{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:38:13Z","timestamp":1785368293623,"version":"3.55.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jconrel.2024.07.061","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T13:32:56Z","timestamp":1722519176000},"page":"667-687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Evaluation of Pregabalin bioadhesive multilayered microemulsion IOP-lowering eye drops"],"prefix":"10.1016","volume":"373","author":[{"given":"Doaa N.","family":"Maria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjae J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangDi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Jablonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.07.061_bb0005","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0015","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.genom.6.080604.162209","article-title":"Complex genetics of glaucoma susceptibility","volume":"6","author":"Libby","year":"2005","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0025","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1167\/iovs.04-1070","article-title":"Glaucoma: macrocosm to microcosm the Friedenwald lecture","volume":"46","author":"Quigley","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0030","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1001\/archopht.1980.01020041015002","article-title":"Biostatistical analysis of the collaborative Glaucoma study: I. Summary report of the risk factors for glaucomatous visual-field defects","volume":"98","author":"Armaly","year":"1980","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0035","doi-asserted-by":"crossref","DOI":"10.1001\/archopht.1995.01100070092031","article-title":"Risk factors for open-angle glaucoma. The Barbados eye study","volume":"113","author":"Leske","year":"1995","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0040","doi-asserted-by":"crossref","DOI":"10.1001\/archopht.1991.01080080050026","article-title":"Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore eye survey","volume":"109","author":"Sommer","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0045","series-title":"Ophthalmology Times, Weighing IOP fluctuation in glaucoma progression. Aguide from Dr. Joseph Caprioli","author":"Caprioli","year":"2016"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0050","series-title":"Glaucoma: what every patient should know. A guide from Dr. Harry Quigley and Dr. Mona Kaleem. (Johns Hopkins Glaucoma Center of Excellence)","author":"Quigley","year":"2020"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0055","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/s41467-017-00837-5","article-title":"Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility","volume":"8","author":"S.R. Chintalapudi, D. Maria, X. Di Wang, J.N.C. Bailey, N. consortium, c. International Glaucoma Genetics, P.G. Hysi, J.L. Wiggs, R.W. Williams, M.M. Jablonski","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0060","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1021\/acsnano.9b07214","article-title":"Once daily Pregabalin eye drops for Management of Glaucoma","volume":"13","author":"Ibrahim","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0065","doi-asserted-by":"crossref","first-page":"17209","DOI":"10.1038\/srep17209","article-title":"Identification of potential inhibitors based on compound proposal contest: tyrosine-protein kinase yes as a target","volume":"5","author":"Chiba","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/jop.2021.0069","article-title":"Eyes on Lipinski's Rule of Five: A New \"Rule of Thumb\" for Physicochemical Design Space of Ophthalmic Drugs","volume":"38","author":"Karami","year":"2022","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0075","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jmgm.2017.11.011","article-title":"Exploring the selectivity of inhibitor complexes with Bcl-2 and Bcl-XL: a molecular dynamics simulation approach","volume":"79","author":"Wakui","year":"2018","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0080","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/acs.jcim.8b00673","article-title":"Improved method of structure-based virtual screening via interaction-energy-based learning","volume":"59","author":"Yasuo","year":"2019","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125829","article-title":"Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method","volume":"10","author":"Yoshino","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ph14090887","article-title":"In silico screening and in vivo evaluation of potential CACNA2D1 antagonists as intraocular pressure-reducing agents in Glaucoma therapy","volume":"14","author":"Li","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101222","article-title":"Computational methods in glaucoma research: current status and future outlook","volume":"94","author":"Kim","year":"2023","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0100","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1021\/ja301454u","article-title":"Magnesium fluctuations modulate RNA dynamics in the SAM-I riboswitch","volume":"134","author":"Hayes","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0105","doi-asserted-by":"crossref","first-page":"14554","DOI":"10.1021\/ja507832e","article-title":"Lipid organization of the plasma membrane","volume":"136","author":"Ingolfsson","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0110","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0006-3495(03)74553-6","article-title":"Molecular dynamics simulation of dimeric and monomeric forms of human prion protein: insight into dynamics and properties","volume":"85","author":"Sekijima","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0115","doi-asserted-by":"crossref","first-page":"10874","DOI":"10.1021\/jp505727w","article-title":"Conformational preferences of DNA in reduced dielectric environments","volume":"118","author":"Yildirim","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0125","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/ar000033j","article-title":"Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/07391102.1998.10508279","article-title":"Continuum solvent studies of the stability of RNA hairpin loops and helices","volume":"16","author":"Srinivasan","year":"1998","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cbdd.13388","article-title":"Homology modeling in drug discovery: overview, current applications, and future perspectives","volume":"93","author":"Muhammed","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0140","first-page":"327","article-title":"A novel method for the determination