{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:09:45Z","timestamp":1793718585775,"version":"4.6.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S32321N"],"award-info":[{"award-number":["1S32321N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G042219N"],"award-info":[{"award-number":["G042219N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G088519N"],"award-info":[{"award-number":["G088519N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jconrel.2025.113626","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T12:12:58Z","timestamp":1741781578000},"page":"113626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy"],"prefix":"10.1016","volume":"381","author":[{"given":"Jeroen","family":"Spanoghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Wynendaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Vergaelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"De Colvenaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Mariman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristl","family":"Vonck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Carrette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wytse","family":"Wadman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erine","family":"Craey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Sprengers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Missinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Van Calenbergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Spiegeleer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"De Bundel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Smolders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robrecht","family":"Raedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neurol.2015.11.003","article-title":"Epidemiology of epilepsy","volume":"172","author":"Behr","year":"2016","journal-title":"Rev. Neurol. (Paris)"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0010","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy","volume":"88","author":"Fiest","year":"2017","journal-title":"Neurology"},{"issue":"17","key":"10.1016\/j.jconrel.2025.113626_bb0015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0000000000011839","article-title":"Incidence and prevalence of drug-resistant epilepsy","volume":"96","author":"Sultana","year":"2021","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0020","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0022-3565(25)21078-3","article-title":"Adenosine A1 receptor activation mediates suppression of (\u2212) bicuculline methiodide-induced seizures in rat prepiriform cortex","volume":"251","author":"Franklin","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0014-2999(93)90521-I","article-title":"Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on induced seizures in mice","volume":"249","author":"Von Lubitz","year":"1993","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0014-2999(97)00139-8","article-title":"The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures","volume":"326","author":"Abdul-Ghani","year":"1997","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0035","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.expneurol.2006.02.133","article-title":"Adenosine A1 receptors are crucial in keeping an epileptic focus localized","volume":"200","author":"Fedele","year":"2006","journal-title":"Exp. Neurol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113626_bb0040","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1528-1167.2010.02700.x","article-title":"Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures","volume":"51","author":"Van Dycke","year":"2010","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.jconrel.2025.113626_bb0045","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/S0028-3908(00)00072-1","article-title":"Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures","volume":"39","author":"Khan","year":"2000","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113626_bb0050","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0028-3908(00)00203-3","article-title":"2-Chloro-N6-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats","volume":"40","author":"Khan","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jconrel.2025.113626_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108213","article-title":"The adenosine A1 receptor agonist WAG 994 suppresses acute kainic acid-induced status epilepticus in vivo","volume":"176","author":"Klaft","year":"2020","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.jconrel.2025.113626_bb0060","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1161\/01.RES.47.4.568","article-title":"Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure","volume":"47","author":"Winn","year":"1980","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00580977","article-title":"Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure","volume":"387","author":"Schrader","year":"1980","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113626_bb0070","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ana.410320504","article-title":"Adenosine: a potential mediator of seizure arrest and postictal refractoriness","volume":"32","author":"During","year":"1992","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0075","first-page":"1","article-title":"The signaling pathways involved in the anticonvulsive effects of the adenosine a1 receptor","volume":"22","author":"Spanoghe","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113626_bb0080","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1098-2396(199712)27:4<322::AID-SYN6>3.0.CO;2-E","article-title":"Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study","volume":"27","author":"Svenningsson","year":"1997","journal-title":"Synapse"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0085","first-page":"17","article-title":"Drug-resistant epilepsy and surgery","volume":"16","author":"Sheng","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113626_bb0090","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1046\/j.1528-1157.2003.03603.x","article-title":"Seizure suppression by adenosine A1 receptor activation in a mouse model of Pharmacoresistant epilepsy","volume":"44","author":"Gouder","year":"2003","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113626_bb0095","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/epi.13360","article-title":"Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices","volume":"57","author":"Klaft","year":"2016","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1006\/exnr.1999.7209","article-title":"Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer","volume":"160","author":"Boison","year":"1999","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.expneurol.2009.05.018","article-title":"Antiepileptic effects of silk-polymer based adenosine release in kindled rats","volume":"219","author":"Szybala","year":"2009","journal-title":"Exp. Neurol."