{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:23:03Z","timestamp":1785252183219,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004358","name":"Samsung","doi-asserted-by":"publisher","award":["SRFC_MA2102_06"],"award-info":[{"award-number":["SRFC_MA2102_06"]}],"id":[{"id":"10.13039\/100004358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jconrel.2024.02.008","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T18:20:30Z","timestamp":1707848430000},"page":"768-778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Nano-chemical priming strategy to enhance TGF-\u03b2 resistance and anti-tumor activity of natural killer cells"],"prefix":"10.1016","volume":"367","author":[{"given":"Seung Hee","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Bang","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seohyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunchong","family":"Maeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hail","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Seo","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Hong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Soon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.02.008_bb0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imr.12132","article-title":"Exploiting the curative potential of adoptive T-cell therapy for cancer","volume":"257","author":"Hinrichs","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0010","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ajh.25418","article-title":"An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer","volume":"94","author":"Feins","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","article-title":"CAR-T cell therapy: current limitations and potential strategies","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0020","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1182\/blood-2004-07-2974","article-title":"Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer","volume":"105","author":"Miller","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1274","article-title":"CAR-NK cells: the next wave of cellular therapy for cancer","volume":"10","author":"Daher","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.732135","article-title":"Current perspectives on \u201coff-the-shelf\u201d allogeneic NK and CAR-NK cell therapies","volume":"12","author":"Heipertz","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0035","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002723","article-title":"Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead","volume":"9","author":"Kirtane","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0040","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0045","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0055","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","article-title":"TGFbeta signalling in context","volume":"13","author":"Massague","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0065","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1084\/jem.20051511","article-title":"CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner","volume":"202","author":"Ghiringhelli","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0070","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4049\/jimmunol.176.3.1582","article-title":"CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer","volume":"176","author":"Smyth","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0075","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.4049\/jimmunol.146.11.3791","article-title":"Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction","volume":"146","author":"Ortaldo","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-3083.1993.tb01667.x","article-title":"Regulation of natural killer cell activity by transforming growth factor-beta and prostaglandin E2","volume":"37","author":"Malygin","year":"1993","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0085","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ni1197","article-title":"Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma","volume":"6","author":"Laouar","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0090","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.4049\/jimmunol.172.12.7335","article-title":"Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients","volume":"172","author":"Lee","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0095","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1158\/1078-0432.CCR-18-3183","article-title":"Engineering the TGFbeta receptor to enhance the therapeutic potential of natural killer cells as an immunotherapy for neuroblastoma","volume":"25","author":"Burga","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0100","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jcyt.2016.12.005","article-title":"Cord blood natural killer cells expressing a dominant negative TGF-beta receptor: implications for adoptive immunotherapy for glioblastoma","volume":"19","author":"Yvon","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004964","article-title":"Chemical priming of natural killer cells with branched polyethylenimine for cancer immunotherapy","volume":"10","author":"Choi","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12964-023-01101-8","article-title":"25KDa branched polyethylenimine increases interferon-gamma production in natural killer cells via improving translation efficiency","volume":"21","author":"Ko","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0115","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1021\/acsnano.9b10103","article-title":"Boosting natural killer cell-based cancer immunotherapy with selenocystine\/transforming growth factor-beta inhibitor-encapsulated nanoemulsion","volume":"14","author":"Liu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0120","doi-asserted-by":"crossref","first-page":"56731","DOI":"10.1021\/acsami.0c16357","article-title":"Cationic nanoparticle-mediated activation of natural killer cells for effective Cancer immunotherapy","volume":"12","author":"Kim","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0125","series-title":"Role of CD44 in CTL and NK cell activity","first-page":"d665","volume":"3","author":"Rafi-Janajreh","year":"1998"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901182","article-title":"Binding and internalization in receptor-targeted carriers: the complex role of CD44 in the uptake of hyaluronic acid-based nanoparticles (siRNA delivery)","volume":"8","author":"Rios de la Rosa","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/107999004323065093","article-title":"The regulation and activation of CD44 by natural killer (NK) cells and its role in the production of IFN-gamma","volume":"24","author":"Sague","year":"2004","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0140","series-title":"Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity","first-page":"7286","volume":"24","author":"Salathia","year":"2023"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0145","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1038\/s41598-020-61465-6","article-title":"Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR\/Cas9 system for genome editing","volume":"10","author":"Rohiwal","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0150","doi-asserted-by":"crossref","first-page":"27033","DOI":"10.18632\/oncotarget.7041","article-title":"Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-beta1-mediated suppression","volume":"7","author":"Yamada","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/icb.2013.96","article-title":"Cell biological steps and checkpoints in accessing NK cell cytotoxicity","volume":"92","author":"Mace","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0160","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1073\/pnas.0730640100","article-title":"Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells","volume":"100","author":"Castriconi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0165","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fimmu.2020.00311","article-title":"NK cell function regulation by TGF-beta-induced epigenetic mechanisms","volume":"11","author":"Regis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119521","article-title":"NK cells in cancer: mechanisms of dysfunction and therapeutic potential","volume":"24","author":"Portale","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jim.2004.08.008","article-title":"CD107a as a functional marker for the identification of natural killer cell activity","volume":"294","author":"Alter","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0180","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.3389\/fimmu.2019.03038","article-title":"Influence of the tumor microenvironment on NK cell function in solid tumors","volume":"10","author":"Melaiu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174131","article-title":"Hepatic tumor microenvironments and effects on NK cell phenotype and function","volume":"20","author":"Pineiro Fernandez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0190","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1021\/acsanm.2c00524","article-title":"Hyaluronic acid\u2013polyethyleneimine nanogels for controlled drug delivery in cancer treatment","volume":"5","author":"Limiti","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0195","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cej.2017.12.071","article-title":"Polyethyleneimine coated nanogels for the intracellular delivery of RNase a for cancer therapy","volume":"340","author":"Kordalivand","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2024.02.008_bb0200","article-title":"CD44-targeted carriers: The role of molecular weight of hyaluronic acid in the uptake of hyaluronic acid-based nanoparticles","volume":"15","author":"Chiesa","year":"2022","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"10.1016\/j.jconrel.2024.02.008_bb0205","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.carbpol.2015.09.053","article-title":"Receptor-mediated gene delivery into human mesenchymal stem cells using hyaluronic acid-shielded polyethylenimine\/pDNA nanogels","volume":"136","author":"Park","year":"2016","journal-title":"Carbohydr. Polym."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924000956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924000956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:58:08Z","timestamp":1759165088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924000956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":41,"alternative-id":["S0168365924000956"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.02.008","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nano-chemical priming strategy to enhance TGF-\u03b2 resistance and anti-tumor activity of natural killer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}