{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:56:27Z","timestamp":1792205787802,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Liaoning Province Educational Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021194","name":"Shenyang Pharmaceutical University Shenyang Key Laboratory of Functional Drug Carrier Materials","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jconrel.2024.02.022","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T22:34:30Z","timestamp":1709159670000},"page":"219-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis"],"prefix":"10.1016","volume":"368","author":[{"given":"Kaili","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.02.022_bb0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0010","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hep.32239","article-title":"Liver fibrosis: extracellular vesicles mediated intercellular communication in perisinusoidal space","volume":"76","author":"Devaraj","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0020","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41575-023-00832-w","article-title":"Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis","volume":"20","author":"Sharma","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0030","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.apsb.2021.12.007","article-title":"Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1","volume":"12","author":"Luo","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jconrel.2023.05.002","article-title":"Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis","volume":"358","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0040","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jconrel.2023.08.021","article-title":"Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice","volume":"361","author":"Younis","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2022.01.038","article-title":"Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis","volume":"343","author":"Zhou","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122133","article-title":"Reversal of hepatic fibrosis by the co-delivery of drug and ribonucleoprotein-based genome editor","volume":"298","author":"Gu","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0055","article-title":"Supramolecular nanoarchitectonics based on antagonist peptide self-assembly for treatment of liver fibrosis","volume":"19","author":"Li","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300002","article-title":"Peptide-based nanoarchitectonics for the treatment of liver fibrosis","volume":"24","author":"Li","year":"2023","journal-title":"Chembiochem"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0065","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.coph.2019.09.006","article-title":"New and emerging anti-fibrotic therapeutics entering or already in clinical trials in chronic liver diseases","volume":"49","author":"Lemoinne","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jconrel.2023.01.052","article-title":"Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells","volume":"355","author":"Xia","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0075","doi-asserted-by":"crossref","first-page":"12630","DOI":"10.1038\/ncomms12630","article-title":"ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion","volume":"7","author":"Chronopoulos","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0080","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1038\/s41467-020-18636-w","article-title":"Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer","volume":"11","author":"Kocher","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122134","article-title":"Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation","volume":"299","author":"Huang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122232","article-title":"Dually fibronectin\/CD44-mediated nanoparticles targeted disrupt the Golgi apparatus and inhibit the hedgehog signaling in activated hepatic stellate cells to alleviate liver fibrosis","volume":"301","author":"Li","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0095","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/hep.27376","article-title":"Liver sinusoidal endothelial cells in hepatic fibrosis","volume":"61","author":"DeLeve","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0100","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.7150\/thno.83714","article-title":"Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis via nitric oxide production","volume":"13","author":"Hwang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0105","article-title":"Restoration of sinusoid fenestrae followed by targeted nanoassembly delivery of an anti-fibrotic agent improves treatment efficacy in liver fibrosis","volume":"35","author":"Li","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0110","doi-asserted-by":"crossref","first-page":"14029","DOI":"10.1021\/acsnano.2c03858","article-title":"Sequential nano-penetrators of capillarized liver sinusoids and extracellular matrix barriers for liver fibrosis therapy","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300127","article-title":"Remodeling collagen microenvironment in liver using a biomimetic nano-regulator for reversal of liver fibrosis","volume":"10","author":"Liang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0120","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119616","article-title":"Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy","volume":"230","author":"Fan","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.08.065","article-title":"Collagenase-I decorated co-delivery micelles potentiate extracellular matrix degradation and hepatic stellate cell targeting for liver fibrosis therapy","volume":"152","author":"Zhou","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119745","article-title":"Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors","volume":"232","author":"Han","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0140","doi-asserted-by":"crossref","first-page":"1903138","DOI":"10.1002\/advs.201903138","article-title":"Nanodrug with ROS and pH dual-sensitivity ameliorates liver fibrosis via multicellular regulation","volume":"7","author":"Lin","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0145","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1021\/acs.nanolett.8b04236","article-title":"Enhanced drug delivery by nanoscale integration of a nitric oxide donor to induce tumor collagen depletion","volume":"19","author":"Dong","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0150","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.7150\/thno.42661","article-title":"S-nitrosothiols loaded mini-sized Au@silica nanorod elicits collagen depletion and mitochondrial damage in solid tumor treatment","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121448","article-title":"Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy","volume":"283","author":"Shi","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0160","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41467-019-08670-8","article-title":"Bio-inspired nitric-oxide-driven nanomotor","volume":"10","author":"Wan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122028","article-title":"Remodeling liver microenvironment by L-arginine loaded hollow polydopamine nanoparticles for liver cirrhosis treatment","volume":"295","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0170","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/smll.201402870","article-title":"The use of nanoparticles to deliver nitric oxide to hepatic stellate cells for treating liver fibrosis and portal hypertension","volume":"11","author":"Duong","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0175","doi-asserted-by":"crossref","first-page":"2002525","DOI":"10.1002\/advs.202002525","article-title":"Nitric oxide-driven nanomotor for deep tissue penetration and multidrug resistance reversal in cancer therapy","volume":"8","author":"Wan","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0180","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jconrel.2022.12.059","article-title":"Delivery of nitric oxide with a pH-responsive nanocarrier for the treatment of renal fibrosis","volume":"354","author":"Lee","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2022.04.004","article-title":"Delivery of sorafenib by myofibroblast-targeted nanoparticles for the treatment of renal fibrosis","volume":"346","author":"Cheng","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0190","doi-asserted-by":"crossref","first-page":"26060","DOI":"10.1021\/acsami.9b03313","article-title":"Gold nanoparticle transforms activated cancer-associated fibroblasts to quiescence","volume":"11","author":"Hossen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0195","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jhep.2014.06.010","article-title":"Inhibition of fibronectin deposition improves experimental liver fibrosis","volume":"62","author":"Altrock","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0200","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1158\/0008-5472.CAN-07-1436","article-title":"The extra-domain a of fibronectin is a vascular marker of solid tumors and metastases","volume":"67","author":"Rybak","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0205","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hep.30193","article-title":"Retinoic acid receptor-\u03b2 is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells","volume":"69","author":"Cortes","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076541","article-title":"Amplified inhibition of stellate cell activation pathways by PPAR-\u03b3, RAR and RXR agonists","volume":"8","author":"Sharvit","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121492","article-title":"Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis","volume":"284","author":"Wu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.02.022_bb0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12951-021-01205-8","article-title":"Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma","volume":"20","author":"Yu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0225","first-page":"278","article-title":"The effects of metformin on age-related changes in the liver sinusoidal endothelial cell","volume":"75","author":"Hunt","year":"2020","journal-title":"J. Gerontol. Biol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.936196","article-title":"The crosstalk between liver sinusoidal endothelial cells and hepatic microenvironment in NASH related liver fibrosis","volume":"13","author":"Du","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0235","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1021\/acs.nanolett.2c04726","article-title":"The combination of sinusoidal perfusion enhancement and apoptosis inhibition by riociguat plus a galactose-PEGylated bilirubin multiplexing nanomedicine ameliorates liver fibrosis progression","volume":"23","author":"Li","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003721","article-title":"Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells","volume":"8","author":"Wu","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.02.022_bb0245","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2021.11.033","article-title":"Sequential delivery for hepatic fibrosis treatment based on carvedilol loaded star-like nanozyme","volume":"341","author":"Lu","year":"2022","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924001093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924001093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:34:28Z","timestamp":1738100068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924001093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"alternative-id":["S0168365924001093"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.02.022","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}