{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:24:04Z","timestamp":1793373844772,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R25NS100118"],"award-info":[{"award-number":["R25NS100118"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009854","name":"Duquesne University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jconrel.2024.07.065","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:10:25Z","timestamp":1722643825000},"page":"803-822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy"],"prefix":"10.1016","volume":"373","author":[{"given":"Kandarp M.","family":"Dave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopal R.","family":"Venna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna B.","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodhi","family":"Brady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria A.","family":"Quaicoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Maniskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella E.","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawson","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadranka","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruti S.","family":"Shiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise D.","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"S Manickam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0005","doi-asserted-by":"crossref","first-page":"924","DOI":"10.14336\/AD.2017.1126","article-title":"Mitochondria in ischemic stroke: new insight and implications","volume":"9","author":"Liu","year":"2018","journal-title":"Aging Dis."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.jconrel.2024.07.065_bb0015","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/CIRCRESAHA.111.300233","article-title":"Mitochondria and endothelial function","volume":"112","author":"Kluge","year":"2013","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12967-023-04493-w","article-title":"Mitochondrial dysfunction in neurodegenerative disorders: potential therapeutic application of mitochondrial transfer to central nervous system-residing cells","volume":"21","author":"Bustamante-Barrientos","year":"2023","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.jconrel.2024.07.065_bb0025","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke Statistics-2017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0030","first-page":"C343","article-title":"Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection","volume":"315","author":"Abdullahi","year":"2018","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"1681","key":"10.1016\/j.jconrel.2024.07.065_bb0035","article-title":"Blood-brain barrier damage in ischemic stroke and its regulation by endothelial Mechanotransduction","volume":"11","author":"Nian","year":"2020","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ana.410010502","article-title":"The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat","volume":"1","author":"Oldendorf","year":"1977","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.jconrel.2024.07.065_bb0045","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1177\/0271678X19900030","article-title":"Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration","volume":"40","author":"Lee","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1605","key":"10.1016\/j.jconrel.2024.07.065_bb0050","article-title":"Pathophysiology of Blood\u2013Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery","volume":"11","author":"Bernardo-Castro","year":"2020","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0055","doi-asserted-by":"crossref","first-page":"15717","DOI":"10.1038\/s41598-019-52083-y","article-title":"Mitochondria damaged by oxygen glucose deprivation can be restored through activation of the PI3K\/Akt pathway and inhibition of calcium influx by amlodipine Camsylate","volume":"9","author":"Park","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0060","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jcb.20837","article-title":"Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia","volume":"98","author":"Tyagi","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.jconrel.2024.07.065_bb0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0070","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jconrel.2022.01.045","article-title":"Delivery of mitochondria via extracellular vesicles \u2013 a new horizon in drug delivery","volume":"343","author":"Manickam","year":"2022","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0075","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41467-021-21984-w","article-title":"Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs","volume":"12","author":"Todkar","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00702-009-0288-8","article-title":"Astrocytes and glioblastoma cells release exosomes carrying mtDNA","volume":"117","author":"Guescini","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCRESAHA.118.314601","article-title":"Mitochondria are a subset of extracellular vesicles released by activated monocytes and induce type I IFN and TNF responses in endothelial cells","volume":"125","author":"Puhm","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0090","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1038\/ncomms9472","article-title":"Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs","volume":"6","author":"Phinney","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.jconrel.2024.07.065_bb0095","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jacc.2020.12.060","article-title":"Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell\u2013Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium","volume":"77","author":"Ikeda","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.jconrel.2024.07.065_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124407","article-title":"Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation","volume":"21","author":"Banks","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0223-5","article-title":"Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking","volume":"51","author":"Murphy","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.07.001","article-title":"Extracellular vesicles: novel promising delivery systems for therapy of brain diseases","volume":"262","author":"Rufino-Ramos","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0115","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jconrel.2023.12.021","article-title":"Simultaneous ischemic regions targeting and BBB crossing strategy to harness extracellular vesicles for therapeutic delivery in ischemic stroke","volume":"365","author":"Liang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0120","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v5.32570","article-title":"High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources","volume":"5","author":"Haraszti","year":"2016","journal-title":"Journal of extracellular vesicles."