{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:38:29Z","timestamp":1785818309785,"version":"3.56.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX114-11323EI"],"award-info":[{"award-number":["NHRI-EX114-11323EI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX113-11323EI"],"award-info":[{"award-number":["NHRI-EX113-11323EI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010613","name":"Taipei Medical University Hospital","doi-asserted-by":"publisher","award":["112TMU-TMUH-06"],"award-info":[{"award-number":["112TMU-TMUH-06"]}],"id":[{"id":"10.13039\/501100010613","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\\u20132314-B-038-127-F"],"award-info":[{"award-number":["112\\u20132314-B-038-127-F"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2314-B-038-106-MY3"],"award-info":[{"award-number":["113-2314-B-038-106-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-038-090-"],"award-info":[{"award-number":["112-2314-B-038-090-"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2622-E-038-003"],"award-info":[{"award-number":["113-2622-E-038-003"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-038-127 -"],"award-info":[{"award-number":["112-2314-B-038-127 -"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111-2320-B-038-039 -"],"award-info":[{"award-number":["111-2320-B-038-039 -"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\\u20132221-E-038-002-MY3"],"award-info":[{"award-number":["112\\u20132221-E-038-002-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\\u20132923-E-038-001"],"award-info":[{"award-number":["112\\u20132923-E-038-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\\u20132622-E-038-006"],"award-info":[{"award-number":["112\\u20132622-E-038-006"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jconrel.2025.113596","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T11:16:22Z","timestamp":1741000582000},"page":"113596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Intranasal delivery of epigallocatechin gallate-laden platelet extracellular vesicles for mitigating retinal glaucoma"],"prefix":"10.1016","volume":"381","author":[{"given":"Wen-Yu","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Wei","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hung","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ru","family":"Jheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh-Ngoc-Truc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Li","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekshmi","family":"Rethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu Trung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Jen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.-Y.","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113596_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.121997","article-title":"A novel biosensing platform for detection of glaucoma biomarker GDF15 via an integrated BLI-ELASA strategy","volume":"294","author":"Gao","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121074","article-title":"Endogenous dual stimuli-activated NO generation in the conventional outflow pathway for precision glaucoma therapy","volume":"277","author":"Fan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0015","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017236","article-title":"Clinical characteristics and current treatment of Glaucoma","volume":"4","author":"Cohen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jconrel.2025.113596_bb0020","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of Glaucoma","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2025.113596_bb0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.survophthal.2019.12.003","article-title":"Current management of uveitis-associated ocular hypertension and glaucoma","volume":"65","author":"Kesav","year":"2020","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0030","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3892\/etm.2021.10669","article-title":"Neuroprotective role of epigallocatechin-3-gallate in acute glaucoma via the nuclear factor-\u03baB signalling pathway","volume":"22","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jconrel.2025.113596_bb0035","first-page":"79","article-title":"Reduction of intraocular pressure and Glaucoma progression: early manifest Glaucoma trial (EMGT)early manifest Glaucoma trial (EMGT)","author":"Penman","year":"2020","journal-title":"in"},{"key":"10.1016\/j.jconrel.2025.113596_bb0040","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.2147\/IJN.S173198","article-title":"Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief","volume":"13","author":"Huang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113596_bb0045","first-page":"726","article-title":"The biology of the platelet with special reference to inflammation, wound healing and immunity","volume":"23","author":"Nurden","year":"2018","journal-title":"FBL"},{"key":"10.1016\/j.jconrel.2025.113596_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121311","article-title":"Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis","volume":"280","author":"Gouel","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120163","article-title":"Intelligent micro\u2212\/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: promising development opportunities and translational challenges","volume":"260","author":"Agrahari","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73005-3","article-title":"Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function","volume":"10","author":"Ferreira","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1026386","article-title":"Platelets and platelet extracellular vesicles in drug delivery therapy: a review of the current status and future prospects","volume":"13","author":"Dai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-023-00972-w","article-title":"Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery","volume":"30","author":"Burnouf","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0075","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tibtech.2020.10.004","article-title":"Prospective therapeutic applications of platelet extracellular vesicles","volume":"39","author":"Johnson","year":"2021","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0080","doi-asserted-by":"crossref","DOI":"10.1080\/09537104.2023.2237134","article-title":"Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization","volume":"34","author":"Wu","year":"2023","journal-title":"Platelets"},{"key":"10.1016\/j.jconrel.2025.113596_bb0085","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.7150\/thno.37097","article-title":"Extracellular vesicle-based drug delivery systems for cancer