},{"issue":"13","key":"10.1016\/j.jconrel.2025.113626_bb0110","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1073\/pnas.131102898","article-title":"Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy","volume":"98","author":"Huber","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.jconrel.2025.113626_bb0115","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1528-1167.2005.61804.x","article-title":"Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants","volume":"46","author":"G\u00fcttinger","year":"2005","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113626_bb0120","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/brain\/awm057","article-title":"Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants","volume":"130","author":"Li","year":"2007","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.jconrel.2025.113626_bb0125","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tibs.2018.05.004","article-title":"Reversible, spatial and temporal control over protein activity using light","volume":"43","author":"Hoorens","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jconrel.2025.113626_bb0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2019.03.003","article-title":"GPCR photopharmacology","volume":"488","author":"Ricart-Ortega","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113626_bb0135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11055-019-00713-3","article-title":"Photopharmacology: a brief review using the control of potassium channels as an example","volume":"49","author":"Bregestovski","year":"2019","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.jconrel.2025.113626_bb0140","first-page":"6","article-title":"Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator","author":"Font","year":"2017","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113626_bb0145","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/bph.15645","article-title":"Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects","volume":"180","author":"L\u00f3pez-Cano","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"24","key":"10.1016\/j.jconrel.2025.113626_bb0150","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1016\/j.neuron.2023.09.017","article-title":"In vivo photopharmacology with light-activated opioid drugs","volume":"111","author":"McClain","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.jconrel.2025.113626_bb0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2018.05.033","article-title":"Remote control of movement disorders using a photoactive adenosine a 2A receptor antagonist","volume":"283","author":"Taura","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113626_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105731","article-title":"Optical control of adenosine A3 receptor function in psoriasis","volume":"170","author":"L\u00f3pez-Cano","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0165","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ana.22596","article-title":"Optical control of focal epilepsy in vivo with caged \u03b3-aminobutyric acid","volume":"71","author":"Yang","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jconrel.2025.113626_bb0170","first-page":"8(MAY)","article-title":"Photolysis of caged-GABA rapidly terminates seizures in vivo: concentration and light intensity dependence","author":"Wang","year":"2017","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/cr300177k","article-title":"Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy","volume":"113","author":"Kl\u00e1n","year":"2013","journal-title":"Chem. Rev."},{"issue":"16","key":"10.1016\/j.jconrel.2025.113626_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23168887","article-title":"Ex vivo feedback control of neurotransmission using a Photocaged adenosine A1 receptor agonist","volume":"23","author":"Craey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113626_bb0185","article-title":"Feedback control of neuronal excitability and epileptiform bursting using a Photocaged adenosine A1 agonist","author":"Craey","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-4886(82)90013-9","article-title":"Evoked potentials and long-term potentiation in the mouse dentate gyrus after stimulation of the entorhinal cortex","volume":"75","author":"Payne","year":"1982","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0195","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0306-4522(98)00401-1","article-title":"Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy","volume":"89","author":"Bouilleret","year":"1999","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0200","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0306-4522(02)00064-7","article-title":"Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy","volume":"112","author":"Riban","year":"2002","journal-title":"Neuroscience"},{"issue":"25","key":"10.1016\/j.jconrel.2025.113626_bb0205","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1016\/0024-3205(81)90636-6","article-title":"Behavioral characterization of two long-lasting adenosine analogs: sedative properties and interaction with diazepam","volume":"29","author":"Crawley","year":"1981","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0210","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0022-3565(25)32898-3","article-title":"Sedative and anticonvulsant effects of adenosine analogs in mouse and rat","volume":"220","author":"Dunwiddie","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113626_bb0215","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1476-5381.1994.tb17151.x","article-title":"Characterization of the adenosine receptors mediating hypothermia in the conscious mouse","volume":"113","author":"Anderson","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113626_bb0220","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","article-title":"The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod","volume":"20","author":"Jones","year":"1968","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0225","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nlm.2010.04.008","article-title":"Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning","volume":"94","author":"Bureau","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113626_bb0230","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1109\/JPROC.2009.2026921","article-title":"Impact of mouse model on preclinical dosimetry in targeted radionuclide therapy","volume":"97","author":"Boutaleb","year":"2009","journal-title":"Proc. IEEE"},{"key":"10.1016\/j.jconrel.2025.113626_bb0235","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-3106-4_5","article-title":"Outlier detection for mass spectrometric data","volume":"1362","author":"Cho","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0240","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/jn.1999.81.1.247","article-title":"A1 adenosine receptors modulate respiratory activity of the neonatal mouse via the cAMP-mediated signaling