{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:17:13Z","timestamp":1788175033475,"version":"build-2803163510"},"reference-count":153,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2B5B01001920"],"award-info":[{"award-number":["NRF-2022R1A2B5B01001920"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jconrel.2023.06.018","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T12:08:43Z","timestamp":1687176523000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury\/acute respiratory distress syndrome"],"prefix":"10.1016","volume":"360","author":[{"given":"Chuanyu","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2023.06.018_bb0005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00134-003-2022-6","article-title":"Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study","volume":"30","author":"Brun-Buisson","year":"2004","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0015","series-title":"Pediatric Critical Care Medicine","first-page":"101","article-title":"Acute lung injury and acute respiratory distress syndrome","author":"Ostwani","year":"2014"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0020","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrmicro.2016.81","article-title":"SARS and MERS: recent insights into emerging coronaviruses","volume":"14","author":"de Wit","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0025","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/ajcp\/aqaa029","article-title":"Three emerging coronaviruses in two decades","volume":"153","author":"Guarner","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0030","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute respiratory distress syndrome: advances in diagnosis and treatment","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pupt.2009.10.012","article-title":"Effects of inhaled nitric oxide and surfactant with extracorporeal life support in recovery phase of septic acute lung injury in piglets","volume":"23","author":"Song","year":"2010","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08820139.2016.1157814","article-title":"Dexamethasone attenuates LPS-induced acute lung injury through inhibition of NF-kappaB, COX-2, and pro-inflammatory mediators","volume":"45","author":"Al-Harbi","year":"2016","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s40121-021-00500-z","article-title":"Potential adverse effects of dexamethasone therapy on COVID-19 patients: review and recommendations","volume":"10","author":"Chen","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0050","article-title":"Gene therapy for acute respiratory distress syndrome","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biomaterials.2010.08.116","article-title":"Combinational therapy of ischemic brain stroke by delivery of heme oxygenase-1 gene and dexamethasone","volume":"32","author":"Hyun","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0060","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s11095-017-2175-6","article-title":"Anti-inflammatory therapeutic effect of adiponectin gene delivery using a polymeric carrier in an acute lung injury model","volume":"34","author":"Piao","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nano.2018.08.009","article-title":"Combined delivery of angiopoietin-1 gene and simvastatin mediated by anti-intercellular adhesion molecule-1 antibody-conjugated ternary nanoparticles for acute lung injury therapy","volume":"15","author":"Jiang","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0070","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.nano.2015.10.004","article-title":"Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury","volume":"12","author":"Ravikumar","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2013.12.008","article-title":"Combined delivery of HMGB-1 box a peptide and S1PLyase siRNA in animal models of acute lung injury","volume":"175","author":"Oh","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0080","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1021\/acs.biomac.7b00572","article-title":"Anti-inflammatory effect of anti-TNF-alpha siRNA cationic phosphorus dendrimer nanocomplexes administered intranasally in a murine acute lung injury model","volume":"18","author":"Bohr","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s10020-020-00184-0","article-title":"The cholinergic anti-inflammatory pathway alleviates acute lung injury","volume":"26","author":"Andersson","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000345688","article-title":"Transfusion-related acute lung injury: the work of DAMPs","volume":"40","author":"Land","year":"2013","journal-title":"Transfus. Med. Hemother."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0095","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2119\/molmed.2009.00097","article-title":"Pattern recognition receptor-dependent mechanisms of acute lung injury","volume":"16","author":"Xiang","year":"2010","journal-title":"Mol. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0100","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1164\/rccm.200509-1477OC","article-title":"Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury","volume":"173","author":"Uchida","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0105","first-page":"L665","article-title":"Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction","volume":"305","author":"Herold","year":"2013","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0110","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00134-007-0661-8","article-title":"Alveolar epithelium and Na,K-ATPase in acute lung injury","volume":"33","author":"Vadasz","year":"2007","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0115","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1084\/jem.20080201","article-title":"Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand","volume":"205","author":"Herold","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0120","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1016\/0002-9343(92)90606-C","article-title":"Pathogenesis of fibrosis in acute lung injury","volume":"92","author":"Bitterman","year":"1992","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0125","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1378\/chest.120.4.1347","article-title":"Treatment of ARDS","volume":"120","author":"Brower","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1164\/rccm.201605-1081CP","article-title":"Mechanical ventilation to minimize progression of lung injury in acute respiratory failure","volume":"195","author":"Brochard","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0135","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1152\/jappl.1990.69.6.2057","article-title":"Mechanical ventilation increases microvascular permeability in oleic