{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:08:38Z","timestamp":1791950918130,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jconrel.2024.11.065","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T06:00:33Z","timestamp":1732860033000},"page":"606-618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["A ROS-responsive hydrogel that targets inflamed mucosa to relieve ulcerative colitis by reversing intestinal mucosal barrier loss"],"prefix":"10.1016","volume":"377","author":[{"given":"Jianwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiwan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.11.065_bb0005","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-med-052919-120048","article-title":"New therapeutics for ulcerative colitis","volume":"72","author":"Hirten","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0015","first-page":"15","article-title":"Clinical implications of mucosal healing for the management of IBD, nature reviews","volume":"7","author":"Pineton de Chambrun","year":"2010","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0020","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1365-2036.2011.04599.x","article-title":"Review article: remission rates achievable by current therapies for inflammatory bowel disease","volume":"33","author":"Peyrin-Biroulet","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0025","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cgh.2018.02.024","article-title":"Combining biologics in inflammatory bowel disease and other immune mediated inflammatory disorders","volume":"16","author":"Hirten","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0030","first-page":"493","article-title":"Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?, nature reviews","volume":"19","author":"Villablanca","year":"2022","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0035","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.3748\/wjg.v16.i34.4264","article-title":"Intestinal epithelial cells in inflammatory bowel diseases","volume":"16","author":"Roda","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0040","article-title":"Inflammatory and microbiota-related regulation of the intestinal epithelial barrier","volume":"8","author":"Barbara","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0045","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/15548627.2021.1909406","article-title":"How autophagy controls the intestinal epithelial barrier","volume":"18","author":"Foerster","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0050","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/15548627.2019.1635384","article-title":"New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD","volume":"16","author":"Larabi","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0055","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41591-019-0393-7","article-title":"Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis","volume":"25","author":"Graham","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0060","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/ijms21030993","article-title":"Contributions of myosin light chain kinase to regulation of epithelial paracellular permeability and mucosal homeostasis","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0065","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1172\/JCI24970","article-title":"Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo","volume":"115","author":"Clayburgh","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0070","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/j.gastro.2013.04.011","article-title":"TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis","volume":"145","author":"Su","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/polym10030267","article-title":"Chitosan and its derivatives for application in mucoadhesive drug delivery systems","volume":"10","author":"Ways","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124235","article-title":"N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: interaction with a model pulmonary surfactant","volume":"239","author":"Szabov\u00e1","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0085","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1039\/D2TB00874B","article-title":"Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118112","article-title":"Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs","volume":"266","author":"Xiong","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0095","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/ptr.7495","article-title":"Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ER\u03b2\/TRIM21\/PHB1 pathway","volume":"36","author":"Tao","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0100","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1096\/fj.201901638RR","article-title":"Pharmacological activation of ER\u03b2 by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases","volume":"34","author":"Tao","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0105","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.intimp.2014.09.026","article-title":"Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice","volume":"23","author":"Wu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0110","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/aps.2018.32","article-title":"Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L","volume":"39","author":"Gao","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0115","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0120","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1021\/acsnano.2c05558","article-title":"Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis","volume":"16","author":"Xu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.carbpol.2018.10.007","article-title":"Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: synthesis, characterization and in vitro investigations","volume":"204","author":"Xiong","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120348","article-title":"Injectable carboxymethyl chitosan-genipin hydrogels encapsulating tea tree oil for wound healing","volume":"301","author":"Hu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0135","first-page":"439","article-title":"Auricularia auricular polysaccharide-low molecular weight chitosan polyelectrolyte complex nanoparticles: preparation and characterization","volume":"11","author":"Xiong","year":"2016","journal-title":"Asian J. Pharmac. Sci."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0140","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.apsb.2020.10.016","article-title":"An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis","volume":"11","author":"Qin","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0145","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijpharm.2016.07.026","article-title":"Design and evaluation of a novel potential carrier for a hydrophilic antitumor drug: auricularia auricular polysaccharide-chitosan nanoparticles as a delivery system for doxorubicin hydrochloride","volume":"511","author":"Xiong","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40820-019-0252-6","article-title":"Synthesis and characterization of a silica-based drug delivery system for spinal cord injury therapy","volume":"11","author":"Sun","year":"2019","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0155","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.2147\/IJN.S163763","article-title":"Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine","volume":"13","author":"Xiong","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0160","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s13346-023-01432-6","article-title":"Development of lactoferrin-coated multifunctional copolymer micelles to cross the blood-brain barrier","volume":"14","author":"Ouyang","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13020-022-00661-0","article-title":"The \u201cwhole ingredients extract\u201d of Astragali Radix improves the symptoms of dextran sulfate sodium-induced ulcerative colitis in mice through systemic immunomodulation","volume":"17","author":"Linghu","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0170","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5657","article-title":"An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease","volume":"7","author":"Zhang","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121937","article-title":"ROS-triggered self-disintegrating and pH-responsive astaxanthin nanoparticles for regulating the intestinal barrier and colitis","volume":"292","author":"Zhang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0180","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.7150\/ijbs.82302","article-title":"Activation of P2Y1R impedes intestinal mucosa repair during colitis","volume":"19","author":"Huan","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0185","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/cpt.1609","article-title":"Achieving mucosal healing in inflammatory bowel diseases: which drug concentrations need to be targeted?","volume":"106","author":"Van den Berghe","year":"2019","journal-title":"Clin. Pharmacol. Ther. (St. Louis, MO, U. S.)"},{"key":"10.1016\/j.jconrel.2024.11.065_bb0190","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3892\/ijmm.2013.1569","article-title":"Comparison of experimental mouse models of inflammatory bowel disease","volume":"33","author":"Oh","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0195","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.0630649100","article-title":"Dynamic behavior of paired claudin strands within apposing plasma membranes","volume":"100","author":"Sasaki","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2024.11.065_bb0200","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1083\/jcb.200711165","article-title":"The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state","volume":"181","author":"Shen","year":"2008","journal-title":"J. Cell Biol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T16:29:40Z","timestamp":1734625780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924008241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"alternative-id":["S0168365924008241"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.11.065","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A ROS-responsive hydrogel that targets inflamed mucosa to relieve ulcerative colitis by reversing intestinal mucosal barrier loss","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.11.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}