of pregabalin in bulk pharmaceutical formulations and human urine samples","volume":"3","author":"Gujral","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0145","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/jat\/bkt081","article-title":"Pregabalin determination in hair by ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"37","author":"Pauly","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109931","article-title":"Closed-state inactivation and pore-blocker modulation mechanisms of human ca(V)2.2","volume":"37","author":"Dong","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0155","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1002\/anie.202011793","article-title":"Structural basis of the modulation of the voltage-gated calcium Ion Channel ca(v) 1.1 by Dihydropyridine compounds*","volume":"60","author":"Gao","year":"2021","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0160","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European molecular biology open software suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0165","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0170","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/ci200583t","article-title":"Testing physical models of passive membrane permeation","volume":"52","author":"Leung","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0175","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1021\/acs.jcim.6b00005","article-title":"Simple predictive models of passive membrane permeability incorporating size-dependent membrane-water partition","volume":"56","author":"Leung","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0180","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1023\/A:1015989929342","article-title":"Heterogeneity effects on permeability-partition coefficient relationships in human stratum Corneum","volume":"5","author":"Anderson","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijpharm.2008.08.004","article-title":"Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine a: in vitro and in vivo results","volume":"365","author":"Gan","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0190","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11095-017-2110-x","article-title":"Nimodipine ophthalmic formulations for management of Glaucoma","volume":"34","author":"Maria","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0195","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/IJG.0000000000001055","article-title":"Intraocular pressure lowering effect of Latanoprost as first-line treatment for Glaucoma","volume":"27","author":"Aspberg","year":"2018","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0200","first-page":"1","article-title":"Investigation of proniosomes gel as a promising carrier for transdermal delivery of glimepiride, universal journal of","volume":"1","author":"Elsaied","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231841","article-title":"Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits","volume":"15","author":"Roy Chowdhury","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0210","article-title":"Center for Drug Evaluation and Research (CDER) & Center for Biologics Evaluation and Research (CBER)","volume":"68","author":"Department of Health and Human Services (HHS), Food and Drug Administration (FDA)","year":"2003","journal-title":"In The Fed. Regist."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0215","first-page":"2241","article-title":"Stress degradation behavior of pregabalin, identification of degradation impurities and development of stability indicating UPLC method","volume":"6","author":"Vukkum","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijpharm.2015.07.058","article-title":"Microemulsion based gel for topical dermal delivery of pseudolaric acid B: in vitro and in vivo evaluation","volume":"493","author":"Wan","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/02713683.2013.833630","article-title":"Physicochemical and pharmacological investigation of water\/oil microemulsion of non-selective beta blocker for treatment of glaucoma","volume":"39","author":"Hegde","year":"2014","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0230","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1021\/acsomega.9b04244","article-title":"Triamcinolone Acetonide-loaded PEGylated microemulsion for the posterior segment of eye","volume":"5","author":"Nayak","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0235","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejps.2016.09.033","article-title":"Preparation, characterization and in-vivo evaluation of microemulsions containing tamoxifen citrate anti-cancer drug","volume":"96","author":"Dehghani","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0240","series-title":"Drug Stabiity for Pharmaceutical Scientists","first-page":"6","author":"Loftsson","year":"2013"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0245","first-page":"656","volume":"63","author":"V. Cojocaru, A.E. Ranetti, L.G. Hinescu, M. Ionescu, C. Cosmescu, A.G. Po\u0219toarc\u0103, L.O. Cintez\u0103","year":"2015","journal-title":"Formulation and Evaluation of In vitro Release Kinetics of NA3CADTPA Decorporation Agent Embedded in Microemulsion-based Gel Formulation for Topical Delivery"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119474","article-title":"Bioresponsive nanostructured systems for sustained naltrexone release and treatment of alcohol use disorder: development and biological evaluation","volume":"585","author":"Santos","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0255","doi-asserted-by":"crossref","first-page":"993351","DOI":"10.3389\/fmed.2022.993351","article-title":"Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1","volume":"9","author":"Fomo","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137366","article-title":"Decoding the effect of hydrostatic pressure on TRPV1 lower-gate conformation by molecular-dynamics simulation","volume":"23","author":"Zamri","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0265","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/13816810.2022.2109682","article-title":"Association of EFEMP1 with juvenile-onset open angle glaucoma in a patient with concomitant COL11A1-related stickler syndrome","volume":"44","author":"Gupta","year":"2023","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0270","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/s41598-017-01498-6","article-title":"An optimal distance cutoff for contact-based protein structure networks using side-chain centers of mass","volume":"7","author":"Salamanca