{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:19:50Z","timestamp":1793049590306,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI082639"],"award-info":[{"award-number":["AI082639"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P51OD010424"],"award-info":[{"award-number":["P51OD010424"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32A1007140"],"award-info":[{"award-number":["T32A1007140"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI120249"],"award-info":[{"award-number":["AI120249"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jconrel.2025.01.011","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T04:23:21Z","timestamp":1737692601000},"page":"696-707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Engineering vaginal film platform for mucoadhesion and sustained drug release for HIV-1 prevention"],"prefix":"10.1016","volume":"379","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravan Kumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Cencia","family":"Rohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.01.011_bb0005","series-title":"Global HIV & AIDS statistics \u2014 Fact sheet","author":"UNAIDS","year":"2023"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0010","series-title":"HIV and adolescent giral and young women - 2023 GLOBAL AIDS UPDATE FACTSHEET","author":"UNAIDS","year":"2023"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0015","unstructured":"HIGHLIGHTS OF PRESCRIBING INFORMATION. SUNLENCA\u00ae (lenacapavir) tablets, for oral use SUNLENCA\u00ae (lenacapavir) injection, for subcutaneous use. [cited 2024 June 30]; Available from: https:\/\/www.gilead.com\/-\/media\/files\/pdfs\/medicines\/hiv\/sunlenca\/sunlenca_pi.pdf."},{"key":"10.1016\/j.jconrel.2025.01.011_bb0020","unstructured":"HIGHLIGHTS OF PRESCRIBING INFORMATION. APRETUDE (cabotegravir extended-release injectable suspension), for intramuscular use [cited 2024 June 30]; Available from: https:\/\/gskpro.com\/content\/dam\/global\/hcpportal\/en_US\/Prescribing_Information\/Apretude\/pdf\/APRETUDE-PI-PIL-IFU.PDF."},{"key":"10.1016\/j.jconrel.2025.01.011_bb0025","unstructured":"HIGHLIGHTS OF PRESCRIBING INFORMATION. TRUVADA\u00ae (emtricitabine and tenofovir disoproxil fumarate) tablets, for oral use 2024 (Revised) [cited 2024 June 30]; Available from: https:\/\/www.gilead.com\/\u223c\/media\/Files\/pdfs\/medicines\/hiv\/truvada\/truvada_pi.pdf."},{"issue":"22","key":"10.1016\/j.jconrel.2025.01.011_bb0030","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women","volume":"375","author":"Baeten","year":"2016","journal-title":"N Engl J Med"},{"issue":"22","key":"10.1016\/j.jconrel.2025.01.011_bb0035","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1602046","article-title":"Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women","volume":"375","author":"Nel","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0040","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/S2352-3018(20)30304-0","article-title":"Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study","volume":"8","author":"Baeten","year":"2021","journal-title":"Lancet HIV"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0045","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/S2352-3018(20)30300-3","article-title":"Safety, adherence, and HIV-1 seroconversion among women using the dapivirine vaginal ring (DREAM): an open-label, extension study","volume":"8","author":"Nel","year":"2021","journal-title":"Lancet HIV"},{"issue":"5","key":"10.1016\/j.jconrel.2025.01.011_bb0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/QAI.0000000000000897","article-title":"A phase 1 trial to assess the safety, acceptability, pharmacokinetics, and pharmacodynamics of a novel dapivirine vaginal film","volume":"71","author":"Bunge","year":"2016","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"10.1016\/j.jconrel.2025.01.011_bb0055","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1089\/jwh.2010.2476","article-title":"Acceptability of vaginal film, soft-gel capsule, and tablet as potential microbicide delivery methods among African women","volume":"20","author":"Nel","year":"2011","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0060","series-title":"Understanding the Potential for Multipurpose Prevention of Pregnancy and HIV: Results from surveys assessing four hypothetical concept profiles of Multipurpose Prevention Technologies (MPTs) in Uganda, Nigeria and South Africa","author":"El-Sahn","year":"2016"},{"issue":"1","key":"10.1016\/j.jconrel.2025.01.011_bb0065","first-page":"56","article-title":"Physiology and ecology of the