{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:33:45Z","timestamp":1792528425343,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009847","name":"CHA University","doi-asserted-by":"publisher","award":["CHA-202301130001"],"award-info":[{"award-number":["CHA-202301130001"]}],"id":[{"id":"10.13039\/501100009847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2021R1A2C2008519"],"award-info":[{"award-number":["2021R1A2C2008519"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2022R1C1C2002949"],"award-info":[{"award-number":["2022R1C1C2002949"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2022R1A5A6000760"],"award-info":[{"award-number":["2022R1A5A6000760"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003663","name":"Small and Medium Business Administration","doi-asserted-by":"publisher","award":["S3209979"],"award-info":[{"award-number":["S3209979"]}],"id":[{"id":"10.13039\/501100003663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jconrel.2024.12.058","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T19:32:15Z","timestamp":1736019135000},"page":"997-1012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles"],"prefix":"10.1016","volume":"378","author":[{"given":"Jain","family":"Koo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuseon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehyun","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongmin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Chan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D.","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaemin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Taek","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.12.058_bb0005","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1039\/D2BM01996E","article-title":"Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery","volume":"11","author":"Nozhat","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1124\/pr.117.014944","article-title":"Current challenges and opportunities in treating glioblastoma","volume":"70","author":"Shergalis","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0015","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3390\/biomedicines9030324","article-title":"Current FDA-approved therapies for high-grade malignant gliomas","volume":"9","author":"Fisher","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.620677","article-title":"Drug resistance in glioblastoma: the two faces of oxidative stress","volume":"7","author":"Olivier","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-022-02349-7","article-title":"Emerging therapies for glioblastoma: current state and future directions","volume":"41","author":"Rong","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0030","article-title":"Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using the OLIG2 inhibitor CT-179","author":"Li","year":"2023","journal-title":"Research Square"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40005-021-00548-6","article-title":"Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches","volume":"52","author":"Hegde","year":"2022","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0040","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s40005-023-00634-x","article-title":"Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel","volume":"53","author":"Lee","year":"2023","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41568-019-0205-x","article-title":"The blood-brain barrier and blood-tumour barrier in brain Tumours and metastases","volume":"20","author":"Arvanitis","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s40005-022-00597-5","article-title":"Nanomedicine approaches for medulloblastoma therapy","volume":"53","author":"Lim","year":"2023","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114619","article-title":"Strategies to overcome\/penetrate the BBB for systemic nanoparticle delivery to the brain\/brain tumor","volume":"191","author":"Liu","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jconrel.2018.05.011","article-title":"Nose-to-brain drug delivery: an update on clinical challenges and progress towards approval of anti-Alzheimer drugs","volume":"281","author":"Agrawal","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0065","article-title":"Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations","volume":"1767\u20131807","author":"Koo","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40005-022-00589-5","article-title":"Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors","volume":"53","author":"Jeong","year":"2023","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bdd.2331","article-title":"The role of the efflux transporter, P-glycoprotein, at the blood\u2013brain barrier in drug discovery","volume":"44","author":"Cox","year":"2023","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0080","doi-asserted-by":"crossref","first-page":"14667","DOI":"10.3390\/ijms232314667","article-title":"Regulation of P-glycoprotein in the brain","volume":"23","author":"Chai","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0085","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jconrel.2021.05.046","article-title":"Tailoring of P-glycoprotein for effective transportation of actives across blood-brain-barrier","volume":"335","author":"Pathan","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40005-023-00645-8","article-title":"Development of core-shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer","volume":"54","author":"Jung","year":"2024","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/life12060897","article-title":"Multidrug resistance of cancer cells and the vital role of P-glycoprotein","volume":"12","author":"Karthika","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2133\/dmpk.DMPK-10-RG-108","article-title":"Nasal delivery of P-Gp substrates to the brain through the nose-brain pathway","volume":"26","author":"Shingaki","year":"2011","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0105","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.4155\/fmc.14.77","article-title":"Drug transporters in the nasal epithelium: an overview of strategies in targeted drug