{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:51:50Z","timestamp":1792212710759,"version":"4.4.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jconrel.2024.10.033","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:20:28Z","timestamp":1729657228000},"page":"470-487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Omnidirectional improvement of mitochondrial health in Alzheimer's disease by multi-targeting engineered activated neutrophil exosomes"],"prefix":"10.1016","volume":"376","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baosheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.10.033_bb0005","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nm0706-780","article-title":"Alzheimer disease: progress or profit?","volume":"12","author":"Mount","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrd2314","article-title":"Therapies for Alzheimer\u2019s disease","volume":"6","author":"Melnikova","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1042986","article-title":"The application of nanotechnology in treatment of Alzheimer\u2019s disease","volume":"10","author":"Cao","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s42255-024-00989-x","article-title":"Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression","volume":"6","author":"Shi","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jalz.2017.12.006","article-title":"The cost of Alzheimer\u2019s disease in China and re-estimation of costs worldwide","volume":"14","author":"Jia","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41582-021-00597-3","article-title":"Psychosis in Alzheimer disease-mechanisms, genetics and therapeutic opportunities","volume":"18","author":"Ismail","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/biomedicines7040097","article-title":"Reasons for failed trials of disease-modifying treatments for Alzheimer disease and their contribution in recent research","volume":"7","author":"Yiannopoulou","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0040","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115218","article-title":"TREM2: potential therapeutic targeting of microglia for Alzheimer\u2019s disease","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0050","article-title":"Cognitive symptoms of Alzheimer\u2019s disease: clinical management and prevention","volume":"367","author":"Joe","year":"2019","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0055","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13195-016-0207-9","article-title":"Drug development in Alzheimer\u2019s disease: the path to 2025","volume":"8","author":"Cummings","year":"2016","journal-title":"Alzheimers Res. Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2024.10.033_bb0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/biomedicines7040097","article-title":"Reasons for failed trials of disease-modifying treatments for Alzheimer disease and their contribution in recent research","volume":"7","author":"Yiannopoulou","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002369","article-title":"Alzheimer\u2019s disease: the challenge of the second century","volume":"3","author":"Holtzman","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0075","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41582-023-00869-0","article-title":"Treatments for AD: towards the right target at the right time","volume":"19","author":"van der Flier","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0080","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41582-022-00749-z","article-title":"Synaptic degeneration in Alzheimer disease","volume":"19","author":"Tzioras","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ph15121560","article-title":"Current pharmacotherapy and multi-target approaches for Alzheimer\u2019s disease","volume":"15","author":"Cheong","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.837649","article-title":"Multi-targets: an unconventional drug development strategy for Alzheimer\u2019s disease","volume":"14","author":"Gong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0100","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1582-4934.2009.00609.x","article-title":"Abeta aggregation and possible implications in Alzheimer\u2019s disease pathogenesis","volume":"13","author":"Bharadwaj","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0105","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094850","article-title":"Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer\u2019s disease","volume":"22","author":"Sharma","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","article-title":"Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation","volume":"5","author":"Norat","year":"2020","journal-title":"npj Regen. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-023-02722-z","article-title":"Amyloid-\u03b2 accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism","volume":"20","author":"Zy\u015bk","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0125","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-\u03b2 overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0130","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0135","doi-asserted-by":"crossref","DOI":"10.1042\/NS20200008","article-title":"Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function","volume":"4","author":"Seager","year":"2020","journal-title":"Neuronal Signal."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0140","first-page":"529","article-title":"Macrophage membrane-coated nanocarriers co-modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer\u2019s disease mice","volume":"6","author":"Han","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0150","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/316523","article-title":"Oxidative stress and the pathogenesis of Alzheimer's disease","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00228-014-1654-5","article-title":"Multitargeted antiangiogenic tyrosine kinase inhibitors combined to chemotherapy in metastatic breast cancer: a systematic review and meta-analysis","volume":"70","author":"Wang","year":"2014","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0160","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41388-023-02907-z","article-title":"ROS production by mitochondria: function or dysfunction?","volume":"43","author":"Palma","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0165","first-page":"300","article-title":"Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease","volume":"11","author":"Xu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0170","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2174\/0929867328666210512005508","article-title":"Multi-target-directed ligands as an effective strategy for the treatment of Alzheimer\u2019s