{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:41:05Z","timestamp":1793108465880,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jconrel.2023.11.053","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T19:19:44Z","timestamp":1701544784000},"page":"521-529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Engineered assemblies from isomeric pentapeptides augment dry eye treatment"],"prefix":"10.1016","volume":"365","author":[{"given":"Yanwen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinglian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jconrel.2023.11.053_bb0005","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jama.2021.19963","article-title":"Dry eye disease an update in 2022","volume":"327","author":"Hakim","year":"2022","journal-title":"JAMA-J. Am. Med. Assoc."},{"issue":"11","key":"10.1016\/j.jconrel.2023.11.053_bb0010","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The pathophysiology of dry eye disease what we know and future directions for research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology"},{"issue":"17","key":"10.1016\/j.jconrel.2023.11.053_bb0015","doi-asserted-by":"crossref","first-page":"2200435","DOI":"10.1002\/advs.202200435","article-title":"Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114582","article-title":"Novel drug delivery systems for the management of dry eye","volume":"191","author":"Nagai","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.addr.2017.04.001","article-title":"Nanoparticles for drug delivery to the anterior segment of the eye","volume":"122","author":"Janagam","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0035","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2018.06.031","article-title":"Polymer-based carriers for ophthalmic drug delivery","volume":"285","author":"Imperiale","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2023.11.053_bb0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.addr.2016.06.015","article-title":"Peptide-drug conjugates as effective prodrug strategies for targeted delivery","volume":"110","author":"Wang","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135240","article-title":"Peptide-based supramolecular photodynamic therapy systems: from rational molecular design to effective cancer treatment","volume":"436","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"44","key":"10.1016\/j.jconrel.2023.11.053_bb0050","doi-asserted-by":"crossref","first-page":"14945","DOI":"10.1021\/jacs.8b09320","article-title":"Self-assembled nanostructures regulate H2S release from constitutionally isomeric peptides","volume":"140","author":"Wang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.jconrel.2023.11.053_bb0055","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1021\/jacs.0c03672","article-title":"Molecular-level control over plasmonic properties in silver nanoparticle\/self-assembling peptide hybrids","volume":"142","author":"Wang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"10.1016\/j.jconrel.2023.11.053_bb0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41570-020-0215-y","article-title":"Biomimetic peptide self-assembly for functional materials","volume":"4","author":"Levin","year":"2020","journal-title":"Nat. Rev. Chem."},{"issue":"10","key":"10.1016\/j.jconrel.2023.11.053_bb0065","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1021\/acs.nanolett.2c00967","article-title":"Collagen-binding peptide-enabled supramolecular hydrogel design for improved organ adhesion and sprayable therapeutic delivery","volume":"22","author":"Anderson","year":"2022","journal-title":"Nano Lett."},{"issue":"7","key":"10.1016\/j.jconrel.2023.11.053_bb0070","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.1021\/acsnano.9b01689","article-title":"Fine-tuning the linear release rate of paclitaxel-bearing supramolecular filament hydrogels through molecular engineering","volume":"13","author":"Chakroun","year":"2019","journal-title":"ACS Nano"},{"issue":"35","key":"10.1016\/j.jconrel.2023.11.053_bb0075","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1021\/ja507051w","article-title":"Amino acid sequence in constitutionally isomeric tetrapeptide amphiphiles dictates architecture of one-dimensional nanostructures","volume":"136","author":"Cui","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"35","key":"10.1016\/j.jconrel.2023.11.053_bb0080","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1039\/C9SC00193J","article-title":"Sequence isomerism-dependent self-assembly of glycopeptide mimetics with switchable antibiofilm properties","volume":"10","author":"Chen","year":"2019","journal-title":"Chem. Sci."},{"issue":"10","key":"10.1016\/j.jconrel.2023.11.053_bb0085","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1039\/D0QM00369G","article-title":"A combined experimental and computational approach reveals how aromatic peptide amphiphiles self-assemble to form ion-conducting nanohelices","volume":"4","author":"Wang","year":"2020","journal-title":"Mat. Chem. Front."},{"issue":"26","key":"10.1016\/j.jconrel.2023.11.053_bb0090","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1021\/ja100613w","article-title":"Direct observation of morphological tranformation from twisted ribbons into helical ribbons","volume":"132","author":"Pashuck","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"26","key":"10.1016\/j.jconrel.2023.11.053_bb0095","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1002\/anie.201801001","article-title":"Tunable pentapeptide self-assembled beta-sheet hydrogels","volume":"57","author":"Clarke","year":"2018","journal-title":"Angew. Chem.-Intern. Ed."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.preteyeres.2016.04.005","article-title":"Goblet cells of the conjunctiva: a review of recent findings","volume":"54","author":"Gipson","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2023.11.053_bb0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.preteyeres.2018.11.007","article-title":"Reconsidering the central role of mucins in dry eye and ocular surface diseases","volume":"71","author":"Baudouin","year":"2019","journal-title":"Prog. Retin. Eye Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923007782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365923007782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:52:54Z","timestamp":1759164774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365923007782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":21,"alternative-id":["S0168365923007782"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.11.053","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered assemblies from isomeric pentapeptides augment dry eye treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2023.11.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}