delivery","volume":"6","author":"Anand","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijpharm.2016.05.010","article-title":"Expression of P-glycoprotein in excised human nasal mucosa and optimized models of RPMI 2650 cells","volume":"508","author":"Dolberg","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0115","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s11095-005-5420-3","article-title":"Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae","volume":"22","author":"Kandimalla","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11095-004-1191-5","article-title":"Pharmacokinetics of substrate uptake and distribution in murine brain after nasal instillation","volume":"22","author":"Graff","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0125","doi-asserted-by":"crossref","first-page":"102039","DOI":"10.1016\/j.jddst.2020.102039","article-title":"Targeted nano-drug delivery system for glioblastoma therapy: in vitro and in vivo study","volume":"60","author":"Hassanzadeganroudsari","year":"2020","journal-title":"J. Drug Deliv. Technol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0130","first-page":"168","article-title":"Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy","volume":"132","author":"Kadari","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0135","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1007\/s13277-014-1630-9","article-title":"Efficacy of cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma","volume":"35","author":"Ebrahimi Shahmabadi","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl5838","article-title":"Enhancing CDK4\/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-Seq\u2013guided combination with sapanisertib","volume":"8","author":"Lim","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0145","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1021\/acs.molpharmaceut.9b00018","article-title":"Validation of thiosemicarbazone compounds as P-glycoprotein inhibitors in human primary brain-blood barrier and glioblastoma stem cells","volume":"16","author":"Salaroglio","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s40005-016-0255-y","article-title":"Nanomedicines for oral administration based on diverse nanoplatform","volume":"46","author":"Sim","year":"2016","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0155","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.addr.2020.09.009","article-title":"Polymeric micelles for the delivery of poorly soluble drugs: from nanoformulation to clinical approval","volume":"156","author":"Hwang","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0160","doi-asserted-by":"crossref","first-page":"2103552","DOI":"10.1002\/smll.202103552","article-title":"Drug-dependent morphological transitions in spherical and worm-like polymeric micelles define stability and pharmacological performance of micellar drugs","volume":"18","author":"Lim","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101884","article-title":"High-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple negative breast cancer","volume":"51","author":"Lim","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0170","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1080\/07391102.2020.1858966","article-title":"Quercetin acts as a P-Gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain","volume":"40","author":"Singh","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0175","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1039\/C6MB00187D","article-title":"Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer","volume":"12","author":"Mohana","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0180","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/ptr.6155","article-title":"Anticancer potential of quercetin: a comprehensive review","volume":"32","author":"Rauf","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biopha.2017.05.044","article-title":"Effects of quercetin on proliferation and migration of human glioblastoma U251 cells","volume":"92","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101862","article-title":"RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR tumor","volume":"50","author":"Shin","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0195","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00289-016-1791-3","article-title":"Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly (ethylene glycol), with different structures for anticancer drug delivery applications","volume":"74","author":"Hoang","year":"2017","journal-title":"Polym. Bull."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2019.07.011","article-title":"Targeting specific membranes with an azide derivative of the pore-forming peptide ceratotoxin a","volume":"1861","author":"Mayer","year":"2019","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0205","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1021\/mp300668e","article-title":"Dose-dependent targeted suppression of P-glycoprotein expression and function in Caco-2 cells","volume":"10","author":"Lee","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0210","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1023\/A:1018825819249","article-title":"Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake","volume":"16","author":"Gutmann","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2015.11.019","article-title":"Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors","volume":"100","author":"Netsomboon","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0220","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbrc.2016.06.035","article-title":"Prediction of cell-penetrating peptides with feature selection techniques","volume":"477","author":"Tang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002101","article-title":"Prediction of cell penetrating peptides by support vector machines","volume":"7","author":"Sanders","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0230","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1021\/acs.biomac.5b01334","article-title":"siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy","volume":"17","author":"Tangsangasaksri","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0235","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.nano.2016.09.016","article-title":"pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery","volume":"13","author":"Teo","year":"2017","journal-title":"Nanomed.: Nanotechnol., Biol. Med."