{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:07:37Z","timestamp":1791691657931,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jconrel.2024.01.032","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T07:37:30Z","timestamp":1705736250000},"page":"732-745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling"],"prefix":"10.1016","volume":"366","author":[{"given":"Meng-Meng","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Fei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Wen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.01.032_bb0005","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1056\/NEJMcibr1811639","article-title":"Revealing the secrets of idiopathic pulmonary fibrosis","volume":"380","author":"Albert","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0010","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","article-title":"Idiopathic pulmonary fibrosis","volume":"389","author":"Richeldi","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S2213-2600(22)00251-X","article-title":"Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study","volume":"11","author":"Allen","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-pathol-012513-104706","article-title":"Pathogenesis of idiopathic pulmonary fibrosis","volume":"9","author":"Wolters","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0025","doi-asserted-by":"crossref","first-page":"1900905","DOI":"10.1183\/13993003.00905-2019","article-title":"New radiological diagnostic criteria: impact on idiopathic pulmonary fibrosis diagnosis","volume":"54","author":"Funke-Chambour","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-med-041317-102715","article-title":"Progress in understanding and treating idiopathic pulmonary fibrosis","volume":"70","author":"Kropski","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0035","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jconrel.2022.09.054","article-title":"Pathological collagen targeting and penetrating liposomes for idiopathic pulmonary fibrosis therapy","volume":"351","author":"Yang","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121731","article-title":"Functional au nanoparticles for engineering and long-term CT imaging tracking of mesenchymal stem cells in idiopathic pulmonary fibrosis treatment","volume":"288","author":"Bao","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119616","article-title":"Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy","volume":"230","author":"Fan","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0050","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1021\/acsnano.2c03858","article-title":"Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115051","article-title":"Progress on the pathological tissue microenvironment barrier-modulated nanomedicine","volume":"200","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0060","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41422-020-0354-1","article-title":"Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis","volume":"30","author":"Wu","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1164\/rccm.201207-1204PP","article-title":"Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing","volume":"188","author":"Toonkel","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007798","article-title":"Targeted dual small interfering ribonucleic acid delivery via non-viral polymeric vectors for pulmonary fibrosis therapy","volume":"33","author":"Ji","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jconrel.2021.02.022","article-title":"Biomimetic lipid nanocomplexes incorporating STAT3-inhibiting peptides effectively infiltrate the lung barrier and ameliorate pulmonary fibrosis","volume":"332","author":"Keum","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0080","doi-asserted-by":"crossref","first-page":"eaba3167","DOI":"10.1126\/sciadv.aba3167","article-title":"Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis","volume":"6","author":"Chang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0085","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1038\/s41467-023-41529-7","article-title":"Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0090","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1038\/s41467-020-18841-7","article-title":"In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition","volume":"11","author":"Mitchel","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0095","doi-asserted-by":"crossref","first-page":"eabo5254","DOI":"10.1126\/scitranslmed.abo5254","article-title":"Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling","volume":"14","author":"Stancil","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0100","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1038\/s41467-021-24853-8","article-title":"Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional","volume":"12","author":"Stancil","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0105","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0394-6","article-title":"A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte","volume":"560","author":"Plasschaert","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0110","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1165\/rcmb.2018-0081OC","article-title":"Integrins \u03b1v\u03b25 and \u03b1v\u03b26 mediate IL-4-induced collective migration in human airway epithelial cells","volume":"60","author":"Lee","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0115","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1164\/rccm.201712-2551OC","article-title":"BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis","volume":"199","author":"Prasse","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0120","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1164\/rccm.202109-2219PP","article-title":"An airway-centric view of idiopathic pulmonary fibrosis","volume":"206","author":"Stancil","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007557","article-title":"Nanoparticle-mediated delivery of inhaled immunotherapeutics for treating lung metastasis","volume":"33","author":"Jin","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0130","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1038\/s41467-020-18397-6","article-title":"Translational pharmacology of an inhaled small molecule \u03b1v\u03b26 integrin inhibitor for idiopathic pulmonary fibrosis","volume":"11","author":"John","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114173","article-title":"Nano-delivery to the lung-by inhalation or other routes and why nano when micro is largely sufficient?","volume":"183","author":"Forest","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0140","article-title":"Inhaled mRNA nanoformulation with biogenic ribosomal protein reverses established pulmonary fibrosis in a bleomycin-induced murine model","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0145","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s11095-022-03363-2","article-title":"Advancements in particle engineering for inhalation delivery of small molecules and biotherapeutics","volume":"39","author":"Chang","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2022.05.039","article-title":"Novel drug delivery systems and disease models for pulmonary fibrosis","volume":"348","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0155","doi-asserted-by":"crossref","first-page":"eabn7162","DOI":"10.1126\/sciadv.abn7162","article-title":"Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge","volume":"8","author":"Bai","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120973","article-title":"Pulmonary surfactants affinity Pluronic-hybridized liposomes enhance the treatment of drug-resistant lung cancer","volume":"607","author":"Wang","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0165","doi-asserted-by":"crossref","first-page":"eadg5358","DOI":"10.1126\/sciadv.adg5358","article-title":"Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice","volume":"9","author":"Han","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0170","doi-asserted-by":"crossref","first-page":"2008960","DOI":"10.1002\/adfm.202008960","article-title":"Pro-peptide-reinforced, mucus-penetrating pulmonary siRNA delivery mitigates cytokine storm in pneumonia","volume":"31","author":"Yang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0175","doi-asserted-by":"crossref","first-page":"17019","DOI":"10.1038\/celldisc.2017.19","article-title":"UHRF1 is required for basal stem cell proliferation in response to airway injury","volume":"3","author":"Xiang","year":"2017","journal-title":"Cell Discov."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0180","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41467-023-36352-z","article-title":"Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation","volume":"14","author":"Crotta","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0185","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41467-017-01201-3","article-title":"TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells","volume":"8","author":"Alpizar","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0190","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1038\/s41467-022-33193-0","article-title":"Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis","volume":"13","author":"Jaeger","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0195","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2147\/IJN.S4937","article-title":"Nanomedicine in pulmonary delivery","volume":"4","author":"Mansour","year":"2009","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2024.01.032_bb0200","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.addr.2017.08.010","article-title":"PEGylation for enhancing nanoparticle diffusion in mucus","volume":"124","author":"Huckaby","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0205","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF (beta-TRCP)","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0210","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1681\/ASN.2016060611","article-title":"Lats1\/2 regulate yap\/Taz to control nephron progenitor epithelialization and inhibit myofibroblast formation","volume":"28","author":"McNeill","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0215","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/nph.13980","article-title":"A pulse-chase strategy for EdU labelling assay is able to rapidly quantify cell division orientation","volume":"211","author":"Yin","year":"2016","journal-title":"New Phytol."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0220","doi-asserted-by":"crossref","first-page":"1901105","DOI":"10.1183\/13993003.01105-2019","article-title":"The importance of interventional timing in the bleomycin model of pulmonary fibrosis","volume":"55","author":"Kolb","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.01.032_bb0225","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fmed.2017.00118","article-title":"Exploring animal models that resemble idiopathic pulmonary fibrosis","volume":"4","author":"Tashiro","year":"2017","journal-title":"Front. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:33:40Z","timestamp":1738100020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":45,"alternative-id":["S0168365924000440"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.01.032","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}