{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:13:44Z","timestamp":1791918824929,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1294"],"award-info":[{"award-number":["2024KY1294"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2023ZY1011"],"award-info":[{"award-number":["2023ZY1011"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jconrel.2025.02.004","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T15:17:24Z","timestamp":1739287044000},"page":"490-502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Hydrophobic vehicles for hydrophilic drugs: Sustained intravitreal caffeine delivery with oleogels"],"prefix":"10.1016","volume":"380","author":[{"given":"Nan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-qing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-xin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-hui","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jconrel.2025.02.004_bb0005","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1021\/acs.jmedchem.1c00261","article-title":"The medicinal chemistry of caffeine","volume":"64","author":"Faudone","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101664","article-title":"The human lens: An antioxidant-dependent tissue revealed by the role of caffeine","volume":"79","author":"Ruiss","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0015","doi-asserted-by":"crossref","first-page":"13390","DOI":"10.1038\/s41598-023-40227-0","article-title":"Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure","volume":"13","author":"Mao","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jconrel.2025.02.004_bb0020","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1021\/am301365h","article-title":"CAF@ZIF-8: one-step encapsulation of caffeine in MOF","volume":"4","author":"Li\u00e9dana","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.jconrel.2025.02.004_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2021.01.004","article-title":"Modifiable lifestyle risk factors for dry eye disease","volume":"44","author":"Wang","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"key":"10.1016\/j.jconrel.2025.02.004_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.737426","article-title":"Caffeine inhibits choroidal neovascularization through mitigation of inflammatory and angiogenesis activities","volume":"9","author":"Sorenson","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.02.004_bb0035","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1096\/fj.201601285R","article-title":"Caffeine preferentially protects against oxygen-induced retinopathy","volume":"31","author":"Zhang","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.824885","article-title":"Caffeine protects against retinal inflammation","volume":"12","author":"Conti","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0045","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12951-022-01567-7","article-title":"Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update","volume":"20","author":"Afarid","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jcis.2019.07.082","article-title":"Extended release of dexamethasone from oleogel based rods","volume":"555","author":"Macoon","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105634","article-title":"Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels","volume":"158","author":"Macoon","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.exer.2015.05.003","article-title":"Rabbit as an animal model for intravitreal pharmacokinetics: clinical predictability and quality of the published data","volume":"137","author":"del Amo","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0065","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jconrel.2020.08.034","article-title":"An anchoring molecule increases intravitreal retention of antibody-based therapeutics used in the treatment of ocular diseases","volume":"328","author":"Gao","year":"2020","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/17425247.2022.2017878","article-title":"Topical drug delivery to the retina: obstacles and routes to success","volume":"19","author":"Loftsson","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114342","article-title":"Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies","volume":"187","author":"Alshaikh","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"10","key":"10.1016\/j.jconrel.2025.02.004_bb0080","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4155\/tde-2019-0051","article-title":"Preliminary evaluation of YUTIQ\u2122 (fluocinolone Acetonide intravitreal implant 0.18 mg) in posterior uveitis","volume":"10","author":"Testi","year":"2019","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0085","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jconrel.2023.01.081","article-title":"Improving ocular bioavailability of hydrophilic drugs through dynamic covalent complexation","volume":"355","author":"Wang","year":"2023","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.jconrel.2025.02.004_bb0090","doi-asserted-by":"crossref","first-page":"eabm8478","DOI":"10.1126\/sciadv.abm8478","article-title":"Development of oil-based gels as versatile drug delivery systems for pediatric applications","volume":"8","author":"Kirtane","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105413","article-title":"In vitro release of hydrophobic drugs by oleogel rods with biocompatible gelators","volume":"152","author":"Macoon","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0100","series-title":"Oleogel compositions for retinal drug delivery","author":"Chauhan","year":"2022"},{"key":"10.1016\/j.jconrel.2025.02.004_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122933","article-title":"In situ formation of injectable organogels for punctal occlusion and sustained release of therapeutics: design, preparation, in vitro and in vivo evaluation","volume":"638","author":"Cao","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.jconrel.2025.02.004_bb0110","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1007\/s13346-024-01560-7","article-title":"Oleogels for the ocular delivery of epalrestat: formulation, in vitro, in ovo, ex vivo and in vivo evaluation","volume":"14","author":"Kattar","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"issue":"31","key":"10.1016\/j.jconrel.2025.02.004_bb0115","doi-asserted-by":"crossref","first-page":"21401","DOI":"10.1021\/jacs.4c03751","article-title":"In situ forming, enzyme-responsive Peptoid-peptide hydrogels: An advanced long-acting injectable drug delivery system","volume":"146","author":"Coulter","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0120","series-title":"Drug Release, the ADME Encyclopedia: A Comprehensive Guide on Biopharmacy and Pharmacokinetics","first-page":"1","author":"Talevi","year":"2021"},{"key":"10.1016\/j.jconrel.2025.02.004_bb0125","series-title":"Baker-Lonsdale Model of Drug Release, the ADME Encyclopedia: A Comprehensive Guide on Biopharmacy and Pharmacokinetics","first-page":"1","author":"Talevi","year":"2021"},{"key":"10.1016\/j.jconrel.2025.02.004_bb0130","series-title":"Drug Stability and Chemical Kinetics","first-page":"155","article-title":"Role of kinetic models in drug stability","author":"Rehman","year":"2020"},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0135","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12660","article-title":"Melatonin attenuates choroidal neovascularization by regulating macrophage\/microglia polarization via inhibition of RhoA\/ROCK signaling pathway","volume":"69","author":"Xu","year":"2020","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.02.004_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00218839.2019.1571556","article-title":"Standard methods for Apis mellifera beeswax research","volume":"58","author":"Sve\u010dnjak","year":"2019","journal-title":"J. Apic. Res."