treatment","volume":"9","author":"Walker","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113596_bb0090","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tibtech.2018.11.012","article-title":"Extracellular microvesicles as new industrial therapeutic Frontiers","volume":"37","author":"Agrahari","year":"2019","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0095","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/09537104.2022.2105829","article-title":"In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration","volume":"33","author":"Widyaningrum","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jconrel.2025.113596_bb0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/MAJ.0000000000000319","article-title":"What do patients with glaucoma see? Visual symptoms reported by patients with glaucoma","volume":"348","author":"Hu","year":"2014","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jconrel.2025.113596_bb0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000455276","article-title":"Drug delivery to the posterior segment of the eye","volume":"58","author":"Moisseiev","year":"2017","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biomaterials.2017.07.018","article-title":"Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease","volume":"142","author":"Chou","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0115","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1093\/brain\/awab205","article-title":"Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment","volume":"144","author":"Nebie","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2025.113596_bb0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00018-022-04397-w","article-title":"Can the administration of platelet lysates to the brain help treat neurological disorders?","volume":"79","author":"Nebie","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0130","doi-asserted-by":"crossref","DOI":"10.1063\/5.0196553","article-title":"Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration","volume":"8","author":"Le","year":"2024","journal-title":"APL Bioeng."},{"key":"10.1016\/j.jconrel.2025.113596_bb0135","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/10717544.2018.1556361","article-title":"Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye","volume":"26","author":"Tao","year":"2019","journal-title":"Drug Deliv."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113596_bb0140","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1177\/08971900221108725","article-title":"Intranasal varenicline: Review of a novel formulation for the treatment of dry eye disease","volume":"36","author":"Zitko","year":"2023","journal-title":"Journal of Pharmacy Practice"},{"key":"10.1016\/j.jconrel.2025.113596_bb0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1039\/D3NH00306J","article-title":"Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases","volume":"9","author":"Khalil","year":"2023","journal-title":"Nanoscale Horizons"},{"key":"10.1016\/j.jconrel.2025.113596_bb0150","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3892\/etm.2021.10669","article-title":"Neuroprotective role of epigallocatechin-3-gallate in acute glaucoma via the nuclear factor-\u03baB signalling pathway","volume":"22","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jconrel.2025.113596_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100849","article-title":"Extracellular vesicle therapy for retinal diseases","volume":"79","author":"Mead","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113596_bb0160","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/jth.14525","article-title":"Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts","volume":"17","author":"Houck","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jconrel.2025.113596_bb0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12929-024-01072-z","article-title":"Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson\u2019s disease models","volume":"31","author":"Delila","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0170","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/09537104.2022.2105829","article-title":"In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration","volume":"33","author":"Widyaningrum","year":"2022","journal-title":"Platelets"},{"key":"10.1016\/j.jconrel.2025.113596_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15717-7","article-title":"Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies","volume":"7","author":"Benedikter","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0180","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1016\/j.bmc.2008.10.009","article-title":"Time-dependent intracellular trafficking of FITC-conjugated epigallocatechin-3-O-gallate in L-929 cells","volume":"16","author":"Han","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jconrel.2025.113596_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.305","article-title":"Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans","volume":"5","author":"Law","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.jconrel.2025.113596_bb0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1085\/jgp.201110596","article-title":"Lysosomal pH and analysis of the counter ion pathways that support acidification","volume":"137","author":"DiCiccio","year":"2011","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12929-018-0494-5","article-title":"Imaging extracellular vesicles: current and emerging methods","volume":"25","author":"Chuo","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0200","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s00347-009-1971-8","article-title":"Messung des Augeninnendrucks (Tonometrie) mit unterschiedlichen Verfahren","volume":"106","author":"Lamparter","year":"2009","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.jconrel.2025.113596_bb0205","unstructured":"J.S. Steger, I. Durai, A. Odayappan, R. Raman, T. Sruthi, A.J. Song, G. Puthuran, R. Venkatesh, E. Colantuoni, A.L. Robin, An Evaluation of the Efficacy and Safety of Timolol Maleate 0.5% Microdrops Administered with the Nanodropper, Ophthalmology n.d."