acid-injured lungs","volume":"69","author":"Hernandez","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.714064","article-title":"Mechanisms of mechanical force induced pulmonary vascular endothelial hyperpermeability","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0145","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1183\/09031936.00057711","article-title":"Dexamethasone in patients with acute lung injury from acute monocytic leukaemia","volume":"39","author":"Azoulay","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0150","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1056\/NEJM198712173172504","article-title":"High-dose corticosteroids in patients with the adult respiratory distress syndrome","volume":"317","author":"Bernard","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0155","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1056\/NEJMoa051693","article-title":"Blood institute acute respiratory distress syndrome clinical trials, efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome","volume":"354","author":"Steinberg","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0160","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.2147\/IJN.S300594","article-title":"Nanomedicine-based therapeutics to combat acute lung injury","volume":"16","author":"Bian","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0165","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jconrel.2020.12.053","article-title":"Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation","volume":"330","author":"Kim","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0170","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1021\/acs.biomac.1c01081","article-title":"Co-delivery of dexamethasone and a microRNA-155 inhibitor using dendrimer-entrapped gold nanoparticles for acute lung injury therapy","volume":"22","author":"Li","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jconrel.2011.06.041","article-title":"Combined delivery of dexamethasone and plasmid DNA in an animal model of LPS-induced acute lung injury","volume":"156","author":"Kim","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0180","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1039\/C8NR00427G","article-title":"Self-assembled polymeric micelles for combined delivery of anti-inflammatory gene and drug to the lungs by inhalation","volume":"10","author":"Kim","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0185","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11095-018-2366-9","article-title":"Nebulization of cyclic arginine-glycine-(D)-aspartic acid-peptide grafted and drug encapsulated liposomes for inhibition of acute lung injury","volume":"35","author":"Desu","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0190","doi-asserted-by":"crossref","first-page":"12356","DOI":"10.1039\/C5NR02377G","article-title":"Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle-peptide hybrids","volume":"7","author":"Lee","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201600490","article-title":"Combined delivery of a lipopolysaccharide-binding peptide and the heme oxygenase-1 gene using deoxycholic acid-conjugated polyethylenimine for the treatment of acute lung injury","volume":"17","author":"Kim","year":"2017","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0200","doi-asserted-by":"crossref","first-page":"13606","DOI":"10.1039\/D0NR01367F","article-title":"A RAGE-antagonist peptide potentiates polymeric micelle-mediated intracellular delivery of plasmid DNA for acute lung injury gene therapy","volume":"12","author":"Piao","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0205","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4049\/jimmunol.1100426","article-title":"Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation","volume":"188","author":"Konter","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0210","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1164\/rccm.200608-1246OC","article-title":"Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury","volume":"176","author":"Mutlu","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0215","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/TA.0b013e31823f0606","article-title":"Electroporation-mediated in vivo gene delivery of the Na+\/K+-ATPase pump reduced lung injury in a mouse model of lung contusion","volume":"72","author":"Machado-Aranda","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1089\/hum.2014.053","article-title":"Aerosol-mediated delivery of AAV2\/6-IkappaBalpha attenuates lipopolysaccharide-induced acute lung injury in rats","volume":"26","author":"MacLoughlin","year":"2015","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0225","article-title":"Keratinocyte growth factor gene delivery via mesenchymal stem cells protects against lipopolysaccharide-induced acute lung injury in mice","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0230","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/sj.gt.3302746","article-title":"Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury","volume":"13","author":"Zhou","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0235","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4049\/jimmunol.167.2.1053","article-title":"Adenoviral delivery of human and viral IL-10 in murine sepsis","volume":"167","author":"Minter","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0240","doi-asserted-by":"crossref","first-page":"e716","DOI":"10.1097\/CCM.0000000000000633","article-title":"Adenovector-mediated gene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats","volume":"42","author":"Zhou","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0245","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1021\/acsami.1c23069","article-title":"Surface coating of pulmonary siRNA delivery vectors enabling mucus penetration, cell targeting, and intracellular radical scavenging for enhanced acute lung injury therapy","volume":"14","author":"Zhu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0250","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1166\/jbn.2021.3046","article-title":"Interferon regulatory factor 5 siRNA-loaded folate-modified cationic liposomes for acute lung injury therapy","volume":"17","author":"Xu","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0255","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jconrel.2022.10.052","article-title":"Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases","volume":"352","author":"Han","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0260","article-title":"An mTOR siRNA-loaded spermidine\/DNA tetrahedron nanoplatform with a synergistic anti-inflammatory effect on acute lung injury","volume":"11","author":"Huang","year":"2022","journal-title":"Adv. Healthc Mater."