disease","volume":"29","author":"Kumar","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2174\/1389200219666180305152553","article-title":"Topical discoveries on multi-target approach to manage Alzheimer\u2019s disease","volume":"19","author":"Batool","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1570159X1203140511153200","article-title":"Multi-target directed drugs: a modern approach for design of new drugs for the treatment of Alzheimer\u2019s disease","volume":"12","author":"Dias","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0185","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1570159X11311040002","article-title":"Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century","volume":"11","author":"Lee","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0190","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/biof.1533","article-title":"Benefits of curcumin in brain disorders","volume":"45","author":"Bhat","year":"2019","journal-title":"BioFactors"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0195","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-021-00465-0","article-title":"Extracellular protein components of amyloid plaques and their roles in Alzheimer\u2019s disease pathology","volume":"16","author":"Rahman","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0200","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1039\/C8CS00034D","article-title":"Effects of in vivo conditions on amyloid aggregation","volume":"48","author":"Owen","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0205","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1021\/acsami.5b00915","article-title":"Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid \u03b2-protein fibrillation and cytotoxicity","volume":"7","author":"Xiong","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100937","article-title":"Amyloidosis inhibition, a new frontier of the protein corona","volume":"35","author":"Chen","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0215","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/chem.201404562","article-title":"Gold-nanoparticle-based multifunctional amyloid-\u03b2 inhibitor against Alzheimer\u2019s disease","volume":"21","author":"Gao","year":"2015","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202102953","article-title":"Binding to amyloid-\u03b2 protein by photothermal blood-brain barrier-penetrating nanoparticles for inhibition and disaggregation of fibrillation","volume":"31","author":"Geng","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0225","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1038\/s41467-019-11762-0","article-title":"Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy","volume":"10","author":"Javed","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0230","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/ar9000026","article-title":"Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications","volume":"42","author":"Gao","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700845","article-title":"Advances in magnetic nanoparticles for biomedical applications","volume":"7","author":"Cardoso","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0240","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijbiomac.2014.12.040","article-title":"Attenuation of lysozyme amyloid cytotoxicity by SPION-mediated modulation of amyloid aggregation","volume":"74","author":"Naik","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0245","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jalz.2005.11.003","article-title":"Synaptic targeting by A\u03b2 oligomers (ADDLS) as a basis for memory loss in early Alzheimer\u2019s disease","volume":"2","author":"Klein","year":"2006","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0250","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0260","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement. (NY)"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0265","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4103\/1673-5374.353484","article-title":"Targeting neuroinflammation in Alzheimer\u2019s disease: from mechanisms to clinical applications","volume":"18","author":"Si","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0270","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer\u2019s disease\u2013like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0275","first-page":"1","article-title":"Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment","volume":"18","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0280","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ni.1691","article-title":"Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module","volume":"10","author":"Bolomini-Vittori","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0285","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nnano.2017.54","article-title":"Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence","volume":"12","author":"Xue","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0290","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1002\/jcp.27615","article-title":"Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes","volume":"234","author":"Oskouie","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0295","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1007\/s12035-020-01911-8","article-title":"Estrogen signaling in Alzheimer\u2019s disease: molecular insights and therapeutic targets for Alzheimer\u2019s dementia","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0300","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","article-title":"Peripheral and central immune system crosstalk in Alzheimer disease-a research prospectus","volume":"17","author":"Bettcher","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0305","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ana.25159","article-title":"Neutrophil hyperactivation correlates with Alzheimer\u2019s disease progression","volume":"83","author":"Dong","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0310","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer\u2019s disease mouse models","volume":"22","author":"Cruz Hern\u00e1ndez","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0315","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The crucial roles of inflammatory mediators in inflammation: a review","volume":"11","author":"Abdulkhaleq","year":"2018","journal-title":"Vet. World"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0320","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-023-02747-4","article-title":"IL-1\u03b2 and TNF-\u03b1 play an important role in modulating the risk of periodontitis and Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0325","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12195-009-0099-x","article-title":"Signaling