},{"key":"10.1016\/j.jconrel.2025.113596_bb0210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12951-018-0388-4","article-title":"Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display","volume":"16","author":"Antes","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0215","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1002\/anie.201913436","article-title":"Drug screening in human cells by NMR spectroscopy allows the early assessment of drug potency","volume":"59","author":"Luchinat","year":"2020","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2025.113596_bb0220","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jmr.2019.07.018","article-title":"Cells, drugs and NMR","volume":"306","author":"Siegal","year":"2019","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jconrel.2025.113596_bb0225","first-page":"29","article-title":"Analysis of mixed lipid extracts using 1H NMR spectra, computer applications in the biosciences","volume":"6","author":"Sparling","year":"1990","journal-title":"CABIOS"},{"key":"10.1016\/j.jconrel.2025.113596_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135364","article-title":"Stability of glycosylated complexes loaded with epigallocatechin 3-gallate (EGCG)","volume":"410","author":"Zhang","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.jconrel.2025.113596_bib471","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12665-019-8127-1","article-title":"Evaluation of epigallocatechin gallate (EGCG) to remove Pb(II) using spectroscopic and quantum chemical calculation method","volume":"78","author":"Wang","year":"2019","journal-title":"Environ. Earth Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bib472","doi-asserted-by":"crossref","first-page":"19868","DOI":"10.1038\/s41598-019-56375-1","article-title":"Detection and phenotyping of extracellular vesicles by size exclusion chromatography coupled with on-line fluorescence detection","volume":"9","author":"Kitka","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bib473","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.3390\/ijms22083839","article-title":"Comparative Analysis of Platelet-Derived Extracellular Vesicles Using Flow Cytometry and Nanoparticle Tracking Analysis","volume":"22","author":"George","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113244","article-title":"Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC-MS: a potential agent for promoting tumor-targeted drug delivery","volume":"185","author":"Wang","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jconrel.2025.113596_bb0255","first-page":"2042","article-title":"pH sensing by lipids in membranes: the fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies","volume":"2018","author":"Angelova","year":"1860","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.jconrel.2025.113596_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19040951","article-title":"The role of auxin in Cell Wall expansion","volume":"19","author":"Majda","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0265","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00396-014-3276-y","article-title":"Application of the zeta potential measurements to explanation of colloidal Cr(2)O(3) stability mechanism in the presence of the ionic polyamino acids","volume":"292","author":"Ostolska","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.jconrel.2025.113596_bb0270","doi-asserted-by":"crossref","first-page":"16701","DOI":"10.1021\/acsomega.0c01582","article-title":"Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability","volume":"5","author":"Midekessa","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.jconrel.2025.113596_bb0275","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1001\/archsurg.1979.01370300061009","article-title":"pH-induced platelet ultrastructural alterations. A possible mechanism for impaired platelet aggregation","volume":"114","author":"Djaldetti","year":"1979","journal-title":"Archiv. Surg. (Chicago, Ill.: 1960)"},{"key":"10.1016\/j.jconrel.2025.113596_bb0280","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/s41598-020-59448-8","article-title":"Power of scanning electron microscopy and energy dispersive X-ray analysis in rapid microbial detection and identification at the single cell level","volume":"10","author":"Khan","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0285","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/2211-5463.13107","article-title":"Environmental pH stress influences cellular secretion and uptake of extracellular vesicles","volume":"11","author":"Nakase","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jconrel.2025.113596_bb0290","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13238-018-0529-4","article-title":"Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes","volume":"10","author":"Cheng","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.jconrel.2025.113596_bb0295","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1021\/acsnano.5b06939","article-title":"Blood exosomes endowed with magnetic and targeting properties for Cancer therapy","volume":"10","author":"Qi","year":"2016","journal-title":"ACS Nano"},{"issue":"2\u20134","key":"10.1016\/j.jconrel.2025.113596_bib474","article-title":"Recent advances in macrophage-derived exosomes as delivery vehicles","volume":"1","author":"Wang","year":"2022","journal-title":"Nano Trans Med"},{"key":"10.1016\/j.jconrel.2025.113596_bb0305","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/life12050697","article-title":"Impact of storage conditions on EV integrity\/surface markers and cargos","volume":"12","author":"Sivanantham","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.jconrel.2025.113596_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122502","article-title":"Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia\/reperfusion injury","volume":"306","author":"Livkisa","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113596_bb0315","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v2i0.21494","article-title":"Cryo-electron microscopy of extracellular vesicles in fresh plasma","volume":"2","author":"Yuana","year":"2013","journal-title":"J. Extracel. Vesicl."},{"key":"10.1016\/j.jconrel.2025.113596_bb0325","series-title":"Encyclopedia of Microbiology (Third Edition)","first-page":"513","article-title":"Lipopolysaccharides (endotoxins)","author":"Tran","year":"2009"},{"key":"10.1016\/j.jconrel.2025.113596_bb0330","article-title":"The role of lipopolysaccharide-induced cell Signalling in chronic inflammation","volume":"6","author":"Page","year":"2022","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.jconrel.2025.113596_bb0335","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jconrel.2025.113596_bb0340","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41598-017-03147-4","article-title":"Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes","volume":"7","author":"Y\u00fccel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0345","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.freeradbiomed.2015.11.011","article-title":"Carboxylesterase converts Amplex red to resorufin: implications for mitochondrial H2O2 release assays","volume":"90","author":"Miwa","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2025.113596_bb0350","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2020.11.064","article-title":"Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy","volume":"329","author":"Ma","year":"2021","journal-title":"J. Control. Release: Off. J. Control. Rel. Soc."