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0265","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/rccm.200804-534OC","article-title":"Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis","volume":"179","author":"Matsuda","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0270","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0002-9440(10)61240-0","article-title":"Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis","volume":"167","author":"Perl","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0275","first-page":"L801","article-title":"Blockade of endothelial, but not epithelial, cell expression of PD-L1 following severe shock attenuates the development of indirect acute lung injury in mice","volume":"318","author":"Xu","year":"2020","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0280","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s10753-016-0494-0","article-title":"Exosomes from iPSCs delivering siRNA attenuate intracellular adhesion molecule-1 expression and neutrophils adhesion in pulmonary microvascular endothelial cells","volume":"40","author":"Ju","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0285","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.ymthe.2019.07.003","article-title":"Peripheral circulating exosome-mediated eelivery of miR-155 as a novel mechanism for acute lung inflammation","volume":"27","author":"Jiang","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0290","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1166\/jbn.2021.3102","article-title":"Delivery of miRNA-92a inhibitor using RP1-linked peptide elicits anti-inflammatory effects in an acute lung injury model","volume":"17","author":"Zhuang","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0295","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/08916934.2022.2094370","article-title":"microRNA-130b-3p delivery by mesenchymal stem cells-derived exosomes confers protection on acute lung injury","volume":"55","author":"Wang","year":"2022","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0300","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1165\/rcmb.2009-0170TR","article-title":"Heme oxygenase-1\/carbon monoxide: from metabolism to molecular therapy","volume":"41","author":"Ryter","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0305","first-page":"L1131","article-title":"Biliverdin administration protects against endotoxin-induced acute lung injury in rats","volume":"289","author":"Sarady-Andrews","year":"2005","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0310","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1513\/pats.200503-023AC","article-title":"Cytoprotection of heme oxygenase-1\/carbon monoxide in lung injury","volume":"2","author":"Jin","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0315","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1089\/ars.2007.1811","article-title":"Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system","volume":"9","author":"Ryter","year":"2007","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0320","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/bjp.2008.342","article-title":"Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders","volume":"155","author":"Syapin","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0325","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jacc.2008.06.019","article-title":"Hemoxygenase-1 in cardiovascular disease","volume":"52","author":"Idriss","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0330","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2337\/db06-0495","article-title":"Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice","volume":"56","author":"Hu","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0335","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.molimm.2010.06.013","article-title":"Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor","volume":"47","author":"Yin","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0340","doi-asserted-by":"crossref","first-page":"47313","DOI":"10.1021\/acsami.1c08107","article-title":"Dual-functional dendrimer micelles with glycyrrhizic acid for anti-inflammatory therapy of acute lung injury","volume":"13","author":"Choi","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0345","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phymed.2018.09.240","article-title":"Combined delivery of curcumin and the heme oxygenase-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury","volume":"56","author":"Kim","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0350","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1039\/C8NR00427G","article-title":"Self-assembled polymeric nanomicelles for combined delivery of anti-inflammatory gene and drug to the lungs by inhalation","volume":"10","author":"Kim","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0355","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cytogfr.2018.01.004","article-title":"Adiponectin: a potential therapeutic target for metabolic syndrome","volume":"39","author":"Ghadge","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0360","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2006.05.008","article-title":"Non-viral adiponectin gene therapy into obese type 2 diabetic mice ameliorates insulin resistance","volume":"114","author":"Park","year":"2006","journal-title":"J. Control. Release"},{"issue":"Suppl. 1","key":"10.1016\/j.jconrel.2023.06.018_bb0365","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00592-005-0175-1","article-title":"Obesity, hypertension and insulin resistance","volume":"42","author":"Sharma","year":"2005","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0370","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1096\/fj.14-253831","article-title":"Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response","volume":"29","author":"van Stijn","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0375","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.biocel.2013.03.003","article-title":"Adiponectin affects lung epithelial A549 cell viability counteracting TNFalpha and IL-1ss toxicity through AdipoR1","volume":"45","author":"Nigro","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0380","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1021\/acsbiomaterials.9b00004","article-title":"Inhalable gene delivery system using a cationic RAGE-antagonist peptide for gene delivery to inflammatory lung cells","volume":"5","author":"Piao","year":"2019","journal-title":"ACS Bioimater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0385","doi-asserted-by":"crossref","first-page":"20862","DOI":"10.1038\/s41598-021-99897-3","article-title":"Gene transfer of MRCKalpha rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function","volume":"11","author":"Liu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0390","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/SHK.0000000000000228","article-title":"Electroporation-mediated gene delivery of Na+,K+ -ATPase, and ENaC subunits to the lung attenuates acute respiratory distress syndrome in a two-hit porcine model","volume":"43","author":"Emr","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0395","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/gt.2016.19","article-title":"beta1-Na(+),K(+)-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury","volume":"23","author":"Lin","year":"2016","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0400","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF03256650","article-title":"The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy","volume":"2","author":"Wright","year":"2003","journal-title":"Am. J. Respir. