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Sci."},{"key":"10.1016\/j.jconrel.2025.02.055_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124540","article-title":"Optimization of polyethylene glycol shielding and mannose density on the lipid nanoparticles for efficient delivery to macrophages and spleens","volume":"662","author":"Yeo","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.02.055_bb0400","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jconrel.2021.05.021","article-title":"Impact of lipid nanoparticle size on mRNA vaccine immunogenicity","volume":"335","author":"Hassett","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0405","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jconrel.2024.07.046","article-title":"A perspective on bleb and empty LNP structures","volume":"373","author":"Simonsen","year":"2024","journal-title":"J. Control. 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Release"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0580","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jconrel.2008.09.048","article-title":"Fluorescence correlation spectroscopy to study the degradation of oligonucleotides, both naked and complexed, to cationic carriers","volume":"132","author":"Remaut","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0585","doi-asserted-by":"crossref","first-page":"23422","DOI":"10.1021\/acsami.5b08805","article-title":"Disregarded effect of biological fluids in siRNA delivery: human ascites fluid severely restricts cellular uptake of nanoparticles","volume":"7","author":"Dakwar","year":"2015","journal-title":"ACS Appl. Mater. 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A"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0635","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1021\/acs.molpharmaceut.8b01033","article-title":"Measuring particle size distribution by asymmetric flow field flow fractionation: a powerful method for the preclinical characterization of lipid-based nanoparticles","volume":"16","author":"Caputo","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.02.055_bb0640","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejpb.2021.03.004","article-title":"Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery","volume":"163","author":"Mildner","year":"2021","journal-title":"Eur. J. Pharm. 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Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0685","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202103025","article-title":"Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery","volume":"17","author":"van der Meel","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0690","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41551-019-0378-3","article-title":"Visualization of early events in mRNA vaccine delivery in non-human primates via PET\u2013CT and near-infrared imaging","volume":"3","author":"Lindsay","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0695","series-title":"Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates","author":"Buckley","year":"2025"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0700","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.fmre.2022.09.011","article-title":"Characterization of lipid-based nanomedicines at the single-particle level","volume":"3","author":"Chen","year":"2023","journal-title":"Fundamental Research"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0705","first-page":"E3351","article-title":"Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles","volume":"115","author":"Arteta","year":"2018","journal-title":"Proc. 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USA"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0725","author":"Almgren"},{"key":"10.1016\/j.jconrel.2025.02.055_bb0730","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nmeth.1353","article-title":"Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)","volume":"6","author":"Hura","year":"2009","journal-title":"Nat. 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