vagina","volume":"51","author":"Bernal","year":"1986","journal-title":"Rev Chil Obstet Ginecol"},{"issue":"10","key":"10.1016\/j.jconrel.2025.01.011_bb0070","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1461-5347(00)00296-0","article-title":"The scope and potential of vaginal drug delivery","volume":"3","author":"Vermani","year":"2000","journal-title":"Pharm Sci Technolo Today"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.addr.2015.02.001","article-title":"Mucoadhesive and thermogelling systems for vaginal drug delivery","volume":"92","author":"Caramella","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0080","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.coph.2017.07.011","article-title":"Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles","volume":"36","author":"Morales","year":"2017","journal-title":"Curr Opin Pharmacol"},{"issue":"7","key":"10.1016\/j.jconrel.2025.01.011_bb0085","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1007\/s11095-013-1287-x","article-title":"Biodistribution and pharmacokinetics of dapivirine-loaded nanoparticles after vaginal delivery in mice","volume":"31","author":"das Neves","year":"2014","journal-title":"Pharm Res"},{"issue":"11","key":"10.1016\/j.jconrel.2025.01.011_bb0090","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.addr.2005.07.002","article-title":"Thiomers: a new generation of mucoadhesive polymers","volume":"57","author":"Bernkop-Schnurch","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0095","unstructured":"ThioMatriX, Thiomers - Potent Auxiliary Agents in Vaginal Drug Delivery."},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0378-5173(03)00271-0","article-title":"Thiolated polymers\u2014thiomers: synthesis and in vitro evaluation of chitosan\u20132-iminothiolane conjugates","volume":"260","author":"Bernkop-Schn\u00fcrch","year":"2003","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jconrel.2014.06.047","article-title":"Thiomers--from bench to market","volume":"195","author":"Bonengel","year":"2014","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.01.011_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12010001","article-title":"Rational Design of a Multipurpose Bioadhesive Vaginal Film for Co-Delivery of Dapivirine and Levonorgestrel","volume":"12","author":"Li","year":"2019","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0115","first-page":"203","article-title":"Synthesis and characterization of copoly(L-lactic acid-caprolactone) and its stereo-effect with poly D-lactic acid and biodegradabilit. Bangladesh","volume":"47","author":"Hoquea","year":"2012","journal-title":"J. Sci. Ind. Res."},{"issue":"5","key":"10.1016\/j.jconrel.2025.01.011_bb0120","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1163\/156856204323046906","article-title":"Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering","volume":"15","author":"Jeong","year":"2004","journal-title":"J Biomater Sci Polym Ed"},{"issue":"28","key":"10.1016\/j.jconrel.2025.01.011_bb0125","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1016\/j.biomaterials.2004.01.057","article-title":"In vivo biocompatibilty and degradation behavior of elastic poly(L-lactide-co-epsilon-caprolactone) scaffolds","volume":"25","author":"Jeong","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejps.2018.01.028","article-title":"Lamotrigine loaded poly-varepsilon-(d,l-lactide-co-caprolactone) nanoparticles as brain delivery system","volume":"115","author":"Ammar","year":"2018","journal-title":"Eur J Pharm Sci"},{"issue":"3","key":"10.1016\/j.jconrel.2025.01.011_bb0135","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1567201813666151130221806","article-title":"PEO-PPO-PEO\/Poly(DL-lactide-co-caprolactone) Nanoparticles as Carriers for SN-38: Design, Optimization and Nano-Bio Interface Interactions","volume":"13","author":"Koliqi","year":"2016","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.colsurfb.2016.04.013","article-title":"Fabrication and characterization of vitamin B5 loaded poly (l-lactide-co-caprolactone)\/silk fiber aligned electrospun nanofibers for schwann cell proliferation","volume":"144","author":"Bhutto","year":"2016","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"11","key":"10.1016\/j.jconrel.2025.01.011_bb0145","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1166\/jbn.2015.2138","article-title":"Heparin and Vascular Endothelial Growth Factor Loaded Poly(L-lactide-co-caprolactone) Nanofiber Covered Stent-Graft for Aneurysm Treatment","volume":"11","author":"Wang","year":"2015","journal-title":"J Biomed