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0125","doi-asserted-by":"crossref","first-page":"1302705","DOI":"10.1080\/20013078.2017.1302705","article-title":"Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure","volume":"6","author":"Dozio","year":"2017","journal-title":"Journal of Extracellular Vesicles."},{"issue":"4","key":"10.1016\/j.jconrel.2024.07.065_bb0130","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/21541248.2016.1215283","article-title":"Biology and biogenesis of shed microvesicles","volume":"8","author":"Tricarico","year":"2017","journal-title":"Small GTPases."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0135","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles"},{"issue":"2","key":"10.1016\/j.jconrel.2024.07.065_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles."},{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0145","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow\u2013derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.redox.2018.06.009","article-title":"Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells","volume":"18","author":"Hough","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mito.2020.08.005","article-title":"The existence and function of mitochondrial component in extracellular vesicles","volume":"54","author":"Liu","year":"2020","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0160","doi-asserted-by":"crossref","first-page":"2002978","DOI":"10.1183\/13993003.02978-2020","article-title":"Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS","volume":"58","author":"Dutra Silva","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0165","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jconrel.2023.01.025","article-title":"Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV\/HSP27 protect ischemic brain endothelial cultures","volume":"354","author":"Dave","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2021.08.038","article-title":"Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells","volume":"338","author":"D\u2019Souza","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0175","doi-asserted-by":"crossref","unstructured":"Dave KM, Stolz DB, Manickam DS. Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy. Expert Opinion on Drug Delivery.1\u201320.","DOI":"10.1080\/17425247.2023.2279115"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0180","doi-asserted-by":"crossref","first-page":"1324730","DOI":"10.1080\/20013078.2017.1324730","article-title":"Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells","volume":"6","author":"Zhu","year":"2017","journal-title":"J Extracell Vesicles."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0185","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1208\/s12249-020-01892-w","article-title":"Extracellular vesicles derived from a human brain endothelial cell line increase cellular ATP levels","volume":"22","author":"Dave","year":"2021","journal-title":"AAPS PharmSciTech"},{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0190","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12195-022-00738-8","article-title":"Engineering extracellular vesicles to modulate their innate mitochondrial load","volume":"15","author":"Dave","year":"2022","journal-title":"Cell. Mol. Bioeng."},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0195","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/0271678X19830791","article-title":"TGF\u03b1 preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia","volume":"40","author":"Dai","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"18","key":"10.1016\/j.jconrel.2024.07.065_bb0200","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2013-09-529420","article-title":"Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation","volume":"123","author":"Cardenes","year":"2014","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.jconrel.2024.07.065_bb0205","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144898","article-title":"Exogenous inter-\u03b1 inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice","volume":"131","author":"McCullough","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.jconrel.2024.07.065_bb0210","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/jcbfm.2009.5","article-title":"Changes in experimental stroke outcome across the life span","volume":"29","author":"Liu","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0215","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00401-012-0990-8","article-title":"NF-\u03baB contributes to the detrimental effects of social isolation after experimental stroke","volume":"124","author":"Venna","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"21","key":"10.1016\/j.jconrel.2024.07.065_bb0220","doi-asserted-by":"crossref","first-page":"20493","DOI":"10.1074\/jbc.M409985200","article-title":"Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke","volume":"280","author":"McCullough","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.jconrel.2024.07.065_bb0225","doi-asserted-by":"crossref","first-page":"E5673","DOI":"10.1073\/pnas.1607002114","article-title":"Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk","volume":"114","author":"Ritzel","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0230","first-page":"575","article-title":"Early retinal inflammatory biomarkers in the middle cerebral artery occlusion model of ischemic stroke","volume":"22","author":"Ritzel","year":"2016","journal-title":"Mol. Vis."