and dynamics of activation of LFA-1 and Mac-1 by immobilized IL-8","volume":"3","author":"Lomakina","year":"2010","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0330","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbi.2021.11.021","article-title":"ICAM-1 protects neurons against amyloid-\u03b2 and improves cognitive behaviors in 5xFAD mice by inhibiting NF-\u03baB","volume":"100","author":"Guha","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0335","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer\u2019s disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0340","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41573-020-0065-9","article-title":"Leveraging preclinical models for the development of Alzheimer disease therapeutics","volume":"19","author":"Scearce-Levie","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fnume.2022.1001722","article-title":"The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier","volume":"2","author":"Lopes van den Broek","year":"2022","journal-title":"Front. Nucl. Med."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0350","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1038\/ncomms9997","article-title":"EPPS rescues hippocampus-dependent cognitive deficits in APP\/PS1 mice by disaggregation of amyloid-\u03b2 oligomers and plaques","volume":"6","author":"Kim","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0355","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11915","article-title":"Early synaptic deficits in the APP\/PS1 mouse model of Alzheimer\u2019s disease involve neuronal adenosine A2A receptors","volume":"7","author":"Viana da Silva","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0360","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/NEN.0000000000000176","article-title":"Neuroinflammatory signals in Alzheimer disease and APP\/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species","volume":"74","author":"L\u00f3pez-Gonz\u00e1lez","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0365","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nature17172","article-title":"Memory retrieval by activating engram cells in mouse models of early Alzheimer\u2019s disease","volume":"531","author":"Roy","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0370","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jns.2017.03.031","article-title":"Role of inflammatory molecules in the Alzheimer\u2019s disease progression and diagnosis","volume":"376","author":"Bagyinszky","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00211","article-title":"NETosis in Alzheimer\u2019s disease","volume":"8","author":"Pietronigro","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0380","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer\u2019s disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0385","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110651","article-title":"Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo","volume":"39","author":"O\u2019Brien","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0395","article-title":"Transforming weakness into strength: photothermal-therapy-induced inflammation enhanced cytopharmaceutical chemotherapy as a combination anticancer treatment","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0400","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23432","article-title":"Exosomes from hepatitis B virus-infected hepatocytes activate hepatic stellate cells and aggravate liver fibrosis through the miR-506-3p\/Nur77 pathway","volume":"37","author":"Yin","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116224","article-title":"Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury","volume":"172","author":"Xiao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0410","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jconrel.2021.08.024","article-title":"Exosome membrane-modified M2 macrophages targeted nanomedicine: treatment for allergic asthma","volume":"338","author":"Pei","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0415","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1021\/acs.nanolett.1c03110","article-title":"A pH-reversible fluorescent probe for in situ imaging of extracellular vesicles and their secretion from living cells","volume":"21","author":"Liu","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0420","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/acsnano.8b09776","article-title":"In vivo real-time imaging of extracellular vesicles in liver regeneration via aggregation-induced emission luminogens","volume":"26","author":"Cao","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0425","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0430","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejpb.2020.07.026","article-title":"Exosomes as drug delivery systems: a brief overview and progress update","volume":"154","author":"Patil","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0435","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3233\/JAD-2012-120688","article-title":"Curcumin-mediated neuroprotection against amyloid-\u03b2-induced mitochondrial dysfunction involves the inhibition of GSK-3\u03b2","volume":"32","author":"Huang","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0440","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat2297","article-title":"Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis","volume":"4","author":"Yu","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0445","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72355-2","article-title":"Extracellular vesicles from amyloid-\u03b2 exposed cell cultures induce severe dysfunction in cortical neurons","volume":"10","author":"Beretta","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0450","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2018.10.043","article-title":"Photosensitizing materials and platforms for light-triggered modulation of Alzheimer's \u03b2-amyloid self-assembly","volume":"190-191","author":"Lee","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0455","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive nanocarriers for drug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114778","article-title":"Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment","author":"Li","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0465","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1096\/fj.02-1202fje","article-title":"Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro","volume":"18","author":"Kwan","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0470","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-2011-101974","article-title":"Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer\u2019s