Nanotechnol"},{"issue":"1","key":"10.1016\/j.jconrel.2025.01.011_bb0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1556-276X-6-260","article-title":"Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies","volume":"6","author":"Sanna","year":"2011","journal-title":"Nanoscale Res Lett"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0155","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.colsurfb.2009.09.014","article-title":"Encapsulation of proteins in poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning","volume":"75","author":"Li","year":"2010","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0160","first-page":"389","article-title":"Preclinical animal study and human clinical trial data of co-electrospun poly(L-lactide-co-caprolactone) and fibrinogen mesh for anterior pelvic floor reconstruction","volume":"11","author":"Wu","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0165","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1039\/C7TB03073H","article-title":"Micropatterned poly(D,L-lactide-co-caprolactone) films entrapped with gelatin for promoting the alignment and directional migration of Schwann cells","volume":"6","author":"Zhang","year":"2018","journal-title":"Journal of Materials Chemistry B"},{"issue":"18","key":"10.1016\/j.jconrel.2025.01.011_bb0170","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1128\/JVI.01164-10","article-title":"Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor","volume":"84","author":"Bar-Magen","year":"2010","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.jconrel.2025.01.011_bb0175","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13346-011-0022-6","article-title":"Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission","volume":"1","author":"Akil","year":"2011","journal-title":"Drug Deliv Transl Res"},{"issue":"10-11","key":"10.1016\/j.jconrel.2025.01.011_bb0180","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1089\/aid.2016.0014","article-title":"The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal Tissue","volume":"32","author":"Hu","year":"2016","journal-title":"Aids Research and Human Retroviruses"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0185","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11095-014-1474-4","article-title":"Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention","volume":"32","author":"Akil","year":"2015","journal-title":"Pharm Res"},{"issue":"8","key":"10.1016\/j.jconrel.2025.01.011_bb0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/01.olq.0000170444.13666.e9","article-title":"Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials","volume":"32","author":"Moncla","year":"2005","journal-title":"Sexually Transmitted Diseases"},{"issue":"1","key":"10.1016\/j.jconrel.2025.01.011_bb0195","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejpb.2007.01.010","article-title":"Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer","volume":"67","author":"Thirawong","year":"2007","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"6","key":"10.1016\/j.jconrel.2025.01.011_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/polym14061196","article-title":"Development and Evaluation of Nanoparticles-in-Film Technology to Achieve Extended In Vivo Exposure of MK-2048 for HIV Prevention","volume":"14","author":"Tong","year":"2022","journal-title":"Polymers (Basel)"},{"issue":"4","key":"10.1016\/j.jconrel.2025.01.011_bb0205","first-page":"119","article-title":"From the patient\u2019s point of view: The data-brain might harm the B-set, it does not forget my foolish youth","volume":"88","author":"Benneche","year":"1973","journal-title":"Nord Med"},{"issue":"12","key":"10.1016\/j.jconrel.2025.01.011_bb0210","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/OLQ.0b013e3180f62f81","article-title":"Assessment of Adherence to Product Dosing in a Pilot Microbicide Study","volume":"34","author":"Hogarty","year":"2007","journal-title":"Sexually Transmitted Diseases"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0215","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-7622-5-8","article-title":"Persisting with prevention: the importance of adherence for HIV prevention","volume":"5","author":"Weiss","year":"2008","journal-title":"Emerg Themes Epidemiol"},{"issue":"7","key":"10.1016\/j.jconrel.2025.01.011_bb0220","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s10461-012-0248-4","article-title":"Vaginal ring adherence in sub-Saharan Africa: expulsion, removal, and perfect use","volume":"16","author":"Montgomery","year":"2012","journal-title":"AIDS Behav"},{"issue":"6","key":"10.1016\/j.jconrel.2025.01.011_bb0225","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s10461-013-0429-9","article-title":"Adherence