{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:10:29Z","timestamp":1778631029310,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005063","name":"Anhui Province Excellent Young Talents Fund Program of Higher Education Institutions","doi-asserted-by":"publisher","award":["2023AH030065"],"award-info":[{"award-number":["2023AH030065"]}],"id":[{"id":"10.13039\/501100005063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015801","name":"Anhui Provincial Quality Engineering Project","doi-asserted-by":"publisher","award":["2022xscx100"],"award-info":[{"award-number":["2022xscx100"]}],"id":[{"id":"10.13039\/100015801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["2022AH040077"],"award-info":[{"award-number":["2022AH040077"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["gxbjZD2021056"],"award-info":[{"award-number":["gxbjZD2021056"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203154"],"award-info":[{"award-number":["52203154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021ZC06"],"award-info":[{"award-number":["2021ZC06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009004","name":"Anhui University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jconrel.2025.02.040","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T18:13:59Z","timestamp":1740420839000},"page":"1080-1094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transforming tumors into \u2018high-risk bombs\u2019 triggers a neoantigen storm and amplifies immune responses"],"prefix":"10.1016","volume":"380","author":[{"given":"Yunlong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengke","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.02.040_bb0005","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/cancers12030738","article-title":"Review of indications of FDA-approved immune checkpoint inhibitors per NCCN guidelines with the level of evidence","volume":"12","author":"Vaddepally","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0010","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for recurrent squamous-cell carcinoma of the head and neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-021-03704-y","article-title":"Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma","volume":"596","author":"Oliveira","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.trecan.2023.02.004","article-title":"Neoantigen-directed therapeutics in the clinic: where are we?","volume":"9","author":"Lybaert","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-019-0224-6","article-title":"TIM3 comes of age as an inhibitory receptor","volume":"20","author":"Wolf","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0030","doi-asserted-by":"crossref","first-page":"eadg6752","DOI":"10.1126\/scitranslmed.adg6752","article-title":"Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models","volume":"15","author":"Ma","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41586-018-0792-9","article-title":"Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial","volume":"565","author":"Keskin","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0040","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41586-018-0810-y","article-title":"Actively personalized vaccination trial for newly diagnosed glioblastoma","volume":"565","author":"Hilf","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41577-023-00937-y","article-title":"Challenges in developing personalized neoantigen cancer vaccines","volume":"24","author":"Katsikis","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0050","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004389","article-title":"Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models","volume":"10","author":"Chen","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0055","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cell.2020.09.015","article-title":"Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction","volume":"183","author":"Wells","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0060","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrc.2016.154","article-title":"Targeting neoantigens to augment antitumour immunity","volume":"17","author":"Yarchoan","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0065","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.aaa3828","article-title":"Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells","volume":"348","author":"Carreno","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0070","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/onc.2015.270","article-title":"Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells","volume":"35","author":"Calabretta","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0075","doi-asserted-by":"crossref","first-page":"eade2886","DOI":"10.1126\/scitranslmed.ade2886","article-title":"Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy","volume":"16","author":"Li","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0080","doi-asserted-by":"crossref","first-page":"eade2774","DOI":"10.1126\/scitranslmed.ade2774","article-title":"Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML","volume":"16","author":"Wheeler","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0085","doi-asserted-by":"crossref","first-page":"eabn6056","DOI":"10.1126\/scitranslmed.abn6056","article-title":"Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer","volume":"14","author":"Matsushima","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0090","doi-asserted-by":"crossref","first-page":"14184","DOI":"10.1038\/s41598-019-50738-4","article-title":"RNA transcription and splicing errors as a source of cancer frameshift neoantigens for vaccines","volume":"9","author":"Shen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0095","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1158\/2159-8290.CD-20-0555","article-title":"Splicing patterns in SF3B1-mutated uveal melanoma generate shared immunogenic tumor-specific neoepitopes","volume":"11","author":"Bigot","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0100","doi-asserted-by":"crossref","first-page":"eaau5516","DOI":"10.1126\/scitranslmed.aau5516","article-title":"Noncoding regions are the main source of targetable tumor-specific antigens","volume":"10","author":"Laumont","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-022-01270-x","article-title":"Neoantigens: promising targets for cancer therapy","volume":"8","author":"Xie","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0110","doi-asserted-by":"crossref","first-page":"eaal3755","DOI":"10.1126\/science.aal3755","article-title":"Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15","volume":"356","author":"Han","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0115","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1016\/j.cell.2021.05.038","article-title":"Pharmacologic modulation of RNA splicing enhances anti-tumor immunity","volume":"184","author":"Lu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0120","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1056\/NEJMcibr2110736","article-title":"RNA splicing and immune-checkpoint inhibition","volume":"385","author":"Ding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0125","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","article-title":"Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I","volume":"581","author":"Yamamoto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.30416","article-title":"Autophagy-dependent regulation of MHC-I molecule presentation","volume":"125","author":"Gestal-Mato","year":"2024","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105582","article-title":"Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms","volume":"168","author":"Ferreira","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0140","doi-asserted-by":"crossref","first-page":"djw261","DOI":"10.1093\/jnci\/djw261","article-title":"Role of antigen spread and distinctive characteristics of immunotherapy in cancer treatment","volume":"109","author":"Gulley","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0145","first-page":"7","article-title":"Pathogen-boosted adoptive cell transfer therapy induces endogenous antitumor immunity through antigen spreading, cancer","volume":"8","author":"Xin","year":"2020","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acsami.3c13162","article-title":"Targeting lysosome for enhanced cancer photodynamic\/photothermal therapy in a \u201cone stone two birds\u201d pattern","volume":"16","author":"Sun","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0155","article-title":"Breaking-down tumoral physical barrier by remotely unwrapping metal-polyphenol-packaged hyaluronidase for optimizing photothermal\/photodynamic therapy-induced immune response","volume":"36","author":"Sun","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0160","article-title":"In situ vaccination with mitochondria-targeting immunogenic death inducer elicits CD8+ T cell-dependent antitumor immunity to boost tumor immunotherapy","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0165","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1021\/acsnano.3c06987","article-title":"Engineered bacterial biomimetic vesicles reprogram tumor-associated macrophages and remodel tumor microenvironment to promote innate and adaptive antitumor immune responses","volume":"18","author":"Zheng","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0170","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/CM9.0000000000002181","article-title":"Neoantigens in precision cancer immunotherapy: from identification to clinical applications","volume":"135","author":"Zhang","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jconrel.2025.02.040_bb0175","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature23003","article-title":"Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer","volume":"547","author":"Sahin","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.trecan.2020.04.011","article-title":"RNA Splicing and cancer","volume":"6","author":"Wang","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2025.02.040_bb0185","first-page":"143","article-title":"Bystander T cells in cancer immunology and therapy","volume":"3","author":"Meier","year":"2022","journal-title":"Nat. Can."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925001531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925001531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:21:13Z","timestamp":1778628073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925001531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":37,"alternative-id":["S0168365925001531"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.02.040","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transforming tumors into \u2018high-risk bombs\u2019 triggers a neoantigen storm and amplifies immune responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.02.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}