Viloria","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0275","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.jcim.2c00044","article-title":"GROMACS in the cloud: a global supercomputer to speed up alchemical drug design","volume":"62","author":"Kutzner","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0280","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0285","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-023-06175-5","article-title":"EMC chaperone-ca(V) structure reveals an ion channel assembly intermediate","volume":"619","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0290","doi-asserted-by":"crossref","first-page":"2167563","DOI":"10.1080\/19336950.2023.2167563","article-title":"The importance of cache domains in alpha(2)delta proteins and the basis for their gabapentinoid selectivity","volume":"17","author":"Page","year":"2023","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0295","first-page":"1699","article-title":"Current primary open-angle glaucoma treatments and future directions","volume":"6","author":"Beidoe","year":"2012","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061638","article-title":"A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features","volume":"8","author":"Shah","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0305","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/bjophthalmol-2014-305908","article-title":"A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study","volume":"99","author":"Weinreb","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15061646","article-title":"Corneal permeability and uptake of twenty-five drugs: species comparison and quantitative structure-permeability relationships","volume":"15","author":"Santana","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0315","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejps.2018.03.034","article-title":"Corneal and conjunctival drug permeability: systematic comparison and pharmacokinetic impact in the eye","volume":"119","author":"Ramsay","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0320","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","article-title":"Medicinal chemical properties of successful central nervous system drugs","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0325","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2014.02.021","article-title":"Mechanisms of angiotensin converting enzyme inhibitor-induced IOP reduction in normotensive rats","volume":"730","author":"Agarwal","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0330","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1208\/s12249-009-9268-4","article-title":"Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride","volume":"10","author":"Ammar","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0335","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1089\/jop.2016.0168","article-title":"Consequences of puberty on efficacy of intraocular pressure-lowering drugs in male Dutch-belted rabbits","volume":"34","author":"Hays","year":"2018","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0340","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1089\/jop.2014.0146","article-title":"Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits","volume":"31","author":"Kiel","year":"2015","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0345","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1167\/iovs.62.3.17","article-title":"NCX 667, a novel nitric oxide donor, lowers intraocular pressure in rabbits, dogs, and non-human Primates and enhances TGFbeta2-induced outflow in HTM\/HSC constructs","volume":"62","author":"Bastia","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/polym10111221","article-title":"Strategies for improving ocular drug bioavailability and corneal wound healing with chitosan-based delivery systems","volume":"10","author":"Irimia","year":"2018","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0355","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1208\/s12248-008-9036-5","article-title":"Application of the biopharmaceutical classification system in clinical drug development--an industrial view","volume":"10","author":"Cook","year":"2008","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0360","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2307\/3282754","article-title":"Simultaneous purification of merozoites and schizonts of Eimeria tenella (Apicomplexa) by Percoll flotation and assessment of cell viability with a double fluorescent dye assay","volume":"77","author":"Geysen","year":"1991","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0365","doi-asserted-by":"crossref","first-page":"08","DOI":"10.31782\/IJCRR.2023.15902","article-title":"Screening for efflux pump mediated resistance in Enterobacterales by Acridine Orange agar cartwheel method","volume":"15","author":"Anusha","year":"2023","journal-title":"International Journal of Current Research and Review"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0370","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/0975-7406.76478","article-title":"Mucoadhesive drug delivery systems","volume":"3","author":"Shaikh","year":"2011","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0375","first-page":"135","article-title":"Bioadhesion in mucosal drug delivery","author":"Yang","year":"1998","journal-title":"Biorelated Polymers and Gels."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0380","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1248\/yakushi.127.183","article-title":"Preparation and evaluation of a Carbopol\/HPMC-based in situ gelling ophthalmic system for puerarin","volume":"127","author":"Wu","year":"2007","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0385","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1001\/archopht.1981.03930010303017","article-title":"Normal human tear PH by direct measurement","volume":"99","author":"Abelson","year":"1981","journal-title":"Arch. Ophthalmol., Arch Ophthalmol"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0390","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14061246","article-title":"Design of Topical Moxifloxacin Mucoadhesive Nanoemulsion for the Management of Ocular Bacterial Infections","volume":"14","author":"Youssef","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0395","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/nn506599f","article-title":"Ocular drug delivery Nanowafer with enhanced therapeutic efficacy","volume":"9","author":"Yuan","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0400","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1167\/iovs.11-7846","article-title":"Circadian (24-hour) pattern of intraocular pressure and visual field damage