pathway","volume":"81","author":"Mironov","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jconrel.2025.113626_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/cptc.202100134","article-title":"The issue of tissue: approaches and challenges to the light control of drug activity","author":"Sharma","year":"2021","journal-title":"ChemPhotoChem"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113626_bb0250","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/epi.17625","article-title":"Intracerebroventricular administration for delivery of antiseizure therapeutics: challenges and opportunities","volume":"64","author":"Fahoum","year":"2023","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.jconrel.2025.113626_bb0255","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1046\/j.1460-9568.2003.02815.x","article-title":"Decrease of adenosine A1 receptor density and of adenosine neuromodulation the hippocampus of kindled rats","volume":"18","author":"Rebola","year":"2003","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.jconrel.2025.113626_bb0260","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/sj.bjp.0703736","article-title":"Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats","volume":"131","author":"Sebasti\u00e3o","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.113626_bb0265","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/sj.bjp.0701291","article-title":"Influence of metabotropic glutamate receptor agonists on the inhibitory effects of adenosine A1 receptor activation in the rat hippocampus","volume":"121","author":"De Mendon\u00e7a","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.113626_bb0270","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.phrs.2015.11.023","article-title":"Implication of coumarins towards central nervous system disorders","volume":"103","author":"Skalicka-Wo\u017aniak","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113626_bb0275","doi-asserted-by":"crossref","first-page":"126","DOI":"10.21307\/ane-2019-011","article-title":"Coumarins as potential supportive medication for the treatment of epilepsy","volume":"79","author":"Bryda","year":"2019","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"issue":"21","key":"10.1016\/j.jconrel.2025.113626_bb0280","doi-asserted-by":"crossref","first-page":"11420","DOI":"10.3390\/ijms222111420","article-title":"Comparative antiseizure analysis of diverse natural coumarin derivatives in zebrafish","volume":"22","author":"Kozio\u0142","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113626_bb0285","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1528-1157.1987.tb03697.x","article-title":"Differential effects of adenosine analogs on amygdala, Hippocampus, and caudate nucleus kindled seizures","volume":"28","author":"Rosen","year":"1987","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(25)10160-2","article-title":"Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility","volume":"264","author":"Zhang","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.jconrel.2025.113626_bb0295","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1364\/BOE.7.004450","article-title":"Characterization of fiber-optic light delivery and light-induced temperature changes in a rodent brain for precise optogenetic neuromodulation","volume":"7","author":"Shin","year":"2016","journal-title":"Biomed. Opt. Express"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0300","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1523\/ENEURO.0059-15.2015","article-title":"Realistic numerical and analytical modeling of light scattering in brain tissue for optogenetic applications","volume":"3","author":"Yona","year":"2016","journal-title":"eNeuro"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113626_bb0305","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.neuron.2013.03.007","article-title":"The Theta-gamma neural code","volume":"77","author":"Lisman","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0310","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0167-8760(00)00172-0","article-title":"Different frequencies for different scales of cortical integration: from local gamma to long range alpha\/theta synchronization","volume":"38","author":"von Stein","year":"2000","journal-title":"Int. J. Psychophysiol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0315","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-4347(93)80058-C","article-title":"High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats","volume":"620","author":"Math\u00f4t","year":"1993","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113626_bb0320","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0022-3565(24)37077-6","article-title":"8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo","volume":"283","author":"Van Schaick","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113626_bb0325","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.seizure.2011.03.003","article-title":"Local delivery strategies in epilepsy; A focus on adenosine","volume":"20","author":"Van Dycke","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.jconrel.2025.113626_bb0330","series-title":"Closed-Loop Neuromodulation in Physiological and Translational Research","volume":"vol. 9(11)","author":"Zanos","year":"2019"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113626_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-35540-7","article-title":"Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially","volume":"13","author":"Kang","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113626_bb0340","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14656","article-title":"Effect of the closed-loop hippocampal low-frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model","volume":"30","author":"Zare","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"16","key":"10.1016\/j.jconrel.2025.113626_bb0345","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.3390\/ijms23168887","article-title":"Ex vivo feedback control of neurotransmission using a Photocaged adenosine A1 receptor agonist","volume":"23","author":"Craey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113626_bb0350","doi-asserted-by":"crossref","first-page":"2105989","DOI":"10.1002\/adfm.202105989","article-title":"Lighting the path: light delivery strategies to activate Photoresponsive biomaterials in vivo","author":"Pearson","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.jconrel.2025.113626_bb0355","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3390\/ma11081283","article-title":"Biocompatible and implantable optical fibers and waveguides for biomedicine","volume":"11","author":"Nazempour","year":"2018","journal-title":"Materials (Basel)."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:58:52Z","timestamp":1769219932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925002457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":71,"alternative-id":["S0168365925002457"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113626","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113626"}}