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.actbio.2018.10.028","article-title":"Gallol-derived ECM-mimetic adhesive bioinks exhibiting temporal shear-thinning and stabilization behavior","volume":"95","author":"Shin","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130717","article-title":"Development of lactic acid based chain extender and soybean oil-derived polyurethanes for ecofriendly sustained drug delivery systems","volume":"265","author":"Iqbal","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"14","key":"10.1016\/j.jconrel.2025.02.004_bb0155","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1021\/cm400798p","article-title":"Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal\u2013Organic Frameworks","volume":"25","author":"Cunha","year":"2013","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2022.110148","article-title":"Studies on radiation stability of natural caffeine","volume":"183","author":"Mitra","year":"2022","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijbiomac.2021.01.043","article-title":"Encapsulation of caffeine into starch matrices: bitterness evaluation and suppression mechanism","volume":"173","author":"Shao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"23","key":"10.1016\/j.jconrel.2025.02.004_bb0170","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.1021\/acs.chemmater.9b02802","article-title":"In situ self-Cross-linkable, long-term stable hyaluronic acid filler by Gallol autoxidation for tissue augmentation and wrinkle correction","volume":"31","author":"Lee","year":"2019","journal-title":"Chem. Mater."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106325","article-title":"Validation of a compartmental model to predict drug release from porous structures produced by ScCO2 techniques","volume":"180","author":"Gonz\u00e1lez-Garcinu\u00f1o","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/gels9010024","article-title":"Self-healing alginate hydrogel formed by dynamic Benzoxaborolate chemistry protects retinal pigment epithelium cells against oxidative damage","volume":"9","author":"Liu","year":"2023","journal-title":"Gels"},{"issue":"737","key":"10.1016\/j.jconrel.2025.02.004_bb0190","doi-asserted-by":"crossref","first-page":"eadk3868","DOI":"10.1126\/scitranslmed.adk3868","article-title":"Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice","volume":"16","author":"Yang","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0195","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1038\/s41467-023-38563-w","article-title":"Antibody blockade of Jagged1 attenuates choroidal neovascularization","volume":"14","author":"Gj\u00f8lberg","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0200","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jconrel.2022.05.009","article-title":"Penetrating-peptide-mediated non-invasive Axitinib delivery for anti-neovascularisation","volume":"347","author":"Huang","year":"2022","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.02.004_bb0205","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12951-021-00939-9","article-title":"RGD-modified multifunctional nanoparticles encapsulating salvianolic acid a for targeted treatment of choroidal neovascularization","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.02.004_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269937","article-title":"Suppression of choroidal neovascularization and epithelial-mesenchymal transition in retinal pigmented epithelium by adeno-associated virus-mediated overexpression of CCN5 in mice","volume":"17","author":"Im","year":"2022","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jconrel.2025.02.004_bb0215","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.3390\/ijms24119172","article-title":"Characterization of macroglia response during tissue repair in a laser-induced model of retinal degeneration","volume":"24","author":"Jahnke","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.jconrel.2025.02.004_bb0220","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2121875119","article-title":"Compartmentalized citrullination in Muller glial endfeet during retinal degeneration","volume":"119","author":"Palko","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2025.02.004_bb0225","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.65.2.42","article-title":"M\u00fcller glial cells in the macula: their activation and cell-cell interactions in age-related macular degeneration","volume":"65","author":"Navneet","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122403","article-title":"A novel capsid-XL32-derived adeno-associated virus serotype prompts retinal tropism and ameliorates choroidal neovascularization","volume":"304","author":"Luo","year":"2024","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jconrel.2025.02.004_bb0235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.immuni.2020.07.021","article-title":"The 10q26 risk haplotype of age-related macular degeneration aggravates subretinal inflammation by impairing monocyte elimination","volume":"53","author":"Beguier","year":"2020","journal-title":"Immunity"},{"issue":"15","key":"10.1016\/j.jconrel.2025.02.004_bb0240","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.7150\/ijbs.49890","article-title":"The role of inflammation in age-related macular degeneration","volume":"16","author":"Tan","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107513","article-title":"Keep an eye on adenosine: its role in retinal inflammation","volume":"210","author":"Santiago","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2025.02.004_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04107","article-title":"Aging - oxidative stress, antioxidants and computational modeling","volume":"6","author":"Warraich","year":"2020","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.jconrel.2025.02.004_bb0255","doi-asserted-by":"crossref","first-page":"2204994","DOI":"10.1002\/adma.202204994","article-title":"Injectable anti-inflammatory supramolecular nanofiber hydrogel to promote anti-VEGF therapy in age-related macular degeneration treatment","volume":"35","author":"Gao","year":"2023","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2025.02.004_bb0260","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.1221729110","article-title":"JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration","volume":"110","author":"Du","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2025.02.004_bb0265","article-title":"An injectable thermosensitive hydrogel encapsulating tetramethylpyrazine nanocrystals alleviates angiogenesis and apoptosis in a choroidal neovascularization mouse model","volume":"33","author":"Chen","year":"2023","journal-title":"Appl. Mater. Today"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925001099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925001099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:52:30Z","timestamp":1770141150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":53,"alternative-id":["S0168365925001099"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.02.004","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrophobic vehicles for hydrophilic drugs: Sustained intravitreal caffeine delivery with oleogels","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}