{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:59:08Z","timestamp":1792900748655,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210424"],"award-info":[{"award-number":["BK20210424"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473866"],"award-info":[{"award-number":["82473866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471394"],"award-info":[{"award-number":["32471394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jconrel.2025.01.046","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T08:45:27Z","timestamp":1739004327000},"page":"362-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Biomimetic calcium-chelation nanoparticles reprogram tumor metabolism to enhance antitumor immunity"],"prefix":"10.1016","volume":"380","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.01.046_bb0005","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Mart\u00ednez-Reyes","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0010","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41556-022-01002-x","article-title":"Metabolic communication in the tumour-immune microenvironment","volume":"24","author":"Kao","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0015","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of immune cells in cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41571-019-0203-7","article-title":"Navigating metabolic pathways to enhance antitumour immunity and immunotherapy","volume":"16","author":"Li","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41573-019-0032-5","article-title":"Targeting metabolism to regulate immune responses in autoimmunity and cancer","volume":"18","author":"Patel","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0030","first-page":"333","article-title":"Chang Wei Qing Decoction enhances the anti-tumor effect of PD-1 inhibitor therapy by regulating the immune microenviron-ment and gut microbiota in colorectal cancer","volume":"21","author":"Wang","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0035","first-page":"481","article-title":"The circadian clock of anti-tumor immunity","volume":"21","author":"Xiang","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cmet.2019.04.002","article-title":"Cholesterol induces CD8+ T cell exhaustion in the tumor microenvironment","volume":"30","author":"Ma","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0045","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1182\/blood-2016-06-724807","article-title":"LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis","volume":"128","author":"Ceroi","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13578-023-01138-9","article-title":"Glycolysis-cholesterol metabolic axis in immuno-oncology microenvironment: emerging role in immune cells and immunosuppressive signaling","volume":"13","author":"Jin","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0060","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.3390\/ijms21218363","article-title":"Lactic acid and an acidic tumor microenvironment suppress anticancer immunity","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tibs.2018.10.011","article-title":"Lactate: a metabolic driver in the tumour landscape","volume":"44","author":"Ippolito","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0070","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood-2005-05-1795","article-title":"Tumor-derived lactic acid modulates dendritic cell activation and antigen expression","volume":"107","author":"Gottfried","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ccell.2022.01.001","article-title":"Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments","volume":"40","author":"Kumagai","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0085","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1073\/pnas.0914433107","article-title":"Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression","volume":"107","author":"Le","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s42255-020-0174-0","article-title":"Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities","volume":"2","author":"Huang","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0095","first-page":"411","article-title":"Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in NAFLD mice","volume":"21","author":"Fan","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nri.2017.99","article-title":"The spectrum of T cell metabolism in health and disease","volume":"18","author":"Bantug","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0110","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s42255-020-00280-9","article-title":"Metabolic and epigenetic regulation of T-cell exhaustion","volume":"2","author":"Franco","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/imr.13215","article-title":"Lipid metabolism in dendritic cell biology","volume":"317","author":"You","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-28240-9","article-title":"Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance","volume":"13","author":"Lebeau","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0125","article-title":"Organellar calcium handling in the cellular reticular network","volume":"11","author":"Wang","year":"2019","journal-title":"CSH Perspect. Biol."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/198268","article-title":"A comprehensive review on cyclodextrin-based carriers for delivery of chemotherapeutic cytotoxic anticancer drugs","volume":"2015","author":"Gidwani","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0135","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1021\/acs.nanolett.9b00934","article-title":"Biomimetic hybrid nanozymes with self-supplied H+ and accelerated O2 generation for enhanced starvation and photodynamic therapy against hypoxic tumors","volume":"19","author":"Yang","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0140","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2008.10.008","article-title":"Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance","volume":"8","author":"Radhakrishnan","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2025.01.046_bb0145","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ijc.31812","article-title":"Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase","volume":"144","author":"Golias","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jconrel.2025.01.046_bb0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fonc.2018.00081","article-title":"Metabolic symbiosis and immunomodulation: how tumor cell-derived lactate may disturb innate and adaptive immune responses","volume":"8","author":"Morrot","year":"2018","journal-title":"Front. Oncol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:50:52Z","timestamp":1770141052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":30,"alternative-id":["S0168365925000562"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.01.046","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic calcium-chelation nanoparticles reprogram tumor metabolism to enhance antitumor immunity","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}