},{"key":"10.1016\/j.jconrel.2025.113596_bb0355","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/jf505531w","article-title":"Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced toll-like receptor 4 (TLR4) activity via 67 kDa laminin receptor (67LR) in 3T3-L1 adipocytes","volume":"63","author":"Bao","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jconrel.2025.113596_bib475","doi-asserted-by":"crossref","first-page":"101380","DOI":"10.1016\/j.mtbio.2024.101380","article-title":"An injectable shape-adaptive hydrogel system for subconjunctival injuries: In situ and permanently releases rapamycin to prevent fibrosis via promoting autophagy","volume":"30","author":"Sun","year":"2025","journal-title":"Materials Today Bio."},{"key":"10.1016\/j.jconrel.2025.113596_bb0365","doi-asserted-by":"crossref","DOI":"10.1177\/09636897231177356","article-title":"Dexamethasone induces senescence-associated changes in trabecular meshwork cells by increasing ROS levels via the TGF\u03b2\/Smad3-NOX4 Axis","volume":"32","author":"Li","year":"2023","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2025.113596_bb0370","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2025.113596_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.573955","article-title":"Increased hydrostatic pressure promotes primary M1 reaction and secondary M2 polarization in macrophages","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0380","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/jth.15172","article-title":"Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4","volume":"19","author":"Heffron","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jconrel.2025.113596_bb0385","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25122853","article-title":"Epigallocatechin-3-Gallate (EGCG), an active compound of green tea attenuates acute lung injury regulating macrophage polarization and Kr\u00fcpple-like-factor 4 (KLF4) expression","volume":"25","author":"Almatroodi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2025.113596_bb0390","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1038\/s41598-023-32158-7","article-title":"Label-free macrophage phenotype classification using machine learning methods","volume":"13","author":"Hourani","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0400","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.apsb.2020.12.014","article-title":"Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses","volume":"11","author":"Hu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2025.113596_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104743","article-title":"(\u2212)-Epigallocatechin-3-gallate (EGCG) modulates polarized macrophages to suppress M1 phenotype and promote M2 polarization in vitro and in vivo","volume":"87","author":"Hu","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jconrel.2025.113596_bb0410","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1570159X14666151204122017","article-title":"LPS-induced murine Neuroinflammation model: Main features and suitability for pre-clinical assessment of nutraceuticals","volume":"14","author":"Catorce","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0415","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12951-023-02068-x","article-title":"Enhanced diabetic wound healing using platelet-derived extracellular vesicles and reduced graphene oxide in polymer-coordinated hydrogels","volume":"21","author":"Hao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0420","first-page":"164","article-title":"Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis","volume":"32","author":"Yu","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.113596_bb0425","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s004030050353","article-title":"Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783","volume":"290","author":"Travers","year":"1998","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jconrel.2025.113596_bb0430","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01975","article-title":"Microglia in retinal degeneration","volume":"10","author":"Rashid","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113596_bib476","doi-asserted-by":"crossref","first-page":"673090","DOI":"10.1155\/2015\/673090","article-title":"Contribution of microglia\u2010mediated neuroinflammation to retinal degenerative diseases","volume":"1","author":"Madeira","year":"2015","journal-title":"Mediators of inflammation"},{"key":"10.1016\/j.jconrel.2025.113596_bb0440","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s40135-019-00212-1","article-title":"Immunomodulation as a neuroprotective strategy for Glaucoma treatment","volume":"7","author":"Bari\u015f","year":"2019","journal-title":"Curr. Ophthalmol. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.624983","article-title":"Glial Cells in Glaucoma: friends, foes, and potential therapeutic targets","volume":"12","author":"Garc\u00eda-Berm\u00fadez","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0450","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ijpharm.2018.12.015","article-title":"Gelatinized core liposomes: a new Trojan horse for the development of a novel timolol maleate glaucoma medication","volume":"556","author":"Hathout","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113596_bb0455","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijpharm.2018.04.059","article-title":"Exploring gelatin nanoparticles as novel nanocarriers for Timolol maleate: augmented in-vivo efficacy and safe histological profile","volume":"545","author":"Shokry","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113596_bb0460","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle Glaucoma","volume":"115","author":"Kerrigan","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113596_bb0465","article-title":"Neuroprotective effects of low-dose G-CSF plus meloxicam in a rat model of anterior ischemic optic neuropathy","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113596_bb0470","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.freeradbiomed.2019.02.015","article-title":"An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury","volume":"134","author":"Gupta","year":"2019","journal-title":"Free Radic. Biol. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:43:31Z","timestamp":1778730211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925002056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":92,"alternative-id":["S0168365925002056"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113596","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal delivery of epigallocatechin gallate-laden platelet extracellular vesicles for mitigating retinal glaucoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113596"}}