{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:54:36Z","timestamp":1793044476385,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273863"],"award-info":[{"award-number":["82273863"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jconrel.2024.12.014","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T09:20:11Z","timestamp":1734081611000},"page":"236-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["\u201c3D channel maze\u201d to control drug release from multiple unit tablets"],"prefix":"10.1016","volume":"378","author":[{"given":"Huipeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longwei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunwei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"York","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiaoqiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoma","family":"Basang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.12.014_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejpb.2017.09.007","article-title":"New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release systems","volume":"121","author":"Saeidipour","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0010","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/17425247.2020.1788541","article-title":"Release mechanisms and applications of drug delivery systems for extended-release","volume":"17","author":"Wang","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijpharm.2011.01.019","article-title":"Modeling of drug release from matrix systems involving moving boundaries: approximate analytical solutions","volume":"418","author":"Lee","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpharm.2010.12.020","article-title":"Modeling of drug release from bulk-degrading polymers","volume":"418","author":"Lao","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpharm.2010.11.048","article-title":"Mathematical modeling of polymer erosion: consequences for drug delivery","volume":"418","author":"Sackett","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5173(02)00539-2","article-title":"Drug release modeled by dissolution, diffusion, and immobilization","volume":"250","author":"Frenning","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0035","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jconrel.2011.10.006","article-title":"Modeling of diffusion controlled drug delivery","volume":"161","author":"Siepmann","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0040","doi-asserted-by":"crossref","first-page":"571","DOI":"10.18433\/J38W25","article-title":"Osmotically controlled drug delivery system with associated drugs","volume":"13","author":"Gupta","year":"2010","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0045","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1208\/s12248-016-9974-2","article-title":"Scientific and regulatory considerations in solid oral modified release drug product development","volume":"18","author":"Li","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0050","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1208\/s12249-014-0236-2","article-title":"Development of modified-release tablets of zolpidem tartrate by biphasic quick\/slow delivery system","volume":"16","author":"Mahapatra","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jps.2600830225","article-title":"Development and evaluation of a monolithic floating dosage form for furosemide","volume":"83","author":"Menon","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijpharm.2011.04.013","article-title":"Simultaneous controlled vitamin release from multiparticulates: theory and experiment","volume":"412","author":"Seidenberger","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0065","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijpharm.2011.02.036","article-title":"Preparation and characterization of poly (lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug","volume":"409","author":"D\u2019Aurizio","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijpharm.2011.07.015","article-title":"Mathematical modeling of drug release from lipid dosage forms","volume":"418","author":"Siepmann","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jconrel.2017.07.043","article-title":"Tablets of multi-unit pellet system for controlled drug delivery","volume":"262","author":"Chen","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/03639047809055639","article-title":"Controlled-release multiple-units and single-unit doses a literature review","volume":"4","author":"Bechgaard","year":"1978","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejpb.2004.11.003","article-title":"Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D","volume":"60","author":"Sawicki","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0090","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ejps.2003.09.009","article-title":"Drug release from reservoir pellets compacted with some excipients of different physical properties","volume":"20","author":"Tun\u00f3n","year":"2003","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0939-6411(96)00028-8","article-title":"Tableting of coated pellets","volume":"43","author":"Bodmeier","year":"1997","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0100","first-page":"847","article-title":"MUPS tablets","volume":"2","author":"Mangesh","year":"2010","journal-title":"Int. J. Pharmtech Res."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0105","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5138\/ijdd.2010.0975.0215.02030","article-title":"Recent trends in pulsatile drug delivery systems","volume":"2","author":"Sharma","year":"2011","journal-title":"Int. J. Drug Deliv."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12247-010-9091-1","article-title":"Purdue ontology for pharmaceutical engineering: part II. Applications","volume":"5","author":"Hailemariam","year":"2010","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0115","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1007\/BF00578406","article-title":"Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: a comparison with conventional tablets","volume":"33","author":"Sandberg","year":"1988","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0120","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF00578405","article-title":"Design of a new multiple-unit controlled-release formulation of metoprolol\u2014metoprolol CR","volume":"33","author":"Sandberg","year":"1988","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0125","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/02652040210141075","article-title":"Modelling of drug-release from poly-disperse microencapsulated spherical particles","volume":"19","author":"Sirotti","year":"2002","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0168-3659(02)00033-0","article-title":"Simulation and parametric study of a film-coated controlled-release pharmaceutical","volume":"80","author":"Borgquist","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0168-3659(00)00349-7","article-title":"Mechanistic modeling of drug release from chitosan coated tablets","volume":"70","author":"Koizumi","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0140","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/03639040701662453","article-title":"Mechanistic analysis of drug release from theophylline pellets coated by films containing pectin, chitosan and Eudragit\u00ae RS","volume":"34","author":"Ghaffari","year":"2008","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2018.01.017","article-title":"Characterisation of pore structures of pharmaceutical tablets: a review","volume":"538","author":"Markl","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0150","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.74.011504","article-title":"Observations of coarsening of air voids in a polymer\u2013highly-soluble crystalline matrix during dissolution","volume":"74","author":"Karakosta","year":"2006","journal-title":"Phys. Rev. E Stat. Nonlinear Soft Matter Phys."