{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:07:34Z","timestamp":1791166054023,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23520712500"],"award-info":[{"award-number":["23520712500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2254900"],"award-info":[{"award-number":["20DZ2254900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52350710203"],"award-info":[{"award-number":["52350710203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A2096"],"award-info":[{"award-number":["U23A2096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003245","name":"Ministerie van Onderwijs, Cultuur en Wetenschap","doi-asserted-by":"publisher","award":["024.005.020"],"award-info":[{"award-number":["024.005.020"]}],"id":[{"id":"10.13039\/501100003245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003245","name":"Ministerie van Onderwijs, Cultuur en Wetenschap","doi-asserted-by":"publisher","award":["SPI 72-259"],"award-info":[{"award-number":["SPI 72-259"]}],"id":[{"id":"10.13039\/501100003245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003245","name":"Ministerie van Onderwijs, Cultuur en Wetenschap","doi-asserted-by":"publisher","award":["024.003.013"],"award-info":[{"award-number":["024.003.013"]}],"id":[{"id":"10.13039\/501100003245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jconrel.2024.06.021","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:17:28Z","timestamp":1718342248000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Nanogel-based nitric oxide-driven nanomotor for deep tissue penetration and enhanced tumor therapy"],"prefix":"10.1016","volume":"372","author":[{"given":"Jianhong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u01e7itcan","family":"S\u00fcmbelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan C.M.","family":"van Hest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.06.021_bb0005","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1038\/s41591-022-02061-1","article-title":"The landscape of mRNA nanomedicine","volume":"28","author":"Huang","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0015","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41565-018-0254-4","article-title":"Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0020","doi-asserted-by":"crossref","first-page":"10980","DOI":"10.1073\/pnas.1106634108","article-title":"Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform","volume":"108","author":"Hu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0025","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature04394","article-title":"Membranes are more mosaic than fluid","volume":"438","author":"Engelman","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-2272-7_3","article-title":"Getting across the cell membrane: an overview for small molecules, peptides, and proteins","volume":"1266","author":"Yang","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2016.01.001","article-title":"Special issue: extracellular matrix: therapeutic tools and targets in cancer treatment","volume":"97","author":"Schaefer","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0040","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jconrel.2013.09.013","article-title":"Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles","volume":"172","author":"Ernsting","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0045","doi-asserted-by":"crossref","first-page":"18632","DOI":"10.1073\/pnas.1318415110","article-title":"Combining two strategies to improve perfusion and drug delivery in solid tumors","volume":"110","author":"Stylianopoulos","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nnano.2012.45","article-title":"Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner","volume":"7","author":"Chauhan","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0055","doi-asserted-by":"crossref","first-page":"2101301","DOI":"10.1002\/advs.202101301","article-title":"Swarming aqua sperm micromotors for active bacterial biofilms removal in confined spaces","volume":"8","author":"Mayorga-Martinez","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0060","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41563-022-01360-9","article-title":"Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia","volume":"21","author":"Zhang","year":"2022","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0065","doi-asserted-by":"crossref","first-page":"eade645","DOI":"10.1126\/sciadv.ade6455","article-title":"Extremophile-based biohybrid micromotors for biomedical operations in harsh acidic environments","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0070","doi-asserted-by":"crossref","first-page":"16918","DOI":"10.1002\/anie.202003748","article-title":"Photoactivated Polymersome Nanomotors: traversing biological barriers","volume":"59","author":"Shao","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0075","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1021\/jacs.6b00902","article-title":"Near infrared light-powered Janus mesoporous silica nanoparticle motors","volume":"138","author":"Xuan","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0080","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1038\/s41467-021-22279-w","article-title":"Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy","volume":"12","author":"Cao","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0085","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1038\/s41467-023-40474-9","article-title":"Hyperthermia-triggered biomimetic bubble nanomachines","volume":"14","author":"Gao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0090","doi-asserted-by":"crossref","first-page":"eadh1736","DOI":"10.1126\/sciadv.adh1736","article-title":"Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy","volume":"9","author":"Peng","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0095","doi-asserted-by":"crossref","first-page":"2211626","DOI":"10.1002\/adma.202211626","article-title":"Chemotaxis-guided self-propelled macrophage Motorfor targeted treatment of acute pneumonia","volume":"35","author":"Yue","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0100","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/acs.accounts.8b00254","article-title":"Light-driven Micro\/Nanomotor for promising biomedical tools: principle, challenge, and Prospect","volume":"51","author":"Wang","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0105","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1021\/acsnano.2c09380","article-title":"Light-triggered mechanical disruption of extracellular barriers by swarms of enzyme-powered Nanomotors for enhanced delivery","volume":"17","author":"Fraire","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0110","doi-asserted-by":"crossref","first-page":"2200208","DOI":"10.1002\/smll.202200208","article-title":"Magnetic biohybrid robots as efficient drug carrier to generate plant cell clones","volume":"18","author":"Huska","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0115","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1002\/anie.201806759","article-title":"Self-propelled nanomotors for thermomechanically percolating cell membranes","volume":"57","author":"Xuan","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0120","doi-asserted-by":"crossref","first-page":"eaaz9519","DOI":"10.1126\/scirobotics.aaz9519","article-title":"Dual-responsive biohybrid neutrobots for active target delivery","volume":"6","author":"Zhang","year":"2021","journal-title":"Sci. Robot."