},{"issue":"7","key":"10.1016\/j.jconrel.2024.07.065_bb0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1101\/lm.038083.115","article-title":"Inhibition of glycogen synthase kinase-3\u03b2 enhances cognitive recovery after stroke: the role of TAK1","volume":"22","author":"Venna","year":"2015","journal-title":"Learn. Mem."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0240","doi-asserted-by":"crossref","first-page":"25530","DOI":"10.3402\/jev.v4.25530","article-title":"Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer","volume":"4","author":"Pospichalova","year":"2015","journal-title":"J Extracell Vesicles."},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0245","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jaccao.2021.05.006","article-title":"Mitochondria-rich extracellular vesicles rescue patient-specific cardiomyocytes from doxorubicin injury: insights into the SENECA trial","volume":"3","author":"O\u2019Brien","year":"2021","journal-title":"JACC CardioOncol."},{"issue":"7613","key":"10.1016\/j.jconrel.2024.07.065_bb0250","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jconrel.2024.07.065_bb0255","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0260","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.1038\/srep17319","article-title":"Isolation of exosomes by differential centrifugation: theoretical analysis of a commonly used protocol","volume":"5","author":"Livshits","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jconrel.2024.07.065_bb0265","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1418401112","article-title":"Differential fates of biomolecules delivered to target cells via extracellular vesicles","volume":"112","author":"Kanada","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0270","doi-asserted-by":"crossref","first-page":"8545347","DOI":"10.1155\/2018\/8545347","article-title":"Isolation of extracellular vesicles: general methodologies and latest trends","volume":"2018","author":"Konoshenko","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.jconrel.2024.07.065_bb0275","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.jconrel.2024.07.065_bb0280","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/cyto.a.22795","article-title":"Analytical challenges of extracellular vesicle detection: a comparison of different techniques","volume":"89","author":"Erdbr\u00fcgger","year":"2016","journal-title":"Cytometry A"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0285","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fimmu.2014.00442","article-title":"Tetraspanins in extracellular vesicle formation and function","volume":"5","author":"Andreu","year":"2014","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.jconrel.2024.07.065_bb0290","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.cub.2009.09.059","article-title":"ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles","volume":"19","author":"Muralidharan-Chari","year":"2009","journal-title":"Curr. Biol."},{"issue":"9","key":"10.1016\/j.jconrel.2024.07.065_bb0295","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/stem.2856","article-title":"Protective effects of endothelial progenitor cell-derived extracellular mitochondria in brain endothelium","volume":"36","author":"Hayakawa","year":"2018","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0300","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1073\/pnas.1014918108","article-title":"Yatsukawa Y-i, Momose T, Makio T, Matsunaga M, Yokota M, Esaki M, Shodai T, Kohda D, Hobbs AEA, Jensen RE, Endo T. Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria","volume":"108","author":"Yamamoto","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.07.065_bb0305","series-title":"Hypoxia Modulates Cellular Endocytic Pathways and Organelles with Enhanced Cell Migration and 3D Cell Invasion**. ChemBioChem.n\/a(n\/a):e202300506","author":"A. Naveena H, Bhatia D","year":"2024"},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0310","doi-asserted-by":"crossref","first-page":"37959","DOI":"10.1038\/srep37959","article-title":"TDB protects vascular endothelial cells against oxygen-glucose deprivation\/reperfusion-induced injury by targeting miR-34a to increase Bcl-2 expression","volume":"6","author":"Liao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2024.07.065_bb0315","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-1-4939-6960-9_7","article-title":"Assaying mitochondrial respiration as an Indicator of cellular metabolism and fitness","volume":"1601","author":"Smolina","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2024.07.065_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085436","article-title":"Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort","volume":"9","author":"Rose","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jconrel.2024.07.065_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231267","article-title":"Sex-specific stress response and HMGB1 release in pulmonary endothelial cells","volume":"15","author":"Zemskova","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jconrel.2024.07.065_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100508","article-title":"Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle","volume":"2","author":"Conchinha","year":"2021","journal-title":"STAR Protocols."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924005236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924005236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T20:57:05Z","timestamp":1725742625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924005236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":66,"alternative-id":["S0168365924005236"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.07.065","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.07.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}