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Bioelectron."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0335","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1021\/acs.chemrev.7b00027","article-title":"SERS-activated platforms for immunoassay: probes, encoding methods, and applications","volume":"117","author":"Wang","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0340","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1021\/acsami.5b01056","article-title":"SERS detection of amyloid oligomers on metallorganic-decorated plasmonic beads","volume":"7","author":"Guerrini","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0345","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1021\/acs.analchem.9b05837","article-title":"Label-free SERS strategy for in situ monitoring and real-time imaging of A\u03b2 aggregation process in live neurons and brain tissues","volume":"92","author":"Zhou","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0350","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1021\/acssensors.9b00974","article-title":"Robust and universal SERS sensing platform for multiplexed detection of Alzheimer\u2019s disease core biomarkers using PAapt-AuNPs conjugates","volume":"4","author":"Zhang","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0355","article-title":"Reaction kinetics-mediated control over silver Nanogap shells as surface-enhanced Raman scattering Nanoprobes for detection of Alzheimer\u2019s disease biomarkers","volume":"15","author":"Yang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0360","article-title":"Chiral plasmonic triangular nanorings with SERS activity for ultrasensitive detection of amyloid proteins in Alzheimer's disease","volume":"33","author":"Wang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0365","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1039\/D2AN00717G","article-title":"Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA","volume":"147","author":"Zhan","year":"2022","journal-title":"Analyst"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0370","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/brain\/awac407","article-title":"Brain-derived tau: a novel blood-based biomarker for Alzheimer\u2019s disease-type neurodegeneration","volume":"146","author":"Gonzalez-Ortiz","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0375","doi-asserted-by":"crossref","DOI":"10.1021\/cbmi.3c00041","article-title":"Simple plasma test based on a MoSe2 SERS platform for the specific diagnosis of Alzheimer\u2019s disease","author":"Zhou","year":"2023","journal-title":"Chem. Biomed. Imaging"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.131288","article-title":"Nanoparticle-based multiplex biosensor utilising dual dielectrophoretic forces for clinical diagnosis of Alzheimer\u2019s disease","volume":"355","author":"Kim","year":"2022","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0385","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41467-019-13901-z","article-title":"Clinically accurate diagnosis of Alzheimer\u2019s disease via multiplexed sensing of core biomarkers in human plasma","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0390","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00604-022-05199-4","article-title":"Portable electrochemical micro-workstation platform for simultaneous detection of multiple Alzheimer\u2019s disease biomarkers","volume":"189","author":"Liu","year":"2022","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0395","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(18)30033-4","article-title":"Technological advances and changing indications for lumbar puncture in neurological disorders","volume":"17","author":"Costerus","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0400","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jalz.2016.09.008","article-title":"Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia","volume":"13","author":"Simonsen","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0405","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202000948","article-title":"Analysis of the human plasma proteome using multi-nanoparticle protein Corona for detection of Alzheimer\u2019s disease","volume":"10","author":"Corbo","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0410","first-page":"40","article-title":"Plasma proteomics to identify biomarkers\u2013application to cardiovascular diseases","volume":"7","author":"Beck","year":"2015","journal-title":"Transl. Proteome"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0415","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1021\/acsnano.1c00658","article-title":"Nanoparticle-enabled enrichment of longitudinal blood proteomic fingerprints in Alzheimer\u2019s disease","volume":"15","author":"Hadjidemetriou","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0420","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/jon.12643","article-title":"The cingulate island sign on FDG-PET vs. IMP-SPECT to assess mild cognitive impairment in Alzheimer's disease vs. dementia with Lewy bodies","volume":"29","author":"Chiba","year":"2019","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-020-00595-5","article-title":"Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging","volume":"12","author":"Doecke","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0430","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1148\/radiol.212400","article-title":"Choroid plexus volume and permeability at brain MRI within the Alzheimer disease clinical spectrum","volume":"304","author":"Choi","year":"2022","journal-title":"Radiology"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0435","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s43587-022-00269-x","article-title":"Designing the next-generation clinical care pathway for Alzheimer\u2019s disease","volume":"2","author":"Hampel","year":"2022","journal-title":"Nat. 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Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0445","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaneurol.2021.1858","article-title":"Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid positron emission tomography and magnetic resonance imaging","volume":"78","author":"Ossenkoppele","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0450","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41574-021-00584-0","article-title":"Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD","volume":"18","author":"Tamaki","year":"2022","journal-title":"Nat. Rev. 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Biomed. Eng."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0470","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.bioconjchem.9b00695","article-title":"Development of near-infrared fluorescent probes for use in Alzheimer\u2019s disease diagnosis","volume":"31","author":"Yang","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100285","article-title":"In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice","volume":"23","author":"Ni","year":"2021","journal-title":"Photoacoustics"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0480","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1021\/acsnano.2c00054","article-title":"Optical nanosensor for intracellular and intracranial detection of amyloid-beta","volume":"16","author":"Antman-Passig","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0485","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s44222-022-00002-8","article-title":"Near-infrared luminescence high-contrast in vivo biomedical imaging","volume":"1","author":"Chen","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0490","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainresbull.2018.11.025","article-title":"Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain","volume":"144","author":"Koike","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0495","doi-asserted-by":"crossref","first-page":"10011","DOI":"10.1021\/acs.jafc.2c03411","article-title":"Dietary methylglyoxal exposure induces