{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:42:08Z","timestamp":1793716928285,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004452","name":"International Research and Exchanges Board","doi-asserted-by":"publisher","award":["YJ20220429"],"award-info":[{"award-number":["YJ20220429"]}],"id":[{"id":"10.13039\/100004452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jconrel.2025.113664","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T12:14:00Z","timestamp":1742991240000},"page":"113664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"special_numbering":"C","title":["Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering"],"prefix":"10.1016","volume":"382","author":[{"given":"Jieru","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0005","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/annrheumdis-2018-214065","article-title":"Prevalence and incidence of psoriasis and psoriatic arthritis","volume":"78","author":"Sewerin","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113664_bb0010","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jaad.2020.02.044","article-title":"Joint American Academy of Dermatology\u2013National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies","volume":"82","author":"Menter","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113664_bb0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/cmi.2012.15","article-title":"New insights of T cells in the pathogenesis of psoriasis","volume":"9","author":"Cai","year":"2012","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113664_bb0020","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/1346-8138.14139","article-title":"Pathogenesis of psoriasis and development of treatment","volume":"45","author":"Ogawa","year":"2018","journal-title":"J. Dermatol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113664_bb0025","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/jid.2009.399","article-title":"Circulating Th17, Th22, and Th1 cells are increased in psoriasis","volume":"130","author":"Kagami","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113664_bb0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/annrheumdis-2017-212127","article-title":"Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation","volume":"77","author":"Glatt","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113664_bb0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/dth.12251","article-title":"New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors","volume":"28","author":"Gaspari","year":"2015","journal-title":"Dermatol. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jaad.2016.08.012","article-title":"Tumor necrosis factor-\u03b1 inhibitor-induced psoriasis: systematic review of clinical features, histopathological findings, and management experience","volume":"76","author":"Brown","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113664_bb0050","doi-asserted-by":"crossref","first-page":"19468","DOI":"10.1021\/acsnano.1c06225","article-title":"A facile low-dose photosensitizer-incorporated dissolving microneedles-based composite system for eliciting antitumor immunity and the abscopal effect","volume":"15","author":"Bian","year":"2021","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113664_bb0055","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1158\/0008-5472.CAN-11-2544","article-title":"Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity","volume":"72","author":"Pietra","year":"2012","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113664_bb0060","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1021\/acs.nanolett.0c00929","article-title":"Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury","volume":"20","author":"Li","year":"2020","journal-title":"Nano Lett."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0065","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1158\/2326-6066.CIR-19-0522","article-title":"MicroRNAs in tumor exosomes drive immune escape in melanoma","volume":"8","author":"Vignard","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.jconrel.2025.113664_bb0070","first-page":"1","article-title":"Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle","author":"Villa","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113664_bb0075","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1002\/eji.200838535","article-title":"Induction, function and regulation of IL-17-producing T cells","volume":"38","author":"Mills","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.113664_bb0080","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fasebj.5.8.1850705","article-title":"Matrix metalloproteinases and their inhibitors in connective tissue remodeling","volume":"5","author":"Woessner","year":"1991","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/07388551.2011.594423","article-title":"Antimicrobial peptides: key components of the innate immune system","volume":"32","author":"Pasupuleti","year":"2012","journal-title":"Crit. Rev. Biotechnol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113664_bb0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.jbchem.a003101","article-title":"Phospholipase A2","volume":"131","author":"Murakami","year":"2002","journal-title":"J. Biochem."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113664_bb0095","first-page":"1092","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways","volume":"159","author":"Nograles","year":"2008","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113664_bb0100","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"Vlassov","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA)-General Subj"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113664_bb0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/boc.201400081","article-title":"Immunomodulatory role of microRNAs transferred by extracellular vesicles","volume":"107","author":"Fern\u00e1ndez-Messina","year":"2015","journal-title":"Biol. Cell."