{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:35:13Z","timestamp":1793928913588,"version":"4.8.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2024-00467046"],"award-info":[{"award-number":["RS-2024-00467046"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Korea Ministry of Trade Industry and Energy","doi-asserted-by":"publisher","award":["20019452"],"award-info":[{"award-number":["20019452"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2021M3A9I2080490"],"award-info":[{"award-number":["2021M3A9I2080490"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2021M3A9I2080489"],"award-info":[{"award-number":["2021M3A9I2080489"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2024-00507060"],"award-info":[{"award-number":["RS-2024-00507060"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2024-00507223"],"award-info":[{"award-number":["RS-2024-00507223"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HV22C0009"],"award-info":[{"award-number":["HV22C0009"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["22213MFDS421"],"award-info":[{"award-number":["22213MFDS421"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["RS-2023-00217074"],"award-info":[{"award-number":["RS-2023-00217074"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2023-ER1701-00"],"award-info":[{"award-number":["2023-ER1701-00"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jconrel.2025.113735","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T21:13:51Z","timestamp":1744492431000},"page":"113735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The therapeutic potential of mRNA-encoded SFTSV human monoclonal antibody encapsulated lipid nanoparticle in vivo"],"prefix":"10.1016","volume":"382","author":[{"given":"Soo-Yeon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebeen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-In","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahyeon","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoung","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"Ro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Jin","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Won","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daegeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Myeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hyuk","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hwan","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113735_bb0005","series-title":"Current ICTV Taxonomy Release","author":"ICTV","year":"2020"},{"key":"10.1016\/j.jconrel.2025.113735_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41541-020-00257-5","article-title":"Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development","volume":"5","author":"Bopp","year":"2020","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2025.113735_bb0015","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1038\/s41598-023-35328-9","article-title":"Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113735_bb0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s12276-021-00610-1","article-title":"Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy","volume":"53","author":"Casel","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0025","doi-asserted-by":"crossref","first-page":"E7564","DOI":"10.1073\/pnas.1705176114","article-title":"Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2025.113735_bb0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12250-016-3931-1","article-title":"Current status of severe fever with thrombocytopenia syndrome in China","volume":"32","author":"Zhan","year":"2017","journal-title":"Virol. Sin."},{"key":"10.1016\/j.jconrel.2025.113735_bb0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41541-023-00771-2","article-title":"mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice","volume":"8","author":"Kim","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2025.113735_bb0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/rmv.1776","article-title":"Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics","volume":"24","author":"Liu","year":"2014","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0045","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.129531","article-title":"Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea","volume":"5","author":"Yun","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jconrel.2025.113735_bb0050","author":"WHO"},{"key":"10.1016\/j.jconrel.2025.113735_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111736","article-title":"Age is a critical risk factor for severe fever with thrombocytopenia syndrome","volume":"9","author":"Ding","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.113735_bb0060","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/v16010128","article-title":"Current Progress of severe fever with thrombocytopenia syndrome virus (SFTSV) vaccine development","volume":"16","author":"Kim","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.jconrel.2025.113735_bb0065","series-title":"Emerging Infectious Diseases\/Pathogens","author":"National Institute of Allergy and Infectious Diseases","year":"2018"},{"key":"10.1016\/j.jconrel.2025.113735_bb0070","doi-asserted-by":"crossref","first-page":"167.133","DOI":"10.4049\/jimmunol.204.Supp.167.33","article-title":"Development of a DNA vaccine for SFTSV that confers complete protection against lethal infection in ferrets","volume":"204","author":"Kwak","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007813","article-title":"Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice","volume":"14","author":"Kang","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0080","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fmicb.2020.01473","article-title":"Recombinant human adenovirus type 5 co-expressing RABV G and SFTSV Gn induces protective immunity against rabies virus and severe fever with thrombocytopenia syndrome virus in mice","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actbio.2018.08.033","article-title":"Engineering DNA vaccines against infectious diseases","volume":"80","author":"Lee","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113735_bb0090","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.3390\/ijms19113605","article-title":"DNA vaccines\u2014how far from clinical use?","volume":"19","author":"Hobernik","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113735_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-91445-3","article-title":"Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant","volume":"11","author":"Bang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113735_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007375","article-title":"An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus","volume":"15","author":"Kim","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jconrel.2025.113735_bb0105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-022-00950-y","article-title":"Advances in COVID-19 mRNA vaccine development","volume":"7","author":"Fang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.113735_bb0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12967-019-1804-8","article-title":"How mRNA therapeutics are entering the monoclonal antibody field","volume":"17","author":"Van Hoecke","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0115","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113735_bb0120","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1038\/s12276-023-01086-x","article-title":"Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0125","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1128\/MMBR.00024-15","article-title":"Deconstructing the antiviral neutralizing-antibody response: implications for vaccine development and immunity","volume":"80","author":"VanBlargan","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jconrel.2025.113735_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29099","article-title":"A natural variation in the RNA polymerase of severe fever with thrombocytopenia syndrome virus enhances viral replication and in vivo virulence","volume":"95","author":"Jeon","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0135","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1073\/pnas.1120246109","article-title":"Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57\/BL6 mouse model","volume":"109","author":"Jin","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2025.113735_bb0140","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fmicb.2017.00104","article-title":"Animal models of emerging tick-borne phleboviruses: determining target cells in a lethal model of SFTSV infection","volume":"8","author":"Matsuno","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0145","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.abj5508","article-title":"4\u2032-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication","volume":"375","author":"Sourimant","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.113735_bb0150","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/cid\/cit530","article-title":"Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in China who had severe fever with thrombocytopenia syndrome","volume":"57","author":"Liu","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0155","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fmicb.2020.00150","article-title":"Antiviral