{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:36:30Z","timestamp":1786818990718,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221391"],"award-info":[{"award-number":["BK20221391"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["XYRHCX2021016"],"award-info":[{"award-number":["XYRHCX2021016"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20220663"],"award-info":[{"award-number":["BK20220663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302366"],"award-info":[{"award-number":["82302366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jconrel.2025.113788","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:57:39Z","timestamp":1745899059000},"page":"113788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Amplifying STING activation by biomimetic manganese mRNA nanovaccines for local and systemic cancer immunotherapy"],"prefix":"10.1016","volume":"383","author":[{"given":"Chunyan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhou","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingfu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10432","key":"10.1016\/j.jconrel.2025.113788_bb0005","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0140-6736(23)02444-3","article-title":"mRNA-based therapeutics: looking beyond COVID-19 vaccines","volume":"403","author":"Parhiz","year":"2024","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28572","article-title":"mRNA vaccines: the future of prevention of viral infections?","volume":"95","author":"Rzymski","year":"2023","journal-title":"J. Med. Virol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113788_bb0015","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.3390\/ijms24032700","article-title":"A comprehensive review of mRNA vaccines","volume":"24","author":"Gote","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s12274-022-4627-5","article-title":"mRNA-based modalities for infectious disease management","volume":"16","author":"Zhang","year":"2023","journal-title":"Nano research"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113788_bb0025","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.3390\/pharmaceutics15071972","article-title":"Recent advancement in mRNA vaccine development and applications","volume":"15","author":"Al Fayez","year":"2023","journal-title":"Pharmaceutics"},{"issue":"10","key":"10.1016\/j.jconrel.2025.113788_bb0030","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad214","article-title":"STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy","volume":"10","author":"Zhou","year":"2023","journal-title":"Natl Sci Rev"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/v13020270","article-title":"Synthetic messenger RNA-based vaccines: from scorn to hype","volume":"13","author":"Pascolo","year":"2021","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwab159","article-title":"In situ phase transitional polymeric vaccines for improved immunotherapy","volume":"9","author":"Wang","year":"2022","journal-title":"Natl Sci Rev"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113788_bb0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41565-020-0663-z","article-title":"Targeting immune cells within lymph nodes","volume":"15","author":"Porter","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113788_bb0050","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41587-019-0247-3","article-title":"Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation","volume":"37","author":"Miao","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/vaccines7020037","article-title":"A comparison of plasmid DNA and mRNA as vaccine technologies","volume":"7","author":"Liu","year":"2019","journal-title":"Vaccines (Basel)"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113788_bb0060","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwac169","article-title":"Nanocatalytic bacteria disintegration reverses immunosuppression of colorectal cancer","volume":"9","author":"Jiang","year":"2022","journal-title":"Natl Sci Rev"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/pharmaceutics12020102","article-title":"Opportunities and challenges in the delivery of mRNA-based vaccines","volume":"12","author":"Wadhwa","year":"2020","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113788_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk2444","article-title":"Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113788_bb0075","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1021\/acs.nanolett.9b02834","article-title":"Nanoparticle size influences antigen retention and presentation in lymph node follicles for humoral immunity","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113788_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202201595","article-title":"Rough nanovaccines boost antitumor immunity through the enhancement of vaccination cascade and immunogenic cell death induction","volume":"7","author":"Zhao","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.jconrel.2025.113788_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/IJN.S346044","article-title":"Hybrid membrane nanovaccines combined with immune checkpoint blockade to enhance cancer immunotherapy","volume":"17","author":"Zhao","year":"2022","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12951-022-01251-w","article-title":"Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy","volume":"20","author":"Lei","year":"2022","journal-title":"J Nanobiotechnology"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113788_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202002081","article-title":"Recent advances in cell membrane-derived biomimetic nanotechnology for cancer immunotherapy","volume":"10","author":"Raza","year":"2021","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s40820-019-0330-9","article-title":"Cell membrane coating technology: a promising strategy for biomedical applications","volume":"11","author":"Liu","year":"2019","journal-title":"Nano-micro Lett"},{"issue":"null","key":"10.1016\/j.jconrel.2025.113788_bb0105","first-page":"1","article-title":"Hybrid cell membrane-coated nanoparticles: a multifunctional biomimetic platform for cancer diagnosis and therapy","volume":"112","author":"Chen","year":"2020","journal-title":"Acta Biomater."},{"issue":"26","key":"10.1016\/j.jconrel.2025.113788_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300935","article-title":"Black phosphorus nanosheets assist nanoerythrosomes for efficient mRNA vaccine delivery and immune activation","volume":"12","author":"Yang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0115","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.1038\/s41467-021-27386-2","article-title":"Thawing Yedoma permafrost is a neglected nitrous oxide source","volume":"12","author":"Marushchak","year":"2021","journal-title":"Nat. Commun."},{"issue":"33","key":"10.1016\/j.jconrel.2025.113788_bb0120","article-title":"Dendritic cell-mimicking nanoparticles promote mRNA delivery to lymphoid organs","volume":"10","author":"Cao","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"51","key":"10.1016\/j.jconrel.2025.113788_bb0125","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq3500","article-title":"Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants","volume":"8","author":"Fan","year":"2022","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113788_bb0130","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113788_bb0135","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113788_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114172","article-title":"Merging data curation and machine learning to improve nanomedicines","volume":"183","author":"Chen","year":"2022","journal-title":"Adv Drug Deliver Rev"},{"issue":"12","key":"10.1016\/j.jconrel.2025.113788_bb0145","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/j.immuni.2021.11.009","article-title":"Fatballs foster fabulous follicles","volume":"54","author":"Turley","year":"2021","journal-title":"Immunity"},{"issue":"15","key":"10.1016\/j.jconrel.2025.113788_bb0150","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1039\/D2CS00848C","article-title":"Adjuvant physiochemistry and advanced nanotechnology for vaccine development","volume":"52","author":"Ren","year":"2023","journal-title":"Chem. Soc. Rev."