in eyes with normal-tension glaucoma","volume":"53","author":"Lee","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0405","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jps.2600840315","article-title":"Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methylcellulose","volume":"84","author":"Kumar","year":"1995","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0410","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jps.10412","article-title":"Lecithin-based oil-in-water microemulsions for parenteral use: Pseudoternary phase diagrams, characterization and toxicity studies","volume":"92","author":"Moreno","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0415","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1023\/B:PHAM.0000016282.77887.1f","article-title":"Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations","volume":"21","author":"Kaukonen","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0420","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijpharm.2017.07.036","article-title":"Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: structure characterization and in vitro\/in vivo performances","volume":"529","author":"Savic","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0425","doi-asserted-by":"crossref","first-page":"24","DOI":"10.14227\/DT270420P24","article-title":"In vitro bioequivalence of Pregabalin capsules (150 mg): an alternative to in vivo bioequivalence studies","volume":"27","author":"Usman","year":"2020","journal-title":"Dissolut. Technol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1735-5362.305184","article-title":"Preparation and characterization of ethylcellulose microspheres for sustained-release of pregabalin","volume":"16","author":"Yasin","year":"2021","journal-title":"Res Pharm Sci"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0435","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1081\/DDC-120002997","article-title":"Penetration enhancers and ocular bioadhesives: two new avenues for ophthalmic drug delivery","volume":"28","author":"Kaur","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0440","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin","volume":"49","author":"Bockbrader","year":"2010","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/nano10091657","article-title":"Microemulsion microstructure(s): a tutorial review","volume":"10","author":"Tartaro","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0450","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1208\/s12249-022-02282-0","article-title":"Oxidative stability in lipid formulations: a review of the mechanisms","volume":"23","author":"Musakhanian","year":"2022","journal-title":"Drivers, and Inhibitors of Oxidation, AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0455","first-page":"1288","article-title":"Intrinsic lipolysis rate for systematic design of lipid-based formulations, drug Deliv","volume":"13","author":"Jacobsen","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0460","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s11743-016-1814-y","article-title":"Formation and phase behavior of Winsor type III Jatropha curcas-based microemulsion systems","volume":"19","author":"Nordiyana","year":"2016","journal-title":"J. Surfactant Deterg."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0465","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00396-014-3276-y","article-title":"Application of the zeta potential measurements to explanation of colloidal Cr(2)O(3) stability mechanism in the presence of the ionic polyamino acids","volume":"292","author":"Ostolska","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0470","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jiec.2018.06.022","article-title":"Effects of HLB value on oil-in-water emulsions: droplet size, rheological behavior, zeta-potential, and creaming index","volume":"67","author":"Hong","year":"2018","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0475","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1208\/s12249-010-9455-3","article-title":"Stability assessment of injectable castor oil-based nano-sized emulsion containing cationic droplets stabilized by poloxamer-chitosan emulsifier films","volume":"11","author":"Tamilvanan","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0480","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijpharm.2009.05.019","article-title":"Microemulsion-based hydrogel formulation of penciclovir for topical delivery","volume":"378","author":"Zhu","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0485","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1442-9071.2004.00914.x","article-title":"New vehicle based on a microemulsion for topical ocular administration of dexamethasone","volume":"32","author":"Fialho","year":"2004","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0490","doi-asserted-by":"crossref","DOI":"10.1186\/s40543-022-00317-6","article-title":"Systematic strategies for degradation kinetic study of pharmaceuticals: an issue of utmost importance concerning current stability analysis practices","volume":"13","author":"Bhangare","year":"2022","journal-title":"J Anal Sci Technol"},{"key":"10.1016\/j.jconrel.2024.07.061_bb0495","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/btpr.1892","article-title":"The role of microemulsions in lipase-catalyzed hydrolysis reactions","volume":"30","author":"Lopez","year":"2014","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0500","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1081\/DDC-100108370","article-title":"Release kinetics of acyclovir from a suspension of acyclovir incorporated in a cubic phase delivery system","volume":"27","author":"Helledi","year":"2001","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2024.07.061_bb0505","first-page":"118","article-title":"Design and development of Oral Transmucosal film for delivery of salbutamol Sulphate","volume":"2","author":"Gupta","year":"2014","journal-title":"J. Pharm. Chem. Biol. Sci."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924005194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924005194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T01:57:44Z","timestamp":1728525464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924005194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":101,"alternative-id":["S0168365924005194"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.07.061","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Pregabalin bioadhesive multilayered microemulsion IOP-lowering eye drops","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.07.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}