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Horiz."},{"issue":"49","key":"10.1016\/j.jconrel.2025.02.048_bb0320","article-title":"Transparent, highly stretchable, self-healing, adhesive, freezing-tolerant, and swelling-resistant multifunctional hydrogels for underwater motion detection and information transmission","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.02.048_bb0325","article-title":"Citric acid-modified pH-sensitive bone-targeted delivery of estrogen for the treatment of postmenopausal osteoporosis","volume":"22","author":"Chen","year":"2023","journal-title":"Mater. 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