drugs against severe fever with thrombocytopenia syndrome virus infection","volume":"11","author":"Takayama-Ito","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0160","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7883\/yoken.67.423","article-title":"Effects of ribavirin on severe fever with thrombocytopenia syndrome virus in vitro","volume":"67","author":"Shimojima","year":"2014","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0165","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1473-3099(18)30293-7","article-title":"Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011\u201317: a prospective observational study","volume":"18","author":"Li","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0170","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/infdis\/jiac135","article-title":"Favipiravir treatment of uncomplicated influenza in adults: results of two phase 3, randomized, double-blind, placebo-controlled trials","volume":"226","author":"Hayden","year":"2022","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107512","article-title":"Favipiravir, an anti-influenza drug against life-threatening RNA virus infections","volume":"209","author":"Shiraki","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.113735_bb0180","article-title":"Experimental treatment with favipiravir for Ebola virus disease (the JIKI trial): a historically controlled, single-arm proof-of-concept trial in Guinea","volume":"13","author":"Sissoko","year":"2016","journal-title":"PLoS Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0185","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1016\/j.vaccine.2017.10.109","article-title":"Re-evaluating the effect of Favipiravir treatment on rabies virus infection","volume":"37","author":"Banyard","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113735_bb0190","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01400-17","article-title":"Extinction of West Nile virus by favipiravir through lethal mutagenesis","volume":"61","author":"Escribano-Romero","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2025.113735_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009103","article-title":"A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome","volume":"15","author":"Suemori","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103591","article-title":"Clinical efficacy and safety evaluation of favipiravir in treating patients with severe fever with thrombocytopenia syndrome","volume":"72","author":"Yuan","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jconrel.2025.113735_bb0205","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00061-15","article-title":"Efficacy of T-705 (Favipiravir) in the treatment of infections with lethal severe fever with thrombocytopenia syndrome virus","volume":"1","author":"Tani","year":"2016","journal-title":"MSphere"},{"key":"10.1016\/j.jconrel.2025.113735_bb0210","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2018.07.009","article-title":"A role for fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus","volume":"24","author":"Gunn","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jconrel.2025.113735_bb0215","article-title":"Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113735_bb0220","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1056\/NEJMoa1608243","article-title":"Effect of HIV antibody VRC01 on viral rebound after treatment interruption","volume":"375","author":"Bar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0225","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nri.2017.148","article-title":"Passive immunotherapy of viral infections:\u2019super-antibodies\u2019 enter the fray","volume":"18","author":"Walker","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0230","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature18929","article-title":"HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption","volume":"535","author":"Scheid","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.113735_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaj1928","article-title":"A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants","volume":"9","author":"Zhu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0240","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJMoa1604330","article-title":"A randomized controlled trial of ZMapp for Ebola virus infection","volume":"375","author":"PREVAIL II Writing Group","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0245","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2017.08.011","article-title":"A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin","volume":"22","author":"Yu","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jconrel.2025.113735_bb0250","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/infdis\/jix292","article-title":"The hemagglutinin a stem antibody MEDI8852 prevents and controls disease and limits transmission of pandemic influenza viruses","volume":"216","author":"Paules","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113735_bb0255","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1128\/JVI.00912-14","article-title":"Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies","volume":"88","author":"Ying","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0260","doi-asserted-by":"crossref","first-page":"10473","DOI":"10.1073\/pnas.1510199112","article-title":"Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus","volume":"112","author":"Corti","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2025.113735_bb0265","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1073\/pnas.1510830112","article-title":"Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection","volume":"112","author":"Pascal","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2025.113735_bb0270","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature20564","article-title":"Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice","volume":"540","author":"Sapparapu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.113735_bb0275","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113735_bb0280","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2017.04.024","article-title":"Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico","volume":"169","author":"Robbiani","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.113735_bb0285","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-022-01007-w","article-title":"mRNA-based therapeutics: powerful and versatile tools to combat diseases","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.113735_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw6647","article-title":"A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection","volume":"4","author":"Kose","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0295","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.1038\/s41467-023-43798-8","article-title":"A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection","volume":"14","author":"Tai","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113735_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030708","article-title":"Aging and interferons: impacts on inflammation and viral disease outcomes","volume":"10","author":"Feng","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2025.113735_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.797189","article-title":"Animal model of severe fever with thrombocytopenia syndrome virus infection","volume":"12","author":"Sun","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113735_bb0310","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41541-023-00684-0","article-title":"Analyzing immune responses to varied mRNA and protein vaccine sequences","volume":"8","author":"Park","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2025.113735_bb0315","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41541-023-00751-6","article-title":"Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability","volume":"8","author":"Zhang","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2025.113735_bb0320","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bioactmat.2024.05.012","article-title":"A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety","volume":"38","author":"Bae","year":"2024","journal-title":"Bioactive Mater."},{"key":"10.1016\/j.jconrel.2025.113735_bb0325","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1128\/JVI.03432-14","article-title":"Reverse genetics system for severe fever with thrombocytopenia syndrome virus","volume":"89","author":"Brennan","year":"2015","journal-title":"J. Virol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925003554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925003554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:55:25Z","timestamp":1777870525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925003554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":65,"alternative-id":["S0168365925003554"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113735","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic potential of mRNA-encoded SFTSV human monoclonal antibody encapsulated lipid nanoparticle in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113735","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113735"}}