},{"issue":"20","key":"10.1016\/j.jconrel.2025.113788_bb0155","doi-asserted-by":"crossref","first-page":"11420","DOI":"10.1021\/acs.chemrev.9b00833","article-title":"Chemical strategies to boost cancer vaccines","volume":"120","author":"Li","year":"2020","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0160","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2020.09.040","article-title":"Why and how vaccines work","volume":"183","author":"Iwasaki","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41551-023-01082-6","article-title":"Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA","volume":"9","author":"Li","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0170","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41392-023-01579-1","article-title":"mRNA vaccines in disease prevention and treatment","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Tar"},{"issue":"4","key":"10.1016\/j.jconrel.2025.113788_bb0175","first-page":"491","article-title":"mRNA vaccines: past, present, future","volume":"17","author":"Karam","year":"2022","journal-title":"Asian J Pharm Sci"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113788_bb0180","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/intimm\/dxac012","article-title":"Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation","volume":"34","author":"Temizoz","year":"2022","journal-title":"Int. Immunol."},{"issue":"10","key":"10.1016\/j.jconrel.2025.113788_bb0185","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1038\/s41596-022-00713-7","article-title":"Nanocarriers based on bacterial membrane materials for cancer vaccine delivery","volume":"17","author":"Zhao","year":"2022","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113788_bb0190","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.20892\/j.issn.2095-3941.2022.0452","article-title":"Bacterial outer membrane vesicle-based cancer nanovaccines","volume":"19","author":"Gao","year":"2022","journal-title":"Cancer Biol. Med."},{"issue":"601","key":"10.1016\/j.jconrel.2025.113788_bb0195","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc2816","article-title":"Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines","volume":"13","author":"Chen","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113788_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121810","article-title":"A heterogenic membrane-based biomimetic hybrid nanoplatform for combining radiotherapy and immunotherapy against breast cancer","volume":"289","author":"Pan","year":"2022","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113788_bb0205","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"41","key":"10.1016\/j.jconrel.2025.113788_bb0210","doi-asserted-by":"crossref","first-page":"34954","DOI":"10.1021\/acsami.8b12355","article-title":"Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET\/MR imaging","volume":"10","author":"Zhu","year":"2018","journal-title":"ACS Appl Mater Inter"},{"key":"10.1016\/j.jconrel.2025.113788_bb0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2017.08.009","article-title":"Lymph node targeting strategies to improve vaccination efficacy","volume":"267","author":"Jiang","year":"2017","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12951-023-02122-8","article-title":"Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles","volume":"21","author":"Chong","year":"2023","journal-title":"J Nanobiotechnology"},{"issue":"51","key":"10.1016\/j.jconrel.2025.113788_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904639","article-title":"Intra\/extracellular lactic acid exhaustion for synergistic metabolic therapy and immunotherapy of tumors","volume":"31","author":"Gao","year":"2019","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113788_bb0230","article-title":"Long-term stability and immunogenicity of lipid nanoparticle COVID-19 mRNA vaccine is affected by particle size","volume":"20","author":"Shi","year":"2024","journal-title":"Hum Vacc Immunother"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113788_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41551-024-01208-4","article-title":"Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers","volume":"9","author":"Yin","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"20","key":"10.1016\/j.jconrel.2025.113788_bb0240","doi-asserted-by":"crossref","first-page":"19550","DOI":"10.1021\/acsnano.3c05635","article-title":"mRNA cancer vaccines: construction and boosting strategies","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113788_bb0245","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41565-018-0342-5","article-title":"Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy","volume":"14","author":"Shae","year":"2019","journal-title":"Nat. Nanotechnol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.113788_bb0250","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm7950","article-title":"In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles","volume":"8","author":"Su","year":"2022","journal-title":"Sci. Adv."},{"issue":"85","key":"10.1016\/j.jconrel.2025.113788_bb0255","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add4817","article-title":"Restoring tumor immunogenicity with dendritic cell reprogramming","volume":"8","author":"Zimmermannova","year":"2023","journal-title":"Sci Immunol"},{"issue":"4","key":"10.1016\/j.jconrel.2025.113788_bb0260","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41590-020-0635-3","article-title":"Lymph node stromal cells: cartographers of the immune system","volume":"21","author":"Krishnamurty","year":"2020","journal-title":"Nat. Immunol."},{"issue":"17","key":"10.1016\/j.jconrel.2025.113788_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207017","article-title":"CCR7 mediated mimetic dendritic cell vaccine homing in lymph node for head and neck squamous cell carcinoma therapy","volume":"10","author":"Xu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.113788_bb0270","article-title":"Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113788_bb0275","article-title":"Lipid-based nanoparticles in the clinic and clinical trials: from cancer nanomedicine to COVID-19 vaccines","volume":"9","author":"Hoang","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.jconrel.2025.113788_bb0280","first-page":"18","article-title":"Robust nanovaccine based on polydopamine-voated mesoporous silica nanoparticles for effective photothermal-immunotherapy against melanoma","volume":"31","author":"Huang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.113788_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121491","article-title":"Immuno-modulation of tumor and tumor draining lymph nodes through enhanced immunogenic chemotherapy by nano-complexed hyaluronic acid\/polyvinyl alcohol microneedle","volume":"325","author":"Shi","year":"2024","journal-title":"Carbohydr. Polym."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:24:14Z","timestamp":1762269854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":57,"alternative-id":["S0168365925004080"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113788","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amplifying STING activation by biomimetic manganese mRNA nanovaccines for local and systemic cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113788"}}