":"MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury","volume":"163","author":"Otterbein","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0280","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.resuscitation.2006.06.021","article-title":"Hemorrhagic shock resuscitation with carbon monoxide saturated blood","volume":"72","author":"Cabrales","year":"2007","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0285","first-page":"527","article-title":"Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation","volume":"23","author":"Zuckerbraun","year":"2005","journal-title":"Shock: Injury Inflam. Sepsis Lab. Clin. Approach."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0290","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1208\/s12249-011-9715-x","article-title":"Recovery of skin barrier after stratum corneum removal by microdermabrasion","volume":"12","author":"Andrews","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0295","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.rinphs.2014.09.002","article-title":"Development and validation of an alternative disturbed skin model by mechanical abrasion to study drug penetration","volume":"4","author":"Schlupp","year":"2014","journal-title":"Results Pharma Sci."},{"issue":"31","key":"10.1016\/j.jconrel.2023.03.034_bb0300","doi-asserted-by":"crossref","DOI":"10.1088\/0022-3727\/49\/31\/315201","article-title":"Comparison of atmospheric microplasma and plasma jet irradiation for increasing of skin permeability","volume":"49","author":"Shimizu","year":"2016","journal-title":"J. Phys. D. Appl. Phys."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9040360","article-title":"Probing skin barrier recovery on molecular level following acute wounds: an in vivo\/ex vivo study on pigs","volume":"9","author":"Mojumdar","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0310","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.meatsci.2016.06.013","article-title":"Carbon monoxide concentration and exposure time effects on the depth of CO penetration and surface color of raw and cooked beef longissimus lumborum steaks","volume":"121","author":"Sakowska","year":"2016","journal-title":"Meat Sci."},{"issue":"11","key":"10.1016\/j.jconrel.2023.03.034_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10110707","article-title":"Diffusion of carbon monoxide and hydrogen cyanide to muscles and blood-an experimental study","volume":"10","author":"Baj","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0320","first-page":"253","article-title":"The elimination of carbon monoxide from the human body with reference to the possible conversion of CO to CO2","volume":"145","author":"Tobias","year":"1945","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0325","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/B0-12-464970-X\/00115-X","article-title":"Chemical and physical characteristics of meat - colour and pigment","author":"Cornforth","year":"2004","journal-title":"Encyclop. Meat Sci."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0330","doi-asserted-by":"crossref","first-page":"6302391","DOI":"10.1155\/2020\/6302391","article-title":"Carbon monoxide-releasing Molecule-3 suppresses tumor necrosis factor-alpha- and interleukin-1beta-induced expression of junctional molecules on human gingival fibroblasts via the Heme Oxygenase-1 pathway","volume":"2020","author":"Lv","year":"2020","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0335","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","article-title":"Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule","volume":"93","author":"Clark","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2023.03.034_bb0340","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2147\/DDDT.S300356","article-title":"Carbon monoxide releasing Molecule-3 enhances osteogenic differentiation of human periodontal ligament stem cells by carbon monoxide release","volume":"15","author":"Chen","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2023.03.034_bb0345","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s10753-021-01450-x","article-title":"Carbon monoxide-releasing Molecule-3 regulates the polarization of lipopolysaccharide-induced macrophages","volume":"44","author":"Liu","year":"2021","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.jconrel.2023.03.034_bb0350","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1159\/000494891","article-title":"Carbon monoxide releasing molecule 3 inhibits Osteoclastogenic differentiation of RAW264.7 cells by Heme Oxygenase-1","volume":"50","author":"Pan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.jconrel.2023.03.034_bb0355","first-page":"2297","article-title":"Carbon monoxide releasing molecule3 promotes the osteogenic differentiation of rat bone marrow mesenchymal stem cells by releasing carbon monoxide","volume":"41","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0360","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.bjp.0706241","article-title":"Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages","volume":"145","author":"Sawle","year":"2005","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.jconrel.2023.03.034_bb0365","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123444","article-title":"Carbon monoxide regulates macrophage differentiation and polarization toward the M2 phenotype through upregulation of Heme oxygenase 1","volume":"10","author":"Kang","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jconrel.2023.03.034_bb0370","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10787-017-0371-y","article-title":"Carbon monoxide-releasing molecule, CORM-3, modulates alveolar macrophage M1\/M2 phenotype in vitro","volume":"26","author":"Yamamoto-Oka","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.jconrel.2023.03.034_bb0375","doi-asserted-by":"crossref","first-page":"H920","DOI":"10.1152\/ajpheart.00305.2009","article-title":"CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase","volume":"297","author":"Mizuguchi","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"12","key":"10.1016\/j.jconrel.2023.03.034_bb0380","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"issue":"13","key":"10.1016\/j.jconrel.2023.03.034_bb0385","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1182\/blood-2007-02-072587","article-title":"Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells","volume":"110","author":"Duluc","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0390","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"Roszer","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"6","key":"10.1016\/j.jconrel.2023.03.034_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/biom11060837","article-title":"Macrophage plasticity and polarization are altered in the experimental model of multiple sclerosis","volume":"11","author":"Leuti","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0400","series-title":"Systems and Methods for Promoting Wound Healing","author":"Malinski","year":"2010"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0405","author":"MallinckrodtPharmaceuticals"},{"key":"10.1016\/j.jconrel.2023.03.034_bb0430","series-title":"Transdermal Therapeutic System Comprising Active Substances Representing Carbon Monoxide Sources","author":"Herrmann","year":"1995"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923002018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923002018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:41:13Z","timestamp":1759164073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365923002018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":82,"alternative-id":["S0168365923002018"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.03.034","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transdermal carbon monoxide delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}