{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:13:56Z","timestamp":1782537236848,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["QY23191"],"award-info":[{"award-number":["QY23191"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1206800"],"award-info":[{"award-number":["2022YFA1206800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371520"],"award-info":[{"award-number":["32371520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2022166"],"award-info":[{"award-number":["2022166"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jconrel.2024.12.070","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T20:57:31Z","timestamp":1736197051000},"page":"1103-1113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Clickable liposomes for on-demand reversal of antiplatelet drugs: Towards a safe management of bleeding risks associated with antithrombotic therapy"],"prefix":"10.1016","volume":"378","author":[{"given":"Xiaoyu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyue","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2024.12.070_bb0005","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1056\/NEJMoa1500857","article-title":"Long-term use of ticagrelor in patients with prior myocardial infarction","volume":"372","author":"Bonaca","year":"2015","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0010","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.jacc.2020.09.584","article-title":"Ticagrelor or prasugrel in patients with non\u2013st-segment elevation acute coronary syndromes","volume":"76","author":"Valina","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0015","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1056\/NEJMoa1908419","article-title":"Ticagrelor with or without aspirin in high-risk patients after PCI","volume":"381","author":"Mehran","year":"2019","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0020","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0140-6736(21)01445-8","article-title":"Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (talos-ami): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial","volume":"398","author":"Kim","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.12.070_bb0025","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Nejm-ticagrelor versus clopidogrel in patients with acute coronary syndromes","volume":"361","author":"Lars","year":"2009","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0030","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jacc.2023.05.062","article-title":"Bleeding and ischemic risks of ticagrelor monotherapy after coronary interventions","volume":"82","author":"Mendieta","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0035","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nrcardio.2013.4","article-title":"Repair of infrarenal aortic aneurysm\u2014the debate is over","volume":"10","author":"Karthikesalingam","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0040","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1056\/NEJMc1409373","article-title":"Inefficacy of platelet transfusion to reverse ticagrelor","volume":"372","author":"Godier","year":"2015","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0045","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1161\/CIRCULATIONAHA.117.028566","volume":"136","author":"Easton","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2024.12.070_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2020.11.014","article-title":"Gastroprotection in patients on antiplatelet and\/or anticoagulant therapy: a position paper of national association of hospital cardiologists (anmco) and the italian association of hospital gastroenterologists and endoscopists (aigo)","volume":"85","author":"Abrignani","year":"2021","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0055","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1111\/jocs.15636","article-title":"Ticagrelor use and practice patterns among Canadian cardiac surgeons","volume":"36","author":"Makhdoum","year":"2021","journal-title":"J. Card. Surg."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0060","article-title":"Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor","volume":"8","author":"O\u2019Connor","year":"2015","journal-title":"Circ-Cardiovasc. Inte."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0065","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1056\/NEJMoa1901778","article-title":"Antibody-based ticagrelor reversal agent in healthy volunteers","volume":"380","author":"Bhatt","year":"2019","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0070","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/CIRCRESAHA.122.321034","article-title":"Platelet-mimicking nanosponges for functional reversal of antiplatelet agents","volume":"132","author":"Xu","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(07)61198-2","article-title":"Platelet transfusions","volume":"370","author":"Stroncek","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2024.12.070_bb0080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40262-023-01245-3","article-title":"Clinical and pre-clinical pharmacokinetics and pharmacodynamics of bentracimab","volume":"62","author":"Ortega-Paz","year":"2023","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0085","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1021\/acs.bioconjchem.9b00457","article-title":"Targeting delivery of platelets inhibitor to prevent tumor metastasis","volume":"30","author":"Geranpayehvaghei","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0090","doi-asserted-by":"crossref","first-page":"1900795","DOI":"10.1002\/adma.201900795","article-title":"Engineering biomimetic platesomes for ph-responsive drug delivery and enhanced antitumor activity","volume":"31","author":"Liu","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0095","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrcardio.2017.223","article-title":"Reversal agents for non-vitamin k antagonist oral anticoagulants","volume":"15","author":"Levy","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0100","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1056\/NEJMoa1510991","article-title":"Andexanet alfa for the reversal of factor xa inhibitor activity","volume":"373","author":"Siegal","year":"2015","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jconrel.2024.12.070_bb0105","article-title":"Development of supramolecular anticoagulants with on-demand reversibility","author":"Dockerill","year":"2024","journal-title":"Nat. Biotechnol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924009258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365924009258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:42:59Z","timestamp":1778244179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365924009258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":21,"alternative-id":["S0168365924009258"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.070","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clickable liposomes for on-demand reversal of antiplatelet drugs: Towards a safe management of bleeding risks associated with antithrombotic therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2024.12.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}