{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:38:01Z","timestamp":1786991881928,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jconrel.2024.10.056","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T16:05:43Z","timestamp":1730909143000},"page":"972-984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling"],"prefix":"10.1016","volume":"376","author":[{"given":"Xing-Yue","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Meng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Ji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Heon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.10.056_bb0005","doi-asserted-by":"crossref","first-page":"2102583","DOI":"10.1183\/13993003.02583-2021","article-title":"Asthma remission: what is it and how can it be achieved?","volume":"60","author":"Thomas","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0015","article-title":"From mesenchymal stem cells to their extracellular vesicles: progress and prospects for asthma therapy","volume":"19","author":"Chen","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0020","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jaci.2016.06.054","article-title":"Acute asthma, prognosis, and treatment","volume":"139","author":"Fergeson","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0025","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1073\/pnas.1816734116","article-title":"Development of highly potent glucocorticoids for steroid-resistant severe asthma","volume":"116","author":"He","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0030","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1067\/mai.2003.117","article-title":"Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation","volume":"111","author":"Dorscheid","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abl8146","article-title":"Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma","volume":"14","author":"Guidi","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0040","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1111\/all.15376","article-title":"Airway remodeling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma","volume":"77","author":"Khalfaoui","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0045","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jaci.2021.07.010","article-title":"Airway remodeling: shifting the trigger point for exacerbations in asthma","volume":"148","author":"Winkler","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0050","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.pharmthera.2006.05.001","article-title":"Airway remodeling in asthma: current understanding and implications for future therapies","volume":"112","author":"Tang","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0055","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaci.2011.04.047","article-title":"Remodeling in asthma","volume":"128","author":"Al-Muhsen","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0060","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1183\/09031936.00146905","article-title":"Clinical relevance of airway remodeling in airway diseases","volume":"30","author":"James","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100995","article-title":"Cellular and molecular mechanisms of allergic asthma","volume":"85","author":"Koml\u00f3si","year":"2022","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0070","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1111\/jcmm.13576","article-title":"Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: relationship with airway remodeling","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0075","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/all.13373","article-title":"Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited","volume":"73","author":"Samitas","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0080","article-title":"Spatiotemporal single-cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage","volume":"10","author":"Su","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12931-015-0197-3","article-title":"IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model","volume":"16","author":"Yao","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.7150\/thno.16627","article-title":"Anti-angiogenic nanotherapy inhibits airway remodeling and hyper-responsiveness of dust mite triggered asthma in the brown Norway rat","volume":"7","author":"Lanza","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0095","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jaci.2022.09.032","article-title":"Airway epithelial ITGB4 deficiency induces airway remodeling in a mouse model","volume":"151","author":"Yuan","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0100","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1164\/rccm.201810-1931CI","article-title":"Mechanisms and management of asthma exacerbations","volume":"199","author":"Ramsahai","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0105","doi-asserted-by":"crossref","first-page":"2300700","DOI":"10.1183\/13993003.00700-2023","article-title":"Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?","volume":"62","author":"Cazzola","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0110","article-title":"Inhibition of spleen tyrosine kinase restores glucocorticoid sensitivity to improve steroid-resistant asthma","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0115","article-title":"Cellular mechanisms underlying steroid-resistant asthma","volume":"28","author":"Wadhw","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(19)33005-3","article-title":"Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma","volume":"395","author":"Peters","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0125","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jconrel.2023.12.024","article-title":"Engineered stem cell-based strategy: a new paradigm of next-generation stem cell product in regenerative medicine","volume":"365","author":"Han","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0130","doi-asserted-by":"crossref","first-page":"eaba3167","DOI":"10.1126\/sciadv.aba3167","article-title":"Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis","volume":"6","author":"Chang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0135","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.alit.2019.08.001","article-title":"Mesenchymal stem cells in allergic diseases: current status","volume":"69","author":"Li","year":"2020","journal-title":"Allergol. Int."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0140","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1096\/fj.201700178R","article-title":"Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease","volume":"31","author":"Royce","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0145","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1096\/fj.201802307R","article-title":"iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid","volume":"33","author":"Royce","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.scr.2015.09.007","article-title":"Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease","volume":"15","author":"Royce","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-015-0156-7","article-title":"Cellular uptake and intracellular degradation of poly (alkyl cyanoacrylate) nanoparticles","volume":"14","author":"Sulheim","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.10.028","article-title":"Bioengineering a non-genotoxic vector for genetic modification of mesenchymal stem cells","volume":"152","author":"Chen","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107839","article-title":"Therapeutic targets in lung tissue remodelling and fibrosis","volume":"225","author":"Liu","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0170","doi-asserted-by":"crossref","first-page":"eadg5358","DOI":"10.1126\/sciadv.adg5358","article-title":"Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice","volume":"9","author":"Han","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12931-023-02478-3","article-title":"LPS binding protein and activation signatures are upregulated during asthma exacerbations in children","volume":"24","author":"Jones","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0180","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/ijerph15061189","article-title":"A muscarinic antagonist reduces airway inflammation and bronchoconstriction induced by ambient particulate matter in a mouse model of asthma","volume":"15","author":"Kurai","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0185","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.173.5.3535","article-title":"Protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy","volume":"173","author":"Matsumoto","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0190","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pharmthera.2013.10.008","article-title":"Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis","volume":"141","author":"Royce","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0195","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1111\/all.14607","article-title":"Advances and recent developments in asthma in 2020","volume":"75","author":"Cevhertas","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0200","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0205","article-title":"Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbation","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0210","article-title":"Recent advances in targeted antibacterial therapy basing on nanomaterials","volume":"3","author":"Geng","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2024.10.056_bb0215","first-page":"90","article-title":"Nanoparticles as carriers in medical applications: a review focusing on the preparation and use of nanoparticles in tissue regeneration","volume":"14","author":"Andres","year":"2022","journal-title":"Nano Biomed. Eng."},{"key":"10.1016\/j.jconrel.2024.10.056_bb0220","doi-asserted-by":"crossref","first-page":"191","DOI":"10.26599\/NBE.2023.9290023","article-title":"Comprehensive review of available nanotechnological techniques for treating nonsolid tumors","volume":"15","author":"Shekhar","year":"2023","journal-title":"Nano Biomed. Eng."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924007296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924007296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T08:37:44Z","timestamp":1733560664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924007296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"alternative-id":["S0168365924007296"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.10.056","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.10.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}