Alzheimer\u2019s disease by promoting amyloid \u03b2 accumulation and disrupting autophagy in caenorhabditis elegans","volume":"70","author":"Wei","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0500","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1021\/acs.analchem.0c02447","article-title":"Fluorophore-promoted facile deprotonation and exocyclic five-membered ring cyclization for selective and dynamic tracking of labile glyoxals","volume":"92","author":"Xu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0505","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1039\/C9CC08265D","article-title":"An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice","volume":"56","author":"Dang","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0510","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1039\/D2SC05242C","article-title":"Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations","volume":"13","author":"Lai","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0515","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/acschemneuro.7b00260","article-title":"Functionalization and characterization of magnetic nanoparticles for the detection of ferritin accumulation in Alzheimer\u2019s disease","volume":"9","author":"Fern\u00e1ndez","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0520","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201870130","article-title":"Dual-modal NIR-fluorophore conjugated magnetic nanoparticle for imaging amyloid-\u03b2 species in vivo","volume":"14","author":"Li","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-013-1448-1","article-title":"Effect of silica shell thickness of Fe 3 O 4\u2013SiO x core\u2013shell nanostructures on MRI contrast","volume":"15","author":"Joshi","year":"2013","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0530","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00247-021-05042-7","article-title":"Basics of magnetic resonance imaging and quantitative parameters T1, T2, T2*, T1rho and diffusion-weighted imaging","volume":"52","author":"Serai","year":"2022","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0535","doi-asserted-by":"crossref","first-page":"26812","DOI":"10.1021\/acsami.0c01597","article-title":"Ultrasmall T 1\u2013T 2 magnetic resonance multimodal imaging nanoprobes for the detection of \u03b2-amyloid aggregates in Alzheimer\u2019s disease mice","volume":"12","author":"Cai","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0540","doi-asserted-by":"crossref","first-page":"16213","DOI":"10.1021\/acs.analchem.2c03765","article-title":"Brain glucose activated MRI contrast agent for early diagnosis of Alzheimer\u2019s disease","volume":"94","author":"Liu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111623","article-title":"Advances in developing therapeutic strategies for Alzheimer's disease","volume":"139","author":"Nguyen","year":"2021","journal-title":"Biomed. 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A."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0560","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103791","article-title":"The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking","volume":"39","author":"Montesinos","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100652","article-title":"The C99 domain of the amyloid precursor protein resides in the disordered membrane phase","volume":"296","author":"Capone","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0570","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A critical appraisal of amyloid-\u03b2-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0575","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1021\/acschemneuro.8b00622","article-title":"Impact of gold nanoparticles on amyloid \u03b2-induced Alzheimer\u2019s disease in a rat animal model: involvement of STIM proteins","volume":"10","author":"Sanati","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-18525-2","article-title":"Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Hou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0585","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-11762-0","article-title":"Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy","volume":"10","author":"Javed","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0590","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201807965","article-title":"Magnetite\/ceria nanoparticle assemblies for extracorporeal cleansing of amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"31","author":"Kim","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0595","doi-asserted-by":"crossref","first-page":"21702","DOI":"10.1021\/jacs.0c08395","article-title":"Self-protecting biomimetic nanozyme for selective and synergistic clearance of peripheral amyloid-\u03b2 in an Alzheimer\u2019s disease model","volume":"142","author":"Ma","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101756","article-title":"Nanoparticle cluster depolymerizes and removes amyloid fibrils for Alzheimer\u2019s disease treatment","volume":"48","author":"Feng","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0605","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3233\/JAD-180098","article-title":"Role of the blood-brain barrier in Alzheimer\u2019s disease","volume":"63","author":"Cai","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0610","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(16)30029-1","article-title":"Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study","volume":"15","author":"Arvanitakis","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0615","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimer\u2019s disease: a matter of blood-brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0620","doi-asserted-by":"crossref","first-page":"16962","DOI":"10.1039\/C8NR04073G","article-title":"Treatment of neurodegenerative disorders through the blood-brain barrier using nanocarriers","volume":"10","author":"Poovaiah","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0625","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1021\/acs.molpharmaceut.6b00781","article-title":"Biomimetic ApoE-reconstituted high-density lipoprotein nanocarrier for blood-brain barrier penetration and amyloid beta-targeting drug delivery","volume":"13","author":"Song","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0630","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc7031","article-title":"Blood-brain barrier\u2013penetrating siRNA nanomedicine for Alzheimer\u2019s disease therapy","volume":"6","author":"Zhou","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0635","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood\u2013brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0640","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-\u03b2 and tau in Alzheimer\u2019s disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0645","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/brain\/awaa223","article-title":"Phosphorylated tau interactome in the human Alzheimer\u2019s disease brain","volume":"143","author":"Drummond","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0650","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/acsnano.7b07625","article-title":"Tau-targeted multifunctional nanocomposite for combinational therapy of Alzheimer\u2019s disease","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2023.07.004_bb0655","doi-asserted-by":"crossref","first-page":"23328","DOI":"10.1021\/acsami.1c00257","article-title":"Tau-targeted multifunctional nanoinhibitor for Alzheimer\u2019s disease","volume":"13","author":"Zhu","year":"2021","journal-title":"ACS Appl. Mater. 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Bioelectron."},{"key":"10.1016\/j.jconrel.2023.07.004_bb0820","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41587-021-00950-3","article-title":"Wearable materials with embedded synthetic biology sensors for biomolecule detection","volume":"39","author":"Nguyen","year":"2021","journal-title":"Nat. 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