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/1743280413Y.0000000023","article-title":"Quantitative X-ray tomography","volume":"59","author":"Maire","year":"2014","journal-title":"Int. Mater. Rev."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0168-583X(02)01689-0","article-title":"X-ray micro-tomography an attractive characterisation technique in materials science","volume":"200","author":"Salvo","year":"2003","journal-title":"Nucl. Instrum. Methods Phys. Res., Sect. B"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0165","series-title":"Medical Imaging 2008: Physiology, Function, and Structure from Medical Images","first-page":"395","article-title":"Synchrotron radiation CT methods for 3D quantitative assessment of mechanically relevant ultrastructural properties in murine bone","author":"Schneider","year":"2008"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1179\/095066099101528261","article-title":"X-ray microtomography of materials","volume":"44","author":"Stock","year":"1999","journal-title":"Int. Mater. Rev."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0175","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1021\/acs.molpharmaceut.3c00514","article-title":"Advances in structure pharmaceutics from discovery to evaluation and design","volume":"20","author":"Xu","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0180","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1208\/s12248-013-9498-y","article-title":"Quantification of swelling and erosion in the controlled release of a poorly water-soluble drug using synchrotron X-ray computed microtomography","volume":"15","author":"Yin","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0185","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/jphp.12056","article-title":"Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets","volume":"65","author":"Yin","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0190","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1208\/s12248-014-9611-x","article-title":"Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile","volume":"16","author":"Yang","year":"2014","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0195","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijpharm.2012.02.017","article-title":"Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography","volume":"427","author":"Li","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0200","first-page":"326","article-title":"Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography","volume":"12","author":"Wu","year":"2017","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0205","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.apsb.2021.05.010","article-title":"Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0210","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.apsb.2021.11.008","article-title":"Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism","volume":"12","author":"Maharjan","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2024.12.014_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105324","article-title":"Static and dynamic structural features of single pellets determine the release behaviors of metoprolol succinate sustained-release tablets","volume":"149","author":"Sun","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0220","first-page":"60","article-title":"Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets","volume":"15","author":"Zhang","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0225","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejps.2016.08.039","article-title":"Three dimensional structural insight of laser drilled orifices in osmotic pump tablets","volume":"93","author":"Wu","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.110583","article-title":"The structural diversity of ibuprofen sustained-release pellets on the same goal of bioequivalence consistency","volume":"217","author":"Cao","year":"2022","journal-title":"Mater. Des."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0235","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1021\/acs.analchem.7b04726","article-title":"Synchrotron radiation microcomputed tomography guided chromatographic analysis for displaying the material distribution in tablets","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0240","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1107\/S0909049512029731","article-title":"PITRE: software for phase-sensitive X-ray image processing and tomography reconstruction","volume":"19","author":"Chen","year":"2012","journal-title":"J. Synchrotron Radiat."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0245","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1118\/1.4915532","article-title":"An adaptive filtered back-projection for photoacoustic image reconstruction","volume":"42","author":"Huang","year":"2015","journal-title":"Med. Phys."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1107\/S0365110X58000232","article-title":"The structures of the pyrimidines and purines. VI. The crystal structure of theophylline","volume":"11","author":"Sutor","year":"1958","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0255","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.2042-7158.1990.tb06616.x","article-title":"Effect of surface characteristics of theophylline anhydrate powder on hygroscopic stability","volume":"42","author":"Otsuka","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0260","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1107\/S0108270197001960","article-title":"Methylxanthines. I. Anhydrous theophylline","volume":"53","author":"Ebisuzaki","year":"1997","journal-title":"Acta Crystallogr. Sect. C: Cryst. Struct. Commun."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0265","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1021\/cg060299i","article-title":"Solid-state polymorphic transition of theophylline anhydrate and humidity effect","volume":"7","author":"Matsuo","year":"2007","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2024.12.014_bb0270","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1021\/cg100165t","article-title":"Solid state forms of theophylline: presenting a new anhydrous polymorph","volume":"10","author":"Seton","year":"2010","journal-title":"Cryst. Growth Des."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:42:34Z","timestamp":1778244154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924008563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":54,"alternative-id":["S0168365924008563"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.014","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201c3D channel maze\u201d to control drug release from multiple unit tablets","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}