{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:42:33Z","timestamp":1794008553326,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K08252"],"award-info":[{"award-number":["JP23K08252"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jconrel.2025.113623","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:15:09Z","timestamp":1741608909000},"page":"113623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Effective transcatheter intracoronary delivery of mRNA-lipid nanoparticles targeting the heart"],"prefix":"10.1016","volume":"381","author":[{"given":"Kazuma","family":"Handa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Sasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akima","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Whitehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Komukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anri","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jconrel.2025.113623_bb0005","article-title":"Mortality from ischemic heart disease","volume":"12","author":"Nowbar","year":"2019","journal-title":"Circulation: Cardiovasc. Qual. Outcomes"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113623_bb0010","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"27","key":"10.1016\/j.jconrel.2025.113623_bb0015","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10287","key":"10.1016\/j.jconrel.2025.113623_bb0020","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(21)00947-8","article-title":"Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data","volume":"397","author":"Haas","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113623_bb0025","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/srep18743","article-title":"Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment","volume":"6","author":"Aini","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113623_bb0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.omtn.2019.06.016","article-title":"Enhancement of motor function recovery after spinal cord injury in mice by delivery of brain-derived neurotrophic factor mRNA","volume":"17","author":"Crowley","year":"2019","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.113623_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120681","article-title":"Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle","volume":"270","author":"Fukushima","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113623_bb0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.omtn.2019.02.012","article-title":"Treatment of intervertebral disk disease by the administration of mRNA encoding a cartilage-anabolic transcription factor","volume":"16","author":"Lin","year":"2019","journal-title":"Mol. Ther. - Nucleic Acids"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113623_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054737","article-title":"Modified mRNA as a treatment for myocardial infarction","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113623_bb0055","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.omtm.2018.04.003","article-title":"Biocompatible, purified VEGF-A mRNA improves cardiac function after Intracardiac injection 1 week post-myocardial infarction in swine","volume":"9","author":"Carlsson","year":"2018","journal-title":"Mol. Ther. - Methods Clin. Develop."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0060","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900424","article-title":"aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model","volume":"3","author":"Chen","year":"2019","journal-title":"Life Sci. Alliance"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113623_bb0065","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/mp5006239","article-title":"Synthetic chemically modified mRNA-based delivery of Cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial infarction","volume":"12","author":"Huang","year":"2015","journal-title":"Mol. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113623_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/ten.tea.2017.0494","article-title":"Aligned Nanofibrillar scaffolds for controlled delivery of modified mRNA","volume":"25","author":"Zaitseva","year":"2019","journal-title":"Tissue Eng. Part A"},{"issue":"15","key":"10.1016\/j.jconrel.2025.113623_bb0075","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.119.043067","article-title":"Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration","volume":"141","author":"Magadum","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2025.113623_bb0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.omtn.2018.08.021","article-title":"Ablation of a single N-glycosylation site in human FSTL 1 induces cardiomyocyte proliferation and cardiac regeneration","volume":"13","author":"Magadum","year":"2018","journal-title":"Mol. Ther. - Nucleic Acids"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113623_bb0085","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ymthe.2022.11.017","article-title":"Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting","volume":"31","author":"Anttila","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113623_bb0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2022.01.027","article-title":"Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles","volume":"343","author":"Evers","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113623_bb0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2015.08.007","article-title":"Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes","volume":"217","author":"Pardi","year":"2015","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/mt.2015.193","article-title":"Myocardial delivery of Lipidoid nanoparticle carrying modRNA induces rapid and transient expression","volume":"24","author":"Turnbull","year":"2016","journal-title":"Mol. Ther."},{"issue":"20","key":"10.1016\/j.jconrel.2025.113623_bb0105","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1016\/j.bpj.2022.08.037","article-title":"mRNA lipid nanoparticle phase transition","volume":"121","author":"Trollmann","year":"2022","journal-title":"Biophys. J."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113623_bb0110","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.jconrel.2025.113623_bb0115","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2024.08.016","article-title":"The role of helper lipids in optimising nanoparticle formulations of self-amplifying RNA","volume":"374","author":"Barbieri","year":"2024","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113623_bb0120","first-page":"H959","article-title":"A novel method of standardized myocardial infarction in aged rabbits","volume":"312","author":"Morrissey","year":"2017","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113623_bb0125","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nbt.2682","article-title":"Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction","volume":"31","author":"Zangi","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113623_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10557-012-6437-6","article-title":"Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia\/reperfusion rat model","volume":"27","author":"Takahama","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-019-0451-9","article-title":"Mitochondria-targeted cyclosporin a delivery system to treat myocardial ischemia reperfusion injury of rats","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113623_bb0140","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2967\/jnumed.121.263555","article-title":"Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with MR tissue characterization and subsequent functional outcome","volume":"63","author":"Diekmann","year":"2022","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113623_bb0145","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction\u2014from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12876-022-02507-3","article-title":"New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review","volume":"22","author":"Alhumaid","year":"2022","journal-title":"BMC Gastroenterol."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113623_bb0155","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/ckj\/sfad196","article-title":"mRNA as a medicine in nephrology: the future is now","volume":"16","author":"Granata","year":"2023","journal-title":"Clin. Kidney J."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113623_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11020241","article-title":"Vaccine formulation strategies and challenges involved in RNA delivery for modulating biomarkers of cardiovascular diseases: a race from laboratory to market","volume":"11","author":"Shaharyar","year":"2023","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0165","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113623_bb0170","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1016\/j.ymthe.2021.07.014","article-title":"Direct reprogramming induces vascular regeneration post muscle ischemic injury","volume":"29","author":"Kaur","year":"2021","journal-title":"Mol. Ther."},{"issue":"6576","key":"10.1016\/j.jconrel.2025.113623_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113623_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06936-1","article-title":"Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes","volume":"9","author":"Veiga","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113623_bb0185","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2021.01.018","article-title":"Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction","volume":"331","author":"Kang","year":"2021","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113623_bb0190","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.xphs.2022.12.026","article-title":"Effect of cholesterol content of lipid composition in mRNA-LNPs on the protein expression in the injected site and liver after local Administration in Mice","volume":"112","author":"Kawaguchi","year":"2023","journal-title":"J. Pharm. Sci."},{"issue":"19","key":"10.1016\/j.jconrel.2025.113623_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.07.023","article-title":"Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles","volume":"187","author":"Brown","year":"2024","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113623_bb0200","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307801120","article-title":"Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart","volume":"121","author":"Radmand","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:53:12Z","timestamp":1769219592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925002408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":40,"alternative-id":["S0168365925002408"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113623","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective transcatheter intracoronary delivery of mRNA-lipid nanoparticles targeting the heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113623"}}