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0240","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","article-title":"Polymeric micelles in drug delivery: an insight of the techniques for their characterization and assessment in biorelevant conditions","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115676","article-title":"Recent advancements in the targeted delivery of etoposide nanomedicine for cancer therapy: a comprehensive review","volume":"259","author":"Fathi Karkan","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0250","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fneur.2018.00459","article-title":"Topoisomerase II poisons for glioblastoma: existing challenges and opportunities to personalize therapy","volume":"9","author":"Mehta","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0255","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.bjc.6602105","article-title":"Phase II trial of carboplatin and etoposide for patients with recurrent high-grade glioma","volume":"91","author":"Franceschi","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0260","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1215\/15228517-2007-006","article-title":"Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults","volume":"9","author":"Kesari","year":"2007","journal-title":"Neuro-Oncol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0265","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3171\/2009.5.JNS081738","article-title":"Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme","volume":"112","author":"Aoki","year":"2010","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0270","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/sj.bjc.6605412","article-title":"Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study","volume":"101","author":"Reardon","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0275","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2017.11.047","article-title":"Nanosystems in nose-to-brain drug delivery: a review of non-clinical brain targeting studies","volume":"270","author":"Pires","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0280","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejps.2017.02.032","article-title":"Nose-to-brain transport of imatinib mesylate: a pharmacokinetic evaluation","volume":"102","author":"Hada","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0285","doi-asserted-by":"crossref","first-page":"11746","DOI":"10.3390\/ijms231911746","article-title":"A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells","volume":"23","author":"Biswas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11033-020-06087-x","article-title":"The natural flavones, acacetin and apigenin, induce Cdk-cyclin mediated G2\/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells","volume":"48","author":"Shendge","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0295","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/cancers14030701","article-title":"Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells","volume":"14","author":"Vlatkovic","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0300","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s11658-024-00578-6","article-title":"Targeted inhibition of the PI3K\/AKT\/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer","volume":"29","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0305","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijbiomac.2020.03.094","article-title":"Self-assembled micelles prepared from bio-based hydroxypropyl methyl cellulose and polylactide amphiphilic block copolymers for anti-tumor drug release","volume":"154","author":"Lu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0310","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3390\/molecules27072178","article-title":"Functional polyion complex micelles for potential targeted hydrophobic drug delivery","volume":"27","author":"Kalinova","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0315","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1002\/pat.5423","article-title":"Biocompatibility, drug REelease, and anti-tumor effect of pH-sensitive micelles prepared from poly (2-ethyl-2-oxazoline)-poly (DL-lactide) block copolymers","volume":"32","author":"Wang","year":"2021","journal-title":"Polym. Advan. Technol"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0320","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1021\/mp400644e","article-title":"Prolongation of life in rats with malignant glioma by intranasal siRNA\/drug codelivery to the brain with cell-penetrating peptide-modified micelles","volume":"11","author":"Kanazawa","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2024.12.058_bb0325","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jconrel.2021.12.034","article-title":"Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy","volume":"342","author":"Yang","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0330","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3390\/pharmaceutics14091870","article-title":"Nose-to-brain delivery of therapeutic peptides as nasal aerosols","volume":"14","author":"Alabsi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2024.12.058_bb0335","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s40005-023-00626-x","article-title":"Polysaccharide-based platforms for nasal delivery: design, features, and perspectives","volume":"53","author":"Elmowafy","year":"2023","journal-title":"J. Pharm. Investig."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924009131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924009131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:44:48Z","timestamp":1778244288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924009131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":67,"alternative-id":["S0168365924009131"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.058","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}