{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:08:43Z","timestamp":1793412523985,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jconrel.2024.05.028","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:06:33Z","timestamp":1716336393000},"page":"16-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis"],"prefix":"10.1016","volume":"371","author":[{"given":"Junmei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My Hanh","family":"Ta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.05.028_bb0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0010","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0015","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.cell.2023.03.003","article-title":"Metastasis","volume":"186","author":"Gerstberger","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0020","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s43018-023-00595-y","article-title":"Cancer cell plasticity during tumor progression, metastasis and response to therapy","volume":"4","author":"P\u00e9rez-Gonz\u00e1lez","year":"2023","journal-title":"Nat. Can."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.semcancer.2022.10.006","article-title":"Mechanisms of cancer metastasis","volume":"87","author":"Castaneda","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13073-020-00728-3","article-title":"Tracking cancer progression: from circulating tumor cells to metastasis","volume":"12","author":"Castro-Giner","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","article-title":"Targeting metastatic cancer","volume":"27","author":"Ganesh","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0040","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2017.08.009","article-title":"EMT: mechanisms and therapeutic implications","volume":"182","author":"Singh","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0050","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrc.2017.118","article-title":"EMT in cancer","volume":"18","author":"Brabletz","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial-mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41586-019-1526-3","article-title":"E-cadherin is required for metastasis in multiple models of breast cancer","volume":"573","author":"Padmanaban","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0065","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ncb3425","article-title":"Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer","volume":"18","author":"Ni","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0070","doi-asserted-by":"crossref","first-page":"E62","DOI":"10.1002\/ijc.29177","article-title":"Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT","volume":"136","author":"D\u00edaz-L\u00f3pez","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41568-022-00536-4","article-title":"Biology, vulnerabilities and clinical applications of circulating tumour cells","volume":"23","author":"Ring","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrclinonc.2016.144","article-title":"Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape","volume":"14","author":"Mohme","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0085","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","article-title":"Role of platelets and platelet receptors in cancer metastasis","volume":"11","author":"Schlesinger","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41571-020-0403-1","article-title":"TGF\u03b2 biology in cancer progression and immunotherapy","volume":"18","author":"Derynck","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0095","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41581-021-00429-z","article-title":"Nitric oxide signalling in kidney regulation and cardiometabolic health","volume":"17","author":"Carlstr\u00f6m","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0105","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","volume":"120","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0110","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1152\/physrev.00005.2022","article-title":"The superoxide radical switch in the biology of nitric oxide and peroxynitrite","volume":"102","author":"Piacenza","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0115","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1089\/ars.2018.7527","article-title":"Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism","volume":"30","author":"Somasundaram","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0120","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.trecan.2017.07.005","article-title":"Nitric oxide: the forgotten child of tumor metabolism","volume":"3","author":"Salimian Rizi","year":"2017","journal-title":"Trend. Cancer"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2023.08.038","article-title":"Nitric oxide-driven nanotherapeutics for cancer treatment","volume":"362","author":"Zhao","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2010.10.001","article-title":"Dual role of NO donors in the reversal of tumor cell resistance and EMT: downregulation of the NF-\u03baB\/snail\/YY1\/RKIP circuitry","volume":"24","author":"Bonavida","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0135","first-page":"125","article-title":"Inhibition of epithelial-to-mesenchymal transition (EMT) in cancer by nitric oxide: pivotal roles of nitrosylation of NF-\u03baB, YY1 and snail","volume":"3","author":"Bonavida","year":"2012","journal-title":"For. Immunopathol. Dis. Therap."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101381","article-title":"Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy","volume":"42","author":"Li","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0145","doi-asserted-by":"crossref","first-page":"37466","DOI":"10.1021\/acsami.2c10098","article-title":"Black phosphorus-synergic nitric oxide nanogasholder spatiotemporally regulates tumor microenvironments for self-amplifying immunotherapy","volume":"14","author":"Huang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0150","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1021\/acsnano.1c09048","article-title":"Nitric oxide induces immunogenic cell death and potentiates cancer immunotherapy","volume":"16","author":"Jiang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0155","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.7150\/thno.62572","article-title":"Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation","volume":"11","author":"Ji","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trsl.2019.03.003","article-title":"Immunomodulatory roles of nitric oxide in cancer: tumor microenvironment says \u201cNO\u201d to antitumor immune response","volume":"210","author":"Pe\u00d1arando","year":"2019","journal-title":"Transl. Res."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0165","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1124\/pharmrev.121.000500","article-title":"Opportunities for nitric oxide in potentiating cancer immunotherapy","volume":"74","author":"Kim","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0170","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jconrel.2022.12.030","article-title":"Surface programmed bacteria as photo-controlled NO generator for tumor immunological and gas therapy","volume":"353","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801964","article-title":"Gas-generating nanoplatforms: material chemistry, multifunctionality, and gas therapy","volume":"30","author":"Yu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2022.10.012","article-title":"Recent progress in nitric oxide-generating nanomedicine for cancer therapy","volume":"352","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0185","doi-asserted-by":"crossref","first-page":"1701043","DOI":"10.1002\/advs.201701043","article-title":"Progress and promise of nitric oxide-releasing platforms","volume":"5","author":"Yang","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0190","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1021\/acsnano.3c02303","article-title":"Advanced nitric oxide generating nanomedicine for therapeutic applications","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0195","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/s41565-019-0570-3","article-title":"Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies","volume":"14","author":"Sung","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0200","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1021\/acs.nanolett.0c01532","article-title":"Carry-on nitric-oxide luggage for enhanced chemotherapeutic efficacy","volume":"20","author":"Sun","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0205","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","article-title":"Nitric oxide donors: chemical activities and biological applications","volume":"102","author":"Wang","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0210","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1039\/C8TB00566D","article-title":"Biodegradable crosslinked polyesters derived from thiomalic acid and S-nitrosothiol analogues for nitric oxide release","volume":"6","author":"Yapor","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0215","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108647","article-title":"Dynamic EMT: a multi-tool for tumor progression","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0220","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.semcancer.2015.03.004","article-title":"Immune evasion in cancer: mechanistic basis and therapeutic strategies","volume":"35","author":"Vinay","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0230","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0235","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.molmed.2018.02.002","article-title":"Nitric oxide signaling in t cell-mediated immunity","volume":"24","author":"Garc\u00eda-Ortiz","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0240","doi-asserted-by":"crossref","first-page":"37733","DOI":"10.1074\/jbc.M003030200","article-title":"Identification of the hyaluronan receptor for endocytosis (hare)","volume":"275","author":"Zhou","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2024.05.028_bb0245","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2006.08.020","article-title":"Cd44 is the signaling component of the macrophage migration inhibitory factor-cd74 receptor complex","volume":"25","author":"Shi","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0250","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.niox.2008.04.018","article-title":"Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and immunosensitization to apoptosis and inhibition of metastases","volume":"19","author":"Bonavida","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jconrel.2024.05.028_bb0255","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.redox.2015.08.013","article-title":"Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics","volume":"6","author":"Bonavida","year":"2015","journal-title":"Redox Biol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924003122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924003122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:08:03Z","timestamp":1719295683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924003122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":51,"alternative-id":["S0168365924003122"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.05.028","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}