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0125","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.3390\/pharmaceutics15071986","article-title":"Inherently fluorescent Peanut-shaped Polymersomes for active cargo transportation","volume":"15","author":"Wang","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202214754","article-title":"Achieving control in Micro-\/Nanomotor mobility","volume":"62","author":"Fusi","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0135","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.1021\/jacs.7b02347","article-title":"Chemically propelled molecules and machines","volume":"139","author":"Dey","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0140","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1021\/ja3029872","article-title":"Entrapment of metal nanoparticles in polymer Stomatocytes","volume":"134","author":"Wilson","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0145","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1021\/acs.nanolett.0c01268","article-title":"Hybrid biodegradable Nanomotors through compartmentalized synthesis","volume":"20","author":"Pijpers","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0150","doi-asserted-by":"crossref","first-page":"2102286","DOI":"10.1002\/smll.202102286","article-title":"Self-propelled asymmetrical nanomotor for self-reported gas therapy","volume":"17","author":"Yue","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0155","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1021\/acs.nanolett.5b03100","article-title":"Enzyme-powered hollow mesoporous Janus Nanomotors","volume":"15","author":"Ma","year":"2015","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41467-023-35895-5","article-title":"Molecularly self-fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0165","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41467-019-08670-8","article-title":"Bio-inspired nitric-oxide-driven nanomotor","volume":"10","author":"Wan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0170","doi-asserted-by":"crossref","first-page":"2002525","DOI":"10.1002\/advs.202002525","article-title":"Nitric oxide-driven Nanomotor for deep tissue penetration and multidrug resistance reversal in Cancer therapy","volume":"8","author":"Wan","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0175","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1021\/ma00064a011","article-title":"Self-aggregates of hydrophobized polysaccharides in water-formation and characteristics of nanoparticles","volume":"26","author":"Akiyoshi","year":"1993","journal-title":"Macromolecules"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2023.101167","article-title":"Nanogels: synthesis, properties, and recent biomedical applications","volume":"139","author":"Duan","year":"2023","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1021\/cr3002643","article-title":"Cationic polymer nanoparticles and Nanogels: from synthesis to biotechnological applications","volume":"114","author":"Ramos","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0190","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1021\/acsami.6b14219","article-title":"Gadolinium-loaded poly(\u2212vinylcaprolactam) nanogels: synthesis, characterization, and application for enhanced tumor MR imaging","volume":"9","author":"Sun","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0195","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.1002\/anie.202002331","article-title":"Nanogel multienzyme mimics synthesized by biocatalytic ATRP and metal coordination for bioresponsive fluorescence imaging","volume":"59","author":"Qi","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0200","doi-asserted-by":"crossref","first-page":"14760","DOI":"10.1002\/anie.201911048","article-title":"Rational design of nanogels for overcoming the biological barriers in various administration routes","volume":"60","author":"Zhao","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0205","doi-asserted-by":"crossref","first-page":"2300967","DOI":"10.1002\/adhm.202300967","article-title":"A biomimetic nanogel system restores macrophage phagocytosis for magnetic resonance imaging-guided synergistic chemoimmunotherapy of breast cancer","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0210","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1039\/D2CS00247G","article-title":"Bioengineered nanogels for cancer immunotherapy","volume":"51","author":"Ma","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0215","doi-asserted-by":"crossref","first-page":"22343","DOI":"10.1039\/C9NR08309J","article-title":"Core-shell tecto dendrimers formed via host-guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0220","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.7150\/thno.43402","article-title":"Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2024.06.021_bb0225","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/emm.1998.32","article-title":"The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase","volume":"30","author":"Kim","year":"1998","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jconrel.2024.06.021_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215592","article-title":"Sonodynamic therapy: rapid progress and new opportunities for non-invasive tumor cell killing with sound","volume":"532","author":"Nowak","year":"2022","journal-title":"Cancer Lett."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924003699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924003699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T19:28:59Z","timestamp":1721935739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924003699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":46,"alternative-id":["S0168365924003699"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.06.021","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanogel-based nitric oxide-driven nanomotor for deep tissue penetration and enhanced tumor therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}