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Soc."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0455","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2015.01.001","article-title":"Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye","volume":"200","author":"Huu","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.08.041_bb0460","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pbiomolbio.2006.02.005","article-title":"Acute effects of UVR on human eyes and skin","volume":"92","author":"Young","year":"2006","journal-title":"Prog. Biophys. Mol. 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Pharm."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.821288","article-title":"Reactive oxygen species-based biomaterials for regenerative medicine and tissue engineering applications","volume":"9","author":"Shafiq","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0480","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/pharmaceutics13050687","article-title":"Ferulic acid-loaded polymeric nanoparticles for potential ocular delivery","volume":"13","author":"Romeo","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0485","first-page":"1","article-title":"RGD-modified multifunctional nanoparticles encapsulating salvianolic acid a for targeted treatment of choroidal neovascularization","volume":"19","author":"Zhang","year":"2021","journal-title":"J. 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Sci."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0565","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/nnm-2018-0297","article-title":"Noninvasive biodegradable nanoparticles-in-nanofibers single-dose ocular insert: in vitro, ex vivo and in vivo evaluation","volume":"14","author":"Khalil","year":"2019","journal-title":"Nanomedicine."},{"key":"10.1016\/j.jconrel.2023.08.041_bb0570","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.600384","article-title":"In situ gelling amphotericin B nanofibers: a new option for the treatment of keratomycosis","volume":"8","author":"G\u00f6ttel","year":"2020","journal-title":"Front. Bioeng. 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