support approaches in biomedical HIV prevention trials: experiences, insights and future directions from four multisite prevention trials","volume":"17","author":"Amico","year":"2013","journal-title":"AIDS Behav"},{"issue":"5","key":"10.1016\/j.jconrel.2025.01.011_bb0230","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s10461-014-0751-x","article-title":"Adherence in the CAPRISA 004 tenofovir gel microbicide trial","volume":"18","author":"Mansoor","year":"2014","journal-title":"AIDS Behav"},{"issue":"4","key":"10.1016\/j.jconrel.2025.01.011_bb0235","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nm0414-323","article-title":"Long-acting HIV drugs advanced to overcome adherence challenge","volume":"20","author":"Dolgin","year":"2014","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jconrel.2025.01.011_bb0240","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/cid\/ciy652","article-title":"Phase 1 Pharmacokinetic Trial of 2 Intravaginal Rings Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048","volume":"68","author":"Liu","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.jconrel.2025.01.011_bb0245","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/cid\/ciy653","article-title":"Phase 1 Safety and Pharmacokinetics Study of MK-2048\/Vicriviroc (MK-4176)\/MK-2048A Intravaginal Rings","volume":"68","author":"Hoesley","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.jconrel.2025.01.011_bb0250","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1007\/s11095-015-1678-2","article-title":"Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission","volume":"32","author":"Zhang","year":"2015","journal-title":"Pharm Res"},{"issue":"2","key":"10.1016\/j.jconrel.2025.01.011_bb0255","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12247-017-9274-0","article-title":"Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention","volume":"12","author":"Gong","year":"2017","journal-title":"J Pharm Innov"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0260","first-page":"10","article-title":"Takayuhi Nakamura, and Yoshito Ikada, In vitro evaluation of sustained drug release from biodegradable elastromer","volume":"8","author":"Ryoichi Wada","year":"1991","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/607351","article-title":"Novel Poly(L-lactide-co-epsilon-caprolactone) Matrices Obtained with the Use of Zr[Acac](4) as Nontoxic Initiator for Long-Term Release of","volume":"2013","author":"Jelonek","year":"2013","journal-title":"Immunosuppressive Drugs, Biomed Research International"},{"key":"10.1016\/j.jconrel.2025.01.011_bb0270","series-title":"Low Molecular Weight Poly(Lactide-co-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management Advances in Chemical Engineering and Science","first-page":"15","volume":"2","author":"Sriputtirat","year":"2012"},{"issue":"3","key":"10.1016\/j.jconrel.2025.01.011_bb0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2012.12.001","article-title":"Thiomer-coated liposomes harbor permeation enhancing and efflux pump inhibitory properties","volume":"165","author":"Gradauer","year":"2013","journal-title":"J Control Release"},{"issue":"3","key":"10.1016\/j.jconrel.2025.01.011_bb0280","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jconrel.2005.05.016","article-title":"Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts","volume":"106","author":"Song","year":"2005","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.01.011_bb0285","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0939-6411(00)00130-2","article-title":"Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs","volume":"51","author":"Clausen","year":"2001","journal-title":"Eur J Pharm Biopharm"},{"issue":"4","key":"10.1016\/j.jconrel.2025.01.011_bb0290","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00465-15","article-title":"The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency","volume":"6","author":"Mousseau","year":"2015","journal-title":"MBio"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592500015X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592500015X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T12:28:25Z","timestamp":1762259305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592500015X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":58,"alternative-id":["S016836592500015X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.01.011","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering vaginal film platform for mucoadhesion and sustained drug release for HIV-1 prevention","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}