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3892\/etm.2020.9499","article-title":"miR-126-5p regulates H9c2 cell proliferation and apoptosis under hypoxic conditions by targeting IL-17A","volume":"21","author":"Ren","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0115","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1139\/bcb-2019-0174","article-title":"MiR-126 targets IL-17A to enhance proliferation and inhibit apoptosis in high-glucose-induced human retinal endothelial cells","volume":"98","author":"Chen","year":"2020","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0120","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/pharmaceutics13010122","article-title":"Unlocking the power of exosomes for crossing biological barriers in drug delivery","volume":"13","author":"Elliott","year":"2021","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113664_bb0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.addr.2012.08.008","article-title":"Exosomes for targeted siRNA delivery across biological barriers","volume":"65","author":"Andaloussi","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12951-018-0389-3","article-title":"Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties","volume":"16","author":"Gu","year":"2018","journal-title":"J. Nanobiotechnol."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113664_bb0135","doi-asserted-by":"crossref","first-page":"13853","DOI":"10.1021\/acsnano.9b04397","article-title":"Tumor-derived extracellular vesicles breach the intact blood\u2013brain barrier via transcytosis","volume":"13","author":"Morad","year":"2019","journal-title":"ACS Nano"},{"issue":"10","key":"10.1016\/j.jconrel.2025.113664_bb0140","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrm1740","article-title":"Semaphorins command cells to move","volume":"6","author":"Kruger","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.biochem.68.1.459","article-title":"Regulation of the cytoskeleton and cell adhesion by the rho family GTPases in mammalian cells","volume":"68","author":"Kaibuchi","year":"1999","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0150","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ncb895","article-title":"Signalling and crosstalk of rho GTPases in mediating axon guidance","volume":"5","author":"Yuan","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.jconrel.2025.113664_bb0155","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ejcb.2016.10.002","article-title":"Netrin-1: a regulator of cancer cell motility?","volume":"95","author":"Ylivinkka","year":"2016","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.113664_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12896-021-00683-w","article-title":"Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope","volume":"21","author":"Aslan","year":"2021","journal-title":"BMC Biotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113664_bb0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/ijms17010013","article-title":"Biobanking of exosomes in the era of precision medicine: are we there yet?","volume":"17","author":"Mora","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113664_bb0170","first-page":"23","article-title":"Niosomal drug delivery for transdermal targeting: recent advances","author":"Muzzalupo","year":"2015","journal-title":"Rese. Reports Transd. Drug Deliv."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0175","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2007.08.005","article-title":"Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes","volume":"123","author":"Dubey","year":"2007","journal-title":"J. Control. Release"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113664_bb0180","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijpharm.2014.06.001","article-title":"Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy","volume":"471","author":"Zhang","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08982104.2013.847956","article-title":"Fluidity enhancement: a critical factor for performance of liposomal transdermal drug delivery system","volume":"24","author":"Sharma","year":"2014","journal-title":"J. Liposome Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113664_bb0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-3659(98)00152-7","article-title":"Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers","volume":"58","author":"Kirjavainen","year":"1999","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2025.113664_bb0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.plipres.2005.08.001","article-title":"The significance of lipid composition for membrane activity: new concepts and ways of assessing function","volume":"44","author":"Vigh","year":"2005","journal-title":"Prog. Lipid Res."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113664_bb0200","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1021\/acs.chemrev.8b00439","article-title":"Biological membrane organization and cellular signaling","volume":"119","author":"Cheng","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2025.113664_bb0205","series-title":"Structure and Properties of Cell Membrane Structure and Properties of Cell Membranes","first-page":"93","article-title":"Membrane fluidity: Molecular basis and physiological significance","author":"Lenaz","year":"2018"},{"key":"10.1016\/j.jconrel.2025.113664_bb0210","first-page":"1","article-title":"Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds","author":"Wei","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.113664_bb0215","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113664_bb0220","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1\u2013deficient mice","volume":"156","author":"Furuse","year":"2002","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113664_bb0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-1605(03)00075-8","article-title":"Inactivation of microbes using ultrasound: a review","volume":"87","author":"Piyasena","year":"2003","journal-title":"Int. J. Food Microbiol."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113664_bb0230","first-page":"59","article-title":"Immunomodulation in choroidal melanoma: reversal of inverted CD4\/CD8 ratios following treatment with ultrasonic hyperthermia","volume":"5","author":"Rosberger","year":"1994","journal-title":"Biotechnol. Ther."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113664_bb0235","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1089\/fpd.2009.0515","article-title":"Inactivation of human enteric virus surrogates by high-intensity ultrasound","volume":"7","author":"Su","year":"2010","journal-title":"Foodborne Pathog. Dis."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925002846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:58:54Z","timestamp":1777870734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925002846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":47,"alternative-id":["S0168365925002846"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113664","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113664"}}