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0405","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.RES.86.1.24","article-title":"Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase\/Akt signal transduction pathway","volume":"86","author":"Kim","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0410","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/01.CCM.0000297955.02633.A4","article-title":"Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury","volume":"36","author":"Huang","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0415","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1164\/rccm.200609-1370OC","article-title":"Cell-based angiopoietin-1 gene therapy for acute lung injury","volume":"175","author":"McCarter","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0420","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/08958378.2013.872213","article-title":"Adenovirus-delivered angiopoietin-1 suppresses NF-kappaB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury","volume":"26","author":"He","year":"2014","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040269","article-title":"Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1","volume":"4","author":"Mei","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0430","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1097\/CCM.0b013e31819fc81a","article-title":"Keratinocyte growth factor expression is suppressed in early acute lung injury\/acute respiratory distress syndrome by smad and c-Abl pathways","volume":"37","author":"Chandel","year":"2009","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0435","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/MCB.01512-06","article-title":"Role of phosphocholine cytidylyltransferase alpha in lung development","volume":"27","author":"Tian","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0440","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.1098313","article-title":"Derivatives of erythropoietin that are tissue protective but not erythropoietic","volume":"305","author":"Leist","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0445","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.biomaterials.2011.12.031","article-title":"Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0450","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2012.02.004","article-title":"Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin","volume":"160","author":"Ishii","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0455","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1073\/pnas.0409329102","article-title":"A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia-reperfusion injury","volume":"102","author":"Fiordaliso","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174178","article-title":"siRNA: mechanism of action, challenges, and therapeutic approaches","volume":"905","author":"Alshaer","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0465","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.actbio.2018.08.012","article-title":"Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy","volume":"78","author":"Merckx","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0470","article-title":"Progress in preclinical studies of macrophage autophagy in the regulation of ALI\/ARDS","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0475","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1164\/rccm.200611-1743OC","article-title":"Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury","volume":"176","author":"Perl","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0480","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1165\/rcmb.2010-0422OC","article-title":"Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression","volume":"45","author":"Zhao","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0485","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.imbio.2009.06.003","article-title":"Regulation of macrophage function by sphingosine-1-phosphate","volume":"214","author":"Weigert","year":"2009","journal-title":"Immunobiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0490","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00134-008-1235-0","article-title":"Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury","volume":"35","author":"Calfee","year":"2009","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0495","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40635-017-0155-0","article-title":"Whole blood microRNA markers are associated with acute respiratory distress syndrome","volume":"5","author":"Zhu","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0500","first-page":"L494","article-title":"Macrophage micro-RNA-155 promotes lipopolysaccharide-induced acute lung injury in mice and rats","volume":"311","author":"Wang","year":"2016","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0505","first-page":"61","article-title":"Extracellular vesicles in the pathogenesis and treatment of acute lung injury","volume":"9","author":"Hu","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0510","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.biopha.2018.08.040","article-title":"MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN\/AKT\/NF-kappaB signaling pathway","volume":"107","author":"Fu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0515","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jconrel.2010.11.004","article-title":"Endosomal escape pathways for delivery of biologicals","volume":"151","author":"Varkouhi","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0520","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biochi.2019.02.012","article-title":"Strategies in the design of endosomolytic agents for facilitating endosomal escape in nanoparticles","volume":"160","author":"Ahmad","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0525","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.tibtech.2018.02.006","article-title":"Design