disease","volume":"26","author":"Lim","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0475","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1523\/JNEUROSCI.2085-06.2006","article-title":"Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-\u03b2 peptide catabolism","volume":"26","author":"Yin","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0480","doi-asserted-by":"crossref","DOI":"10.1021\/acsanm.8b01558","article-title":"Colloidal stability of aqueous suspensions of polymer-coated iron oxide nanorods: implications for biomedical applications","volume":"1","author":"Marins","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0485","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0490","article-title":"Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0495","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biomaterials.2018.06.029","article-title":"NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo","volume":"178","author":"Jia","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0500","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","article-title":"Nanoparticle-mediated brain drug delivery: overcoming blood\u2013brain barrier to treat neurodegenerative diseases","volume":"235","author":"Saraiva","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0505","first-page":"497","article-title":"Potential Alzheimer\u2019s disease therapeutic nano-platform: discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles","volume":"24","author":"Kim","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0510","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/bph.15346","article-title":"Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1\/NRF2\/Prx2\/ASK1\/p38 after traumatic brain injury in mice","volume":"178","author":"Zhang","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0515","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14397","article-title":"RIPK3 activation promotes DAXX-dependent neuronal necroptosis after intracerebral hemorrhage in mice","volume":"30","author":"Bai","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0520","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","article-title":"Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight","volume":"74","author":"Bhat","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0525","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12974-019-1492-6","article-title":"Adiponectin suppresses amyloid-\u03b2 oligomer (A\u03b2O)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-\u03baB signaling pathway","volume":"16","author":"Jian","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0530","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41573-020-0078-4","article-title":"Soluble ligands as drug targets","volume":"19","author":"Attwood","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0535","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/acsnano.7b02044","article-title":"Effect of alkylation on the cellular uptake of polyethylene glycol-coated gold nanoparticles","volume":"11","author":"Ho","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0540","article-title":"Extracellular vesicles mediate the intercellular exchange of nanoparticles","volume":"9","author":"Wu","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0545","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1021\/acsnano.4c00699","article-title":"Iron oxide nanoparticles engineered macrophage-derived exosomes for targeted pathological angiogenesis therapy","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"issue":"Suppl. 3","key":"10.1016\/j.jconrel.2024.10.033_bb0550","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2202-9-S3-S2","article-title":"Developing drugs that can cross the blood-brain barrier: applications to Alzheimer\u2019s disease","volume":"9","author":"Banks","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","article-title":"Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain","volume":"142","author":"Yuan","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0560","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2009.09.001","article-title":"Minimal penetration of lipopolysaccharide across the murine blood-brain barrier","volume":"24","author":"Banks","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41583-023-00768-9","article-title":"Avoiding bias in fluorescence sensor readout","volume":"25","author":"Rusakov","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0570","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020665","article-title":"Advances in analysis of biodistribution of exosomes by molecular imaging","volume":"21","author":"Yi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer\u2019s disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0580","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0585","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-023-02616-7","article-title":"Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels","volume":"146","author":"Judd","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0590","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0165-5728(02)00114-5","article-title":"The adhesion molecule ICAM-1 and its regulation in relation with the blood\u2013brain barrier","volume":"128","author":"Dietrich","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0595","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1248\/bpb.b19-00012","article-title":"Helicid ameliorates learning and cognitive ability and activities cAMP\/PKA\/CREB signaling in chronic unpredictable mild stress rats","volume":"42","author":"Li","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2024.10.033_bb0600","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.2147\/IJN.S104856","article-title":"Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro","volume":"11","author":"Wang","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2024.10.033_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107744","article-title":"Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-\u03b3-Shh-BDNF pathway","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924007065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924007065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T13:36:42Z","timestamp":1733578602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924007065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":121,"alternative-id":["S0168365924007065"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.10.033","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Omnidirectional improvement of mitochondrial health in Alzheimer's disease by multi-targeting engineered activated neutrophil exosomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}