{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:24:43Z","timestamp":1783524283607,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272522"],"award-info":[{"award-number":["82272522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82422044"],"award-info":[{"award-number":["82422044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101647"],"award-info":[{"award-number":["82101647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y23H060039"],"award-info":[{"award-number":["Y23H060039"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR22H060001"],"award-info":[{"award-number":["LR22H060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jconrel.2024.12.019","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T14:55:12Z","timestamp":1734447312000},"page":"294-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Delivery of FBXO6 with highly branched poly(\u03b2-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis"],"prefix":"10.1016","volume":"378","author":[{"given":"Yongxiang","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamuran","family":"Yilamu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jconrel.2024.12.019_bb0005","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1136\/bjsports-2016-097240","article-title":"Aquatic exercise for osteoarthritis of the knee or hip (PEDro synthesis)","volume":"51","author":"Dannaway","year":"2016","journal-title":"Brit. J. Sport Med."},{"issue":"10","key":"10.1016\/j.jconrel.2024.12.019_bb0010","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/art.41312","article-title":"Comment on: deletion of c-Jun N-terminal kinase enhances senescence in joint tissues and increases the severity of age-related osteoarthritis in mice","volume":"72","author":"Xu","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrrheum.2018.43","article-title":"Osteoarthritis: hydroxychloroquine no HERO for hand OA","volume":"14","author":"Sarah","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.jconrel.2024.12.019_bb0020","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/annrheumdis-2018-214724","article-title":"Exploration of CRISPR\/Cas9-based gene editing as therapy for osteoarthritis","volume":"78","author":"Zhao","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.jconrel.2024.12.019_bb0025","article-title":"DNA-grafted hyaluronic acid system with enhanced injectability and biostability for photo-controlled osteoarthritis gene therapy","volume":"8","author":"Chen","year":"2021","journal-title":"Adv. Sci. (Weinh.)."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0030","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/s41467-024-48938-2","article-title":"A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk","volume":"15","author":"Jermy","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12951-024-02632-z","article-title":"Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration","volume":"22","author":"Feng","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1477-3155-9-23","article-title":"Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy","volume":"21","author":"Wang","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"11","key":"10.1016\/j.jconrel.2024.12.019_bb0045","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/art.40668","article-title":"Disease-modifying osteoarthritis treatment with interleukin-1 receptor antagonist gene therapy in small and large animal models","volume":"70","author":"Nixon","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0050","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12951-022-01629-w","article-title":"Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis","volume":"20","author":"Jiang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2024.12.019_bb0055","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/annrheumdis-2019-216911","article-title":"TGF\u03b2 attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination","volume":"79","author":"Wang","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12951-022-01534-2","article-title":"PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment","volume":"20","author":"Liang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.jconrel.2024.12.019_bb0065","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41419-021-03580-4","article-title":"FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer","volume":"12","author":"Ji","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28203","article-title":"FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival","volume":"95","author":"Cen","year":"2023","journal-title":"J. Med. Virol."},{"issue":"3","key":"10.1016\/j.jconrel.2024.12.019_bb0075","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1021\/pr2010204","article-title":"Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells","volume":"11","author":"Liu","year":"2012","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0080","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2316814","article-title":"RES-Xre toxin-antitoxin locus knaAT maintains the stability of the virulence plasmid in Klebsiella pneumoniae","volume":"13","author":"Chen","year":"2024","journal-title":"Emerg. Microbes Infect."