of polymeric gene carriers for effective intracellular delivery","volume":"36","author":"Lai","year":"2018","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0530","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9070803","article-title":"Ultrasound and microbubbles for targeted drug delivery to the lung endothelium in ARDS: cellular mechanisms and therapeutic opportunities","volume":"9","author":"Sanwal","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0535","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.939312","article-title":"Nanoscale porphyrin metal-organic frameworks deliver siRNA for alleviating early pulmonary fibrosis in acute lung injury","volume":"10","author":"Weng","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0540","article-title":"Pro-peptide-reinforced, mucus-penetrating pulmonary siRNA delivery mitigates cytokine strom in pneumonia","volume":"31","author":"Yang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0545","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1016\/j.biomaterials.2012.05.046","article-title":"Amphiphilic peptide carrier for the combined delivery of curcumin and plasmid DNA into the lungs","volume":"33","author":"Park","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0550","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/1061186X.2014.916711","article-title":"Combination of TAT-HMGB1A and R3V6 amphiphilic peptide for plasmid DNA delivery with anti-inflammatory effect","volume":"22","author":"Kim","year":"2014","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0555","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/1061186X.2010.547584","article-title":"Lung epithelial binding peptide-linked high mobility group box-1 a box for lung epithelial cell-specific delivery of DNA","volume":"19","author":"Kim","year":"2011","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0560","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2009.08.013","article-title":"Viral vector approaches to modify gene expression in the brain","volume":"185","author":"Papale","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0565","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1378\/chest.119.2.613","article-title":"Gene therapy for pulmonary diseases","volume":"119","author":"West","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0570","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ccc.2011.04.002","article-title":"Gene therapy for ALI\/ARDS","volume":"27","author":"Lin","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0575","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1517\/14740338.1.1.79","article-title":"Safety of adeno-associated virus gene therapy vectors: a current evaluation","volume":"1","author":"Monahan","year":"2002","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0580","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ymthe.2004.07.003","article-title":"Site-specific integration of functional transgenes into the human genome by adeno\/AAV hybrid vectors","volume":"10","author":"Recchia","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0585","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phrs.2009.10.002","article-title":"Viral vectors for neurotrophic factor delivery: a gene therapy approach for neurodegenerative diseases of the CNS","volume":"61","author":"Lim","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0590","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1148\/radiol.12112368","article-title":"Cationic versus neutral microbubbles for ultrasound-mediated gene delivery in cancer","volume":"264","author":"Wang","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0595","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1021\/la0603828","article-title":"Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA","volume":"22","author":"Lentacker","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0600","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.CIR.98.1.1","article-title":"Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells","volume":"98","author":"Villanueva","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0605","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.2147\/DDDT.S282227","article-title":"Sinapultide-loaded microbubbles combined with ultrasound to attenuate lipopolysaccharide-induced acute lung injury in mice","volume":"14","author":"Liu","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0610","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1164\/rccm.201711-2259LE","article-title":"Lung ultrasound and microbubbles enhance aminoglycoside efficacy and delivery to the lung in escherichia coli-induced pneumonia and acute respiratory distress syndrome","volume":"198","author":"Sugiyama","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0615","doi-asserted-by":"crossref","first-page":"E1763","DOI":"10.21037\/jtd.2016.12.74","article-title":"Lung ultrasound in acute respiratory distress syndrome and beyond","volume":"8","author":"Baston","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0620","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0301-5629(02)00518-5","article-title":"DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro","volume":"28","author":"Frenkel","year":"2002","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0625","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.biomaterials.2013.01.064","article-title":"Nanoparticle diffusion in respiratory mucus from humans without lung disease","volume":"34","author":"Schuster","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0630","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1615\/CritRevEukarGeneExpr.v15.i4.30","article-title":"Polymeric gene carriers","volume":"15","author":"Kang","year":"2005","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0635","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpharm.2006.05.002","article-title":"Dexamethasone conjugated poly(amidoamine) dendrimer as a gene carrier for efficient nuclear translocation","volume":"320","author":"Choi","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0640","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejps.2017.12.019","article-title":"Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury","volume":"114","author":"Lee","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0645","doi-asserted-by":"crossref","first-page":"14745","DOI":"10.1039\/D1NR03455C","article-title":"Intranasal delivery of self-assembled nanoparticles of therapeutic peptides and antagomirs elicits anti-tumor effects in an intracranial glioblastoma model","volume":"13","author":"Ha","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0650","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1179\/096805102125001091","article-title":"HMGB1 