},{"issue":"5","key":"10.1016\/j.jconrel.2024.12.019_bb0085","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jaad.2022.07.063","article-title":"An update on Epstein-Barr virus-and human T-lymphotropic virus type-1-induced cutaneous manifestations. CME Part II","volume":"88","author":"Gru","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0090","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2300461","article-title":"A modified recombinant adenovirus vector containing dual rabies virus G expression cassettes confers robust and long-lasting humoral immunity in mice, cats, and dogs","volume":"13","author":"Zhang","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0095","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jconrel.2023.07.038","article-title":"pH-responsive polyzwitterion covered nanocarriers for DNA delivery","volume":"360","author":"Shen","year":"2023","journal-title":"J. Control. Rel."},{"issue":"12","key":"10.1016\/j.jconrel.2024.12.019_bb0100","article-title":"Lipid nanoparticles deliver the therapeutic VEGFA mRNA in vitro and in vivo and transform extracellular vesicles for their functional extensions","volume":"10","author":"Nawaz","year":"2023","journal-title":"Adv. Sci. (Weinh.)."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0105","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jconrel.2023.07.038","article-title":"pH-responsive polyzwitterion covered nanocarriers for DNA delivery","volume":"360","author":"Shen","year":"2023","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jconrel.2024.02.002","article-title":"Enhancing gene transfection of poly(\u03b2-amino ester)s through modulation of amphiphilicity and chain sequence","volume":"368","author":"Li","year":"2024","journal-title":"J. Control. Rel."},{"issue":"6","key":"10.1016\/j.jconrel.2024.12.019_bb0115","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600102","article-title":"The transition from linear to highly branched poly(b-amino ester)s: branching matters for gene delivery","volume":"2","author":"Zhou","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0120","doi-asserted-by":"crossref","first-page":"13196","DOI":"10.1039\/C7TA03364H","article-title":"Novel porous tungsten carbide hybrid nanowires on carbon cloth for high-performance hydrogen evolution","volume":"5","author":"Wang","year":"2017","journal-title":"J. Mater. Chem. A."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jconrel.2024.02.002","article-title":"Enhancing gene transfection of poly(\u03b2-amino ester)s through modulation of amphiphilicity and chain sequence","volume":"368","author":"Li","year":"2024","journal-title":"J. Control. Rel."},{"issue":"7","key":"10.1016\/j.jconrel.2024.12.019_bb0130","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1039\/C6TB02945K","article-title":"Disulfide modified self-assembly of lipopeptides with arginine-rich periphery achieve excellent gene transfection efficiency at relatively low nitrogen to phosphorus ratios","volume":"5","author":"Chen","year":"2017","journal-title":"J. Mater. Chem. B."},{"issue":"44","key":"10.1016\/j.jconrel.2024.12.019_bb0135","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1021\/ja0015388","article-title":"Degradable poly(beta-amino esters): synthesis, characterization, and self-assembly with plasmid DNA","volume":"122","author":"Lynn","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.actbio.2016.05.040","article-title":"Synthesis and application of poly(ethylene glycol)-co-poly(\u03b2-amino ester) copolymers for small cell lung cancer gene therapy","volume":"41","author":"Kim","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120966","article-title":"Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles","volume":"275","author":"Kaczmarek","year":"2021","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.jconrel.2024.12.019_bb0150","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jconrel.2005.04.022","article-title":"Formulation and characterization of poly (\u03b2 amino ester) microparticles for genetic vaccine delivery","volume":"107","author":"Little","year":"2005","journal-title":"J. Control. Rel."},{"issue":"10","key":"10.1016\/j.jconrel.2024.12.019_bb0155","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/adma.201204346","article-title":"Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability","volume":"25","author":"Eltoukhy","year":"2013","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2024.12.019_bb0160","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1038\/s41467-019-11190-0","article-title":"Highly branched poly(\u03b2-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jconrel.2024.01.046","article-title":"Backbone cationized highly branched poly(\u03b2-amino ester)s as enhanced delivery vectors in non-viral gene therapy","volume":"367","author":"Li","year":"2024","journal-title":"J. Control. Rel."},{"key":"10.1016\/j.jconrel.2024.12.019_bb0170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jconrel.2016.02.030","article-title":"Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(\u03b2-amino ester)\/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma","volume":"226","author":"Zhang","year":"2016","journal-title":"J. Control. Rel."},{"issue":"16","key":"10.1016\/j.jconrel.2024.12.019_bb0175","article-title":"Bacterial tRNase-based gene therapy with poly(\u03b2-amino ester) nanoparticles for suppressing melanoma tumor growth and relapse","volume":"7","author":"Sungjin","year":"2018","journal-title":"Adv. Healthc. Mater."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924008629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:48:59Z","timestamp":1778629739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924008629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":35,"alternative-id":["S0168365924008629"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.019","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delivery of FBXO6 with highly branched poly(\u03b2-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}