as a cytokine and therapeutic target","volume":"8","author":"Yang","year":"2002","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0655","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s10529-008-9695-4","article-title":"Expression, purification and characterization of TAT-high mobility group box-1A peptide as a carrier of nucleic acids","volume":"30","author":"Kim","year":"2008","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117766","article-title":"Stem cell derived exosomes-based therapy for acute lung injury and acute respiratory distress syndrome: a novel therapeutic strategy","volume":"254","author":"Xu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0665","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1517\/14712598.2016.1170804","article-title":"Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases","volume":"16","author":"Monsel","year":"2016","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0670","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0675","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1166\/jbn.2019.2866","article-title":"Delivery of high mobility group box-1 siRNA using brain-targeting exosomes for ischemic stroke therapy","volume":"15","author":"Kim","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0680","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jconrel.2013.08.014","article-title":"Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles","volume":"172","author":"Kooijmans","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0685","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/mt.2016.126","article-title":"Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing","volume":"24","author":"Didiot","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0690","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10426","article-title":"Brain-targeted exosome-mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti-tumor effects in glioblastoma animal models","volume":"8","author":"Lee","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107983","article-title":"Boosting extracellular vesicle secretion","volume":"59","author":"Debbi","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0700","doi-asserted-by":"crossref","first-page":"1700611","DOI":"10.1002\/advs.201700611","article-title":"Exosome-liposome hybrid nanoparticles deliver CRISPR\/Cas9 system in MSCs","volume":"5","author":"Lin","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0705","first-page":"1765","article-title":"Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis","volume":"14","author":"Ding","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0710","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1021\/mp900107v","article-title":"Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance","volume":"6","author":"Merkel","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0715","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijpharm.2019.05.016","article-title":"Biodistribution\/biostability assessment of siRNA after intravenous and intratracheal administration to mice, based on comprehensive analysis of in vivo\/ex vivo\/polyacrylamide gel electrophoresis fluorescence imaging","volume":"565","author":"Okuda","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0720","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijpharm.2017.02.025","article-title":"Fluorescence- and computed tomography for assessing the biodistribution of siRNA after intratracheal application in mice","volume":"525","author":"Geyer","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0725","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2014.01.007","article-title":"Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier","volume":"178","author":"Suk","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0730","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1021\/bm201226x","article-title":"Biodegradable nanoparticles meet the bronchial airway barrier: how surface properties affect their interaction with mucus and epithelial cells","volume":"12","author":"Mura","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0735","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/CCM.0000000000002284","article-title":"Randomized clinical trial of a combination of an inhaled corticosteroid and beta agonist in patients at risk of developing the acute respiratory distress syndrome","volume":"45","author":"Festic","year":"2017","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0740","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1007\/s12015-022-10398-w","article-title":"Nebulization therapy with umbilical cord mesenchymal stem cell-derived exosomes for COVID-19 pneumonia","volume":"18","author":"Chu","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0745","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/EJA.0000000000001245","article-title":"A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury: a randomised, placebo-controlled pilot study","volume":"37","author":"Ryan","year":"2020","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0750","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.7150\/ijms.35369","article-title":"Exosomes released by bone marrow mesenchymal stem cells attenuate lung injury induced by intestinal ischemia reperfusion via the TLR4\/NF-kappaB pathway","volume":"16","author":"Liu","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0755","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40364-019-0159-x","article-title":"Exosomes from mesenchymal stem\/stromal cells: a new therapeutic paradigm","volume":"7","author":"Yin","year":"2019","journal-title":"Biomark. Res."},{"key":"10.1016\/j.jconrel.2023.06.018_bb0760","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jconrel.2022.08.049","article-title":"Delivery of self-replicating messenger RNA into the brain for the treatment of ischemic stroke","volume":"350","author":"Kim","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.06.018_bb0765","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1023\/A:1014861900478","article-title":"A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity","volume":"16","author":"Fischer","year":"1999","journal-title":"Pharm. Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923003917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923003917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:43:29Z","timestamp":1759164209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365923003917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":153,"alternative-id":["S0168365923003917"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.06.018","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury\/acute respiratory distress syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}